Tag: M.W=200-300

91-13-4, Name is 1,2-Bis(bromomethyl)benzene, molecular formula is C8H8Br2, Name: 1,2-Bis(bromomethyl)benzene, belongs to bromides-buliding-blocks compound, is a common compound. In a patnet, author is Yang, Ping, once mentioned the new application about 91-13-4.

Copper(ii) complexes with NNO ligands: synthesis, crystal structures, DNA cleavage, and anticancer activities

Three novel copper(ii) complexes, Cu(L1)(2) (1), Cu(L2)(2)2DMF (2), and Cu(L3)(2)2DMF (3), were synthesized using three aroylhydrazone ligands, (E)-2-hydroxy-N ‘-(1-(pyrazin-2-yl)ethylidene)benzohydrazide (HL1), (E)-3-hydroxy-N ‘-(1-(pyrazin-2-yl)ethylidene)benzohydrazide (HL2) and (E)-4-hydroxy-N ‘-(1-(pyrazin-2-yl)ethylidene)benzohydrazide (HL3). The complexes were characterized by elemental analysis, infrared (IR), and Ultraviolet-visible light (UV-vis) spectroscopy. The X-ray crystal structures of the complexes all possess a distorted octahedral coordination geometry. Both an absorption spectral titration and a competitive binding assay (ethidium bromide, 4 ‘,6-diamidino-2-phenylindole (DAPI), and methyl green) revealed that complexes 2 and 3 bind readily to calf thymus DNA (ctDNA) through intercalative and minor groove binding modes. Complexes 2 and 3 also exhibited oxidative cleavage of supercoiled plasmid DNA (pUC19) in the presence of ascorbic acid as an activator. Cytotoxicity studies showed that complexes 2 and 3 possessed high cytotoxicities toward the HeLa human cervical cancer cell line, but weak toxicities toward the L929 normal mouse fibroblast cell line. We therefore have reason to believe that complexes 2 and 3 both show potential as promising anticancer candidate drugs.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 91-13-4 help many people in the next few years. Name: 1,2-Bis(bromomethyl)benzene.

Electric Literature of 2746-25-0, As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 2746-25-0, Name is 1-(Bromomethyl)-4-methoxybenzene, SMILES is COC1=CC=C(CBr)C=C1, belongs to bromides-buliding-blocks compound. In a article, author is Liu, Z-D, introduce new discover of the category.

MicroRNA-130b inhibits cerebral ischemia/reperfusion induced cell apoptosis via regulation of IRF1

OBJECTIVE: Cerebral ischemia/reperfusion (CIR) frequently causes serious disabilities and correlates with certain neurological processes. Some studies have shown that microRNAs (miRNAs) exert a neuroprotective effect by modulating the inflammatory process in CIR. However, the biofunction and the mechanism of miR-130b in CIR need to be fully elucidated. MATERIALS AND METHODS: An oxygen-glucose deprivation/reperfusion (OGD/R) model was constructed using SH-SYSY cell line to analyze the function of miR-130b in CIR. Quantitative Real Time-Polymerase Chain Reaction (qRT-PCR) was used to examine the expression levels of miR-130b and IRF1. Western blot was performed to detect the protein levels of IRF1, Bax, and Bcl-2. Cell viability was determined using MTT (3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assays. Dual-Luciferase reporter assay was conducted to confirm the target gene of miR-130b. RESULTS: In this study, we found that miR-130b level was prominently decreased after treatment with OGD/R. Through gain and loss assays, we concluded that miR-130b restoration promoted cell proliferation and inhibited cell apoptosis in OGD/R-treated cells. Moreover, we also identified IRF1 as an important target of miR-130b. Additionally, IRF1 knockdown remarkably abrogated the protection mediated by miR-130b against the injuries in OGD/R-treated cells. CONCLUSIONS: Taken together, our results suggested that miR-130b facilitated cell viability and suppressed cell apoptosis of CIR via negatively regulating of IRF1.

Electric Literature of 2746-25-0, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 2746-25-0.

Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, Category: bromides-buliding-blocks392-83-6, Name is 2-Bromobenzotrifluoride, SMILES is FC(F)(F)C1=CC=CC=C1Br, belongs to bromides-buliding-blocks compound. In a article, author is Teychene, Johanne, introduce new discover of the category.

Formulation induces direct DNA UVA photooxidation. Part I. Role of the formulating cationic surfactant

Cetyltriethylammonium bromide (CTEAB) was considered as a cationic surfactant to form lipoplexes with DNA. In TRIS/HCI buffer, CTEAB self-assembles above its critical micelle concentration (CMC = 0.15 mM) into small spherical micelles as determined by complementary scattering techniques. This surfactant readily interacts with the supercoiled plasmid DNA pBR322 via electrostatics and hydrophobic interactions. Upon increasing surfactant concentration, successive phase transitions are observed from partial neutralization to full compaction of DNA as evidenced by agarose gel electrophoresis, tensiometry, pyrene fluorescence, UV-Vis absorbance and circular dichroism measurements. Under UVA radiation (lambda >= 335 nm), we show that the presence of the surfactant increases photooxidized damage on DNA especially in the compacted state. A mechanistic study using selective scavengers shows the involvement of singlet oxygen in these oxidative processes due to the direct UVA absorption of DNA itself. (C) 2019 Elsevier B.V. All rights reserved.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 392-83-6. Category: bromides-buliding-blocks.

Electric Literature of 3433-80-5, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 3433-80-5, Name is 2-Bromobenzyl bromide, SMILES is BrC1=CC=CC=C1CBr, belongs to bromides-buliding-blocks compound. In a article, author is Desiree, Larenas-Linnemann, introduce new discover of the category.

An online survey detected knowledge gaps and cost-saving opportunities in asthma maintenance treatment among allergists, pulmonologists, ENTs and primary care

Background: In April 2017 the Mexican Asthma Guidelines (GUIMA) were published. Before the launch, physicians’ knowledge was explored related to key issues of the guideline. Methods: A SurveyMonkey (R) survey was sent out to board-certified physicians of 5 medical specialties treating asthma. Replies were analyzed per specialty against the GUIMA evidence-based recommendations. We present the treatment part here. Results: A total of 364 allergists (ALLERG), 161 pulmonologists (PULM), 34 ENTs, 239 pediatricians (PED) and 62 general practitioners (GPs) replied to the survey and 247-83-14-135-37 respectively finished it. Spirometry is not routinely indicated when asthma is very probable by ALLERG 54%, PULM 47%, ENT 39%, PED 65%, GP 64%. A fictitious case proposed to the physicians with intermittent asthma was erroneously treated with ICS by ALLERG 9%, PULM 11%, ENT 28%, PED 10%, GP 11%. The mild persistent case received mistakenly ICS-LABA by ALLERG 25%, PULM 26%, ENT 33%, PED 27%, GP 23%. The first-line option for moderate persistent asthma was ICS(median dose) instead of ICS(low)+LABA for ALLERG 29%, PULM 25%, ENT 17%, PED 27%, GP 23% and in severe asthma maintenance treatment PULM20%, ALLERG-ENT-PED-GP 22-34% failed to indicate LABA. Concerning the guidelines’ recommendation to use one inhaler for maintenance & rescue in moderate-to-severe asthma, PULM45%, ALLERG-ENT-PED-GP 56-80% (p < 0.00001), erroneously indicated ICS-salmeterol could be used, instead of ICS-formoterol. Oral beta 2 or theophylline are no longer recommended, but PULM 37% and ALLERG-ENT-PED-GP 42-62% (p < 0.01) still indicate their use. In severe asthma 61-73% of physicians consider adding LTRA to the treatment; only PULM38%, OTHERS12-25% consider adding tiotropium (p < 0.001) and 3-17% consider adding omalizumab, both guideline recommended add-ons. As for asthma in pregnancy, most surveyed are not aware budesonide is the 1st line option ICS. Finally, 81-97% of the group-members recognized allergen immunotherapy, as a viable add-on, in line with GINA/GEMA/GUIMA recommendations. Conclusions: An online survey could detect knowledge-gaps related to asthma treatment. Interestingly, surveyed physicians tended to over-treat the milder asthma cases, thus clearly leaving room for cost-savings. Caution should be taken in the promotion of the SMART (single-maintenance-and-reliever-treatment) approach, which can only be done with ICS-formoterol. Many physicians opt for other combinations not apt for this approach. Among all surveyed specialties there is ample room for improvement in mild and severe asthma management. Electric Literature of 3433-80-5, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 3433-80-5.

In an article, author is Ochensberger, Sandra, once mentioned the application of 344-04-7, Formula: C6BrF5, Name is 1-Bromo-2,3,4,5,6-pentafluorobenzene, molecular formula is C6BrF5, molecular weight is 246.96, MDL number is MFCD00000287, category is bromides-buliding-blocks. Now introduce a scientific discovery about this category.

Phenolic compounds of Iris adriatica and their antimycobacterial effects

Little is known about the pharmacological activities of Iris adriatica (Iridaceae), a plant endemic to Dalmatia (Croatia). We therefore performed a bioassay-guided fractionation including high-performance counter current chromatography (HPCCC) and antibacterial tests using Mycobacterium smegmatis mc(2) 155. One obtained fraction was found to be antimycobacterially active with a MIC of 64 mg L-1. Furthermore, fractions were tested for resistance modulatory effects using ethidium bromide as substrate. We were able to identify the pure isoflavonic compounds irigenin and irilone and a fraction containing mainly benzophenone 2,4,6-trihydroxy-4-methoxy-benzo-phenone, responsible for the resistance-modulatory activity of this plant.

If you are interested in 344-04-7, you can contact me at any time and look forward to more communication. Formula: C6BrF5.

Related Products of 344-04-7, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C¨CH bond functionalisation has revolutionised modern synthetic chemistry. 344-04-7, Name is 1-Bromo-2,3,4,5,6-pentafluorobenzene, SMILES is FC1=C(Br)C(F)=C(F)C(F)=C1F, belongs to bromides-buliding-blocks compound. In a article, author is Zhou, Xuebing, introduce new discover of the category.

Enhanced performance on CO2 adsorption and release induced by structural transition that occurred in TBAB center dot 26H(2)O hydrates

The applications of ionic clathrate hydrates have greatly improved the efficiency and the conditions required for hydrate-based CO2 capture, but high energy input for hydrate growth and complicated treatment of hydrate slurry still hinder their commercial use. Here we chose TBAB center dot 26H(2)O hydrate particles to adsorb CO2 molecules instead of TBAB solutions below 2 MPa and release them at ambient pressure. Results showed that the TBAB center dot 26H(2)O hydrate could adsorb CO2 without induction time and enhance the gas storage capacity by structural transition, especially under high pressure. By using in situ Raman, CO2 molecules were found to fill the empty cages in TBAB center dot 26H(2)O hydrate first, the formed nCOZTBAB center dot 26H(2)O hydrate then converted to nCOZTBAB center dot 38H(2)O and TBAB center dot 2(1)/3H2O hydrates at 2 MPa. Macroscopic measurements revealed that around 20 volume of CO2 in standard state could be adsorbed by 1 volume of TBAB center dot 26H(2)O hydrate sample at 1 MPa, but this volume ratio could reach 67 v/v at 2 MPa where structural change was thought to take place. The pressurized CO2 trapped in hydrate phase was assumed to destroy the structure of TBAB center dot 26H(2)O hydrate easily, and force the water molecules to form a structure that more compatible with CO2 molecules. This may explain why nCOZTBAB center dot 26H(2)O hydrates barely grow from TBAB solutions when pressurized CO2 is injected. In the CO2 release process, the nCOZTBAB center dot 38H(2)O and TBAB center dot 2(1)/3H2O hydrates quickly transformed back to nCO(2)center dot TBAB center dot 26H(2)O hydrates and 60-80% of the captured CO2 could be released. Combing with their excellent gas selectivity, TBAB center dot 26H(2)O hydrate particles would be an ideal material for hydrate-based CO2 capture.

Related Products of 344-04-7, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 344-04-7.

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 109-64-8, Name is 1,3-Dibromopropane, molecular formula is C3H6Br2. In an article, author is Wang, Zhe,once mentioned of 109-64-8, Category: bromides-buliding-blocks.

Efficient cleavage of tertiary amide bonds via radical-polar crossover using a copper(ii) bromide/Selectfluor hybrid system

A novel approach for the efficient cleavage of the amide bonds in tertiary amides is reported. Based on the selective radical abstraction of a benzylic hydrogen atom by a CuBr2/Selectfluor hybrid system followed by a selective cleavage of an N-C bond, an acyl fluoride intermediate is formed. This intermediate may then be derivatized in a one-pot fashion. The reaction proceeds under mild conditions and exhibits a broad substrate scope with respect to the tertiary amide moiety as well as to nitrogen, oxygen, and carbon nucleophiles for the subsequent derivatization. Mechanistic studies suggest that the present reaction proceeds via a radical-polar crossover process that involves benzylic carbon radicals generated by the selective radical abstraction of a benzylic hydrogen atom by the CuBr2/Selectfluor hybrid system. Furthermore, a synthetic application of this method for the selective cleavage of peptides is described.

If you¡¯re interested in learning more about 109-64-8. The above is the message from the blog manager. Category: bromides-buliding-blocks.

102169-44-8, name is 4-Bromo-5-methylbenzene-1,2-diamine, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 4-Bromo-5-methylbenzene-1,2-diamine

A mixture of (rac)-1-{[2,2-difluorocyclopropyl]methyl}-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole and (1 .50 g), 4-bromo-5-fluorobenzene-1,2-diamine (833 mg), bis(triphenylphosphine)palladium(ll)chloride (143 mg), triphenylphosphine (53 mg) and potassium carbonate solution (2 M in water, 6.1 mL) were dissolved in 39 mL 1-propanol. This mixture was stirred at 120 C for 2 hours. The reaction mixture was concentrated under reduced pressure. The residue was diluted with water and dichloromethane/lsopropanol (7:3). The layers were separated and the aqueous layer was extracted with dichloromethane/lsopropanol twice. The combined organic layers were concentrated under reduced pressure. The crude product was purified by flash chromatography to provide the target compound: 850 mg, 85% purity. LC-MS (Method 2): Rt = 0.87 min; MS (ESIpos): m/z = 283 [M+H]+ 1H-NMR (400MHz, DMSO-d6): _ [ppm]= 1 .42 – 1 .57 (m, 1H), 1 .60 – 1 .78 (m, 1H), 2.14 – 2.31 (m, 1H), 4.24 (br d, 2H), 4.28 – 4.45 (m, 2H), 4.79 (s, 2H), 6.36 (d, 1H), 6.71 (d, 1H), 7.59 -7.68 (m, 1H), 7.86 (d, 1H).

The synthetic route of 102169-44-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; LEFRANC, Julien; MENGEL, Anne; SCHULZE, Volker; CHRIST, Clara; PRINZ, Florian; WENGNER, Antje, Margret; STOeCKIGT, Detlef; BOeMER, Ulf; BADER, Benjamin; (288 pag.)WO2017/207534; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 54962-75-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 54962-75-3, name is 3-Bromo-5-(trifluoromethyl)aniline, This compound has unique chemical properties. The synthetic route is as follows.

3-Bromo-5-(trifluoromethyl)aniline (20 g, 83 mmol) in acetic acid (150 ml) was treated portionwise with N-iodosuccinimide (20.62 g, 92 mmol). The reaction was stirred 24 h at ambient temperature. The reaction was diluted with ethyl acetate (600 mL) and was washed with aqueous sodium bisulfie (100 mL) and brine (100 mL). The organic layer was dried with magnesium sulfate and evaporated. The residue was purified on a silica gel column with a gradient of ethyl acetate/hexanes from 7% to 15% to give 23.5 g (77%) of slightly impure product. 1H-NMR (CDCl3, 400 MHz) delta 7.21 (d, J=1.3 Hz, 1H), 6.82 (d, J=1.5 Hz, 1H), 4.57 (bs, 2H); LC/MS (HPLC method 4): tR=3.578 min, 365.80(MH)+.

The chemical industry reduces the impact on the environment during synthesis 3-Bromo-5-(trifluoromethyl)aniline. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Bristol-Myers Squibb Company; US2009/18132; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 52723-82-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 52723-82-7 as follows.

Example 47 4-Amino-2-fluoro-5-methylbenzonitrile Using the method of Example 15, 4-bromo-3-fluoro-6-methylaniline is converted into the title compound.

According to the analysis of related databases, 52723-82-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AMERICAN CYANAMID COMPANY; EP224001; (1991); B1;,
Bromide – Wikipedia,
bromide – Wiktionary