Tag: M.W=200-300

Reference of 67567-26-4, The chemical industry reduces the impact on the environment during synthesis 67567-26-4, name is 4-Bromo-2,6-difluoroaniline, I believe this compound will play a more active role in future production and life.

A solution of 4-bromo-2,6-difluoroaniline (15g) in dry DMF (180ml) was degassed for SOmin. Water (42ml) was added and the solution was further degassed for 10min. n-Butyl vinyl ether (46.60ml), 1,3-bis(diphenylphosphiho)propane (1.96g), potassium carbonate (11.76g), and palladium (II) acetate (0.48g) were added and the mixture was stirred at 80C under nitrogen for 6h and then at ambient temperature for 18h. The5 mixture was concentrated under reduced pressure. The residue was partitioned between ethyl acetate and water. The separated organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was treated with MeCN (100ml), water (100ml) and formic acid (2ml) and stirred at ambient temperature for 45min. The mixture was concentrated under reduced pressure and partitioned between) DCM and saturated aqueous sodium bicarbonate solution. The separated organic layer was dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by flash vacuum chromatography (silica, eluting withether). Trituration with cyclohexane afforded a solid which was filtered and dried undervacuum at ambient temperature to give the title compound (10.47g) as a cream solid.Mass spectrum: Found MM* 172H.p.l.c. Rt 2.27 min

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-2,6-difluoroaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXO GROUP LIMITED; WO2004/110997; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 960203-41-2, name is (2-Bromophenyl)(2,4-dimethylphenyl)sulfane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 960203-41-2, Quality Control of (2-Bromophenyl)(2,4-dimethylphenyl)sulfane

Under nitrogen protection, In a 500-mL reactor were charged 13.8 g (0.1 mol) The compound of the formula (4) 2,4-dimethylthiophenol, 28.3 g (0.1? Bromoiodobenzene, 53.0 g (0.25 mol) Potassium phosphate and 1. 9 g (0. Olmol) Cuprous iodide, 1.15 g (0.01 mol) L-proline, 300 mL of dimethylformamide was added, Stirring heated to 70-80 ° C, Reaction 5h, After completion of the reaction, To the reaction solution, 9. 46 g (0.11 mol) Piperazine, Heating was continued for 5-8 hours, After completion of the reaction, a portion of the solvent was distilled off. The residue was added with water and extracted three times with 300 ml of methylene chloride. The organic layers were combined, dried and evaporated to give methylene chloride. The residue was recrystallized from 200 mL of acetonitrile to give 28.8 g of a white solid, yield 96.7percent, purity 99.2percent (HPLC): Luna Phenyl-Hexyl column (4.6 mm × 150 mm, 3 um) was used as the mobile phase. The mobile phase consisted of 0 · 05percent trifluoroacetic acid (60:40) Temperature 40 ° C; flow rate lml / min].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (2-Bromophenyl)(2,4-dimethylphenyl)sulfane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Feng, Xiuwu; (7 pag.)CN104098530; (2016); B;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 25462-61-7, The chemical industry reduces the impact on the environment during synthesis 25462-61-7, name is 2,5-Dibromobenzene-1,4-diamine, I believe this compound will play a more active role in future production and life.

Under a stream of nitrogen 2,5-dibromobenzene-1 ,4-diamine (53.18 g, 200.0 mmol), phenyl acetylene (40.86 g, 400.0 mmol), Cs2CO3 (260.66 g, 800.0 mmol), [Cu(phen)(PPh3)2]NO3 (33.21 g, 40.0 mmol), were combined and mixed to toluene (2 L) was stirred at 110 C for 24 hours. Put Sodium butoxide (115.32 g, 1200.0 mmol) was stirred for for 2 h at 110 C. After completion of the reaction, and extracted with methylene chloride, it was put into the filter MgSO4. The solvent of the filtered organic layer was purified by column chromatography to Sub 1-1 (39.47 g, yield: 64%) was obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,5-Dibromobenzene-1,4-diamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Doosan Corporation; Jo, Hung Sang; Son, Hyo Suk; (40 pag.)KR2016/78138; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3972-65-4, name is 1-Bromo-4-(tert-butyl)benzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: bromides-buliding-blocks

A screw-cap vial equipped with a magnetic stir bar was charged with aryl halide (1 mmol), hexa-n-butylditin (0.5 mmol),palladium acetate (0.01 mmol) and tricyclohexylphosphine (0.02 mmol),followed by anhydrous cesium fluoride (1.5 mmol). The resulting mixture was manually homogenized with a magnet. A vial was transferred to a preheated oil bath (110 C). After 24 h, the mixture was cooled, dissolved in CH2Cl2-H2O mixture (1:1), the organic phase was separated, the solvent was evaporated in vacuo and the product was isolated by flash chromatography on a silica gel by elution with hexane-CH2Cl2 mixture.

The synthetic route of 3972-65-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Gribanov, Pavel S.; Golenko, Yulia D.; Topchiy, Maxim A.; Philippova, Anna N.; Kirilenko, Nikita Yu.; Krivoshchapov, Nikolai V.; Sterligov, Grigorii K.; Asachenko, Andrey F.; Bermeshev, Maxim V.; Nechaev, Mikhail S.; Mendeleev Communications; vol. 28; 3; (2018); p. 323 – 325;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 68322-84-9, name is 2-Bromo-1-fluoro-4-(trifluoromethyl)benzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 68322-84-9, Computed Properties of C7H3BrF4

A solution of 2-bromo-1-fluoro-4-(trifluoromethyl)benzene (4.6 g), 3-hydroxypyrrolidine (1.5 g), palladium(II) acetate (193 mg), (+/-)-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (1.07 g) and cesium carbonate (16.8 g) in toluene (90 ml) was stirred under an argon gas atmosphere at 85 C. for 16 hr. After cooling to room temperature, water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and filtered. The filtrate was concentrated, and the residue was purified by silica gel column chromatography (hexane/ethyl acetate 90:10-65:35) to give the title compound (2.12 g, yield 49%) as a brown oil.1H-NMR (300 MHz, CDCl3) delta: 1.67 (d, J=4.3 Hz, 1H), 1.96-2.23 (m, 2H), 3.35-3.49 (m, 2H), 3.56-3.76 (m, 2H), 4.49-4.65 (m, 1H), 6.79-6.88 (m, 1H), 6.88-6.96 (m, 1H), 6.97-7.10 (m, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Kasai, Shizuo; Kamaura, Masahiro; Cho, Nobuo; US2011/251187; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 58971-11-2, name is 3-Bromophenethylamine, A new synthetic method of this compound is introduced below., Safety of 3-Bromophenethylamine

A mixture of 2-(3-bromophenyl)ethanamine (0.7 mL, 4.9 mmol), acetic anhydride (1 mL, 10.6 mmol), triethylamine (1.4 mL, 10.0 mmol) and DCM (25 mL) was stirred at RT or 18 h, diluted with DCM (50 mL) and washed with NaHCO3 (aq. sat.) (50 mL). The organic phase was separated and dried over Na2SO4, filtered reduced in vacuo. The residue was purified by silica column chromatography eluting with 20-100% EtOAc in Pet. Ether to afford N-[2-(3-bromophenyl)ethyl]acetamide (1.19 g, 4.92 mmol, 99% yield). UPLC-MS (ES+, Method A): 1.41 min, m/z 243.9 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; REDX PHARMA PLC; JONES, Clifford, D.; BUNYARD, Peter; PITT, Gary; BYRNE, Liam; PESNOT, Thomas; GUISOT, Nicolas, E.S.; (318 pag.)WO2019/145729; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 138526-69-9,Some common heterocyclic compound, 138526-69-9, name is 1-Bromo-3,4,5-trifluorobenzene, molecular formula is C6H2BrF3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of the styrene (3 mmol), the halogenated benzene (3 mmol), triethanolamine (3 mmol) and Pd(II) acetate (0.03 g) was stirred under argon at 100 C for 24 h. The reaction was cooled to 25 C, quenched by the addition of dil. aq. hydrochloric acid (2 N, 10 ml), and extracted with ether (3 × 100 ml). The organic phases were dried (Na2SO4), the solvents evaporated, and the crude product subjected to chromatography (silica gel, hexane/ethyl acetate mixtures).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-3,4,5-trifluorobenzene, its application will become more common.

Reference:
Article; Albert, Sabrina; Horbach, Ralf; Deising, Holger B.; Siewert, Bianka; Csuk, Rene; Bioorganic and Medicinal Chemistry; vol. 19; 17; (2011); p. 5155 – 5166;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 57946-63-1, name is 2-Bromo-4-(trifluoromethyl)aniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 57946-63-1, HPLC of Formula: C7H5BrF3N

Example 139 Synthesis of 5- [Acetyl- (3, 5-bis-trifluoromethyl-benzyl)-amino]-7-trifluoromethyl-2, 3,4, 5- tetrahydro-benzo [b] azepine-1-carboxylic acid tert-butyl ester. Step 1. Preparation of Methyl-3-trifluoromethyl-2-aminobenzoate Add palladium (II) acetate (1.89 g, 8.4 mmol), 1,1- bis (diphenylphosphino) ferrocene (6.83 g, 12.3 mmol), and triethyl amine (32 mL, 44.0 mmol) to a solution of 2-bromo-4-trifluoromethylanaline (10.0 g, 42.0 mmol) in dimethylsulfoxide (283 mL) and methanol (187 mL). At 100 psi of carbon monoxide, heat the mixture to 80 °C. After heating for 14-16 h cool the reaction to room temperature and filter. Dilute the organics with ethyl acetate (500 mL), wash with water (3×200 mL) and brine (200 mL). Dry the organics over sodium sulfate and filter. Remove solvent under vacuum and chromatograph the crude product using ethyl acetate/hexane (10 percent) to elute. This provides the title compound (8.0 g, 88percent) as an off white solid: H NMR (CDC13,400 MHz) 8 3.93 (s, 3H), 6.11 (bs, 2H), 6.73 (d, J = 8.4 Hz, 1H), 7.49 (dd, J = 2.0, 8.4 Hz, 1H), 8.17 (d, J = 2.0 Hz, 1H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; ELI LILLY AND COMPANY; WO2005/37796; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 418762-26-2, name is 4-Bromo-2-fluoro-5-methylaniline, molecular formula is C7H7BrFN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C7H7BrFN

To a solution of 4-bromo-2-fluoro-5-methylaniline (1.10 g, 5.39 mmol), ethyl 4-(3-methylbutanoyl)benzoate (1.26 g, 5.39 mmol) and Et3N (2.25 ml, 16.2 mmol) in DCM (100 ml) was added TiCl4 (2.7 ml, 2.7 mmol) dropwise and the reaction was monitored by TLC. The mixture was kept stirring at room temperature for 16 h, then 5N NaOH was added to adjust pH=14, extracted with DCM and the organic layer was washed with brine, dried and concentrated. The resulting residue was used for the next step reaction directly.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 418762-26-2, its application will become more common.

Reference:
Patent; Janssen Pharmaceutica NV; Gaul, Micheal; Xu, Guozhang; Zhao, Bao-Ping; (53 pag.)US2018/64686; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 393-36-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 393-36-2, name is 4-Bromo-3-(trifluoromethyl)aniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A mixture of [6-CHLORO-4-ISOPROPYL-N- (TETRAHYDROPYRAN-4-YLMETHYL)-NICOTINAMIDE] (Description 8) (100mg), [4-BROMO-3-TRIFLUOROMETHYL-] (ex Lancaster, 162mg), [METHANESULFONIC] acid [(44NL)] in 1,4-dioxane [(1MI)] was irradiated under microwave conditions at [180FOR] 30 minutes. After removal of the 1,4-dioxane under reduced pressure, the mixture was partitioned between ethyl acetate [(5ML)] and brine [(2ML)] and the aqueous layer separated. The organic layer was evaporated under reduced pressure and the residue purified using the Biotage Horizon system. Purification afforded the title compound as a white solid (47mg). NMR [(DMSO-D6)] [No.1. ]16-1.23 (8H, d, m), 1.60-1. 63 (2H, d), 1.75 (1H, m), 3.10 (2H, t), 3.28 (2H, t), 3.41 (1H, m), 3.85 (2H, d), 6.80 (1H, s), 7.73 (1H, d), 7.83 (1H, d), 8.16 (1H, s), 8.38-8. 42 (2H, m), 9.70 (1H, s). LC/MS t = 3.5 min, [MH+] 500, consistent with molecular formula [C22H2579BR F3N302]

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-3-(trifluoromethyl)aniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXO GROUP LIMITED; WO2004/29026; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary