Tag: M.W=200-300

Reference of 626-40-4, These common heterocyclic compound, 626-40-4, name is 3,5-Dibromoaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

cross-coupling reaction, the 11.87g, 40mmo 1 of 3,5-dibromoaniline, 9mL, 1OOmmo 1 of ethyl acrylate, 10.35g, 75mmol of anhydrous potassium carbonate, 3.22g, lOmmol tetrad Ammonium bromide and 1.122g, 5mmol of palladium acetate (catalyst) according to the set stoichiometric ratio uniformly dissolved in 100mL of DMF, the reaction was stirred at 130 C for 1 ~ 2 days, through a mixture of ethyl acetate and water Times extraction, drying over anhydrous magnesium sulfate, purification by chromatography and subsequent hydrolysis to obtain 5-amino-1,3-benzenediacrylic acid with high chemical purity.

Statistics shows that 3,5-Dibromoaniline is playing an increasingly important role. we look forward to future research findings about 626-40-4.

Reference:
Patent; Zhejiang University; Qian Guodong; Zhang Ling; Jiang Ke; Yang Yu; Cui Yuanjing; (7 pag.)CN106588960; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 112734-22-2, name is (4-Bromo-2-fluorophenyl)methanamine, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C7H7BrFN

Step 1 : (4-Bromo-2-fluorophenyl)methanamine (924 mg, 4.53 mmol) was dissolved in pyridine and ethane sulfonyl chloride (0.82 mL, 8.60 mmol) was added to the solution at 0 C. The mixture was stirred for 1 h at 0 C. Then, the mixture was quenched with 1 N HCI and extracted with ethyl acetate. Drying over magnesium sulfate and evaporation of the ethyl acetate and purified by column chromatography gave N-(4-bromo-2-fluorobenzyl)ethane- sulfonamide in pure form (1 .06 g, 79 %).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 112734-22-2.

Reference:
Patent; GRUeNENTHAL GMBH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; LESCH, Bernhard; LEE, Jeewoo; WO2013/45452; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 66417-30-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 66417-30-9 name is 2-Bromo-1-methyl-4-(trifluoromethyl)benzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2-Bromo-4- (trifluoromethyl) toluene (23b, 5g, 21 mmol) was placed in round-bottom flask and dissolved in 150 ml DMF.Then KOAc (6.2g, 63 mmol, 3eq) was added to the reaction mixture in one portion followed by addition of PdCl2 (dppf)(0.46g, 0.63 mmol, 0.03eq) and Bis (pinacolato) diboron 5.9g,23.1 mmol, l.leq). The solution was stirred at 80C for 48h. Then the solvent was removed and the black residue was subjected to plug column chromatography (EtOAc) resulting in dark green oily residue. The compound was further purified by second column chromatography (2% MeOH/DCM) .Pure product (3.5g, 58%) as a slightly green oil was collected.Structure determination:RP-HPLC Conditions: HP 1100 HPLC chromatograph, Waters 3.9 x 150 mm NovaPak HR C18 column with guard column, 0.010 mL injection, 1.5 mL/min, 1.500 mL injection loop, 254 nm detection, A = water (0.1% v/v TFA) and B = MeCN (0.1% v/v TFA), gradient 10% B 1 min, 10-80% B over 9 min, 80-100% B over 1 min, 100 %B 1 min, retention time 7.9 min (for boronic acid) and 12.6 min (for pinacol ester). 1H NMR (400 MHz, CDCl3): delta 1.35 (s, 12H), 2.58 (s, 3H), 7.26 (d, IH), 7.55 (d, IH), 8.00 (s, IH).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-1-methyl-4-(trifluoromethyl)benzene, and friends who are interested can also refer to it.

Reference:
Patent; SENSORS FOR MEDICINE AND SCIENCE, INC.; WO2008/66921; (2008); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 69321-60-4, name is 2,6-Dibromotoluene, A new synthetic method of this compound is introduced below., Recommanded Product: 69321-60-4

A mixture of 1,3-dibromo-2-methylbenzene (6.0 g, 24 mmol), phenylboronic acid(2.9 g, 24 mmol), [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium(II) complexedwith dichloromethane (1: 1) (817 mg, 1. 0 mmol) and potassium carbonate (1 0 g, 725 mmol) in 1,4-dioxane (100 mL) and water (70 mL) was stirred at room temperatureovernight. The reaction was quenched with water, and extracted with ethyl acetate (3x 150mL). The combined organic layers were washed with brine, dried over Na2S04, filtered andconcentrated under reduced pressure. The residue was purified by chromatography on silicagel, eluting with 0-5% EtOAc/hexanes, to give the desired product (4.7 g).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; INCYTE CORPORATION; LU, Liang; QIAN, Ding-Quan; WU, Liangxing; YAO, Wenqing; (103 pag.)WO2017/205464; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 345965-54-0, name is 1-(4-Bromophenyl)cyclopropanamine, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 1-(4-Bromophenyl)cyclopropanamine

Step 1: tert-butyl (l-(4-bromophenyl)cyclopropyl)carbamate: A stirred solution of l-(4- bromophenyl)cyclopropanamine (1.00 g, 4.72 mmol) in DCM (10 ml) was treated with B0C2O (1.08 g, 4.95 mmol) and the resultant mixture stirred overnight. The solution was diluted with DCM (20 ml), was washed with brine (20 ml) and filtered through a phase separation cartridge. The filtrate was concentrated in vacuo to afford the title compound (1.43 g, 4.50 mmol, 98% purity) as a white solid. 1H NMR (400 MHz, Chloroform-d) (two rotamers in a 3: 1 ratio) delta 7.44 – 7.36 (m, 2H), 7.10 (d, / = 8.3 Hz, 2H), 5.22 (br s, 1H, major), 5.01 (br s, 1H, minor), 1.43 (br s, 9H), 1.32 – 1.11 (m, 4H).

According to the analysis of related databases, 345965-54-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BERGENBIO AS; SHIERS, Jason John; WATTS, John Paul; ONIONS, Stuart Thomas; QUDDUS, Mohammed Abdul; WRIGGLESWORTH, Joseph William; SAMBROOK-SMITH, Colin Peter; NAYLOR, Alan; LONDESBROUGH, Derek; (444 pag.)WO2016/102672; (2016); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 176317-02-5, name is 1-Bromo-2,3,4-trifluorobenzene, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 1-Bromo-2,3,4-trifluorobenzene

Step 1: 5-bromo-2,3,4-trifluorobenzoic acid To a solution of diisopropylamine (10.14 g, 100.20 mmol) in THF (100 mL) was added n-BuLi (40.08 mL, 2.5 M in hexane, 100.20 mmol) at -78 C. under nitrogen atmosphere. The stirring was maintained at this temperature for 1 h. Then a solution of 1-bromo-2,3,4-trifluorobenzene (17.62 g, 83.50 mmol) in THF (120 mL) was added. After stirring for 1 h at -78 C., the mixture was transferred to a bottle with dry ice. The mixture was stirred overnight at room temperature. The reaction was quenched with 10% aqueous HCl and pH was adjusted to 1-2. The mixture was extracted with ethyl acetate (100 mL*3). The combined organic extracts were washed with water (100 mL) and brine (100 mL) sequentially, dried over Na2SO4, filtered and concentrated under reduced pressure to afford the desired product (20.12 g, 94.5% yield). 1H NMR (400 MHz, DMSO-d6): delta 13.95 (s, 1H), 7.97 (m, 1H).

According to the analysis of related databases, 176317-02-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TIANJIN BINJIANG PHARMA, INC.; Tian, Hongqi; Ji, Conghui; Liu, Chunlei; Kong, Li; Cheng, Ying; Huang, Gongchao; US2014/371278; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 698-19-1, These common heterocyclic compound, 698-19-1, name is 1-(2-Bromophenyl)-N-methylmethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of compound 1A (1.0 g, 5 mmol) in 50 mL of DCM was added N-Boc-glycine (950 mg, 5.4 mmol), followed by [1-HYDROXY-7-AZABENZOTRIAZOLE] (800 mg, 5.84 mmol) and [1- (3-DIMETHYLAMINOPROPYL)-3-ETHYLCARBODIIMIDE] hydrochloride (4.41 g, 7.38 mmol). The reaction mixture was stirred at rt for 4 hours and concentrated under reduced pressure. The resulting oil was dissolved in EtOAc and washed successively with saturated sodium bicarbonate, 1N-hydrochloric acid, dried over sodium sulfate and concentrated under reduced pressure to give the title compound (1.8 g, 99%) as a colorless oil, which was used for the subsequent step without further purification

Statistics shows that 1-(2-Bromophenyl)-N-methylmethanamine is playing an increasingly important role. we look forward to future research findings about 698-19-1.

Reference:
Patent; Bristol-Myers Squibb Company; WO2004/214; (2003); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 615-87-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 615-87-2, name is 1,5-Dibromo-2,4-dimethylbenzene, This compound has unique chemical properties. The synthetic route is as follows.

Into an eggplant type flask having a capacity of 200 milliliter, dbb in an amount of 5.11 mmol (1.35 g), (2-pyridyl)trimethyl tin in an amount of 15.3 mmol (3.71 g), Pd (PPh3)2Cl2 in an amount of 0.408 mmol (0.286 g), lithium chloride in an amount of 51.1 mmol (2.17 g) and toluene as a solvent in an amount of 20 milliliter were placed and the resultant solution was refluxed for 3 days. After the resultant solution was cooled by leaving it standing, saturated potassium fluoride aqueous solution was added and the resultant solution was stirred for 30 minutes. After filtering the resultant solution, dichloromethane and 5 % sodium hydrogen carbonate aqueous solution were added to the filtrate and the resultant solution was extracted. Adding sodium sulfate into an organic layer and dehydrating the resultant mixture, the organic layer was removed through pressure reduction, and the remained substance was refined by means of silica gel column chromatography (hexane : ether= 4:1). After re-crystallizing the resultant substance with the use of heated hexane, white crystals of dpyx in an amount of 0.31 g was obtained (yield: 33 %). m.p.: 89 to 90 C

The chemical industry reduces the impact on the environment during synthesis 1,5-Dibromo-2,4-dimethylbenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; IDEMITSU KOSAN CO., LTD.; Chuo University; EP1816134; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 327-51-5, name is 1,4-Dibromo-2,5-difluorobenzene, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 327-51-5

1,4-dibromo-2, 5-difluorobenzene (49.3 g, 181.5 mmol), 2-methoxyphenylboronic acid (66.2 g, 435.6 mmol), a 2 M aqueous solution of Na2CO3 (363 mL, 726 mmol), DME (360 mL), toluene (360 mL), and Pd[PPh3]4 (21 g, 18.0 mmol) were loaded into a three-necked flask, and the mixture was refluxed under an Ar atmosphere for 8 hours. After the completion of the reaction, the resultant was cooled to room temperature. The resultant sample was transferred to a separating funnel, and water (500 mL) was charged into the funnel. Then, the mixture was extracted with CH2Cl2. The extract was dried with MgSO4, and was then filtrated and concentrated. The resultant sample was purified by silica gel column chromatography, whereby a white solid was obtained in an amount of 38.5 g in 65% yield. FD-MS C20H16F2O2 : theoretical value 326, observed value 326

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 327-51-5.

Reference:
Patent; Idemitsu Kosan Co., Ltd.; EP2301921; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 67567-26-4, name is 4-Bromo-2,6-difluoroaniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 67567-26-4

4-Bromo-2,6-difluoroaniline (65A, 0.50Og, 2.4mmol) was combined with sodium methanesul finale (0.98g, 9.6mmol), cuprous triflate benzene complex (0.121g, 0.24mmol), and N,N’-dimethylethylencdiamine (0.027mL, 0.23mmol) in DMF (5mL). The mixture was heated to 150 C and allowed to stir at this temperature for 24 hours, then was concentrated in vacuo and purified using PLC to provide compound 65B as a yellow solid.

The synthetic route of 67567-26-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SCHERING CORPORATION; WO2009/55331; (2009); A2;,
Bromide – Wikipedia,
bromide – Wiktionary