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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 2645-22-9, is researched, SMILESS is C1(SSC2=CC=NC=C2)=CC=NC=C1, Molecular C10H8N2S2Journal, Article, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov’t, Biomaterials called Yolk-shell nanovesicles endow glutathione-responsive concurrent drug release and T1 MRI activation for cancer theranostics, Author is Liu, Dahai; Zhou, Zijian; Wang, Xinyu; Deng, Hongzhang; Sun, Lin; Lin, Haixin; Kang, Fei; Zhang, Yong; Wang, Zhantong; Yang, Weijing; Rao, Lang; Yang, Kuikun; Yu, Guocan; Du, Jianshi; Shen, Zheyu; Chen, Xiaoyuan, the main research direction is doxorubicin antitumor MRI contrast agent iron oxide; Concurrent theranostics; Iron oxide; MRI; Metal-drug coordination; Nanovesicles.Formula: C10H8N2S2.

The effort of incorporating therapeutic drugs with imaging agents has been one of the mainstreams of nanomedicine, which holds great promise in cancer treatment in terms of monitoring therapeutic drug activity and evaluating prognostic index. However, it is still tech. challenging to develop nanomedicine endowing a spatiotemporally controllable mechanism of drug release and activatable imaging capability. Here, we developed a yolk-shell type of GSH-responsive nanovesicles (NVs) in which therapeutic drug (Doxorubicin, DOX) and magnetic resonance imaging (MRI) contrast agent (ultrasmall paramagnetic iron oxide nanoparticles, USPIO NPs) formed complexes (denoted as USD) and were encapsulated inside the NVs. The formation of USD complexes is mediated by both the electrostatic adsorption between DOX and poly(acrylic acid) (PAA) polymers and the DOX-iron coordination effect on USPIO NPs. The obtained USD NVs showed a unique yolk-shell structure with restrained drug activity and quenched T1 MRI contrast ability which, on the other hand, can respond to glutathione (GSH) and lead to drug release and T1 contrast activation in a spatiotemporally concurrent manner. Furthermore, the USD NVs exhibited great potential to kill HCT116 cancer cells in vitro and effectively inhibit the tumor growth in vivo. This study may shed light on the design of sophisticated nanotheranostics in precision nanomedicine.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 837-52-5, is researched, SMILESS is C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3, Molecular C13H14ClN3Journal, Article, Research Support, Non-U.S. Gov’t, European Journal of Medicinal Chemistry called Squaric acid/4-aminoquinoline conjugates: Novel potent antiplasmodial agents, Author is Ribeiro, Carlos J. A.; Kumar, S. Praveen; Gut, Jiri; Goncalves, Lidia M.; Rosenthal, Philip J.; Moreira, Rui; Santos, Maria M. M., the main research direction is squaric acid aminoquinoline conjugate preparation antiplasmodial SAR; 4-Aminoquinoline; Antiplasmodial activity; Hybrid; Malaria; Squaramide.Related Products of 837-52-5.

We report the synthesis and structure-activity relationship (SAR) anal. of a series of hybrid compounds containing a squaric moiety conjugated with heterocyclic moieties from well-known antimalarials. This novel series of compounds presents improved antiplasmodial activity compared with the squaric derivatives described in our previous work. Three compounds, I (n = 3, IC50 = 99 nM; n = 4, IC50 = 95 nM) and II (IC50 = 105 nM) had greater in vitro potency than chloroquine (IC50 = 140 nM) against chloroquine resistant Plasmodium falciparum. In addition, they were noncytotoxic against NIH 3T3 and Hek 293T cells.

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Formula: C8H15BrO2. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 8-Bromooctanoic acid, is researched, Molecular C8H15BrO2, CAS is 17696-11-6, about The Chiral Twist-Bend Nematic Phase (N*TB). Author is Walker, Rebecca; Pociecha, Damian; Storey, John M. D.; Gorecka, Ewa; Imrie, Corrie T..

The twist-bend nematic, NTB, phase has been observed for chiral materials in which chirality is introduced through a branched 2-methylbutyl terminal tail. The chiral twist-bend nematic phase, N*TB, is completely miscible with the NTB phase of the standard achiral material, CB6OCB. The N*TB phase exhibits optical textures with lower birefringence than those observed for the achiral NTB phase, suggesting an addnl. mechanism of averaging mol. orientations. The N*-N*TB transition temperatures for the chiral materials are higher than the NTB-N transition temperatures seen for the corresponding racemic materials. This suggests the double degeneracy of helical twist sense in the NTB* phase is removed by the intrinsic mol. chirality. A square lattice pattern is observed in the N* phase over a temperature range of several degrees above the N*TB-N phase transition, which may be attributed to a non-monotonic dependence of the bend elastic constant

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So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Liu, Pei; Zhang, Sheng; Pei, Xiaomei; Song, Binglei; Jiang, Jianzhong; Cui, Zhenggang; Binks, Bernard P. researched the compound: 8-Bromooctanoic acid( cas:17696-11-6 ).Recommanded Product: 17696-11-6.They published the article 《Recyclable and re-usable smart surfactant for stabilization of various multi-responsive emulsions alone or with nanoparticles》 about this compound( cas:17696-11-6 ) in Soft Matter. Keywords: octyl dimethylamine quaternary ammonium smart surfactant preparation property. We’ll tell you more about this compound (cas:17696-11-6).

A novel multi-responsive surfactant (abbreviated as N+-8P8-N) was synthesized, in which one octyl trimethylamine group (quaternary ammonium) and one octyl dimethylamine group are connected to a benzene ring through ether bonds. This novel surfactant can stabilize conventional oil-in-water (O/W) emulsions alone, and O/W Pickering emulsions and novel oil-in-dispersion emulsions together with oppositely and similarly charged nanoparticles, resp. In all cases rapid demulsification can be achieved through either pH or CO2/N2 triggers, by which the surfactant is reversibly converted between a normal cationic surfactant form (N+-8P8-N) and a strongly hydrophilic and surface-inactive bola form (N+-8P8-NH+). Notably, the bola form N+-8P8-NH+ dissolves in the aqueous phase alone or together with nanoparticles after demulsification without contamination of the oil phase, and the aqueous phase can be recycled many times triggered by pH or CO2/N2 in accordance with the principle of green chem. This newly designed re-usable smart surfactant is significant for the development of various temporarily stable emulsions, which are extensively applied in emulsion polymerization, new material synthesis, heterogeneous catalysis and oil transportation.

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HPLC of Formula: 17696-11-6. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 8-Bromooctanoic acid, is researched, Molecular C8H15BrO2, CAS is 17696-11-6, about Synthesis and evaluation of aromatic methoxime derivatives against five postharvest phytopathogenic fungi of fruits. Main structure-activity relationships.

The antifungal activity of a library of twenty-four aromatic methoximes was examined against five representative postharvest phytopathogenic fungi. The panel included Penicillium digitatum, Penicillium italicum, Rhizopus stolonifer, Botrytis cinerea and Monilinia fructicola, all of which cause relevant economic losses worldwide as a result of affecting harvested fruits. The min. inhibitory concentrations and min. fungicidal concentrations of each compound were defined and the main structure-activity relationships were determined Although other congeners were more potent, drug likeliness considerations pointed to the methoxime derived from 2,4-dihydroxypropiophenone as the compound with the most suitable profile. The morphol. of the colonies of the fungal strains treated with the methoxime was examined microscopically and the compound was also tested in freshly harvested peaches and oranges, exhibiting promising control profiles in both fruits, similar to those of the com. agents Imazalil and Carbendazim.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline, is researched, Molecular C13H14ClN3, CAS is 837-52-5, about Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates, the main research direction is piperazinyl quinoline Candida fluconazole sensitivity.Recommanded Product: 837-52-5.

The effectiveness of the potent antifungal drug fluconazole is being compromised by the rise of drug-resistant fungal pathogens. While inhibition of Hsp90 or calcineurin can reverse drug resistance in Candida, such inhibitors also impair the homologous human host protein and fungal-selective chemosensitizers remain rare. The MLPCN library was screened to identify compounds that selectively reverse fluconazole resistance in a Candida albicans clin. isolate, while having no antifungal activity when administered as a single agent. A piperazinyl quinoline was identified as a new small-mol. probe (ML189) satisfying these criteria.

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Recommanded Product: 6-Bromo-3-methyl-1H-indole. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 6-Bromo-3-methyl-1H-indole, is researched, Molecular C9H8BrN, CAS is 1219741-50-0, about Formal [3+2] cycloadditions via indole activation: a route to pyrroloindolines and furoindolines. Author is Wang, Ya-Ni; Li, Tian-Ren; Zhang, Mao-Mao; Cheng, Bei-Yi; Lu, Liang-Qiu; Xiao, Wen-Jing.

Here, we describe a novel [3+2] cycloaddition of 3-substituted indoles with vinyl aziridines and vinyl epoxides that provides a straightforward approach to pyrroloindolines and furoindolines bearing vinyl groups (up to 96% yield and 9:1 dr). In contrary to previous reports involving Lewis acid activation, this work reports successful reactions based on the activation of indole using tBuOK and BEt3 (triethylborane), thereby preserving the free N-H group on indoles. In addition, a gram-scale reaction and a ring-closing metathesis reaction are performed to provide good demonstrations of the synthetic utility of this approach.

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Xu, Deyu; Chen, Xiong; Yin, Xiangsheng; Ning, Xiaomin published an article about the compound: 7-Chloro-4-(piperazin-1-yl)quinoline( cas:837-52-5,SMILESS:C1=C(Cl)C=C2C(=C1)C(=CC=N2)N3CCNCC3 ).Recommanded Product: 7-Chloro-4-(piperazin-1-yl)quinoline. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:837-52-5) through the article.

Tripiperaquine derivatives [I; Z, Z1 = (CH2)n where n = 2, 3, 4; CH2CHMe, CH2CHRCH2 where R = Cl, HO, PrCO2] were prepared and showed antimalarial activity at 3 mg/kg. Thus, 0.7 mol glycidyl chloride was added to a solution of 0.3 mol piperazine in EtOH at 40-50° and refluxed to give 87.0% II, which (0.01 mol) was refluxed with 0.021 mol III and 2.5 g Et3N in EtOH to give 79% I [Z = Z1 = CH2CH(OH)CH2].

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Product Details of 2645-22-9. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 4,4-Dipyridyl Disulfide, is researched, Molecular C10H8N2S2, CAS is 2645-22-9, about Electrochemical consideration of electrostatic interaction of charged molecules with partially overlapped electric field: zwitterions and proteins. Author is Sugimoto, Yu; Fujieda, Nobutaka; Kano, Kenji.

Electrostatic interactions greatly affect the interaction and activity of ions and charged mols. In this study, electrochem. techniques were applied to evaluate the electrostatic interactions of zwitterions and proteins as charged mols. that have partially overlapped elec. field. The formal potential of a probe redox couple, [Fe(CN)6]3-/4-, was used as a measure of the electrostatic interaction between the probe ions and linear amino acids as zwitterions. The zwitterions clearly showed electrostatic interaction with [Fe(CN)6]3-/4-, but the strength was weakened by the partial overlapping of the elec. field of oppositely charged sites. Furthermore, we investigated the electrostatic interaction between proteins as multivalent polymeric ions using quinohemoprotein amine dehydrogenase and its electron accepter proteins (amicyanin, cytochrome c550, and horse heart cytochrome c). The second-order reaction rate constant (k) of the intermol. electron transfer between the proteins was electrochem. determined in various ionic strengths (I). The I dependences of k were explained not by the net charges but by the local charges around the interaction interfaces of the proteins.

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The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 7-Chloro-4-(piperazin-1-yl)quinoline( cas:837-52-5 ) is researched.Synthetic Route of C13H14ClN3.Umar, Tarana; Shalini, Shruti; Raza, Kausar Md; Gusain, Siddharth; Kumar, Jitendra; Seth, Prerna; Tiwari, Manisha; Hoda, Nasimul published the article 《A multifunctional therapeutic approach: Synthesis, biological evaluation, crystal structure and molecular docking of diversified 1H-pyrazolo[3,4-b]pyridine derivatives against Alzheimer’s disease》 about this compound( cas:837-52-5 ) in European Journal of Medicinal Chemistry. Keywords: piperazinyl pyrazolopyridinyl acetamide preparation docking cholinesterase inhibitor amyloid aggregation; AChE inhibitors; Amyloid β aggregation inhibitors; Docking; N-(1H-pyrazolo[3,4-b]pyridin-3-yl)acetamides; Selectivity. Let’s learn more about this compound (cas:837-52-5).

2-(Piperazin-1-yl)-N-(1H-pyrazolo[3,4-b]pyridin-3-yl)acetamides I [R = piperidin-1-yl, 4-methylpiperazin-1-yl, Et 4-((4-yl)piperazin-1-yl)quinoline-3-carboxylate, etc.] were described as a new class of selective and potent acetylcholinesterase (AChE) inhibitors and amyloid β aggregation inhibitors. Formation of synthesized compounds I was justified via 1H NMR, 13C NMR, mass spectra and single crystal X-Ray diffraction study. All compounds were evaluated for their acetylcholinesterase and butyrylcholinesterase inhibitory activity, inhibition of self-mediated Aβ aggregation and Cu(II)-mediated Aβ aggregation. Also, docking study was carried out in concordance with in vitro results. The most potent mol. amongst the derivatives exhibited excellent anti-AChE activity (IC50 = 4.8 nM). Kinetic study of I [R = 2-((4-yl)piperazin-1-yl)-N-(1H-pyrazolo[3,4-b]pyridin-3-yl)acetamide] suggested it to be a mixed type inhibitor. In vitro study revealed that all the compounds were capable of inhibiting self-induced β-amyloid (Aβ) aggregation with the highest inhibition percentage to be 81.65%. Potency of I [R = Et 4-((4-yl)piperazin-1-yl)quinoline-3-carboxylate, 2-((4-yl)piperazin-1-yl)-N-(1H-pyrazolo[3,4-b]pyridin-3-yl)acetamide] to inhibit self-induced Aβ1-42 aggregation was ascertained by TEM anal. Compounds were also evaluated for their Aβ disaggregation, antioxidation, metal-chelation activity.

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