Tag: M.W=200-300

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 40161-54-4, name is 1-Bromo-2-fluoro-4-(trifluoromethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows., 40161-54-4

Step D 8-(2-Fluoro-4-trifluoromethyl-phenyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one A sealed tube was charged with 4-bromo-3-fluorobenzotrifluoride (40 mg, 0.16 mmol), 2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one (5

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Ackermann, Jean; Conte, Aurelia; Hunziker, Daniel; Neidhart, Werner; Nettekoven, Matthias; Schulz-Gasch, Tanja; Wertheimer, Stanley; US2012/41013; (2012); A1;

937046-98-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 937046-98-5 as follows.

Intermediate Rl-A: 7-Bromo-5-iodopyrrolo[2,l-f][l,2,4]triazin-4-amine (Rl-A) To a solution of 7-bromopyrrolo[2,l-f][l,2,4]triazin-4-amine (4 g, 18.78 mmol) in anhydrous DMF (200 mL) was added NIS (4.65 g, 20.65 mmol) and the mixture was stirred in the dar

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 937046-98-5, and friends who are interested can also refer to it.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; BHIDE, Rajeev S.; RUAN, Zheming; CHERNEY, Robert J.; CORNELIUS, Lyndon A.M.; DHAR, T.G. Murali; GONG, Hua; MARCOUX, David; POSS, M

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 142808-15-9 name is 4-Bromo-2-fluorobenzotrifluoride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 142808-15-9

Preparatory Example27 (3-Fluoro-4- (trifluoromethyl) phenyl) (1-methylcyclopropyl) methanone (Scheme 7): To a solution of 4-bromo-2-fluoro-1- (trifluoromethyl) benzene (0.34 g, 1.4 mmol) in THF (5 mL) at -78under N2was added a solution of isopropylmagnesi

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 4-Bromo-2-fluorobenzotrifluoride, and friends who are interested can also refer to it.

Reference:
Patent; MERCK SHARP & DOHME CORP.; MSD R&D (CHINA) CO. LTD.; SHEN, Dong-Ming; DWYER, Michael; SINZ, Christopher J.; WANG, Deping; STACHEL, Shawn; PAONE, Daniel;

A common compound: 67567-26-4, name is 4-Bromo-2,6-difluoroaniline, belongs to bromides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 67567-26-4

Step 1: Preparation of N-(4-bromo-2,6-difluorophenyl)-4-chlorobutanamide. [0804] To a solution of 4-bromo-2,6-difluoroaniline (5.00 g, 24.0 mmol) and EbN (5.0 mL, 36 mmol) in anhydrous THF (50 mL) was added 4-chlorobutanoyl chloride (3.5 mL, 31 mmol) drop

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 67567-26-4, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; PETRA PHARMA CORPORATION; LINDSTROeM, Johan; PERSSON, Lars Boukharta; VIKLUND, Jenny; KESICKI, Edward A.; HICKEY, Eugene R.; DAHLGREN, Markus K.; GERASYUTO, Ale

699-03-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 699-03-6, name is 1-(4-Bromophenyl)-N-methylmethanamine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a mixture of (S)-2-{(4-morpholin-4-yl-benzyl)-[3-(6-trifluoromethyl-pyridin-3-yl)-acryloyl]- amino}-3-phenyl-propionic acid (4.00 g, 7.41 mmol), TBTU (4.76 g, 14.83 mmol), and cat. DMAP in dry DCM (45 ml.) was added DIPEA (3.8 ml_, 22.24 mmol). The resulting mixture was stirred at rt for 10 min and then (4-bromo-benzyl)-methyl-amine (1.48 g, 7.41 mmol) was added. The reaction mixture was stirred at rt overnight under nitrogen atmosphere, then concentrated in vacuo. The resulting residue was taken up in EA. The organic layer was washed with water (5x) and brine, dried (MgSO4), filtered and concentrated under reduced pressure. FC (n-heptane/EA 5:5) afforded the N-{1-[(4-bromo-benzyl)-methyl- carbamoyl]-2-phenyl-ethyl}-N-(4-morpholin-4-yl-benzyl)-3-(6-trifluoromethyl-pyridin-3-yl)- acrylamide as a yellow foam (2.38 g, 44%).LC-MS (analytic A, Zorbax SB-AQ column, acidic conditions): tR = 1.16 min; [M+H]+ = 722.76

The synthetic route of 1-(4-Bromophenyl)-N-methylmethanamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ACTELION PHARMACEUTICALS LTD; AISSAOUI, Hamed; BOSS, Christoph; CORMINBOEUF, Olivier; FRANTZ, Marie-Celine; GRISOSTOMI, Corinna; WO2010/58353; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 16518-62-0 name is 3-Bromo-N,N-dimethylaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. 16518-62-0

N,N-dially-3-bromobenzene amine (10.0 g, 39.8 mmol) and N,N-dimethyl-3-bromobenzene amine (2.73 g, 13.6 mmol) were dissolved in acetic acid (150 mL), a 37percent formaldehyde solution (10.9 g, 363 mmol) was added, and the system was heated for 60 minutes at 80¡ãC. The system was cooled to room temperature and subsequently neutralized with a saturated aqueous solution of NaOH, and the precipitates were dissolved in H2O. The resulting mixture was extracted using dichloromethane and washed using a saline solution. The organic layer was dried using Na2SO4, the solvent was removed, and the residue was thereafter refined using column chromatography (silica gel, 1/30 ethyl acetate/hexane) to obtain 4-(2-bromo-4-(dimethylamino)benzyl)-N,N-diallyl-3-bromobenzene amine (3.67 g, 7.91 mmol, yield: 58percent).1H-NMR (300.40 MHz, CDCl3) : delta2.93 (s, 6H), 3.87 (d, 4H, J = 4.2 Hz), 3.98 (s, 2H), 5.13-5.19 (m, 4H), 5.73-5.88 (m, 2H), 6.53 (dd, 1H, J = 1.5 Hz, 8.7 Hz), 6.58 (dd, 1H, J = 1.5 Hz, 8.7 Hz), 6.79 (d, 1H, J = 9.0 Hz), 6.86 (d, 1H, J = 8.7 Hz), 6.90 (d, 1H, J = 1.5 Hz), 6.93 (d, 1H, J = 1.5 Hz). 13C-NMR (75.45 MHz, CDCl3): delta39.8, 40.5, 52.7, 111.7, 111.8, 116.0, 116.2, 125.5, 125.6, 126.9, 127.1, 130.7, 130.8, 133.5, 148.1, 150.0LRMS (ESI+): 465 for [M+H]+

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Bromo-N,N-dimethylaniline, and friends who are interested can also refer to it.

Reference:
Patent; The University of Tokyo; NAGANO Tetsuo; HANAOKA Kenjiro; EGAWA Takahiro; KUSHIDA Yu; NUMASAWA Koji; MYOCHIN Takuya; PIAO Wen; EP2942352; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

454-65-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 454-65-9 as follows.

To a stirred solution of 3-BROMOPHENYLSULFONYL fluoride (D1) (1 g, 4.18 MMOL) in dry THF (20 ml) at-78 C, under argon was added phenylmagnesium bromide (1 M, 1.4 ML, 4.18 MMOL) dropwise. The reaction was left to warm to room temperature overnight and then quenched with ammonium chloride (50 ml), extracted with ethyl acetate (3 X 40 mi) and the combined organic extracts dried (NA2SO4). SOLVENTS WERE EVAPORATED IN VACUO to give A colourless solid (1.09 g, 88 %). 1H NMR (CDCl3) : No. 7.40 (1H, t), 7.50-7. 55 (2H, m), 7.60 (1H, d), 7.69 (1H, d), 7. 86 (1H, d), 7.93 (2H, d), 8. 08 (1H, s).

According to the analysis of related databases, 3-Bromobenzene-1-sulfonyl fluoride, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXO GROUP LIMITED; WO2004/80986; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

A common heterocyclic compound, 73918-56-6, name is 2-(4-Bromophenyl)ethanamine, molecular formula is C8H10BrN, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 73918-56-6.

2-(4-Bromophenyl)-ethylamine (13, 10.0g, 50mmol) and NaOH (3.0g, 75mmol) were dissolved in the mixture of dioxane (150mL) and H2O (150mL). The reaction mixture was cooled to 0C. The solution of di-tert-butyl dicarbonate (16.36g, 75mmol) in dioxane (72mL) was added dropwise to the reaction mixture, which was stirred at room temperature for 5.5h. Dioxane was removed in vacuo and the residue was extracted with ethyl acetate 3 times. The combined organic layer was washed with water and brine, and then dried over anhydrous Na2SO4. Filtration and removal of solvent provided the crude product, which was purified by Combiflash chromatography (5-10% of ethyl acetate in hexane). The title compound 5 (13.5g, 90.0%) was obtained as a white solid; mp 59-60C. 1H NMR (300MHz, chloroform-d): delta=7.42 (d, J=8.0Hz, 2H), 7.07 (d, J=8.0Hz, 2H), 4.51 (br. s, 1H), 3.40-3.27 (m, 2H), 2.75 (t, J=6.9Hz, 2H), 1.43 (s, 9H). MS (EI): m/z=300.1 (M++H).

The synthetic route of 2-(4-Bromophenyl)ethanamine has been constantly updated, and we look forward to future research findings.

Reference:
Article; Qiao, Chang-Jiang; Ali, Hamed I.; Ahn, Kwang H.; Kolluru, Srikanth; Kendall, Debra A.; Lu, Dai; European Journal of Medicinal Chemistry; vol. 121; (2016); p. 517 – 529;,
Bromide – Wikipedia,
bromide – Wiktionary

22385-77-9, The chemical industry reduces the impact on the environment during synthesis 22385-77-9, name is 1-Bromo-3,5-di-tert-butylbenzene, I believe this compound will play a more active role in future production and life.

Preparation 13 ,5-Di-/er/-butylbenzaldehydeDissolve l-bromo-3,5-di-/er/-butylbenzene (5.00 g, 18.57 mmol) in THF (50 mL) under a nitrogen atmosphere. Cool to -78 C. Slowly add w-butyllithium (2.5 M in hexanes) (22.29 mL, 55.72 mmol) at -78 C. Stir at -78 C for about 30 min. Add DMF (4.31 mL, 55.72 mmol) dropwise. Warm the mixture to 0 C and stir for 2.5 h. Pour aqueous NH4CI (30 mL) into the mixture. Extract with EtOAc (3 x 20 mL). Dry the combined organic portions over a2S04; filter; collect the filtrate; and concentrate under reduced pressure. Purify the residue using flash chromatography eluting with a gradient of 0-10% EtO Ac/petroleum ether to afford the title compound (2.96 g, 73%) as a white solid. LC-ES/MS m/z 219 [M+H]+.

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-3,5-di-tert-butylbenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; ELI LILLY AND COMPANY; BLEISCH, Thomas, John; COATES, David, Andrew; HUGHES, Norman, Earle; JONES, Scott, Alan; NORMAN, Bryan, Hurst; WO2013/66640; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

A common compound: 67567-26-4, name is 4-Bromo-2,6-difluoroaniline, belongs to bromides-buliding-blocks compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 67567-26-4

To a solution of 4-bromo-2,6-difluoroaniline (10 g, 48 mmol) in DCM (15mL) was added ethyl 3-chloro-3-oxopropanoate (6.8 mL, 53 mmol) and DIEA (9.2 mL,53 mmol) and the reaction mixture stirred for 1 h. The reaction mixture was partitioned between H20 and DCM and the layers separated. The DCM portion was washed with satd. NH4C1 and H20 then dried (Na2SO4) and filtered. The filtrate was concentrated under reduced pressure to give Compound 90a(10 g, 65% yield). LCMS = 1.60 mmusing analytical method (Q), 321.9 (M+H). 1HNMR(500MHz, CDC13) oe 8.89 (br. s.,1H), 7.20 – 7.15 (m, 2H), 4.29 (q, J=7.2 Hz, 2H), 3.54 (s, 2H), 1.36 – 1.31 (m, 3H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-Bromo-2,6-difluoroaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; JOHNSON, James A.; JIANG, Ji; KIM, Soong-Hoon; PI, Zulan; QIAO, Jennifer X.; TORA, George O.; WANG, Tammy C.; FINLAY, Heather; WO2014/11513; (2014); A1;,
Bromide – Wikipedia,
bromide – Wiktionary