Tag: M.W=200-300

Reference of 59734-92-8,Some common heterocyclic compound, 59734-92-8, name is 1-Bromo-2-cyclohexylbenzene, molecular formula is C12H15Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of CuI (19 mg, 0.10 mmol) and NaI (0.6 g, 4.0 mmol) in pentanol (3 niL) was added (18 mg, 0.2 mmol) and l-bromo-2- cyclohexylbenzene (0.48 g, 2.0 mmol). The mixture was purged for 5 min with argon and heated overnight at reflux. The resulting mixture was purified by silica gel chromatography using hexanes to afford the title compound as clear oil (0.51 g, 90%).[0132] 1H NMR (500 MHz, CDCl3): delta 1.21-1.30 (m, IH), 1.33-1.53 (m, 4H), 1.76-1.90 (m, 5H), 2.77 (tt, J = 11.7, 3.1 Hz, IH), 6.86 (td, J = 7.7, 1.6 Hz, IH), 7.20 (dd, J= 7.8, 1.6 Hz, IH), 7.27 (q, J = 7.5 Hz, IH), 7.81 (d, J = 7.9 Hz, IH)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-2-cyclohexylbenzene, its application will become more common.

Reference:
Patent; TARGEGEN INC.; WO2009/55674; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 52548-00-2, name is 1-Bromo-4-fluoro-2,3-dimethylbenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C8H8BrF

To a 250 ml-round bottle flask equipped with magnetic stir bar were added 1- Boc-piperizine (2.5 g, 13.42 mmol), 1-bromo-4-fluoro-2,3-dimethylbenzene (3.27 g, 16.11 mmol), Cs2CO3 (13.12 g, 40.3 mmol), and RuPhos Pd G2 (1.043 g, 1.342 mmol). To the mixture was charged dioxane (67.1 ml) at RT under N2. The mixture was stirred at RT while flushed with N2 for about 5 min and then warmed up to 90 C. The mixture was stirred at 90 C overnight. The mixture was cooled to RT, and partitioned between EtOAc and water (100 ml x 50 ml). The aqueous was extracted with EtOAc for three times (100 ml x 3). Organic phases were combined and washed with sat. NaCl, separated and dried over Na2SO4, filtered, concentrated, and followed by normal phase purfication (Isco system, 120 g Isco, RediSep gold column, 0-100% EtOAc / hexane as eluting solvent) to afford the title compound as a solid. LCMS m/z (M+H): 309.67

The synthetic route of 52548-00-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK SHARP & DOHME CORP.; CLAUSEN, Dane; CHEN, Ping; FRADERA, Xavier; GUO, Liangqin; HAN, Yongxin; HE, Shuwen; HUANG, Xianhai; KOZLOWSKI, Joseph; LI, Guoqing; MARTINOT, Theodore, A.; PASTERNAK, Alexander; VERRAS, Andreas; XIAO, Li; YU, Wensheng; ZHANG, Rui; (267 pag.)WO2020/112581; (2020); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 30273-40-6,Some common heterocyclic compound, 30273-40-6, name is 4-Bromo-2,5-dimethylaniline, molecular formula is C8H10BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The reaction mixture of 4-bromo-2,5-dimethylaniline (5g, 25mmol) and (Boc)2O (5.4g, 25mmol) in toluene (60ml) was stirred at 100C for 40hrs under nitrogen. After concentration of the reaction mixture under reduced pressure, 5.82 g (78% yield) of boc-NH-4-bromo-2,5- dimethylaniline,2, was obtained as a white solid by columnchromatography (5 -10% ethyl acetate in hexane).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-Bromo-2,5-dimethylaniline, its application will become more common.

Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; PARK, Kyung-Ho; RADU, Nora, Sabina; JOHANSSON, Gary, A.; FENNIMORE, Adam; DELANEY, William, J.; LECLOUX, Daniel, David; WO2011/159872; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 67567-26-4, name is 4-Bromo-2,6-difluoroaniline, molecular formula is C6H4BrF2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C6H4BrF2N

To a suspension of sodium perborate tetrahydrate (1.04 g, 5 mmol) in acetic acid (20 mL), stirred at 55 C., was added a solution of 4-bromo-2,6-difluoroaniline in acetic acid (10 mL) over 1 hour in a dropwise fashion. After stirring at 55 C. for an additional 3 hours, the solution was allowed to cool to room temperature and filtered. The filtrate was poured into ice, and extracted twice with ethyl acetate. The combined organic extracts were washed successively with 5*100-mL portions of water, brine, dried (MgSO4), and concentrated in vacuo. The resulting residue was purified by column chromatography over silica gel eluted with ethyl acetate:hexanes (1:20) to afford 780 mg of the titel compound as a tan solid. 1H NMR (CDCl3) delta 7.32 (dt, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 67567-26-4, its application will become more common.

Reference:
Patent; Charifson, Paul S.; Deininger, David D.; Grillot, Anne-Laure; Liao, Yusheng; Ronkin, Steven M.; Stamos, Dean; Perola, Emanuele; Wang, Tiansheng; LeTiran, Arnaud; Drumm, Joseph; US2004/235886; (2004); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 3972-64-3, name is 1-Bromo-3-(tert-butyl)benzene, A new synthetic method of this compound is introduced below., HPLC of Formula: C10H13Br

In a IL three-necked round-bottom flask equipped with a mechanical stirrer and a reflux condenser were introduced DMF (20OmL), l-bromo-3-tert-butylbenzene (54.3g, 0.25mol), crotyl alcohol (65mL, 0.76mol, 3eq), sodium carbonate (66.2g, 0.62mol, 2.5eq), tetrabutyl ammonium bromide (69.5g, 0.25mol, leq), palladium acetate (5.05g, 7.5mmol, 3molpercent) and tri-o-tolyl phosphine (7.6g, 25mmol, O.leq). After stirring for Ih at 90- 1000C, the reaction mixture was cooled toambient temperature. The reaction mixture was filtered over celite. The organic phase thus obtained was diluted with MTBE (50OmL) and washed three times with water (50OmL portions), dried over magnesium sulphate and concentrated. The resulting crude product was distilled with a bulb-to-bulb distillation (3mBar, 1210C) to give a colourless oil (34.7g, gc purity 73percent). The crude product was chromatographed on a silica gel column with 5percent EtOAc in hexane as elution agent giving 3-(3-fert-butylrhohenyl)butanal (12.3g, gc purity 99percent; yield 39percent).Odour: floral, aldehydic, muguet, marine.Analytical data: EPO 1H NMR (400 MHz, CHLOROFORM-d) ppm: 1.33 (d, 3H, J=5.86 Hz); 1.32 (s, 9H); 2.61-2.80 (m, 2H); 3.36 (qt, IH, J=7.16, 6.96 Hz); 7.01-7.07 (m, IH); 7.23-7.27 (m, 3H); 9.72 (t, IH, /=2.08 Hz).13C NMR (101 MHz, CHLOROFORM-^) ppm: 22.15 (q, 1C); 31.35 (q, 3C); 34.53 (d, 1C); 34.66 (s, 1C); 51.83 (t, 1C); 123.49 (d, 1C); 123.55 (d, 1C); 123.91 (d, 1C); 128.30 (d, 1C); 145.06 (s, 1C); 151.48 (s, 1C); 202.04 (d, 1C).MS: m/z (relative intensity) 204 (M+, 12), 189 (31), 171 (4), 161 (30), 147 (100), 145 (81), 130 (17), 119 (24), 117 (23), 115 (21), 105 (25), 91 (36), 77 (14), 65 (8), 57 (52), 41 (31).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; QUEST INTERNATIONAL SERVICES B.V.; WO2008/53148; (2008); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 1137142-58-5, These common heterocyclic compound, 1137142-58-5, name is 2-Bromoimidazo[2,1-b][1,3,4]thiadiazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate M; 2-(3,4-Dimethoxy-pheny.)-imidazo[2,1-b][1,3,4]thiadiazoleA solution of 2-bromo-imidazo[2,1-b][1,3,4]thiadiazole (0.5 g, 2.5 mmol, 1 eq), 3,4-dimethoxyphenylboronic acid (0.683 g, 3.7 mmol, 1.5 eq), dioxane (12.5 mL) and Na2CO3 (2M aq. solution, 3.8 mL) was degassed for 20 minutes at room temperature. Pd(Ph3P)2CI2 WaS added and the reaction heated at 110 ºC for 2h in an argon atmosphere. The reaction mixture was diluted with EtOAc and washed with water. The combined organic layers were dried (Na2SO4), filtered and concentrated, and the residue was purified by column chromatography (SiO2, cyclohexane / 20-100% ethylacetate). The product was further purified by triturating with Et2O, filtered off and dried affording the desired product (0.080 g). 1H NMR (300 MHz, DMSO) delta/ppm 8.18 (d, J = 1.4, 1 H), 7.47 (m, 2H), 7.33 (d, J = 1.4, 1H), 7.15 (d, J = 8.3, 1H), 3.86 (s, 3H), 3.75 (s, 3H). – The filtrate was concentrated, redissolved in DCM- and purified by flash-chromatography (SiO2, DCM / 1% MeOH) to afford the desired product (0.65 g, containing some Ph3PO) that was used as such in the next step.

The synthetic route of 1137142-58-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO); PASTOR FERNANDEZ, Joaquin; KURZ, Guido; MARTINEZ GONZALEZ, Sonia; WO2010/112874; (2010); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 103977-79-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 103977-79-3 as follows.

A solution of 3-bromo-2, 4-difluorophenylamine (from Example 2, step b) (5. 2 g, 25 mmol) and 5-fluoro-2- (4, 4,5, 5-tetramethyl- [1, 3,2] dioxaborolan-2-yl) benzonitrile (7.10 g, 28.8 mmol) in tetrahydrofuran (95 ml) and water (5 ml) was treated with potassium fluoride (4.8 g, 82.5 mmol) and this mixture was degassed with nitrogen for 10 min before adding tris (dibenzylideneacetone) dipalladium (0) (460 mg, 0. 5 mmol) and tri-tert-butylphosphine (2.5 ml of a 0.2 M solution in 1,4-dioxane, 0. 5 mmol). The reaction was then heated at 50C for 2 h then cooled to ambient temperature. The mixture was poured into ice-cold 0.5 N sodium hydroxide (750 ml), stirred for 10 min and the solid collected by filtration. This was triturated with water and dried to afford 3′-amino- 4, 2′, 6′-triffuorobiphenyl-2-carbonitrile as a grey powder (6.6 g), which was used without further purification: 1H NMR (360 MHz, Cd13) 8 3.74 (2H, br s), 6.79-6. 89 (2H, m), 7.36-7. 42 (1H, m), 7.45-7. 51 (2H, m).

According to the analysis of related databases, 103977-79-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK SHARP & DOHME LIMITED; WO2003/93272; (2003); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 50548-45-3, These common heterocyclic compound, 50548-45-3, name is 1-Bromodibenzo[b,d]furan, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(4) In a 1L reaction flask, add intermediate c (51.65 g, 100 mmol), 9,9-dimethyl-9H-fluoren-2-amine (20.93 g, 100 mmol), and tris (dibenzylideneacetone). ) Dipalladium (2.75g, 3mmol), tri-tert-butylphosphine (1.21g, 6mmol), sodium tert-butoxide (19.22g, 200mmol), 500ml of toluene, under a nitrogen atmosphere, heated to 110 C for 12h, the liquid The phase monitoring reaction was completed, the temperature was reduced, 1-bromodibenzofuran (24.71 g, 100 mmol) was added, and the temperature was raised to 110 C to continue the reaction for 8 hours. After drying, 51.09 g of intermediate e can be obtained with a yield of 63%

The synthetic route of 50548-45-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Wuhan Shang Sai Optoelectric Technology Co., Ltd.; Mu Guangyuan; Zhuang Shaoqing; Ren Chunting; (31 pag.)CN110372570; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 67567-26-4 as follows. Computed Properties of C6H4BrF2N

10 kg of 4-bromo-2,6-difluoroaniline (48.08 mol) and 67 L of toluene were charged into a reactor under nitrogen atmosphere and stirred at 20 C. until complete dissolution. 1.67 kg of Pd(PPh3)4 (1.44 mol) were charged and stirred for 10 min. 48 L of a 20 wt. % aqueous solution of Na2CO3 were then charged, followed by the addition of a solution of 3-methoxyboronic acid (8.77 kg, 57.7 mol) in methanol (32 L) over 20 minutes. The mixture was heated at 72 C. for 4 hours and then cooled to 20 C.2) Purification of 3,5-difluoro-3′-methoxybiphenyl-4-amine2.1. A solution of 123 L of a 10% aqueous solution of Na2CO3, 1.5 L of a 25 wt. % aqueous solution of ammonia and 2.0 kg of a filtration resin (Dicalite) were charged to the reactor and the mixture stirred for 5 minutes. The mixture was recirculated through a filter until clarification of the liquors (35 min) and charged into a reactor. 60 L of isopropyl acetate were added and the mixture was stirred for 10 minutes and the phases (A1+O1) were allowed to separate. The aqueous phase (A1) was transferred to a different reactor and 60 L of isopropyl acetate were charged. The mixture was stirred and the phases (A2+O2) were allowed to separate. Both organic phases (O1+O2) were charged into a reactor and 108 L of a 10 wt. % aqueous solution of Na2CO3 were added. The mixture was stirred and the phases (A3+O3) were allowed to separate. The organic phase (O3) was stirred with 108 L of a 10 wt. % aqueous solution of Na2CO3 and the phases (A4+O4) were allowed to separate. The organic phase (O4) was stirred with 100 L demineralised water and the phases (A5+O5) were allowed to separate. The organic phase (O5) was filtered over a filtration resin (Dicalite) in a filter and charged in to a reactor.2.2. Distillation: The organic phase (O5) was distilled during 2 hours under reduced pressure (approx. 750 mm Hg) keeping the distilled mixture at temperature below 65 C.3) Preparation of the Aminium Salt (Step b)The distillation residue was dissolved in 100 L of isopropyl acetate, the mixture was cooled to 0-5 C. and 4.2 L of a 35 wt. % aqueous solution of HCl were added drop-wise until the pH was lower than 2. The aminium salt precipitated as a white solid from the dark brown coloured solution. The slurry was stirred for 2 hours at 0-5 C., filtered and the cake washed twice with 50 L of previously cooled isopropyl acetate. The cake was pulled dry under reduced pressure. 3,5-difluoro-3′-methoxybiphenyl-4-aminium chloride was isolated as beige solid. The weight of the wet-cake was 13.83 kg, equivalent to 10.25 kg of dry product (37.73 mol) which corresponds to a yield of 78.5%.

According to the analysis of related databases, 67567-26-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Boix Bernardini, Maria Carmen; US2012/245359; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 4549-33-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4549-33-1, name is 1,9-Dibromononane, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a stirred solution of n-dibromoalkane (1 equiv.) in anhydrous THF (0.1M) under an argon atmosphere was added tert-BuOK (1.15 equiv.) in portionwise over 30 min. After being stirred under reflux for 16h, the reaction was cooled and subsequently quenched with water. The resulting mixture was then diluted with diethylether, and the layers were separated. The aqueous layer was extracted several times with diethylether, and the combined organic layers were washed with brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The resultant crude product was purified by flash column chromatography over silica gel using petroleum ether as eluent to afford the desired product.

The chemical industry reduces the impact on the environment during synthesis 1,9-Dibromononane. I believe this compound will play a more active role in future production and life.

Reference:
Article; Saied, Essa M.; Le, Thuy Linh-Stella; Hornemann; Arenz, Christoph; Bioorganic and Medicinal Chemistry; vol. 26; 14; (2018); p. 4047 – 4057;,
Bromide – Wikipedia,
bromide – Wiktionary