Tag: M.W=200-300

Application of 5153-40-2,Some common heterocyclic compound, 5153-40-2, name is 1-Bromo-2,3,4,5,6-pentamethylbenzene, molecular formula is C11H15Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution of 15.92 g (80 mmol) 2,4,6-Me3C6H2Br in 80 mL THF was added dropwise to 2.32 g (96 mmol) Mg, activated with 3 g (16 mmol) 1,2-Br2C2H4, in 20 mL THF. The reaction mixture was refluxed for 2 h and afterward allowed to cool to r.t. To the Grignard reagent solution was added dropwise a solution of 7.55 g (16 mmol) 2,4,6-I3C6H2OH and0.44 g (0.64 mmol) [(IPr)PdCl2(3-ClC5H4N)]. The reaction mixture was refluxed for another 21 h and quenched with2 mL H2O stirring under argon for 30 min. After solvent removal, the obtained residue was dissolved in 80 mL Et2Oand 20 mL CH2Cl2 and filtered over a 2 cm alumina pad. Solvent removal at reduced pressure afforded a brown oil which was eluted over a 10 cm alumina column witha mixture of Et2O-pentane 2:1 (v/v). To the pale-yellow oil obtained after the solvent removal, methanol was added. After sonication, 1 precipitated as a colorless solid. Filtration and vacuum drying afforded 3.8 g (52 %) of 1.

The synthetic route of 5153-40-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; olea, Atena B.; Olaru, Marian; Silvestru, Cristian; Ra, Ciprian I.; Zeitschrift fur Naturforschung – Section B Journal of Chemical Sciences; vol. 70; 1; (2015); p. 77 – 81;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6698-13-1, name is 4-Bromo-1,3-benzodioxole, A new synthetic method of this compound is introduced below., Safety of 4-Bromo-1,3-benzodioxole

[0907] Method 3: To a stirred mixture of 5-(4-fluorophenyl)-4-methylpyridin-2(1H)-one (2.04 g, 10 mmol, 1.0 eq.), 4-bromobenzo[d][1,3]dioxole (3.0 g, 15 mmol, 1.5 eq.), and K2C03 (2.76 g, 20 mmol, 2eq.) in DMF (50 mL) was added CuT (191 mg, 1 mmol, 0.1 eq.) and 8- hydroxyquinoline (140 mg, 1 mmol, 0.1 eq.). The reaction mixture was stuffed at 140C for 3 days under N2 protection. The mixture was cooled to rt, diluted with EA (250 mL), washed with water and brine, concentrated. The residue was purified by flash chromatography on silica gel (PE:EA=5:1-*1:1) to yield Compound 184 (680 mg, 21% yield) as white solid. ?H NMR (CDC13, 400 MHz) (57.35-7.32 (m, 2H), 7.26 (s, 1H), 7.18 (t, J=8.8Hz, 2H), 7.02-6.94 (m, 3H), 6.67 (s, 1H),6.13 (s, 2H), 2.21 (s, 3H). MS (ES) m/z [M+Hf? 323.8.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; INTERMUNE, INC.; RAMPHAL, Johnnie, Y.; BUCKMAN, Brad, Owen; EMAYAN, Kumaraswamy; NICHOLAS, John, Beamond; SEIWERT, Scott, D.; WO2015/153683; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 90562-10-0, name is 1-Bromo-4-(3-bromopropyl)benzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 90562-10-0, Recommanded Product: 90562-10-0

The reaction mixture of 28 (0.20 g, 0.59 mmol) and 1-bromo-4-(3-bromopropyl)benzene (46) (0.22 g, 0.79 mmol) in dry 1,4-dioxane (8 ml) was stirred for 5 days to afford the title compound as a white solid in 60% yield (0.22 g). mp: 219-220 C; 1H-NMR (500 MHz, DMSO-d6): delta = 7.24-7.29 (m, 14H), 6.73 (s, 1H), 5.17 (m, 1H), 3.83 (m, 1H), 3.21-3.38 (m, 6H), 3.05 (m, 1H), 2.53 (m, 2H), 1.47-2.22 (m, 7H); 13C-NMR (125 MHz, DMSO-d6): delta = 172.8, 139.8, 130.7, 128.8, 128.5, 128.3, 128.1, 127.6, 127.5, 81.2, 69.0, 62.9, 59.9, 54.2, 31.5, 23.9, 20.9, 18.1; HRMS calcd. for C30H33Br1N1O3 [M]+: 534.1638; found: m/z = 534.1644; HPLC (Method A): tR (min) = 13.98 (97%).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Yamashita, Yasunobu; Tanaka, Ken-ichiro; Yamakawa; Asano; Kanda, Yuki; Takafuji; Kawahara, Masahiro; Takenaga, Mitsuko; Fukunishi, Yoshifumi; Mizushima; Bioorganic and Medicinal Chemistry; vol. 27; 15; (2019); p. 3339 – 3346;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 69902-83-6, name is 1-Bromo-2-methyl-3-(trifluoromethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows., Formula: C8H6BrF3

Bromo-3- (trifluoromethyl) -2-methylbenzene (5.0 g, 20.9 mmol),Bromosuccinimide (3.72 g, 20.9 mmol),Azobisisobutyronitrile (300 mg) was dissolved in dry carbon tetrachloride (100 mL)Heat under reflux for 16 hours under nitrogen.The reaction was cooled to room temperature and filtered,The filtrate was added imidazole (2.85 g, 42 mmol) and potassium carbonate (4.34 g, 31.37 mmol)Heat under reflux for 5 hours under nitrogen.LC-MS showed the reaction was complete,The reaction solution was filtered,The filtrate was concentrated,The residue was dissolved in dichloromethane (50 mL)Wash with water (2 × 40 mL).Organic phase filtration,concentrate,The residue was purified by flash silica gel column to give 1- (2-bromo-6- (trifluoromethyl) benzyl) -1H-imidazole (5.0 g).

According to the analysis of related databases, 69902-83-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shanghai Hansen Bio-pharmaceutical Technology Co., Ltd.; Jiangsu Haosen Pharmaceutical Group Co., Ltd.; Tong Chaolong; Bao Rudi; Li Yuannian; (67 pag.)CN107312005; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 6683-75-6, name is 1,2-Dibromo-4-tert-butylbenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6683-75-6, name: 1,2-Dibromo-4-tert-butylbenzene

In a three-necked flask equipped with a reflux tube, 292 g (1.0 mol) of p-tert-butyl o-dibromobenzene, 90 g (1.0 mol) of cuprous cyanide, 16.8 g (0.1 mol) of silver carbonate, and 52.4 g of copper acetylacetonate (0.2%) were added. 1460 mL of mol) and DBU were heated to 100 C. After the reaction, the insoluble material was filtered off and the DBU was recovered under reduced pressure. The residue was poured into water and filtered to give 95 g of p-tert-butylphthalonitrile. The yield was 51.6%.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Zhengzhou Gaike Technology Co., Ltd.; Guo Libing; (5 pag.)CN107903190; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 5279-32-3, These common heterocyclic compound, 5279-32-3, name is 5,6-Dibromobenzo[d][1,3]dioxole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 29: Preparation of N-(4-(6-bromobenzo[d] [l,3]dioxol-5-yl)phenyl)-2,6- difluorobenzamide (81):; Preparation of 4-(6-bromobenzo[d] [l,3]dioxol-5-yl)aniline (80):; Palladium tetrakis-triphenylphosphine (67 mg, 58 muiotaetaomicron) was added to a degassed solution of bromide 78 (323 mg, 1.15 mmol) and boronic acid 79 (200 mg, 1.15 mmol) in dioxane : acetonitrile : water (9:9:2, 7.6 mL) and potassium carbonate (679 mg, 3.2 mmol). The resulting mixture was heated under argon at 90 C with stirring for 1 h. The mixture was then cooled, diluted with dichloromethane (9 mL), dried with sodium sulfate and concentrated under reduced pressure. Flash chromatography (ISCO system, silica, 0-2.5% methanol in dichloromethane) provided 80 (150 mg, 45%) as a solid: LRESIMS m/z 292.1 [M+H]+, calcd. for Ci3H11Br1N102 292.0.

Statistics shows that 5,6-Dibromobenzo[d][1,3]dioxole is playing an increasingly important role. we look forward to future research findings about 5279-32-3.

Reference:
Patent; CALCIMEDICA, INC.; WHITTEN, Jeffrey P.; PEI, Yazhong; CAO, Jianguo; WANG, Zhijun; ROGERS, Evan; DYCK, Brian; GREY, Jonathan; WO2011/139765; (2011); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 128259-68-7, name is 1,3-Dibromo-2,5-difluorobenzene, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 1,3-Dibromo-2,5-difluorobenzene

A mixture of 1,3-dibromo-2,5-difluorobenzene (4 g, 14.7 mmol), benzophenone imine (2.6 mL, 15.5 mmol), sodium tert-butoxide (2.1 g, 22.1 mmol), (S)-BINAP (1.4 g, 2.2 mmol), in toluene (15 mL) was sparged with Argon and charged with Pd2(dba)3 (0.67 g, 0.74 mmol). The reaction was then sealed and irradiated at 100° C. for 30 minutes in a microwave reactor. The reaction mixture was diluted with Et2O and stirred for 2 hours with a palladium scavenger (Siliabond DMT). The mixture was filtered through a plug of Celite and the collected filtrate was partitioned between diethyl ether and water, and the resulting layers separated. The organic portion was washed with water, brine, dried (MgSO4), and concentrated to afford a brown red solid. The solid was dissolved in THF (40 mL) and treated with aqueous 6.0 N HCl solution (25 ml, 150 mmol). The reaction was stirred for 1.5 hours at room temperature was partitioned between water and Et2O. The layers were separated and the aqueous portion was brought to a pH of 9 with aqueous 1.0 M NaOH solution. The basic aqueous layer was extracted diethyl ether (3*30 mL) the combined diethyl ether layers were washed with aqueous 1.0 M NaOH solution, water, brine, dried (MgSO4), concentrated. Purification by flash chromatography (SiO2, 0-10percent EtOAc in heptane) afforded 3-bromo-2,5-difluoroaniline (1.7 g, 8.2 mmol, 56percent, trace benzophenone) as an orange solid: 1H NMR (400 MHz, CDCl3) delta 3.93 (br s, 2H) 6.43 (m, 1H) 6.62 (m, 1 H).

According to the analysis of related databases, 128259-68-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Costales, Abran Q.; Huang, Shenlin; Jin, Jeff (Xianming); Liu, Zuosheng; Pecchi, Sabina; Poon, Daniel; Tellew, John; US2011/52578; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 202865-77-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 202865-77-8, name is 2-Bromo-4-fluoro-6-methylaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a suspension of 2-bromo-4-fluoro-6-methylaniline (5 g, 24.51 mmol) in hydrochloric acid (8 M, 22 mL, 176 mmol) at 0 C. was added a solution of sodium nitrite (1.78 g, 25.7 mmol) in water (ca. 5.5 mL) dropwise. After 10 min, the resulting solution was neutralized (pH 4-5) by addition of solid sodium acetate. The resulting solution was added to a solution of 2-methyl-2-propanethiol (2.76 mL, 24.5 mmol) in ethanol (57 mL) at 0 C. The resulting mixture was stirred at 0 C. for 30 min. The resulting mixture was poured onto ice and the resulting mixture was extracted into diethyl ether (2×). The ethereal was washed with water, then brine, dried over magnesium sulfate, and concentrated. The resulting residue was dissolved in dimethylsulfoxide (14 mL) and transferred to a solution of potassium tert-butoxide (22 g, 196 mmol) in dimethylsulfoxide (140 mL) in a cool water bath (ca. 10 C.) via canula. The bath was removed and stirring continued for 30 min. The reaction mixture was poured onto ice/concentrated hydrochloric acid. The resulting mixture was extracted with dichloromethane (2×), washed with water (3×), then brine, dried over magnesium sulfate and concentrated. Prep HPLC gave 1.66 g (31.5%) as a pale solid. LC/MS (HPLC method 3): tR=2.337 min, 215.01(MH)-.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-4-fluoro-6-methylaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Bristol-Myers Squibb Company; US2009/18132; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 179737-33-8, name is 2,3-Dibromo-1,4-difluorobenzene, A new synthetic method of this compound is introduced below., Recommanded Product: 179737-33-8

1,2-dibromo-3,6-difluorobenzene (50.0 g, 183.9 mmol), 2-methoxyphenylboronic acid (67.1 g, 441.4 mmol), a 2 M aqueous solution of Na2CO3 (368 mL, 736 mmol), DME (370 mL), toluene (370 mL), and Pd [PPh3]4 (21.3 g, 18. 4 mmol) were loaded into a three-necked flask, and the mixture was refluxed under an Ar atmosphere for 8 hours. After the completion of the reaction, the resultant was cooled to room temperature. The resultant sample was transferred to a separating funnel, and water (500 mL) was charged into the funnel. Then, the mixture was extracted with CH2Cl2. The extract was dried with MgSO4, and was then filtrated and concentrated. The resultant sample was purified by silica gel column chromatography, whereby a white solid was obtained in an amount of 30.6 g in 51% yield. FD-MS C20H16F2O2: theoretical value 326, observed value 326

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Idemitsu Kosan Co., Ltd.; EP2301921; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 5279-32-3, These common heterocyclic compound, 5279-32-3, name is 5,6-Dibromobenzo[d][1,3]dioxole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 1, Method 25: ll-(2-Chlorophenyl)-4,6,10-trioxa-12- azatricyclo[7.3.0.03’7]dodeca-l,(9),2,7,ll-tetraene[0251] A mixture of 5,6-dibromo-2H-l,3-benzodioxole (500 mg, 1.79 mmol), 2- chlorobenzamide (300 mg, 1.93 mmol), potassium carbonate (1.0 g, 7.24 mmol), N,N-dimethylethane-l,2-diamine (50 mu,, 0.57 mmol) and copper(I) iodide (35 mg, 0.18 mmol) in toluene (30 mL) and 1,4-doxane (30 mL) was stirred under reflux for 24 hours. After cooling to room temperature the mixture was diluted with ethyl acetate (50 mL), filtered and concentrated. The residue was taken up in ethyl acetate (150 mL), washed with water (50 mL) and brine (50 mL), dried over magnesium sulphate, filtered and absorbed onto a small amount of silica. Purification by FCC (silica, 0-20% ethyl acetate in heptane) and recry stallis ation from 5% ethyl acetate in heptane (10 mL) gave the title compound 120 mg (25% yield) as a colourless, crystalline solid. 5H MR (500 MHz, DMSO) 8.09 (dd, J = 7.7, 1.8 Hz, 1H), 7.69 (dd, J = 7.9, 1.2 Hz, 1H), 7.59 (td, J = 7.7, 1.8 Hz, 1H), 7.55 (td, J = 7.5, 1.3 Hz, 1H), 7.51 (s, 1H), 7.41 (s, 1H), 6.14 (s, 2H). Tr(MET-uHPLC-AB-lOl) = 3.66 min, (ES+) (M+H)+274.

The synthetic route of 5279-32-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CHDI FOUNDATION, INC.; DOMINGUEZ, Celia; WITYAK, John; BARD, Jonathan; BROWN, Christopher, John; PRIME, Michael, Edward; WEDDELL, Derek, Alexander; WALTER, Daryl, Simon; GILES, Paul, Richard; WIGGINTON, Ian, James; TAYLOR, Malcolm, George; GALAN, Sebastien, Rene, Gabriel; JOHNSON, Peter, David; KRUeLLE, Thomas, Martin; MORAO, Inaki; CLARK-FREW, Daniel; SCHAERTL, Sabine; HERRMANN, Frank; GRIMM, Steffen, Kaspar; KAHMANN, Jan, Dirk; SCHEICH, Christoph; (120 pag.)WO2016/33460; (2016); A1;,
Bromide – Wikipedia,
bromide – Wiktionary