Tag: M.W=200-300

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 837-52-5, is researched, Molecular C13H14ClN3, about Antimalarials. 7-Chloro-4-(substituted amino)quinolines, the main research direction is quinoline antimalarial; chloroquinolines antimalarial.Recommanded Product: 7-Chloro-4-(piperazin-1-yl)quinoline.

Forty-one 7-chloro-4-(substituted amino)quinolines were prepared from 4,7-dichloroquinoline and tested for antimalarial activity against Plasmodium berghei in mice. Of 27 active compounds, 7-chloro-4-[(1-ethyl-3-piperidyl)-amine]quinoline (I) and 7-chloro-4-[[4-(benzyl-2-propynylamino]-2-butyl]amino]quinoline (II) were curative antimalarial agents at doses of 80 and 160 mg/kg, i.p.,resp.

When you point to this article, it is believed that you are also very interested in this compound(837-52-5)Recommanded Product: 7-Chloro-4-(piperazin-1-yl)quinoline and due to space limitations, I can only present the most important information.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 4,4-Dipyridyl Disulfide. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 4,4-Dipyridyl Disulfide, is researched, Molecular C10H8N2S2, CAS is 2645-22-9, about Porous Metal-Organic Frameworks Containing Reversible Disulfide Linkages as Cathode Materials for Lithium-Ion Batteries. Author is Shimizu, Takeshi; Wang, Heng; Matsumura, Daiju; Mitsuhara, Kei; Ohta, Toshiaki; Yoshikawa, Hirofumi.

Three porous disulfide-ligand-containing metal-organic frameworks (DS-MOFs) and two nonporous coordination polymers with disulfide ligands (DS-CPs) with various structural dimensionalities were used as cathode active materials in lithium batteries. Charge/discharge performance examinations revealed that only porous DS-MOF-based batteries exhibited significant capacities close to the theor. values, which was ascribed to the insertion of electrolyte ions into the DS-MOFs. The insolubility of porous 3 D DS-MOFs in the electrolyte resulted in cycling performances superior to that of their 1 D and 2 D porous counterparts. Battery reactions were probed by instrumental analyses. The dual redox reactions of metal ions and disulfide ligands in the MOFs resulted in higher capacities, and the presence of reversible electrochem. dynamic S-S bonds stabilized the cycling performance. Thus, the strategy of S-S moiety trapping in MOFs and the obtained correlation between the structural features and battery performance could contribute to the design of high-performance MOF-based batteries and the practical realization of Li-S batteries.

In some applications, this compound(2645-22-9)Reference of 4,4-Dipyridyl Disulfide is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Wang, Dan-Yang; Si, Yubing; Li, Junjie; Fu, Yongzhu published an article about the compound: 4,4-Dipyridyl Disulfide( cas:2645-22-9,SMILESS:C1(SSC2=CC=NC=C2)=CC=NC=C1 ).SDS of cas: 2645-22-9. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:2645-22-9) through the article.

S-S bonds in organodisulfides can break and obtain Li+ and e- in the discharge of lithium batteries. Organodisulfides provide precise lithiation sites, and therefore are valuable models for the study of redox reactions in lithium batteries. To understand their electrochem. behavior, we investigate three disulfides with different N-containing heterocycles including 2,2′-dipyridyl disulfide (2,2′-DpyDS), 4,4′-dipyridyl disulfide (4,4′-DpyDS), and 2,2′-dipyridyl disulfide-N,N’-dioxide (DpyDSDO). The three disulfides all show higher discharge voltage plateaus due to the electron-withdrawing groups: DPDS (2.20 V) < 2,2'-DpyDS (2.45 V) = 4,4'-DpyDS (2.45 V) < DpyDSDO (2.80 V). In particular, 2,2'-DpyDS exhibits an outstanding 69% capacity retention over 500 cycles. Our theor. simulations show that lithium pyridine-2-thiolate, the discharge product of 2,2'-DpyDS, forms compact clusters via N···Li···S bridges coordinated by lithium ions, which can help reduce its dissolution in liquid electrolyte, and therefore increase the cycle life. Liquid chromatog.-mass spectrometry is demonstrated to be a powerful tool for the investigation of discharge/recharge products of soluble organodisulfides in rechargeable lithium batteries. In some applications, this compound(2645-22-9)SDS of cas: 2645-22-9 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 6-Bromo-3-methyl-1H-indole, is researched, Molecular C9H8BrN, CAS is 1219741-50-0, about Enantioselective Friedel-Crafts C2-alkylation of 3-substituted indoles with trifluoropyruvates and cyclic N-sulfonyl α-ketiminoesters, the main research direction is indolyl trifluoromethyl hydroxy ester preparation enantioselective; indole trifluoropyruvate Friedel Crafts enantioselective alkylation; dihydro benzoisothiazole carboxylate indolyl preparation enantioselective; cyclic sulfonyl ketimino ester indole Friedel Crafts alkylation enantioselective.SDS of cas: 1219741-50-0.

Enantioselective Friedel-Crafts C2-alkylation reactions of 3-substituted indoles I (R1 = H, 5-MeO, 6-F, etc.; R2 = Me, Ph) with trifluoropyruvates F3CC(O)CO2R3 (R3 = Me, Et) and cyclic N-sulfonyl α-ketiminoesters II (R4 = H, 4-Cl, 4,7-F2, 6-Me, etc.; R5 = Me, Et, i-Pr) were developed by using the complexes of Cu(OTf)2 or Zn(OTf)2 with chiral bisoxazoline ligands. A range of chiral indole-containing trifluoromethylated α-hydroxy esters III and cyclic α-amino esters bearing quaternary stereogenic centers IV was prepared, resp., in good yields and with excellent enantioselectivities (up to 99% ee) under mild conditions.

In some applications, this compound(1219741-50-0)SDS of cas: 1219741-50-0 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Computed Properties of C10H8N2S2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 4,4-Dipyridyl Disulfide, is researched, Molecular C10H8N2S2, CAS is 2645-22-9, about Synthesis of mono/dinuclear rhenium(I) tricarbonyl substituted with 4-mercaptopyridine related ligands: spectral and theoretical evidence of thiolate/thione interconversion. Author is Gomez, Alejandra; Jara, Geraldine; Flores, Erick; Maldonado, Tamara; Godoy, Fernando; Munoz-Osses, Michelle; Vega, Andres; Mera, Raul; Silva, Carlos; Pavez, Jorge.

The synthesis, characterization, and spectroscopic and theor. studies of new κ1-S monometallic Re-spy (1)/Re-thiopy (2) and κ1-N-bimetallic Re2-dps (3)/Re2-dpds (4) complexes substituted with 4-mercaptopyridine derivatives are reported. The obtainment of either monosulfide bridge-complex (3) or disulfide bridge-complex (4) depends on the reaction media. The structure of complex 3 was confirmed by monocrystal x-ray diffraction. Addnl. it was possible to determine the presence of an intramol. interconversion between 1 and 2 mediated by solvent mols. through the intermediate species 1-H+ using UV-Vis and NMR spectroscopy. Electronic spectra calculated by TD-DFT feature distinct MLCT transitions for 2 and show that the π-stacking interaction present in 1 is broken in the methanol/water mixture, leading to a structural distribution similar to 2. Cyclic voltammograms of all complexes display the characteristic reduction process for the rhenium center and the bipyridine ligand. Addnl., an irreversible process associated with the bridging ligand for 3 and 4 is observed

In some applications, this compound(2645-22-9)Computed Properties of C10H8N2S2 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Catch and Anchor Approach To Combat Both Toxicity and Longevity of Botulinum Toxin A, published in 2020-10-08, which mentions a compound: 17696-11-6, Name is 8-Bromooctanoic acid, Molecular C8H15BrO2, Name: 8-Bromooctanoic acid.

Botulinum neurotoxins have remarkable persistence (~weeks to months in cells), outlasting the small-mol. inhibitors designed to target them. To address this disconnect, inhibitors bearing two pharmacophores-a zinc binding group and a Cys-reactive warhead-were designed to leverage both affinity and reactivity. A series of first-generation bifunctional inhibitors was achieved through structure-based inhibitor design. Through X-ray crystallog., engagement of both the catalytic Zn2+ and Cys165 was confirmed. A second-generation series improved on affinity by incorporating known reversible inhibitor pharmacophores; the mechanism was confirmed by exhaustive dialysis, mass spectrometry, and in vitro evaluation against the C165S mutant. Finally, a third-generation inhibitor was shown to have good cellular activity and low toxicity. In addition to our findings, an alternative method of modeling time-dependent inhibition that simplifies assay setup and allows comparison of inhibition models is discussed.

When you point to this article, it is believed that you are also very interested in this compound(17696-11-6)Name: 8-Bromooctanoic acid and due to space limitations, I can only present the most important information.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 4,4-Dipyridyl Disulfide. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 4,4-Dipyridyl Disulfide, is researched, Molecular C10H8N2S2, CAS is 2645-22-9, about Chloromethyl acryl reagents for simple and site-selective cysteine and disulfide modification. Author is Xu, Lujuan; Kuan, Seah Ling; Weil, Tanja.

The generation of protein biotherapeutics with improved features compared to the synthetic drugs has received emerging interest. The conjugation of various synthetic functionalities to proteins provides access to new classes of protein conjugates, where the advantages from both the synthetic world and Nature can be combined in a synergistic fashion. Here, we reported that 2-chloromethyl acryl scaffold can serve as a simple yet versatile platform for synthesizing acrylamide or acrylate derivatives by coupling with different end-group functionalities (amino group or hydroxyl group) via a one-pot reaction. The chem. properties of the amide or ester linkage influence their inherent reactivity as bioconjugation reagents, which in turn allows synthetic customization of their features to achieve selective protein modification at cysteine or disulfide sites on demand. 2-Chloromethyl acrylamide reagents with amide linkage favors selective modification at cysteine site with high efficiency and the resultant bioconjugates exhibit superior stability compared to commonly employed maleimide-thiol conjugates. In contrast, 2-chloromethyl acrylate reagents bearing ester linkage can undergo two successive Michael reaction, allowing the selective modification of disulfides with high labeling efficiency and conjugate stability. These reagents could outperform widely applied maleimide reagents in terms of stability of the resultant bioconjugates without compromising on the ease of reagent preparation, reactivity and reaction speed.

When you point to this article, it is believed that you are also very interested in this compound(2645-22-9)Reference of 4,4-Dipyridyl Disulfide and due to space limitations, I can only present the most important information.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of C8H15BrO2. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 8-Bromooctanoic acid, is researched, Molecular C8H15BrO2, CAS is 17696-11-6, about Reflection absorption infrared spectroscopy characterization of SAM formation from 8-mercapto-N-(phenethyl)octanamide thiols with Phe ring and amide groups. Author is Kuodis, Zenonas; Matulaitiene, Ieva; Spandyreva, Marija; Labanauskas, Linas; Stoncius, Sigitas; Lorka, Olegas Eicher; Sadzeviciene, Rita; Niaura, Gediminas.

Multifunctional amide-containing self-assembled monolayers (SAMs) provide prospects for the construction of interfaces with required physicochem. properties and distinctive stability. In this study, we report the synthesis of amide-containing thiols with terminal phenylalanine (Phe) ring functionality (HS(CH2)7CONH(CH2)2C6H5) and the characterization of the formation of SAMs from these thiols on gold by reflection absorption IR spectroscopy (RAIRS). For reliable assignments of vibrational bands, ring deuterated analogs were synthesized and studied as well. Adsorption time induced changes in Amide-II band frequency and relative intensity of Amide-II/Amide-I bands revealed two-state sigmoidal form dependence with a transition inflection points at 2.2 ± 0.5 and 4.7 ± 0.5 min, resp. The transition from initial (disordered) to final (hydrogen-bonded, ordered) structure resulted in increased Amide-II frequency from 1548 to 1557 cm-1, which is diagnostic for a strongly hydrogen-bonded amide network in trans conformation. However, the lateral interactions between the alkyl chains were found to be somewhat reduced when compared with well-ordered alkane thiol monolayers.

This literature about this compound(17696-11-6)Electric Literature of C8H15BrO2has given us a lot of inspiration, and I hope that the research on this compound(8-Bromooctanoic acid) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

COA of Formula: C13H14ClN3. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Synthesis of oxalamide and triazine derivatives as a novel class of hybrid 4-aminoquinoline with potent antiplasmodial activity. Author is Sunduru, Naresh; Sharma, Moni; Srivastava, Kumkum; Rajakumar, S.; Puri, S. K.; Saxena, J. K.; Chauhan, Prem M. S..

Frequency of malaria and its resistance to chemotherapeutic options are emerging rapidly. To counter this problem, a series of 4-aminoquinolines having oxalamide and triazine functionalities in the side chain were synthesized and screened for their antimalarial activities. Triazine derivative 48 (I) found to be the most active against CQ sensitive strain 3D7 of Plasmodium falciparum in an in vitro assay with an IC50 of 5.23 ng/mL and oxalamide derivative 13 showed an in vivo suppression of 70.45% on day 4 against CQ resistant strain N-67 of Plasmodium yoelii.

This literature about this compound(837-52-5)COA of Formula: C13H14ClN3has given us a lot of inspiration, and I hope that the research on this compound(7-Chloro-4-(piperazin-1-yl)quinoline) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 17696-11-6, is researched, Molecular C8H15BrO2, about Aiming at the tumor-specific accumulation of MGMT-inhibitors: First description of a synthetic strategy towards inhibitor-peptide conjugates, the main research direction is peptide benzylguanine conjugate MGMT inhibitor synthesis antitumor agent; drug target tumor adjuvant alkylating therapy; solid phase peptide synthesis Michael reaction conjugation.HPLC of Formula: 17696-11-6.

In the therapy of cancer, alkylating agents are an efficient and often-used substance class. However, cells can repair the resulting alkyl modifications in the O6-position of guanine using the repair protein methylguanine methyltransferase (MGMT), giving rise to resistance and inefficient therapy. A possibility to overcome this resistance is the use of MGMT inhibitors as adjuvants to alkylating therapies. However, MGMT inhibitors also sensitize healthy cells towards alkylating therapies. A strategy to circumvent this is the development of tumor-specific inhibitors which could be based on peptidic ligands as carriers. Such constructs would enable a receptor-specific uptake into tumors. Furthermore, the MGMT inhibitors could be adapted to the resp. tumor entity by changing the peptide carrier. However, no peptide-based tumor-specific MGMT inhibitors were described so far. Thus, we have developed a synthetic strategy to obtain covalent conjugates of receptor-specific peptides and O6-benzylguanine derivatives As model compounds, the MGMT inhibitor O6-(3-bromobenzyl)guanine and the receptor-specific peptides c(RGDfK), TATE, PESIN, neurotensin-2656 and minigastrin-9 were chosen and successfully assembled to obtain potentially tumor-specific MGMT inhibitors. Both, the O6-(3-bromobenzyl)guanine as well as the peptide derivatives are easily replaceable during the syntheses to tailor peptide-based bioconjugates adaptable to the specific tumor entity.

This literature about this compound(17696-11-6)HPLC of Formula: 17696-11-6has given us a lot of inspiration, and I hope that the research on this compound(8-Bromooctanoic acid) can be further advanced. Maybe we can get more compounds in a similar way.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary