Tag: M.W=200-300

Application of 1786-36-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1786-36-3 as follows.

To a 4 mL vial, N-phenyl-N-(4-piperidyl)propanamide (25.6 mg, 0.11 mmol), K2CO3 (30 mg, 0.22 mmol), KI (9.4 mg, 0.06 mmol) were added with a magnetic stir bar. Acetonitrile (5 ml) was charged to the flask and then (2-bromo-l-fluoroethyl) benzene (37.1 mg, 0.18 mmol) was added. The reaction was allowed to stir at 115 C for 2 days. A sample aliquot was taken from the reaction, diluted with DCM in a microtube, and washed with half-saturated aq. Na2CCb. The organic layer was separated and analyzed by LCMS to confirm reaction completion. The reaction was concentrated under reduced pressure, and the crude material was dissolved in a minimal amount of DCM and dry loaded on celite. The celite/crude material was loaded onto a 10 g column which was connected to a l2 g Cl8 column and purified by reverse phase chromatography (12 g C18; 0-95% MeOH/water) to give S13 as a clear yellow oil (10 mg, 25%). 0.68; LC/MS tR = 1.42 min (Characterization Method A); m/z = 354.85 (M + H); NMR (300 MHz, CD2CI3) d = 7.46 – 7.27 (m, 8 H), 7.12 – 7.04 (m, 2 H), 5.69 – 5.44 (m, 1 H), 4.69 (tt, J = 4.0, 12.2 Hz, 1 H), 3.12 – 2.97 (m, 2 H), 2.87 (ddd, J = 9.3, 14.4, 17.2 Hz, 1 H), 2.64 – 2.43 (m, 1 H), 2.39 – 2.20 (m, 2 H), 1.93 (q, J = 7.4 Hz, 2 H), 1.86 – 1.74 (m, 2 H), 1.58 – 1.37 (m, 2 H), 1.02 (t, J = 7.5 Hz, 3 H).

According to the analysis of related databases, 1786-36-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MARQUETTE UNIVERSITY; DOCKENDORFF, Christopher; ROSAS, Ricardo, Jr.; (0 pag.)WO2020/6563; (2020); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 73790-19-9, name is 5-Bromo-2,2-dimethylbenzo[d][1,3]dioxole, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 73790-19-9

PREPARATION 158 2,2-Dimethyl-1,3-benzodioxol-5-ylboronic acid Obtained as a green solid (47%), m.p. 174-176 C., from 5-bromo-2,2-dimethyl-1,3-benzodioxole (GB-A-2187452) and trimethyl borate, using the procedure of Preparation 101. delta(DMSOd6): 1.60 (s,6H), 6.77 (d,1H), 7.17 (s,1H), 7.28 (d,1H), 7.80 (s,2H).

According to the analysis of related databases, 73790-19-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Pfizer INC; US6387931; (2002); B1;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 138526-69-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 138526-69-9, name is 1-Bromo-3,4,5-trifluorobenzene, This compound has unique chemical properties. The synthetic route is as follows.

Addition of iodine to a mixture of magnesium (264 mg, 11.0 mmol) and THF (5 mL)(5.0 mg) and 5-bromo-1,2,3-trifluorobenzene in THF (0.5 mL)(211 mg, 1 mmol) solution. The mixture is heated to 60 C,And 5-bromo-1,2,3-trifluorobenzene added dropwise in THF (4.5 mL)(1.9 g, 9 mmol) solution. The reaction is heated for two hours,The solution was cooled to room temperature and used directly in the next step.

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-3,4,5-trifluorobenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; PFIZER INC.; KUMPF, ROBERT ARNOLD; MCALPINE, INDRAWAN JAMES; MCTIGUE, MICHELE ANN; PATMAN, RYAN; RUI, EUGENE YUANJIN; TATLOCK, JOHN HOWARD; TRAN-DUBE, MICHELLE BICH; WYTHES, MARTIN JAMES; (445 pag.)TW2018/2074; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 402-43-7, name is 1-Bromo-4-(trifluoromethyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 402-43-7

General procedure: A mixture of CuF2 (102 mg, 1.00 mmol), the aryl halide (500 mumol), 2-aminoethanol (74.9 muL, 1.25 mmol), and NaN3 (65.0 mg, 1.00 mmol) in DMA (1 mL) was stirred under an Ar atmosphere (balloon) at 95 C using a Chemistation personal organic synthesizer (EYELA, Tokyo). After complete consumption of the aryl halide was confirmed by TLC analyses or after 24 h (if the reaction was incomplete within 24 h), the mixture was diluted with EtOAc (10 mL) and then filtered through a Celite pad. The pad was successively washed with EtOAc (20 mL), H2O (25 mL), and concd aq ammonia solution (5 mL). After the two layers were separated, the aqueous layer was extracted with EtOAc (2×10 mL). The combined organic layers were washed with brine (20 mL), dried over MgSO4, filtered, and concentrated under reduced pressure. The residue was purified by silica-gel column chromatography with n-hexane/EtOAc or n-pentane/Et2O as the eluent.

The synthetic route of 1-Bromo-4-(trifluoromethyl)benzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Maejima, Toshihide; Shimoda, Yutaka; Nozaki, Kei; Mori, Shigeki; Sawama, Yoshinari; Monguchi, Yasunari; Sajiki, Hironao; Tetrahedron; vol. 68; 6; (2012); p. 1712 – 1722;,
Bromide – Wikipedia,
bromide – Wiktionary

50548-45-3, name is 1-Bromodibenzo[b,d]furan, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 1-Bromodibenzo[b,d]furan

(4) In a 1L reaction flask, add intermediate c (51.65 g, 100 mmol), 9-phenyl-9H-carbazole-2-amine (25.83 g, 100 mmol), and tris (dibenzylideneacetone) diamine. Palladium (2.75g, 3mmol), tri-tert-butylphosphine (1.21g, 6mmol), sodium tert-butoxide (19.22g, 200mmol), 500ml of toluene, heated to 110 C for 12h under a nitrogen atmosphere, and monitored by liquid phase After the reaction is completed, the temperature is lowered, 1-bromodibenzofuran (24.71 g, 100 mmol) is added, the temperature is raised to 110 C and the reaction is continued for 8 hours. The reaction is monitored by liquid phase, cooled to room temperature, washed with water, filtered, ethyl acetate, dried, 54.18 g of intermediate e can be obtained with a yield of 63%.

The synthetic route of 50548-45-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Wuhan Shang Sai Optoelectric Technology Co., Ltd.; Mu Guangyuan; Zhuang Shaoqing; Ren Chunting; (31 pag.)CN110372570; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 89359-54-6, name is 9-Bromo-1-nonene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 89359-54-6, Recommanded Product: 9-Bromo-1-nonene

General procedure: 4.3.1. ((oct-7-en-1-yloxy)methyl)cyclohexane (H1)To a stirred solution of cyclohexylmethanol (6) (492 muL, 4.0 mmol,2 eq) in DMF (7 mL) under argon was added NaH (60% suspension inmineral oil; 160 mg, 4.0 mmol, 2 eq) at 0 C. The suspension was stirredat 0 C for 30 min, then 8-bromodec-1-octene (7) (336 muL, 2.0 mmol,1 eq) was added dropwise to the mixture. The mixture was allowed towarm to room temperature and stirred for 1 h. After the reaction wasquenched with saturated NH4Cl, the whole was extracted with Et2O.The extract was washed with H2O and brine, then dried over MgSO4.The filtrate was concentrated under reduced pressure to give an oilyresidue, which was purified using silica gel chromatography (petroleum ether_EtOAc=40:1) to afford H1 (341 mg, 76% yield) as a colorless oil.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Yang, Haoran; Li, Ying; Chai, Huining; Yakura, Takayuki; Liu, Bo; Yao, Qingqiang; Bioorganic Chemistry; vol. 98; (2020);,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 149910-98-5,Some common heterocyclic compound, 149910-98-5, name is 7-Bromoisochroman, molecular formula is C9H9BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 4.1. General procedure for the CDC reaction of benzylic ethers with carbonyl compounds To a solution of 1 or 4 (0.25mmol, 1equiv), 2 (1.25 mmol, 5 equiv) and CuBr2 (0.05 mmol, 0.2 equiv) was added Na2S2O8 (0.75 mmol, 3 equiv). Then the mixture was stirred at 80C until the starting material disappeared monitored by TLC. After that, the above mixture was directly purified by flash chromatography (ethyl acetate/petroleum ether as eluent) to give the desired product 3 or 5.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 7-Bromoisochroman, its application will become more common.

Reference:
Article; Pan, Xinhui; Hu, Qingwen; Chen, Wenfang; Liu, Xigong; Sun, Bin; Huang, Zhouli; Zeng, Ziyu; Wang, Liguo; Zhao, Dan; Ji, Mei; Liu, Lei; Lou, Hongxiang; Tetrahedron; vol. 70; 21; (2014); p. 3447 – 3451;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 3638-73-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3638-73-1 as follows.

Sodium nitrite (65.2 mmol) was added in several portions to a solution of 2,5-dibromobenzenamine (55.8 mmol) in trifluoroacetic acid (80 mL) at 0 C. The resulting solution was added to a boiling solution of sodium sulfate (10 g) in 50% sulfuric acid (120 mL) and the reaction mixture was maintained at reflux for 1 h. Then the product was steam-distilled and the distillate was extracted with dichloromethane (2*200 mL). The combined organic layers were dried (sodium sulfate) and concentrated to provide 2,5-dibromophenol in 41% yield as a yellow solid.

According to the analysis of related databases, 3638-73-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Memory Pharmaceuticals Corporation; US2010/22581; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 69321-60-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 69321-60-4, name is 2,6-Dibromotoluene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

6-Dimethylamino-2H-isoquinolin-l-one (50mg, 0.27mmol), cuprous iodide (lOmg, 0.053mmol), and potassium carbonate (37mg, 0.27mmol) were deposited in sealed vessel. 3mL DMSO and 2,6-dibromotoluene (133mg, 0.532mmol) were added. Argon was bubbled through the mixture for 2 minutes and the lid was tightly closed. This was heated at 1500C for 5 hours. The resulting mixture was partitioned between ethyl acetate and water. The organic layer was washed with brine, dried over anhydrous magnesium sulfate, concentrated in vacuo, and purified by flash chromatography (30% ethyl acetate/hexanes) to yield 2-(3-Bromo-2-methyl-phenyl)-6-dimethyl- amino-2H-isoquinolin-l-one (43mg, 0.12mmol). MS (ESI) 357 (M+H)+.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,6-Dibromotoluene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2009/98144; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 21524-34-5, name is 2-Bromo-1,3,5-triisopropylbenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 21524-34-5, Application In Synthesis of 2-Bromo-1,3,5-triisopropylbenzene

Raw materials la (56 mg, 0 · 2 mmol) and 2 j (204 mg, 0 · 72 mmol) were sequentially added to the reaction flask, and cesium carbonate was added.(130 mg, 2.0 eq), double dilute ligand L2_l (2.6 mg, 5 mol%), tricyclohexylphosphine tetrafluoroborate (1.8 mg, 2.5 mol 1%), [Rh (cod) Cl] 2 (2.5 Mg, 2 · 5 mol %), di-tert-butylphosphonium chloride (18 mg, 0 · lmmol) and toluene 2 mL), stirred at 120 C for 24 hours under nitrogen atmosphere, cooled to room temperature, ethyl acetate (5 mL) Dilute, dilute 1M dilute hydrochloric acid (2 mL), and wash with saturated brine (5 mL). The organic phase is dried over anhydrous magnesium sulfate. /15), the product was 3h as a white solid 25mg, yield 18%

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-1,3,5-triisopropylbenzene, and friends who are interested can also refer to it.

Reference:
Patent; UNIV NANKAI; Nankai University; YE MENGCHUN; Ye Mengchun; YANG JINFEI; Yang Jinfei; (18 pag.)CN107840784; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary