Tag: M.W=200-300

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1435-51-4, name is 1,3-Dibromo-5-fluorobenzene, A new synthetic method of this compound is introduced below., Safety of 1,3-Dibromo-5-fluorobenzene

Example 6 a) 20.0 g (78.8 mmol) 1,3-dibromo-5-fluoro-benzene, 16.3 g (78.8 mmol) 6H-benzimidazolo[1,2-a]benzimidazole and 43.5 g (0.315 mmol) potassium carbonate in 200 ml DMF are stirred for 17 h at 170 C. The reaction mixture is filtered hot and the precipitate from the mother liquor is filtered after cooling. The product is washed with water and ethanol and decocted with diethyl ether and ethanol. Yield 21.2 g (61%).1H NMR (400 MHz, THF-d8): delta 8.21-8.26 (m, 4H), 7.98-7.8.00 (m, 1H), 7.68-7.73 (m, 2H), 7.31-7.49 (m, 4H).

The synthetic route of 1435-51-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BASF SE; US2012/241681; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 699-03-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 699-03-6, name is 1-(4-Bromophenyl)-N-methylmethanamine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A mixture of tetrafluoropyridazine 1, DIPEA, amine and THF (10 mL) was stirred for the required time under an atmosphere of nitrogen. The mixture was evaporated to dryness in vacuo, partitioned between ethyl acetate (20 mL) and water (20 mL), the phases were separated and the aqueous phase was extracted further by ethyl acetate (3 x 20 mL). The combined organic phases were dried (MgSO4) and evaporated in vacuo. Purification by column chromatography or HPLC on silica gel using cyclohexane and ethyl acetate as eluent gave the pure product.

The synthetic route of 1-(4-Bromophenyl)-N-methylmethanamine has been constantly updated, and we look forward to future research findings.

Reference:
Article; Pattison, Graham; Sandford, Graham; Wilson, Ian; Yufit, Dmitrii S.; Howard, Judith A.K.; Christopher, John A.; Miller, David D.; Tetrahedron; vol. 73; 5; (2017); p. 437 – 454;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 1000994-95-5, The chemical industry reduces the impact on the environment during synthesis 1000994-95-5, name is 1-Bromo-4-(1,1-difluoroethyl)benzene, I believe this compound will play a more active role in future production and life.

In a 40 ml vial, bromo derivative (250 mg, 1.13 mmol, 1.0 eq.), bispinacolotodiboron (288.6 mg, 1.13 mmol, 1.0 eq.), Pd(dppf)CI2 (92.7 mg, 0.114 mmol, 0.1 eq.) and potassium acetate (354.5 mg, 3.41 mmol, 3.0 eq.) were mixed in dioxane (10 ml) and heated to 80 C for 8 hours. LCMS indicated that the product was formed in major amount. . The crude reaction was purified in the presence of silica (10-15 gm) and purified using hexanes: ethyl acetate (0-100%) to yield desired boron ester. The product was characterized by reverse phase HPLC using method 4. (ES, m/z) [M + H+] 269.0. Retention time = 1.60 mins.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-(1,1-difluoroethyl)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; IRM LLC; NOVARTIS AG; CHATTERJEE, Arnab Kumar; NAGLE, Advait Suresh; PARASELLI, Prasuna; LEONG, Seh Yong; ROLAND, Jason Thomas; MISHRA, Pranab Kumar; YEUNG, Bryan KS; ZOU, Bin; WO2014/78813; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 68322-84-9, name is 2-Bromo-1-fluoro-4-(trifluoromethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 2-Bromo-1-fluoro-4-(trifluoromethyl)benzene

Example 2 [0028] [0029] A 400 mL shaker tube was loaded with 50 g of 3-bromo-4-fluorobenzotrifluoride and 10 g of SbF5. The shaker tube was evacuated, charged with 20 g of TFE, and agitated for 12 h at 25 C. The crude product was unloaded from the shaker tube and washed with water. The organic layer was separated, dried over MgSO4 and filtered to give 37 g of crude product, containing benzotrifluoride and compounds 4 and 5 in a ratio of 10:60:30, respectively, as determined by NMR and GC/MS. The reaction mixture was distilled at atmospheric pressure, using a spinning-band distillation column to give 15.3 g of a fraction (b.p. 142-144 C. at 760 mm Hg) and 13.5 g of residue. According to NMR analysis, the distilled fraction contained compounds 4 and 5 in a ratio of 85:15. The residue was found to be a mixture of 4 and 5 in a ratio of 30:70. [0030] Compound 4. 19F NMR (CDCI3): -80.38 (3F,t), -101.28 (1F, m), -111.56 (2F,m), -126.61(2F, s) ppm. H1 NMR (CDCl3): 7.32 (1H,m), 7.70 (1H,m), 7.92 (1H,m) ppm. [0031] Compound 5. 19F NMR (CDCl3): -79.33 (6F, m)), -102.46 (1F,m), -120.33 (4F, A:B quartet), -181.75, 1F, m) ppm. H1 NMR (CDCl3): 7.32 (1H,m), 7.70 (1H,m), 7.92 (1H,m) ppm.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 68322-84-9.

Reference:
Patent; E I DU PONT DE NEMOURS AND COMPANY; Petrov, Viacheslav A.; US2014/200372; (2014); A1;,
Bromide – Wikipedia,
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Synthetic Route of 6274-57-3, These common heterocyclic compound, 6274-57-3, name is 1-(4-Bromophenyl)-N,N-dimethylmethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

nBuLi (2.5 M in hexanes, 2.15 mL, 5.37 mmol) was added dropwise to a solution of 1-(4- bromophenyl)-N,N-dimethylmethanamine (1.0 g, 4.67 mmol) in THF (10 mL) at -78 C and the reaction was stirred for 15 min. SO2 was bubbled through the solution for 5 min, then the reaction was warmed to RT. After 2 h, the reaction was concentrated to almost dryness then triturated with MTBE (40 mL) and the solid was filtered to afford the title compound (0.8 g, 71% yield) as a yellow solid.1H NMR (DMSO-d6) d 7.45 (d, J = 7.7 Hz, 2H), 7.30 (d, J = 7.6 Hz, 2H), 3.62 (s, 2H), 2.20 (s, 6H).

The synthetic route of 6274-57-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; INFLAZOME LIMITED; MILLER, David; MACLEOD, Angus; THOM, Stephen; MCPHERSON, Christopher G.; ALANINE, Thomas; CARRILLO ARREGUI, Jokin; CIANA, Claire-Lise; SHANNON, Jonathan; VAN WILTENBURG, Jimmy; DEN HARTOG, Jacobus Antonius Joseph; (603 pag.)WO2019/211463; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3972-65-4, name is 1-Bromo-4-(tert-butyl)benzene, A new synthetic method of this compound is introduced below., Safety of 1-Bromo-4-(tert-butyl)benzene

A typical procedure of the electroreductive coupling of aryl bromide1 with catalytic amounts of [OctV2+][Tf2N]2 and Pd species isas follows. Into an undivided cell fitted with a Zn anode(1.5 1 cm2) and a Pt cathode (1.5 1 cm2) was added a DMF(3 mL) solution of 4-bromopropiophenone (1a, 0.25 mmol),[Bu4N+][Tf2N] (0.3 mmol), [OctV2+][Tf2N]2 (0.075 mmol,30 mol %), and PdCl2(PPh3)2 (0.0125 mmol, 5 mol %). The wholemixture was electrolyzed at 60 C under constant current(10 mA) conditions until 2 F/mol-1a of electricity was passed.The reaction mixture was poured into 5% aq HCl and extractedwith AcOEt. Purification by column chromatography (SiO2, toluene/AcOEt = 10/1) afforded 4,40-dipropanoylbiphenyl (2a) in 94%yield

The synthetic route of 3972-65-4 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kuroboshi, Manabu; Shiba, Takuya; Tanaka, Hideo; Tetrahedron Letters; vol. 54; 28; (2013); p. 3666 – 3668;,
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Synthetic Route of 58971-11-2, The chemical industry reduces the impact on the environment during synthesis 58971-11-2, name is 3-Bromophenethylamine, I believe this compound will play a more active role in future production and life.

To a solution of methanesulfonyl chloride(1.60 mmol, 0.12 mL, 1.0 equiv) in ethanol (3 mL), 2-(3-bromophenyl)ethan-1-amine (3.20 mmol, 639mg, 2.0 equiv) was added and the mixture was stirred at room temperature. The reaction wasmonitored by TLC. After completion the solvent was removed under reduced pressure and theremaining solid dissolved in a small amount of water. The solution was applied to a C18 precolumnbefore purification on a 60 g C18 column with a gradient of acetonitrile in water (10-80%). The titlecompound (1.07 mmol, 295 mg, 66%) was obtained as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromophenethylamine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Akhter, Sundus; Lund, Bjarte Aarmo; Ismael, Aya; Langer, Manuel; Isaksson, Johan; Christopeit, Tony; Leiros, Hanna-Kirsti S.; Bayer, Annette; European Journal of Medicinal Chemistry; vol. 145; (2018); p. 634 – 648;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 103977-79-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 103977-79-3 as follows.

A mixture of 106 2,2-dimethyl-1,3-dioxane-4,6-dione (7.62 g, 52.88 mmol) in 107 trimethoxymethane (26.3 mL, 240.38 mmol) was heated at 85 C. and stirred for 1.5 h. 498 3-Bromo-2,4-difluoroaniline (10 g, 48.08 mmol) in 33 ethanol (42.4 mL) was added and the reaction mixture was stirred at 85 C. for 3 h. The mixture was cooled with the resulting solid was filtered and washed with IPA (2¡Á50 mL) and diethyl ether (4¡Á50 mL). The solid was dried under vacuum overnight to afford 499 5-[(3-bromo-2,4-difluoroanilino)methylidene]-2,2-dimethyl-1,3-dioxane-4,6-dione (14.62 g, 84%) as a beige solid; 1H NMR (400 MHz, DMSO, 30 C.) 1.69 (6H, s), 7.33-7.43 (1H, m), 7.86-7.97 (1H, m), 8.56-8.64 (1H, m), 11.24 (1H, s); m/z: ES+ [M+H]+ 362.0.

According to the analysis of related databases, 103977-79-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ASTRAZENECA AB; Kettle, Jason Grant; Bagal, Sharanjeet; Robb, Graeme Richard; Smith, James Michael; Goldberg, Frederick Woolf; Cassar, Doyle Joseph; Feron, James Lyman; US2019/177338; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 937046-98-5, name is 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 937046-98-5, Application In Synthesis of 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine

To a solution of 2-1 (3.85 g, 18.1 mmol, WO 2007/64931, published June 7, 2007) in anhydrous DMF (30 mL) was added NaH (1.08 g, 27.1 mmol) at 0 C. The reaction was stirred under N2 for 0.5 h. MMTrCl (6.14 g, 19.9 mmol) was added. The mixture was stirred at RT for 2 h. Water was added to quench the reaction. The mixture was extracted with EA (3 X 100 mL). The organic phase was combined and then dried over Na2SO4. After filtration, the solution was concentrated in vacuo to give a residue which was further purified by column chromatograph (PE:EA = 20: 1) to give 2-2 (3.8 g, 45%) as a white solid. ESI-LCMS: m/z 485.2 [M+H]+

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; ALIOS BIOPHARMA, INC.; BEIGELMAN, Leonid; WANG, Guangyi; ZHONG, Minghong; (249 pag.)WO2017/156262; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 100189-84-2, name is 2,5-Dibromo-1,3-dimethylbenzene, This compound has unique chemical properties. The synthetic route is as follows., Formula: C8H8Br2

Step 1: A solution of 2,5-dibromoxylene (2.0 g, 7.6 mmol) in DCM (20 ml) was treated with n-BuLi (2.5 M solution in hexane, 3 ml, 1.0 equiv.) at -78C. After stirring for 1h, DMF (1.8 ml, 23 mmol, 3 eq.) was added and the solution was allowed to warm to room temperature. It was acidified to pH 2 with 5% hydrochloric acid and extracted with diethyl ether (3×50 ml). The combined organic phase was dried and evaporated and the residue was purified by column chromatography using PE:EA = 10:1 as eluent to give 4-bromo-3,5-dimethylbenzaldehyde (0.76 g, yield: 47%).

According to the analysis of related databases, 100189-84-2, the application of this compound in the production field has become more and more popular.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary