Tag: M.W=200-300

Adding a certain compound to certain chemical reactions, such as: 7766-50-9, name is 11-Bromo-1-undecene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7766-50-9, Recommanded Product: 7766-50-9

To a solution of 11-Bromoundec-1-ene (2.2 mL, 10.1 mmol) in dry DMF (100 mL) was added 0.75 g (10.1 mmol) of NaN3. The solution was stirred for 12 h at room temperature. The reaction mixture was poured into 20 mL water and extracted with ethyl acetate (2 x 30 mL). The combined organic layer was washed with saturated NaCl solution and dried over anhydrous Na2SO4. Solvent was removed under reduced pressure to obtain the product as yellow oil. The product was used for the next step without any further purification. Yield: 1.9 g (96 %).Rf: 0.96 (1:9 Ethyl acetate & Cyclohexane).1H-NMR (CDCl3, 300 MHz, ppm): delta = 1.30 (s, 12H), 1.60 (m, 2H), 2.05 (m, 2H), 3.26 (t, J = 7.0 Hz, 2H), 4.96 (m, 2H), 5.83 (m, 1H). 13C-NMR (CDCl3, 75 MHz, ppm): delta = 26.9, 29.0, 29.1, 29.3, 29.3, 29.5, 29.6, 34.0, 51.7, 114.3, 139.3.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 11-Bromo-1-undecene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Bhabak, Krishna P.; Proksch, Denny; Redmer, Susanne; Arenz, Christoph; Bioorganic and Medicinal Chemistry; vol. 20; 20; (2012); p. 6154 – 6161;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 103273-01-4, name is 2-Bromo-4-(tert-butyl)aniline, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 103273-01-4, SDS of cas: 103273-01-4

200 mL three-necked eggplant flask fully dried (condenser, three-way cock, To a magnetic stirring bar) was added 2-methoxyphenylboronic acid (Wako Pure Chemical Industries, Ltd.) (3.19 g, 10.5 mmol), (0.05 mmol) of 2-bromo-4-tert-butylaniline (2.8 g, 10 mmol), palladium acetate (manufactured by Wako Pure Chemical Industries, Ltd.), 2-dicyclohexylphosphino-2′,6-dimethoxybiphenyl (Manufactured by Sigma-Aldrich Japan Co., Ltd.) (0.041 g, 0.1 mmol) 6.9 g (30 mmol) of potassium phosphate monohydrate (manufactured by Wako Pure Chemical Industries, Ltd.) In addition, suspended in 20 mL of toluene (manufactured by Kanto Chemical Co., Ltd.) The reaction was carried out at 100 C. for 3 hours. To this reaction solution was added 50 mL of water, After extraction with toluene, the organic layer was dried with MgSO 4 (manufactured by Kanto Kagaku Co., Ltd.) The solvent was distilled off under reduced pressure to obtain a crude product. The crude product was purified by silica gel column chromatography (eluent; hexane (Manufactured by KANTO CHEMICAL CO., LTD.) / Ethyl acetate (manufactured by KANTO CHEMICAL CO., LTD.) = 9/1) to obtain 2.40 g (94%, light yellow liquid) of Compound

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-4-(tert-butyl)aniline, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Mitsui Chemicals Co., Ltd.; Kinoshita, Shinsuke; Kawamura, Kazumori; Ishii, Seiichi; Tanaka, Kenichi; Hanada, shiori; Saito, Yasunori; Hara, Retsu; Mizobuchi, Yusuke; Muroto, Toshihiro; (55 pag.)JP5769443; (2015); B2;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 937046-98-5, name is 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine, A new synthetic method of this compound is introduced below., Recommanded Product: 937046-98-5

To a dry, argon purged round bottom flask (100 mL) were added 7-bromo- pyrrolo[2,l-f][1,2,4]triazin-4-ylamine (234 mg, 1.10 mmol) and anhydrous THF (1 .5 mL). TMSCI (276 L, 2.2 mmol) was then added and the reaction mixture stirred for 2h. The flask was placed into a dry ice/acetone bath (- 78 C) and BuLi (2.5 mL, 4.0 mmol, 1.6 M in hexanes) was added dropwise. After 1 h, a solution of 2b (432 mg, 1.0 mmol) in THF was cooled to 0 C and then added to the reaction flask dropwise. After 1 h of stirring at -78 C, the flask was warmed to 0 C and sat. NH4CI (5 mL) was added to quench the reaction. The organics were extracted using EtOAc (3 10 mL) and the combined organic layers were dried using MgS04. The solvent was removed under reduced pressure and the crude material was purified using flash silica gel chromatography (hexanes / EtOAc). 560 mg (90 %) of the desired material 2c was isolated. LC/MS = 567.2 (M + H+). 1H NMR (300 MHz, CDC13): 5 7.85 (m, 1H), 7.27 (m, 15H), 7.01 (m, 1H), 6.51 (m, 1H), 4.66 (m, 8H), 4.40 (m, 2H), 3.79 (m, 3H), 1.62 (s,.2′-CH3 from the one anomer), 1.18 (s, 2′-CH3 from the other anomer).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; GILEAD SCIENCES, INC.; BUTLER, Thomas; CHO, Aesop; GRAETZ, Benjamin, R.; KIM, Choung, U.; METOBO, Samuel, E.; SAUNDERS, Oliver, L.; WALTMAN, Andrew, W.; XU, Jie; ZHANG, Lijun; WO2011/35250; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 58971-11-2, name is 3-Bromophenethylamine, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 58971-11-2, Application In Synthesis of 3-Bromophenethylamine

[00981] Example 62. Preparation of N-(6-(3-fer?-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-l(2H)-yl)-2- methoxyphenyl)-3,4-dihydroisoquinolin-2(lH)-yl)methanesulfonamide (compound IB-LO-2.43).; [00982] Part A. Preparation of N-(3-bromophenethyl)-2,2,2-trifluoroacetamide.; [00983] To a solution of 2-(3-bromophenyl)ethanamine (1Og, 50.0mmol) in dichloromethane (200ml) atO0C were added 2,6-lutidine (6.40ml, 55.0mmol) and then trifluoroacetic anhydride (7.77ml, 55.0mmol) dropwise, and the reaction was stirred at room temperature overnight. Water was added at 00C and the reaction was washed with IM HCl, H2O, and sat NaHCO3. The organic was dried overmgSO4, filtered and concentrated to provide the title compound as a tan solid (14.7g, 99%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Bromophenethylamine, and friends who are interested can also refer to it.

Reference:
Patent; ABBOTT LABORATORIES; WO2009/39134; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 13633-25-5,Some common heterocyclic compound, 13633-25-5, name is 1-Bromo-4-phenylbutane, molecular formula is C10H13Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

b) 8-(4-phenylbutyl)-1,4-dioxaspiro[4,5]decane-8-carboxylic acid ethyl ester A 2.5 M solution of n-butyl lithium (2.5 g, 15.7 mL, 39.2 mmol) was slowly added in drops to a solution of diisopropylamine (3.96 g, 5.50 mL, 39.2 mmol) in absolute tetrahydrofuran (50 mL) at -78 C. in argon. 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)pyrimidone (DMPU, 10.0 g, 9.42 mL, 78.2 mmol) and a solution of the title compound of the previous step (8.40 g, 39.2 mmol) in absolute tetrahydrofuran (30 mL) were added in drops one after the other to this mixture. The reaction solution was further stirred for 2 h at this temperature before a solution of 1-bromo-4-phenylbutane (10.0 g, 47.0 mmol) in absolute tetrahydrofuran (50 mL) was added in drops. The resulting solution was stirred overnight at room temperature. Saturated ammonium chloride solution (50 mL) was then added and extracted with ether (2*50 mL). The combined organic phases were washed with saturated sodium chloride solution (50 mL), dried with sodium sulphate and concentrated to low volume in a vacuum. The raw product (17.7 g) was purified by means of flash chromatography (400 g, 20*7.5 cm) with cyclohexane/ethyl acetate (9:1). Yield: 10.3 g (76%), colourless oil 1H-NMR (DMSO-d6): 1.12 (t, 3H, J=7.1 Hz); 1.39-1.62 (m, 12H); 1.91-2.03 (m, 2H); 2.54 (t, 2H, J=7.4 Hz); 3.82 (s, 4H); 4.05 (q, 2H, J=7.1 Hz); 7.12-7.17 (m, 3H); 7.22-7.28 (m, 2H).

The synthetic route of 13633-25-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Grunenthal GMBH; US2009/247530; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

89359-54-6, name is 9-Bromo-1-nonene, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 89359-54-6

REFERENCE EXAMPLE 14 Methyl 2-methyl-2-(8-nonenyloxy)propionate To 500 ml of dry N,N-dimethylformamide, 17 g of 60% sodium hydride was added, and 48 g of methyl 2-hydroxyisobutyrate was added dropwise with stirring under ice-cooling, and stirred for 10 minutes. Then, 100 g of 9-bromo-1-nonene (purity: 63.4%) was added, and the mixture was stirred for 15 hours at room temperature. The reaction solution was poured into ice-cold water, extracted with ethyl acetate, washed with brine, dried over anhydrous magnesium sulfate and concentrated. The residue was distilled under reduced pressure to give 29.9 g of the objective compound as yellowish oil. B.p. 124-127 C. (8 mmHg).

The synthetic route of 89359-54-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kuwabara, Kenji; Aoki, Tomiyoshi; US2003/166697; (2003); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 69272-50-0, name is 3,6-Dibromobenzene-1,2-diamine, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 69272-50-0, Recommanded Product: 3,6-Dibromobenzene-1,2-diamine

Preparation of 5,8-dibromodiphenylquinoxaline (CH-b) A solution of 5.3 g (20 mmol) of 3,6-dibromo-1,2-phenylenediamine 1, 4 g (19 mmol) of benzil 2b, 4.2 g of sodium acetate and 150 ml of glacial acetic acid were refluxed for 4 hours. The precipitate was filtered off, washed with 100 ml of water and recrystallized twice from dioxane. Drying under reduced pressure at 50 C. gave the pure product in the form of colorless crystals, which according to HPLC had a purity of about 99.5%. The yield was 6.45 g (73%). 1H NMR (CDCl3, 500 MHz): [ppm]=7.92 (s, 2H), 7.67 (d, 3JHH=1.67 Hz, 2H), 6.66 (d, 3JHH=1.67 Hz, 2H), 7.37 (m, 6H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,6-Dibromobenzene-1,2-diamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Covion Organic Semiconductors GmbH; US2007/265473; (2007); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 40787-48-2,Some common heterocyclic compound, 40787-48-2, name is 1,4-Dibromo-2,5-diethylbenzene, molecular formula is C10H12Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In the glove box the mixture of 1 ,4-dibromo-2,5-diethylbenzene (7.1 1 g, 24.35mmol), 4-chloro-2-methylphenylboronic acid (8.3g,48.70mmol), Aliquat 336 (0.5g), and Pd(PPh3) (1 .4g, 1 .21 mmol, 0.05eq), and Na2CO3 (12.9g, 121 .7mmol) in degassed toluene (200mL) was prepared. Outside dry box, the degassed water (65ml_) was added to the former mixture under nitrogen, and then the resultant mixture was stirred at 88C overnight under nitrogen. The organic layer was separated and the aqueous layer was extracted with ethyl acetate. The combined organic layers were dried over anhydrous MgSO4. Filtration, concentration of the filtrate, and then the silica column chromatography (hexane) provided the desired product, 18, (6.7g, 72% yield) as a white solid.

The synthetic route of 40787-48-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; E. I. DU PONT DE NEMOURS AND COMPANY; PARK, Kyung-Ho; RADU, Nora, Sabina; JOHANSSON, Gary, A.; FENNIMORE, Adam; DELANEY, William, J.; LECLOUX, Daniel, David; WO2011/159872; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 21865-50-9, name is 6-Bromo-2,3,4,9-tetrahydro-1H-carbazole, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 21865-50-9, Quality Control of 6-Bromo-2,3,4,9-tetrahydro-1H-carbazole

A sample of 6-Bromo-2,3,4,9-tetrahydro carbazole (0.498g, 2 mmol) was dissolved in 4 ml of dry DMF. To this stirred solution, NaH (60% suspension; 0.24g, 6 mmol) was added portion wise followed by the addition of diethyl sulfate (0.79ml, 6 mmol). The reaction mixture was heated to 80 0C overnight. The TLC of mixture, with 4:6 dichloromethane/hexane, showed complete consumption of starting material and a new spot with higher Rf value. The reaction mixture was added to 60 ml of ice cold H2O, the mixture was extracted with EtOAc and washed with sat. brine solution. The organic layer was dried over anhyd.MgSO4, solvents were concentrated in vacuo and the crude was purified by column chromatography to obtain 0.4g of the pure product.1H NMR 500 MHz CDCl3: 7.57, s, IH, 7.2, d, J=8.7, IH, 7.12, d, J=8.7, IH, 4.04, q, J=7.2, 2H, 2.73-2.64, m, 4H, 1.98-1.90, m, 2H, 1.88-1.81, m, 2H, 1.30, t, J=7.3, 3H.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 6-Bromo-2,3,4,9-tetrahydro-1H-carbazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; IMMUSOL INCORPORATED; WO2008/21745; (2008); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 337915-79-4, name is 5-Bromo-N1-methylbenzene-1,2-diamine, This compound has unique chemical properties. The synthetic route is as follows., Safety of 5-Bromo-N1-methylbenzene-1,2-diamine

To a cooled (0 0C) and stirred suspension of (2-amino-5-bromophenyl)methylamine (9.5g, may be prepared as described in intermediate 46) in 2M hydrobromic acid was added dropwise a cooled (5 0C) solution of sodium nitrite (4.02 g) in water (50 ml). The resultant mixture was stirred at 5 0C for 0.5 hr and then at 15-20 0C for 4 hr. The mixture was partitioned between EtOAc (500 ml) and saturated aqueous sodium bicarbonate (500 ml). The aqueous phase was separated off and extracted with EtOAc (500 ml). The organic phases were combined, washed with water and brine, dried (magnesium sulphate) and adsorbed on to silica gel prior to flash chromatography over silica gel, eluting with EtOAc / cyclohexane (1 :3). Fractions containing the target compound were combined and evaporated to give a brown solid (4.48 g). 2.61 g of this was further purified by chromatography over silica gel, eluting with 2% MeOH in chloroform. The appropriate fractions were combined and evaporated to give the target compound as a pale brown solid (1.3O g).

According to the analysis of related databases, 337915-79-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXO GROUP LIMITED; BLUNT, Richard; EATHERTON, Andrew John; GARZYA, Vincenzo; HEALY, Mark Patrick; MYATT, James; PORTER, Roderick Alan; WO2011/12622; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary