Tag: M.W=200-300

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Kaur, Hardeep; Balzarini, Jan; de Kock, Carmen; Smith, Peter J.; Chibale, Kelly; Singh, Kamaljit researched the compound: 7-Chloro-4-(piperazin-1-yl)quinoline( cas:837-52-5 ).Electric Literature of C13H14ClN3.They published the article 《Synthesis, antiplasmodial activity and mechanistic studies of pyrimidine-5-carbonitrile and quinoline hybrids》 about this compound( cas:837-52-5 ) in European Journal of Medicinal Chemistry. Keywords: cyanopyridine quinoline preparation SAR antiplasmodial activity; 4-Aminoquinoline; Antiplasmodial agents; Cytotoxic activity; Heme binding; Hybrid antimalarials; Pyrimidine. We’ll tell you more about this compound (cas:837-52-5).

A series of hybrids I [R1 = H, 3-NO2, 4-Me, etc, R2 = SMe, morpholinyl; R3 = -NH(CH2)3NH-, -NH(CH2)4NH-, -O(CH2)3NH-, etc.] comprising of 5-cyanopyrimidine and quinoline moiety were synthesized and tested for in vitro antiplasmodial activity against NF54 and Dd2 strains of Plasmodium falciparum. Hybrid bearing m-nitrophenyl substituent at C-4 of pyrimidine displayed the highest antiplasmodial activity [IC50 = 56 nM] against the CQR (Dd2) strain, which is four-fold greater than CQ.

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 8-Bromooctanoic acid, is researched, Molecular C8H15BrO2, CAS is 17696-11-6, about A nicotinamide phosphoribosyltransferase-GAPDH interaction sustains the stress-induced NMN/NAD+ salvage pathway in the nucleus.Computed Properties of C8H15BrO2.

All cells require sustained intracellular energy flux, which is driven by redox chem. at the subcellular level. NAD+, its phosphorylated variant NAD(P)+, and its reduced forms NAD(P)/NAD(P)H are all redox cofactors with key roles in energy metabolism and are substrates for several NAD-consuming enzymes (e.g. poly(ADP-ribose) polymerases, sirtuins, and others). The nicotinamide salvage pathway, constituted by NMN adenylyltransferase (NMNAT) and nicotinamide phosphoribosyltransferase (NAMPT), mainly replenishes NAD+ in eukaryotes. However, unlike NMNAT1, NAMPT is not known to be a nuclear protein, prompting the question of how the nuclear NAD+ pool is maintained and how it is replenished upon NAD+ consumption. In the present work, using human and murine cells; immunoprecipitation, pulldown, and surface plasmon resonance assays; and immunofluorescence, small-angle X-ray scattering, and MS-based analyses, we report that GAPDH and NAMPT form a stable complex that is essential for nuclear translocation of NAMPT. This translocation furnishes NMN to replenish NAD+ to compensate for the activation of NAD-consuming enzymes by stressful stimuli induced by exposure to H2O2 or S-nitrosoglutathione and DNAdamage inducers. These results indicate that by forming a complex with GAPDH, NAMPT can translocate to the nucleus and thereby sustain the stress-induced NMN/NAD salvage pathway.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Discovery of potent small molecule PROTACs targeting mutant EGFR, published in 2020-12-15, which mentions a compound: 17696-11-6, Name is 8-Bromooctanoic acid, Molecular C8H15BrO2, HPLC of Formula: 17696-11-6.

Epidermal growth factor receptor (EGFR) is an important therapeutic target for the treatment of non-small cell lung cancer. A number of efficacious EGFR tyrosine kinase inhibitors have been developed. However, acquired drug resistance largely encumbered their clin. practicability. Therefore, there is an urgent need to develop new therapeutic regime. Herein, we designed and synthesized a set of EGFR-targeting small mol. PROTACs which showed promising efficacy. In particular, VHL-recruiting compound P3 showed potent anti-proliferative activity against HCC827 and H1975 cell lines with IC50 values of 0.83 and 203.01 nM, resp. Furthermore, both EGFRdel19 and EGFRL858R/T790M could be significantly induced to be degraded under treatment of P3 with DC50 values of 0.51 and 126.2 nM, resp. Compound P3 was able to dramatically suppress EGFR pathway signal transduction. Moreover, compound P3 could significantly induce cell apoptosis, arrest cell cycle and suppress cell colony formation. In addition, we identified that ubiquitination was indispensable in the degradation process, and found that the degradation was related to autophagy. Our work would provide an alternative approach for development of potentially effective EGFR degraders and give a new clue for investigation of PROTAC-induced protein degradation

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Reference of 7-Chloro-4-(piperazin-1-yl)quinoline. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Design and synthesis of chloroquine analogs with anti-breast cancer property. Author is Solomon, V. R.; Hu, Changkun; Lee, Hoyun.

A series of chloroquine (CQ) analogs were designed and synthesized in a repositioning approach to develop compounds with high anti-breast cancer property. The compounds were then examined for their antiproliferative effects on two human breast tumor cell lines and a matching non-cancer cell line. Although many of them showed substantial antiproliferative effects on breast cancer cells examined, two compounds, 7-chloro-N-(3-(4-(7-(trifluoromethyl)quinolin-4-yl)piperazin-1-yl)propyl)quinolin-4-amine I and {3-[4-(7-chloro-quinolin-4-yl)-piperazin-1-yl]-propyl}-(7-trifluoromethyl-quinolin-4-yl)-amine II, emerged as the most active among this series. They were particularly potent against MCF7 cells when compared to CQ and cisplatin, a widely prescribed anti-cancer drug. The results suggest that these CQ analogs could serve as bases for the development of a new group of effective cancer chemotherapeutics.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Synthesis of Alkyl Triphenylphosphonium Ostruthin Derivatives as Potential Cytotoxic Candidates, published in 2020-10-12, which mentions a compound: 17696-11-6, Name is 8-Bromooctanoic acid, Molecular C8H15BrO2, Recommanded Product: 17696-11-6.

Ostruthin, isolated from Paramignya trimera, was used as a scaffold to design its alkyl triphenylphosphonium derivatives With the optimal reaction conditions in hand, five alkyl triphenylphosphonium ostruthin derivatives I [n = 3, 4, 5, etc.] were synthesized. Ostruthin and its derivatives I were tested for cytotoxicity against human PANC-1 pancreatic, HeLa cervical, and HepG2 liver cancer cell lines. Ostruthin and its hexyl and heptyl triphenylphosphonium derivatives I [n = 6, 7] showed strong preferential cytotoxicity against PANC-1 cells with the PC50 values of 10.3 and 14.4μM, resp. In addition, compounds I [n = 6, 7] also exhibited potent cytotoxicity towards HeLa cells with the IC50 values of 24.8 and 18.5μM, resp. The hexyl triphenylphosphonium group in I [n = 6] was found to slightly enhance cytotoxicity against HepG2 cells. Further, the morphol. changes and the live-cell imaging result suggested the anticancer potential against HeLa cells of the synthesized ostruthin derivative I [n = 7].

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Aboul-Enein, Mohamed Nabil; Abd El-Sattar El-Azzouny, Aida M.; Abdel-Fattah Ragab, Fatma; Hamissa, Mohamed Farouk published the article 《Design, Synthesis, and Cytotoxic Evaluation of Certain 7-Chloro-4-(piperazin-1-yl)quinoline Derivatives as VEGFR-II Inhibitors》. Keywords: chloropiperazinyl quinoline derivative preparation VEGFR inhibitor cancer; Chloro-4-(piperazin-1-yl)quinolines; Cytotoxic evaluation; Human breast cancer cell line (MCF-7); Human prostate cancer cell line (PC3); VEGFR-II.They researched the compound: 7-Chloro-4-(piperazin-1-yl)quinoline( cas:837-52-5 ).HPLC of Formula: 837-52-5. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:837-52-5) here.

Signaling pathway inhibition of VEGFR-II is visualized as valuable tool in cancer management. In the current study, the synthesis of novel 1-(4-(7-chloroquinolin-4-yl)piperazin-1-yl)-2-(N-substituted-amino)-ethanone derivatives (4a-t) was achieved through the amination of 2-chloro-1-(4-(7-chloroquinolin-4-yl)piperazin-1-yl)ethanone (3) with different secondary amines. The structures of the target compounds were confirmed by IR, 1H-NMR, 13C-NMR, HRMS, and microanal. Compounds 4a-t were subjected to in vitro anticancer screening against human breast cancer (MCF-7) and prostate cancer (PC3) cell lines. The highest cytotoxicty against both cell lines was displayed by 2-(4-(4-bromobenzyl)piperazin-1-yl)-1-(4-(7-chloroquinolin-4-yl)piperazin-1-yl)ethanone (4q), with IC50 values of 6.502 and 11.751 μM against MCF-7 and PC3 cells, resp., compared with the standard drug doxorubicin (MCF-7: 6.774 μM, PC3: 7.7316 μM). Due to its notable activity toward MCF-7 cells, 4q was further evaluated as VEGFR-II inhibitor, showing an IC50 of 1.38 μM compared to sorafenib (0.33 μM). The docking study proved that 4q has a binding mode akin to that of VEGFR-II inhibitors.

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Sun, Xiao-Peng; Liu, Tao; Yao, Zi-Shuo; Tao, Jun published the article 《Spin crossover and photomagnetic behaviors in one-dimensional looped coordination polymers》. Keywords: dipyridyl disulfide iron complex preparation spin crossover photomagnetic behavior; coordination polymer dipyridyl disulfide iron complex preparation light induced.They researched the compound: 4,4-Dipyridyl Disulfide( cas:2645-22-9 ).Recommanded Product: 4,4-Dipyridyl Disulfide. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:2645-22-9) here.

Three one-dimensional looped coordination polymers with the formula of [Fe(dpds)2{C(CN)3}2]·dpds (1, dpds = 4,4′-dipyridyl disulfide), [Fe(dpds)2(NCBH3)2] (2) and [Fe(dpds)2(NCSe)2]·3.5H2O (3) have been synthesized and characterized by single-crystal x-ray crystallog., Moessbauer spectroscopy and magnetic measurements. The spin-crossover (SCO) behaviors of these compounds depend significantly on axial ligands: compound 1 exhibited thermal-induced complete one-step SCO behavior with a T1/2 of 170 K, and 2 showed incomplete SCO behavior with T1/2 being 130 K, whereas 3 was paramagnetic. Meanwhile, both compounds 1 and 2 displayed light-induced excited spin-state trapping (LIESST) effects, featuring TLIESST values of 45 K and 61 K for 1 and 2, resp., which were independent of exciting laser wavelengths. These results suggest that anions such as C(CN)3- and NCBH3- with much stronger ligand fields are needed in order to realize spin-state switching, if a ligand such as dpds is adopted to synthesize SCO compounds

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Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 6-Bromo-3-methyl-1H-indole, is researched, Molecular C9H8BrN, CAS is 1219741-50-0, about Lewis acid-catalyzed [3+2] coupling of indoles with quinone monoacetals or quinone imine ketal.Computed Properties of C9H8BrN.

The one-pot synthesis of benzofuroindolines and tetrahydroindolo[2,3-b]indoles was accomplished through a mild and concise [3+2] coupling of indoles and quinone monoacetals or quinone imine ketal promoted by a Lewis acid. A wide variety of benzofuroindolines and tetrahydroindolo[2,3-b]indoles were prepared in moderate to good yields. The structures of the products were determined by spectroscopic anal. and their relative configuration was confirmed by single crystal x-ray diffraction anal. of tetrahydroindolo[2,3-b]indole derivative I [triclinic, space group P-1, a 9.0872(4), b 10.6606(4), c 11.1102(5) Å, α 87.728(5), β 81.405(4), γ 81.279(4)°, V 1051.75(8) Å3, Z 2]. The detailed crystallog. data were deposited at the Cambridge Crystallog. Data Center as supplementary publication number CCDC 983833.

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The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 6-Bromo-3-methyl-1H-indole(SMILESS: CC1=CNC2=C1C=CC(Br)=C2,cas:1219741-50-0) is researched.Related Products of 60827-45-4. The article 《Facile synthesis of 9H-pyrrolo[1,2-a]indoles via Bronsted acid catalyzed cascade reactions》 in relation to this compound, is published in Chemical Communications (Cambridge, United Kingdom). Let’s take a look at the latest research on this compound (cas:1219741-50-0).

An efficient Bronsted acid catalyzed Friedel-Crafts alkenylation/1,6-addition/condensation cascade reaction has been developed. This protocol enables effective access to various highly functionalized 9H-pyrrolo[1,2-a]indoles I (R1 = Bu, 3-chlorophenyl, thiophen-2-yl, etc.; R2 = Me, thiophen-2-yl, naphthalen-1-yl, etc.; R3 = H, 7-Me, 8-MeO, 6-F, etc.; R4 = Me, phenyl; R5 = H, 6-Cl, 7-MeO, etc.) in moderate to high yields. Mechanistic studies indicate that the in situ vinylogous reactivity intermediate might be formed in the catalytic system.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 837-52-5, is researched, SMILESS is C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3, Molecular C13H14ClN3Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Medicinal Chemistry called Optimization of 4-Aminoquinoline/Clotrimazole-Based Hybrid Antimalarials: Further Structure-Activity Relationships, in Vivo Studies, and Preliminary Toxicity Profiling, Author is Gemma, Sandra; Camodeca, Caterina; Sanna Coccone, Salvatore; Joshi, Bhupendra P.; Bernetti, Matteo; Moretti, Vittoria; Brogi, Simone; Bonache de Marcos, Maria Cruz; Savini, Luisa; Taramelli, Donatella; Basilico, Nicoletta; Parapini, Silvia; Rottmann, Matthias; Brun, Reto; Lamponi, Stefania; Caccia, Silvio; Guiso, Giovanna; Summers, Robert L.; E. Martin, Rowena; Saponara, Simona; Gorelli, Beatrice; Novellino, Ettore; Campiani, Giuseppe; Butini, Stefania, the main research direction is antimalarial aminoquinoline clotrimazole hybrid preparation toxicity pharmacokinetics modeling; structure activity antimalarial aminoquinoline clotrimazole hybrid preparation modeling.Computed Properties of C13H14ClN3.

Despite recent progress in the fight against malaria, the emergence and spread of drug-resistant parasites remains a serious obstacle to the treatment of infections. We recently reported the development of a novel antimalarial drug that combines the 4-aminoquinoline pharmacophore of chloroquine with that of clotrimazole-based antimalarials. Here we describe the optimization of this class of hybrid drug through in-depth structure-activity relation studies. Antiplasmodial properties and mode of action were characterized in vitro and in vivo, and interactions with the parasite’s ‘chloroquine resistance transporter’ were investigated in a Xenopus laevis oocyte expression system. These tests indicated that piperazine derivatives 4b and 4d may be suitable for coadministration with chloroquine against chloroquine-resistant parasites. The potential for metabolism of the drugs by cytochrome P 450 was determined in silico, and the lead compounds were tested for toxicity and mutagenicity. A preliminary pharmacokinetic anal. undertaken in mice indicated that compound 4b has an optimal half-life.

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