Tag: M.W=200-300

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 18392-81-9, name is 5,6-Dibromobenzo[c][1,2,5]thiadiazole, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C6H2Br2N2S

Take 1.4g (4.76mmol) of 4,7-dibromobenzothiadiazole in a 250mL round-bottom flask, add a mixed solvent of 16mL of tetrahydrofuran and 160mL of absolute ethanol, and add 3.244g at 0 C under a nitrogen atmosphere. 85mmol) sodium borohydride, continue to stir for 10min, then stir at room temperature for 3h, remove the organic solvent, add deionized water, extract the organic phase with anhydrous ether, wash with saturated sodium chloride solution and dry with anhydrous magnesium sulfate, again Remove the solvent to obtain 4,5-dibromo-1,2-phenylenediamine as a light yellow solid powder with a yield of 80%;

According to the analysis of related databases, 18392-81-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shanxi University; Li Juan; Wu Zhenzhen; (8 pag.)CN111057011; (2020); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 937046-98-5, name is 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine, A new synthetic method of this compound is introduced below., Recommanded Product: 937046-98-5

A 3-L round bottom flask equipped with a mechanical stirrer, a heating mantle, a thermal couple, a reflux condenser, a nitrogen inlet and a nitrogen outlet was charged with 7- bromopyrrolo[l,2- |[l,2,4]triazin-4-amine (Compound 11, 100 g, 469 mmol) and fert-butyl 4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-5,6-dihydropyridine-l(2H)-carboxylate (Compound 12, 174 g, 563 mmol) in 1,4-dioxane (876 mL) at room temperature. To the reaction flask was added potassium carbonate (130 g, 939 mmol) and water (218 g) in sequence. The mixture was degassed by exposure to vacuum and refilled with nitrogen atmosphere for three times. After the addition of tetrakis(triphenylphosphine)palladium (0) (Pd(PPh3)4, 13.56 g, 11.7 mmol), the reaction mixture was degassed and refilled with nitrogen for three times at room temperature. Then the reaction mixture was heated to 85 – 90 C, and agitated at that temperature for 16 hours. Upon the completion of the reaction, water (900 mL) was added in 30 minutes while the internal temperature was above 50 C The mixture was cooled to room temperature. Solids gradually precipitated out. The solids were collected by filtration at 18 C, and washed with water (2 x 250 mL) and methyl tert-butyl ether (MTBE, 3 x 200 mL). The wet cake was put back into the reaction flask, and agitated in MTBE (750 mL) at 50 C for 1 hour. The solids were collected at room temperature by filtration. The cake was dried in a vacuum oven at 50 C under vacuum with nitrogen sweeping for 72 hours to provide tert-butyl 4-(4-aminopyrrolo[l,2- | [l,2,4]triazin-7-yl)-5,6- dihydropyridine-l(2H)-carboxylate (Compound 13, 123.7 g, 84%) as a brown solid. NMR (500 MHz, OMSO-de) delta 7.89 (s, 1H), 7.69 (s, 2H), 7.00 (s, 1H), 6.91 (d, J = 4.6 Hz, 1 H), 6.69 (d, J= 4.5 Hz, 1H), 4.06 (s, 2H), 3.55 (t, J = 5.5 Hz, 2H), 2.59 – 2.52 (m, 2H), 1.43 (s, 9H) ppm; C16H21N5O2 (MW 315.37), LCMS (EI) mle 316.1 (M+ + H).

The synthetic route of 937046-98-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; INCYTE CORPORATION; JIA, Zhongjiang; WU, Yongzhong; PAN, Yongchun; ZHOU, Jiacheng; LI, Qun; (139 pag.)WO2019/67594; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 314084-61-2, name is 2-Bromo-1,3-diethyl-5-methylbenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 314084-61-2, Safety of 2-Bromo-1,3-diethyl-5-methylbenzene

1,39 g Tetrahydro-pyrazolo[1,2-.a.]pyridazine-1,3-dion und 2,68 g Natriumtertiaerbutylat werden in 20 ml Dimethylformamid bei 20 geloest und mit 2,66 g 2,6-Diethyl-4-methylbrombenzol sowie 0.82 g Pd (TPP)2 Cl2 versetzt. Nun wird waehrend 2,5 Stunden bei 125 geruehrt. Nach dem Abkuehlen auf Raumtemperatur wird mit 200 ml Essigester und 200 ml Ether versetzt und die Reaktionsmischung auf einen Saugfilter gegeben. Der Filterrueckstand wird mit je 100 ml Wasser und Methylenchlorid versetzt und mit Salzsaeure angesaeuert. Die organische Phase wird abgetrennt, getrocknet und eingedampft. Der Rueckstand (1.4 g) wird an Kieselgel chromatographiert (Essigester/Hexan 3:1). Man erhaelt 2-(2,6-Diethyl-4-methyl-phenyl)-tetrahydro-pyrazolo[1,2-.a.]pyridazine-1,3-dion in Form beiger Kristalle mit einem Schmelzpunkt von 174-175.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-1,3-diethyl-5-methylbenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Syngenta Participations AG; EP1210333; (2004); B1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 40787-48-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 40787-48-2 as follows.

Finally, the final product d was obtained by Suzuki coupling reaction: 9 mmol of 9-benzoquinone-10 borate was obtained.1.5 mmol of 1,4-dibromo-2,5-diethylbenzene, 0.36 mmol of tetrakis(triphenylphosphine)palladium, 60 mL of toluene,15 mL of ethanol, 333 mmol of K2CO, (formed as a solution with 15 mL of water), and added to the reaction flask.The system was then evacuated under reflux of nitrogen at 110 C for 24 hours.After completion of the reaction, the methanol was subjected to hot-washing suction filtration, toluene to recrystallization, and sublimation to obtain the final product d, yield 42%.

According to the analysis of related databases, 40787-48-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Shaanxi Normal University; Hu Jianyong; Zhang Jiali; (19 pag.)CN108383693; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 4766-33-0, name is 5-Bromonaphthalen-1-amine, molecular formula is C10H8BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 5-Bromonaphthalen-1-amine

To a suspension of 1-bromo-5-nitronaphthalene (2 g, 7.94 mmol) in EtOH (50 mL), a solution of NH4Cl (2.2 g, 41.1 mmol) in water (20 mL) was added, followed by iron powder (1.33 g, 23.82 mmol). The resulting mixture was stirred at 75 C. (bath temperature) for 1.5 h. Celite (3 g) was added, and the mixture was allowed to cool down to rt, diluted with CH2Cl2 (100 mL), filtered through a plug of Celite, washing with CH2Cl2 (150 mL). The filtrate was washed with brine and dried over Na2SO4. Upon evaporation of the filtrate, the crude material was redissolved in CH2Cl2 (20 mL), transferred on top of a 80 g SiO2 column, and ran with 20% to 80% EtOAc/hexane gradient. The fractions containing the product were evaporated to viscous light brown oil that quickly crystallized. Yield of 5-bromo-1-aminonaphthalene [West, R. W. J. Chem. Soc. 1925, 127, 494] 1.48 g (84%). 5-Bromo-1-aminonaphthalene (1.37 g, 6.17 mmol) was dissolved in trimethyl phosphate (760 muL, 6.5 mmol) in a 50 mL round-bottom flask, equipped with an air condenser and a CaCl2 drying tube, the apparatus was flushed with nitrogen, and the mixture was heated at 200 C. (bath temperature) for 1.5 h. The flask was then allowed to cool below 100 C., 1 N NaOH (20 mL) was added, the resulting suspension was sonicated briefly and stirred at rt overnight. The mixture was diluted with brine, extracted with CH2Cl2 (3¡Á50 mL), the combined extracts were dried over Na2SO4. The product was isolated by column chromatography (100 g of SiO2, gradient 10% to 50% CH2Cl2/hexane) to yield 1-bromo-5-(dimethylamino)naphthalene 28a [West, R. W. J. Chem. Soc. 1925, 127, 494] as a light-orange viscous oil (1.29 g, 84%). 1H NMR (301 MHz, CDCl3): delta 8.26 (dt, J=8.6, 1.0 Hz, 1H), 7.95 (dt, J=8.6, 0.9 Hz, 1H), 7.78 (dt, J=7.4, 1.0 Hz, 1H), 7.51 (ddd, J=8.5, 7.5, 0.7 Hz, 1H), 7.32 (ddd, J=8.4, 7.3, 0.7 Hz, 1H), 7.14 (dd, J=7.6, 1.0 Hz, 1H), 2.90 (s, 6H) ppm. 13C NMR (76 MHz, CDCl3): delta 151.3, 133.4, 130.4, 130.1, 127.3, 125.4, 124.3, 123.3, 122.0, 115.0, 45.5.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4766-33-0, its application will become more common.

Reference:
Patent; Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e. V.; SEDNEV, Maksim; BUTKEVICH, Alexey; SHOJAEI, Heydar; BELOV, Vladimir; HELL, Stefan; WURM, Christian; KAMIN, Dirk; (68 pag.)US2018/223102; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6627-78-7, name is 1-Bromo-4-methylnaphthalene, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C11H9Br

General procedure: A mixture of 3a-3g (0.1 mol for 3a-3e and 3g; 0.4 molfor 3f) and CuCN (26.87 g, 0.3 mol for 3a-3e and 3g; 21.49g, 0.24 mol for 3f) in DMF (300 mL) were stirred at 130C in N2 atmosphere for 12 h, when TLC analysis indicated completion of reaction. On cooling to room temperature, the reaction mixture was diluted with CH2Cl2 (900 mL) and the resulting mixture was further stirred for 1 h and filtered off. The filtrate was washed with 5% brine (500 mL 5), dried (Na2SO4) and evaporated on a rotary evaporator to afford a black oil, which was purified by column chromatography to afford the pureproduct 4a-4g.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6627-78-7.

Reference:
Article; Zhang, Xiansheng; Wu, Jingwei; Liu, Wei; Liu, Yuqiang; Xie, Yafei; Shang, Qian; Zhou, Zhixing; Xu, Weiren; Tang, Lida; Wang, Jianwu; Zhao, Guilong; Medicinal Chemistry; vol. 13; 3; (2017); p. 260 – 281;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1435-53-6, name is 2,4-Dibromo-1-fluorobenzene, A new synthetic method of this compound is introduced below., Computed Properties of C6H3Br2F

General procedure: To a mixture of 1,3-dibromo-5-fluorobenzene (1.39 g, 5.51 mM), 2-tri-n-butylstannylpyridine(5.00 g, 13.6 mM), bis(triphenylphosphine)palladium dichloride (1.00 g, 1.43 mM),and lithium chloride (0.37 g, 8.84 mM) in an oven dried Schlenk tube, distilled toluene(40 mL) was added. The mixture was degassed via the freeze-pump-thaw method until nogas bubbles were observed and refluxed at 110 C under nitrogen for 48 h. After coolingthe reaction mixture to room temperature, an aqueous solution of potassium fluoride(40 mL) was added and the insoluble black residue was filtered and washed with toluene.The toluene was removed under reduced pressure. Dichloromethane (100 mL) and aqueoussodium bicarbonate (100 mL) were added to the remaining residue. The organic phase wasseparated, washed with sodium bicarbonate (2 ¡Á 100 mL), then dried over anhydroussodium sulfate and evaporated to obtain a yellow residue. This residue was then purifiedover silica with a mixture of 90% hexane: 10% diethyl ether, whose mole fraction was measuredto 50% hexane: 50% diethyl ether to obtain a pale yellow solid (0.8078 g, 58%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Papo, Tshephiso R.; Jaganyi, Deogratius; Journal of Coordination Chemistry; vol. 68; 5; (2015); p. 794 – 807;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 57946-63-1, name is 2-Bromo-4-(trifluoromethyl)aniline, molecular formula is C7H5BrF3N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 57946-63-1

2-Bromo-4-(trifluoromethyl)aniline (3. 5g, 14.58 mmol), 1H-pyrazole (1 .98g, 29.2 mmol), N1,N2-dimethylethane-1,2-diamine (0.78 ml, 7.29 mmol), cesium carbonate (10.45g, 32.1 mmol) was added to degassed 1,4-dioxane (15 ml) in a sealed tube and copper(i) iodide (0.55g, 2.92 mmol) was added. The tube was sealed and heated at 120 ¡ãC for 72h. After the solution was cooled, the mixture was passed through a pad of celite and the filtrate was extracted with ethyl acetate. The ethyl acetate layer was washed withbrine, dried over Na2SO4 and concentrated. The crude was purified by column chromatography to obtain the product as off white solid (2.7g, 83percent). LCMS (ESI): mlz 228.39(M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 57946-63-1, its application will become more common.

Reference:
Patent; LUPIN LIMITED; RAMDAS, Vidya; LORIYA, Rajeshkumar, Maganlal; BANERJEE, Moloy; PATIL, Pradeep, Rangrao; JOSHI, Advait, Arun; DATRANGE, Laxmikant, Shamlal; WALKE, Deepak, Sahebrao; KHAN, Talha, Hussain; DAS, Amit, Kumar; GOTE, Ganesh, Navinchandra; KALHAPURE, Vaibhav, Madhukar; PALLE, Venkata, P.; KAMBOJ, Rajender, Kumar; (234 pag.)WO2017/37682; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

4766-33-0, These common heterocyclic compound, 4766-33-0, name is 5-Bromonaphthalen-1-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The substituted 1-naphthylamine (10 mmol), 2-picolinic acid (12.5 mmol) and Et3N (20 mmol,2.8 mL) were dissolved in DCM (40 mL) followed by dropwise addition of POCl3 (1.88 mL) at 0C. The resulting mixture was stirred at 0C for 0.5 h and warmed to room temperature for 2 h. Then the reaction mixture was cooled to 0C. Ice water was added slowly to quench the reaction. The organic layer was collected, and the aqueous phase was extracted with DCM. The combined organic phase was washed by saturated NaHCO3 and dried over MgSO4. The solvent was evaporated under reduced pressure, and the residue was recrystallized from i-propyl alcohol to give desired product.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4766-33-0.

Reference:
Article; Guan, Dinghui; Han, Lu; Wang, Lulu; Song, He; Chu, Wenyi; Sun, Zhizhong; Chemistry Letters; vol. 44; 6; (2015); p. 743 – 745;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 615-59-8, name is 1,4-Dibromo-2-methylbenzene, molecular formula is C7H6Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 615-59-8

(1) 2,5-dibromotoluene (10 mmol, 2.5 g), 4-methoxycarbonylbenzeneboronic acid (24 mmol, 4.33 g) under N2 protection.caesium fluoride (40 mmol, 6.0 g) was placed in a 250 mL three-necked flask, and 5% (1.2 to 2.0 g) of Pd (PPh3) catalyst was added.100 mL of anhydrous THF was used as a solvent, and refluxed at 67 C.After completion of the reaction, the product was isolated by silica gel column chromatography (petroleum ether, dichloromethane) to give a pink solid 2.91 g, yield 81%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 615-59-8, its application will become more common.

Reference:
Patent; Shandong Normal University; Dong Yubin; Wang Jiancheng; Liu Congxue; Hu Yuhong; (14 pag.)CN108640906; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary