Tag: M.W=200-300

Application of 1219741-50-0. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 6-Bromo-3-methyl-1H-indole, is researched, Molecular C9H8BrN, CAS is 1219741-50-0, about Chiral Diphosphine-Palladium-Catalyzed Sequential Asymmetric Double-Friedel-Crafts Alkylation and N-Hemiketalization for Spiro-polycyclic Indole Derivatives. Author is Li, Nai-Kai; Zhang, Jun-Qi; Sun, Bing-Bing; Li, Hai-Yan; Wang, Xing-Wang.

An efficient cascade asym. Friedel-Crafts alkylation/N-hemiketalization/Friedel-Crafts alkylation reaction of 3-alkylindoles with oxindolyl β,γ-unsaturated α-ketoesters has been developed in the presence of a chiral diphosphine-palladium(II) catalyst. A series of enantiomerically enriched spiro-polycyclic indole derivatives, e.g. I, have been constructed in high yields with excellent enantioselectivities and diastereoselectivities.

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Bromide – Wikipedia,
bromide – Wiktionary

Formula: C10H8N2S2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 4,4-Dipyridyl Disulfide, is researched, Molecular C10H8N2S2, CAS is 2645-22-9, about Mitochondria-Accumulating Rhenium(I) Tricarbonyl Complexes Induce Cell Death via Irreversible Oxidative Stress and Glutathione Metabolism Disturbance. Author is Wang, Fang-Xin; Liang, Jin-Hao; Zhang, Hang; Wang, Ze-Hua; Wan, Qin; Tan, Cai-Ping; Ji, Liang-Nian; Mao, Zong-Wan.

Mitochondria play a critical role in tumorigenesis. Targeting mitochondria and disturbing related events have been emerging as a promising way for chemotherapy. In this work, two binuclear rhenium(I) tricarbonyl complexes of the general formula [Re2(CO)6(dip)2L](PF6)2 (dip = 4,7-diphenyl-1,10-phenanthroline; L = 4,4′-azopyridine (ReN) or 4,4′-dithiodipyridine (ReS)) were synthesized and characterized. ReN and ReS can react with glutathione (GSH). They exhibit good in vitro anticancer activity against cancer cell lines screened. Besides, they can target mitochondria, cause oxidative stress, and disturb GSH metabolism Both ReN and ReS can induce necroptosis and caspase-dependent apoptosis simultaneously. We also demonstrate that ReN and ReS can inhibit tumor growth in nude mice bearing carcinoma xenografts. Our study shows the potential of Re(I) complexes as chemotherapeutic agents to kill cancer cells via a mitochondria-to-cellular redox strategy.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Pilot plant production of anti-malarial drug piperaquine phosphate and synthesis of its metabolites.Electric Literature of C13H14ClN3.

An optimized, convergent, safe synthesis of piperaquine phosphate (I), an antimalarial agent, as well as synthesis of its main metabolites was described. Major improvements for I production were made in the preparation of its intermediate by using directly piperazine instead of N-formyl piperazine. The structures of the synthetic compounds were determined from spectral anal. including MS and 2D NMR.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Safety of 8-Bromooctanoic acid. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 8-Bromooctanoic acid, is researched, Molecular C8H15BrO2, CAS is 17696-11-6, about Rose bengal conjugated gadolinium complex as a new multimodal imaging agent targeting presynaptic vesicular glutamate transporters. Author is Kim, Soyeon; Kim, Hee-Kyung; Baek, Ah Rum; Sung, Bokyung; Yang, Byeong Woo; Kim, Yeoun-Hee; Lee, Jung-jin; Yang, Ji-ung; Shin, Chang-Hoon; Jung, Hoesu; Kim, Minsup; Cho, Art E.; Lee, Taekwan; Chang, Yongmin.

Glutamate is an important excitatory neurotransmitter, and vesicular glutamate transporters (VGLUTs) are critical in regulating the extent of glutamate release. Because initial increase and late stage decrease in VGLUT expression were implicated in progressive Alzheimer′s disease (AD), VGLUTs can be a new imaging target for diagnosing AD. In this study, we have designed and synthesized a new multimodal gadolinium contrast agent conjugated with rose bengal to target VGLUTs (Gd-DO3A-RB). In addition to high kinetic and pH stability, magnetic resonance and fluorescence imaging using Gd-DO3A-RB showed high affinity to VGLUT1. Using the AD animal model (5XFAD), in vivo MRI with a Gd-DO3A-RB showed less MR signal enhancement in 5XFAD mouse brain than that of age-matched normal C57BL/6 mouse, suggesting a late stage decrease in VGLUT expression in AD animal model. Therefore, this new VGLUT targeting gadolinium contrast agent demonstrated a strong potential as a new diagnostic tool for AD with multimodal imaging capability.

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Reference:
Bromide – Wikipedia,
bromide – Wiktionary

COA of Formula: C13H14ClN3. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about An efficient, green chemical synthesis of the malaria drug, piperaquine.

An efficient, robust green chem. synthesis of the malaria drug piperaquine in 92-93% overall yield via nucleophilic substitution reaction of dichloroquinoline and piperazine for potential use in resource-poor settings are described. The piperaquine was obtained in the correct salt form and sufficient purity for use in Artemisinin Combination Therapies. The overall process utilizes modest amounts (about 8 kg/kg) of 2-propanol and Et acetate as the only organic materials not incorporated into the API; roughly 60 % of this waste can be recycled into the production process. The synthesis may be useful for application in resource-poor settings as a means of expanding access to and reducing the cost of ACTs.

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Bromide – Wikipedia,
bromide – Wiktionary

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 2645-22-9, is researched, Molecular C10H8N2S2, about Trimethylsilyl reporter groups for NMR studies of conformational changes in G protein-coupled receptors, the main research direction is trimethylsilyl NMR GPCR conformational change; G protein-coupled receptor; nuclear magnetic resonance; trimethylsilylmethanethiol; β2-adrenergic receptor.Name: 4,4-Dipyridyl Disulfide.

Large membrane proteins such as G protein-coupled receptors (GPCRs) are difficult for NMR study due to severe signal overlaps and unfavorable relaxation properties. The authors used a trimethylsilyl (TMS) group as a reporter group for 1H NMR study of conformational changes in proteins, using high-intensity 1H NMR signals near 0 p.p.m. The β2-adrenergic receptor was labeled with TMS groups at two cysteines located at the cytoplasmic ends of helixes VI and VII. Binding of various ligands led to changes in 1H NMR signals, which manifested that helix VI is sensitive to G protein-specific activation, whereas helix VII is sensitive to β-arrestin-specific activation. Thus, the TMS group is a useful reporter group in NMR for studying conformational changes in membrane proteins such as GPCRs.

There is still a lot of research devoted to this compound(SMILES：C1(SSC2=CC=NC=C2)=CC=NC=C1)Name: 4,4-Dipyridyl Disulfide, and with the development of science, more effects of this compound(2645-22-9) can be discovered.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 8-Bromooctanoic acid, is researched, Molecular C8H15BrO2, CAS is 17696-11-6, about Room temperature helical fluids in single-component systems.Application In Synthesis of 8-Bromooctanoic acid.

Technol. significant chiral nematic (N*) phase is a helicoidal superstructure that is generally formed by the spontaneous self-assembly of entire chiral mesogens (mostly calamitics) or by the LC mixtures where a chiral dopant is being added to the host nematic (N) phase. However, the stabilization of the N* phase at room temperature solely by chiral mesogens is highly challenging where the mol. designing is rather crucial, and thus scarcely reported. New chiral materials namely, non-sym. dimers I (R = n-octyl, n-decyl, n-dodecyl; n = 3, 4, 5, 7) derived from cholesterol were synthesized and characterized. Notably, as expected, some of these dimers I exhibit room temperature N* phase over a wide thermal range. The exclusive occurrence of N* phase has been evidenced unequivocally with the help of polarized optical microscopy (POM) and differential scanning calorimeter (DSC). The chiroptical property of the phase has been studied by recording CD (CD) spectra as a function of temperature where the intense bisignate bands (change of sign within the band) were observed Notably, one of the dimers forms stable gel in an aprotic solvent such as hexadecane. This study reveals a new mol. architecture to stabilize the technol. important N* phase at ambient temperature

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Bromide – Wikipedia,
bromide – Wiktionary

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called 7-Chloro-4-(piperazin-1-yl)quinoline, published in 2012-05-31, which mentions a compound: 837-52-5, Name is 7-Chloro-4-(piperazin-1-yl)quinoline, Molecular C13H14ClN3, COA of Formula: C13H14ClN3.

There are two mols. in the asym. unit (Z’ = 2) of the title compound, C13H14ClN3. Each mol. is linked by N-H···N H bonds to another of the same type in a chain in [110]. The crystal studied was a nonmerohedral twin with components 0.622(2) and 0.378(2). Crystallog. data and at. coordinates are given.

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Bromide – Wikipedia,
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Guantai, Eric M.; Ncokazi, Kanyile; Egan, Timothy J.; Gut, Jiri; Rosenthal, Philip J.; Bhampidipati, Ravi; Kopinathan, Anitha; Smith, Peter J.; Chibale, Kelly published an article about the compound: 7-Chloro-4-(piperazin-1-yl)quinoline( cas:837-52-5,SMILESS:C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3 ).Computed Properties of C13H14ClN3. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:837-52-5) through the article.

Analogs of the previously reported antimalarial hybrid compounds I (R1 = Me, 2,4-di-OMe-C6H3) were proposed with the aim of identifying compounds with improved solubility and retained antimalarial potency. In silico characterization predicted improved solubilities of the analogs, particularly at low pH; they retained acceptable predicted permeability properties but were predicted to be susceptible to hepatic metabolism These analogs were synthesized and found to exhibit notable in vitro antimalarial activity. Compounds II (R1 = 2,4-di-OMe-C6H3; R2 = OMe, H) were the most active of the analogs. In vitro metabolism studies indicated susceptibility of the analogs to hepatic metabolism There was also evidence of primary glucuronidation for analogs II (R1 = Me, 2,4-di-OMe-C6H3; R2 = OMe, H). Presumed cis-trans isomerism of I (R1 = Me) and III (R1 = Me, 2,4-di-OMe-C6H3) under in vitro metabolism assay conditions was also observed, with differences in the nature and rates of metabolism observed between isomers. Biochem. studies strongly suggested that inhibition of hemozoin formation is the primary mechanism of action of these analogs.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 17696-11-6, is researched, SMILESS is O=C(O)CCCCCCCBr, Molecular C8H15BrO2Journal, European Polymer Journal called Alkynyl-functionalized chain-extended PCL for coupling to biological molecules, Author is Izraylit, Victor; Hommes-Schattmann, Paul J.; Neffe, Axel T.; Gould, Oliver E. C.; Lendlein, Andreas, the main research direction is alkynyl chain extended caprolactone polymer biol mol.COA of Formula: C8H15BrO2.

Chem. functionalization of poly(ε-caprolactone) (PCL) enables a mol. integration of addnl. function. Here, the authors report an approach to incorporate reactive alkynyl side-groups by synthesizing a chain-extended PCL, where the reactive site is introduced through the covalently functionalizable chain extender 3-(prop-2-yn-1-yloxy)propane-1,2-diol (YPD). Chain-extended PCL with Mw of 101 to 385 kg·mol-1 were successfully synthesized in a one-pot reaction from PCL-diols with various molar masses, L-lysine Et ester diisocyanate (LDI) or trimethyl(hexamethylene)diisocyanate (TMDI), and YPD, in which the d. of functionalizable groups and spacing between them can be controlled by the composition of the polymer. The employed diisocyanate compounds and YPD possess an asym. structure and form a non-crystallizable segment leaving the PCL crystallites to dominate the material′s mech. properties. The mixed glass transition temperature Tg = -60 to -46° of the PCL/polyurethane amorphous phase maintains the synthesized materials in a highly elastic state at ambient and physiol. conditions. Reaction conditions for covalent attachment in copper(I)-catalyzed azide-alkyne-cycloaddition reactions (CuAAC) in solution were optimized in a series of model reactions between the alkyne moieties of the chain-extended PCL and benzyl azide, reaching conversions over 95% of the alkyne moieties and with yields of up to 94% for the purified functionalized PCL. This methodol. was applied for reaction with the azide-functionalized cell adhesion peptide GRGDS. The required modification of the peptide provides selectivity in the coupling reactions. The obtained results suggest that YPD could potentially be employed as versatile mol. unit for the creation of a variety of functionalizable polyesters as well as polyurethanes and polycarbonates offering efficient and selective click-reactions.

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Reference:
Bromide – Wikipedia,
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