Tag: M.W=200-250

Wang, Ji-Quan published the artcileNovel radiosynthesis of PET HSV-tk gene reporter probes [¹⁸F]FHPG and [¹⁸F]FHBG employing dual Sep-Pak SPE techniques, Recommanded Product: 5-(2-Bromoethyl)-2,2-dimethyl-1,3-dioxane, the publication is Bioorganic & Medicinal Chemistry Letters (2003), 13(22), 3933-3938, database is CAplus and MEDLINE.

Positron emission tomog. (PET) herpes simplex virus thymidine kinase (HSV-tk) gene reporter probes 9-[(3-[¹⁸F]fluoro-1-hydroxy-2-propoxy)methyl]guanine ([¹⁸F]FHPG) [(I); X = O] and 9-(4-[¹⁸F]fluoro-3-hydroxymethylbutyl)guanine ([¹⁸F]FHBG) [I; X = CH₂] were prepared by nucleophilic substitution of the appropriate tosylated precursors with [¹⁸F]KF/Kryptofix 2.2.2 followed by a quick deprotection reaction and purification with a simplified dual Silica Sep-Pak solid-phase extraction (SPE) method in 15-30% radiochem. yield.

Bioorganic & Medicinal Chemistry Letters published new progress about 97845-58-4. 97845-58-4 belongs to bromides-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Bromide, name is 5-(2-Bromoethyl)-2,2-dimethyl-1,3-dioxane, and the molecular formula is C8H6BrClO2, Recommanded Product: 5-(2-Bromoethyl)-2,2-dimethyl-1,3-dioxane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

He, Yang published the artcileImidazolium Gemini ionic liquids for regulating facilely the swelling and dispersion of montmorillonite in water, SDS of cas: 143-15-7, the publication is Applied Clay Science (2022), 106457, database is CAplus.

The imidazolium Gemini ionic liquids (IL), with alkyl groups ranging from Bu to tetradecyl as tail chains and polyoxyethylene group as linker chain, were synthesized and used as novel efficient modifiers for flexibly controlling the swelling and dispersion of Na-montmorillonite (Na-Mt). The correlation between swelling behavior and structure of imidazolium Gemini IL was investigated. Too long or too short tail chains caused greater swelling, obtaining smaller particle size and reductive face-to-face stacking degree of layers. Based on the change of water contact angles, the increased stability of modified Mt in water indicated that the hydrophobicity of the tail chains played an important role in impeding the entry of water mols. into the interlayer. Zeta potential, Fourier transform IR spectra and XPS validated the cation exchange between imidazolium Gemini IL and Na⁺, and confirmed the adsorption site. The mol. arrangement and intercalation were determined through adsorption behavior, interlayer space of Mt and simulation of mol. size. The imidazolium Gemini IL covered the Mt layers in monolayer, finally taking lateral (short tail chains) or paraffin (long tail chains) arrangement. The investigation will provide useful guidance for modifying Mt to obtain desirable properties and broadening the practical application of Mt hybrids.

Applied Clay Science published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, SDS of cas: 143-15-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Yuan, Hua published the artcileAntioxidant and Antibacterial Activities of Dodecyl Tannin Derivative Linked with 1,2,3-Triazole, Formula: C12H25Br, the publication is Chemistry & Biodiversity (2022), 19(1), e202100558, database is CAplus and MEDLINE.

Dodecyl tannin derivative linked with 1,2,3-triazole was prepared by the click reaction of dodecyl azide and alkynylated tannin. The structure of tannin derivative was identified by FT-IR spectrometer and elemental analyzer, and the surface activity, antioxidant activity and antimicrobial activity of tannin derivative were studied. The surface tension of tannin derivative was significantly reduced because of the introduction of long chain alkyl groups, and the lowest surface tension was 38.87 mN/m at 1.0 mg/mL. The tannin derivative had strong ability to scavenge 1,1-diphenyl-2-picrylhydrazyl radical, the scavenging rate could reach 89.08% at 0.25 mg/mL. The tannin derivative exhibited strong antibacterial activity against E. coli and S. aureus due to the increased fat-solubility of tannin derivative and the introduction of antibacterial triazole groups in mol. structure of tannin derivative, and the bacteriostatic ratios of tannin derivative against E. coli and S. aureus were 92.16% and 89.21% at 2.0 mg/mL, resp. The tannin derivative can be used as good candidates for antibacterial packaging or antioxidant supplements.

Chemistry & Biodiversity published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H9NO, Formula: C12H25Br.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhang, Yuchi published the artcileCyclodextrin single isomer-based vesicle for chlorin e6 delivery and enhanced efficiency of photodynamic therapy for cancer treatment, Safety of 1-Bromododecane, the publication is Journal of Molecular Liquids (2022), 118683, database is CAplus.

In the field of cancer therapy, photodynamic therapy (PDT) is an emerging treatment modality that utilized light, photosensitizers (PSs), and oxygen to generate reactive oxygen species (ROS) to destroy tumor sites selectively. Conventional PSs experience issues such as poor water solubility and low bioavailability. The widely developed PS delivery nanosystems can address these problems, but most of them usually depend on relatively complex components and time-consuming synthesis procedures. Therefore, PS delivery vehicles with more easily obtained components and simpler preparation methods need to be explored. In this study, amphiphilic and cationic single-isomer cyclodextrin (CD-IL) was designed, which could co-assemble with chlorin e6 (Ce6, a com. available PS) via multiple non-covalent interactions. The obtained nanovesicles (CD-CE) could not only overcome the inherent drawbacks of free Ce6, but also exhibit improved PDT efficacy in a series of cell-related experiments, including favorable stability, preferable cellular uptake, and enhanced phototoxicity. Thus, CD-CE prepared by the co-assembly of simple building blocks could be a facile option for PDT clin. applications.

Journal of Molecular Liquids published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is CBF6K, Safety of 1-Bromododecane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Snider, Barry B. published the artcileControl of the regioselectivity of oxidative free-radical cyclizations by addition to haloalkenes, Name: (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Journal of Organic Chemistry (1992), 57(15), 4195-205, database is CAplus.

Chlorine substituents on the alkene control the regioselectivity of the cyclization of 5-hexenyl or 6-heptenyl radicals generated by oxidation of an acetoacetate ester or 1,3-diketone with Mn(OAc)₃·2H₂O. 6-exo-Cyclization of the radicals obtained by oxidation of benzoylacetone derivatives RCOCH₂CO(CH₂)₃CH:CHCl [R = Ph, 2,4-(MeO)₂C₆H₃], containing a chlorine on the terminal double bond carbon, gives α-chloroalkyl radicals that add to the aromatic ring which by elimination of HCl leads to naphthols I (R¹ = H, OMe) indicating that this reaction may be useful for aureolic acid synthesis . exo-Cyclization is the exclusive process with acetoacetates e.g., CH₂:CHCH₂CH(CO₂Me)CO(CH₂)₂CH:CHCl, containing a chlorine on the terminal double bond carbon. 6-endo-Cyclization is the exclusive process with acetoacetates e.g., CH₂:CHCH₂CH(CO₂Me)CO(CH₂)₂CCl:CH₂, containing a chlorine on the internal double bond carbon. Intra- and intermol. competition experiments indicate that these effects are primarily steric. The chlorine substituent controls the regioselectivity of the cyclization by sterically hindering attack of the radical on the chlorine bearing double bond carbon thereby retarding formation of the β-chloroalkyl radical. The chlorine substituent does not electronically accelerate attack on the other end of the double bond to give the α-chloroalkyl radical.

Journal of Organic Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H5Br2F, Name: (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhang, Yuxian published the artcileSynthesis of Nitrated N-Alkyl Anilines Using N-Nitroso Anilines as a Self-Providing Nitro Group Source, SDS of cas: 53484-26-7, the publication is Asian Journal of Organic Chemistry (2019), 8(12), 2205-2208, database is CAplus.

In the presence of dioxygen, an efficient synthesis of nitrated N-alkyl anilines was realized using N-nitroso anilines as the starting material. According to the mechanistic study, the N-nitroso anilines served as a self-providing nitro group source to promote the direct nitration of N-alkylanilines, avoiding the undesired protection of amine group.

Asian Journal of Organic Chemistry published new progress about 53484-26-7. 53484-26-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Nitro Compound,Amine,Benzene, name is 4-Bromo-N-methyl-2-nitroaniline, and the molecular formula is C9H6FNO2, SDS of cas: 53484-26-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Fan, Xiaozhong published the artcileEnantioselective Atropisomeric Anilides Synthesis via Cu-Catalyzed Intramolecular Adjacent C-N Coupling, Safety of 2-Bromo-5-methoxybenzene boronic acid, the publication is ACS Catalysis (2019), 9(3), 2286-2291, database is CAplus.

Catalytically asym. synthesis of atropisomeric compounds is an important research area in organic synthesis. However, in comparison with C-C atropisomers, the atropisomers caused by the restricted rotation of C-N single bonds have been given less attention because of the limited methods for accessing these compounds Herein we report a Cu-catalyzed enantioselective intramol. Ullmann-type amination reaction for the synthesis of C-N atropisomers. The C-N axial chirality was induced highly efficiently by the intramol. adjacent C-N cross-coupling. The readily prepared N,N’-(cyclohexane-1,2-diyl)dipicolinamides showed high efficacy and stereoinduction (up to 99% ee).

ACS Catalysis published new progress about 89694-44-0. 89694-44-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 2-Bromo-5-methoxybenzene boronic acid, and the molecular formula is C7H8BBrO3, Safety of 2-Bromo-5-methoxybenzene boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zu, Pengjiao published the artcileStructure design and performance investigation of 2-mercapto-5-methyl thiadiazole based ionic liquids as lubricants and corrosion inhibitors, Application of 1-Bromododecane, the publication is Tribology International (2022), 107682, database is CAplus.

2-Mercapto-5-methyl-1,3,4-thiadiazole (MMT) based ionic liquids were synthesized, their corrosion inhibition behavior and tribol. performance were systematically evaluated. Electrochem. experiments showed MMT based ILs exhibited surprising corrosion inhibition efficiencies. The ILs adsorption behavior obeys Langmuir isotherm. Friction tests demonstrated MMT based ILs performed excellent lubrication properties, compared to [BMIM][BF4]. Combining with anal. of SEM and XPS, it can be concluded that the prominent lubrication performance ascribed to the coexistence of adsorption layer and tribo-film. Therefore, versatile ILs designed in this paper have gathered two significant abilities for industrial applications, which are high corrosion inhibiting performance and excellent lubricating properties. This work is instructive for structure design of multifunctional ILs and will promote industrial application of MMT based ILs in the future.

Tribology International published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C7H16ClNO2, Application of 1-Bromododecane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Mu, Bin published the artcilePositional Isomerism-Mediated Copolymerization Realizing the Continuous Luminescence Color-Tuning of Liquid-Crystalline Polymers, Synthetic Route of 143-15-7, the publication is Macromolecules (Washington, DC, United States) (2022), 55(13), 5332-5341, database is CAplus.

Liquid crystals with color-tunable light emission are important for a variety of applications; however, achieving multicolor light-emitting liquid crystals whose emission colors can be fine-tuned remains challenging because the limited derivatization of mesogenic fluorophores disfavors the diversity of the emission. Here, we present a positional isomerism-mediated copolymerization strategy to obtain liquid-crystalline polymers with continuous luminescence color-tuning ability. The introduced α-/β-cyanostilbene positional isomers possess very similar mol. structures, thus reducing the risk of assembly heterogeneity and facilitating the formation of a homogeneous and consistent liquid crystal mesophase. Meanwhile, a significant electronic effect was caused for fluorophores with positional isomerization, allowing the efficient tuning of emission colors via copolymerization Especially with a gradual change in the composition of the copolymers, the emission color shift behaved in a continuous manner from blue to green. These cyanostilbene-based liquid-crystalline polymers also showed reversible photochromic fluorescence switching ability. This approach highlights the value of positional isomers to prepare color-tunable solid-state light-emitting materials, allowing control and fine-tuning of the emission property while maintaining the ordered assembly ability.

Macromolecules (Washington, DC, United States) published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, Synthetic Route of 143-15-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Shao, Jiahui published the artcileHumic acid rejection and flux decline with negatively charged membranes of different spacer arm lengths and charge groups, Formula: C3H6BrNaO3S, the publication is Journal of Membrane Science (2013), 38-45, database is CAplus.

A series of novel charged ultrafiltration membranes that differed in spacer arm length and charge group were generated by covalent attachment of neg. charged group to a com. available regenerated cellulose membrane. Rejection of humic acid and flux decline were compared with essentially neutral and neg. charged versions of regenerated cellulose membranes of different spacer arm lengths and charge groups. Effects of membrane mol. weight cut-off and solution pH on humic acid removal and flux decline on neutral and neg. charged membranes of different spacer arm lengths were also compared. The membrane with larger spacer arm length has better rejection of humic acid and less membrane fouling compared to that with smaller spacer arm length. The modified neg. charged membrane with a strongly acidic (sulfonic acid) functional group has better rejection of humic acid and less membrane fouling than that with a weakly acidic (carboxylic acid) functional group. These exptl. results are consistent with the larger charge of the membranes having larger spacer arm length and sulfonic acid group. This study confirms that the appropriate design of membrane charge functionality could be an effective way for better removal of humic acid and reduction of membrane fouling due to the electrostatic interactions with the combination effect of membrane pore size.

Journal of Membrane Science published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C8H8O3, Formula: C3H6BrNaO3S.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary