Tag: M.W=200-300

Application of 25121-87-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 25121-87-3 as follows.

Take a 500 ml three-neck round bottom bottle and place the stirrer with the upper addition funnel.After drying, it is filled with nitrogen;First, 92 mL of lithium diisopropylamide (0.184 mol, 2.3 eq) was added at a concentration of 2M, followed by dissolving 23.841 g of compound P01 (0.08 mol, 1 eq) in 150 mL of anhydrous tetrahydrofuran in an addition funnel.And the resulting solution was added dropwise to a three-necked round bottom bottle at -78 C.After the reaction gradually returns to temperature, the reaction is continued for 18 hours;The reaction was stopped with 120 mL of saturated aqueous sodium bicarbonate solution.It was then extracted with 200 mL of ethyl acetate and repeated 3 times.The obtained extract is sequentially added with magnesium sulfate to dry, filtered and spin-dried;The crude product was purified by recrystallization from ethanol to give 22.172 g of 3,6-dibromothieno[3,2-b]thiophene (yield: 93%).

According to the analysis of related databases, 25121-87-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Ningbo Lumilan New Materials Co., Ltd.; Ningbo Jizhichuang New Materials Institute Co., Ltd.; Wei Dingwei; Xie Kunshan; Ding Huanda; Chen Zhikuan; (39 pag.)CN109836436; (2019); A;,
Bromide – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4263-52-9, name is Sodium 2-bromoethanesulphonate, This compound has unique chemical properties. The synthetic route is as follows., name: Sodium 2-bromoethanesulphonate

Phosphorus pentachloride (commercially available, for example, from Aldrich) (1 1.8 g, 57 mmol) was added portionwise to stirred sodium bromoethanesulfonate (commercially available, for example, from Aldrich) (4.0 g, 19 mmol) over five minutes. When the addition was complete, the suspension was heated to 1 10 0C for 2 h before cooling to 21 0C and then pouring onto ice. The product was extracted with dichloromethane and the organic layer was washed successively with water, sodium bicarbonate and water. The organic solution was dried over magnesium sulfate and evaporated to give the title compound (3.24 g), 1H NMR delta (CDCI3) 4.12 (2H, t, J = 8 Hz), 3.79 (2H, t, J = 8 Hz).

According to the analysis of related databases, 4263-52-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GLAXO GROUP LIMITED; WO2009/47336; (2009); A1;,
Bromide – Wikipedia,
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Application of 73918-56-6, These common heterocyclic compound, 73918-56-6, name is 2-(4-Bromophenyl)ethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of compound 31 (99 mg, 0.30 mmol) in anhydrous DMF (5.0 mL) were added EDC (75 mg, 0.39 mmol) and HOBt (45 mg, 0.33 mmol) and then stirred under ice water bath for 5 min, then the selected amine (0.36 mmol) were employed to the reaction mixture for another 15 min at 0 C and stirred at room temperature for 3 h. The mixture was extracted with ethyl acetate, washed with water and brine, and then dried over anhydrous Na2SO4. The crude product was purified by column chromatography (SiO2, petroether/ethyl acetate) to afford target compounds 32-44.

Statistics shows that 2-(4-Bromophenyl)ethanamine is playing an increasingly important role. we look forward to future research findings about 73918-56-6.

Reference:
Article; Wu, Jing; Yu, Linxi; Yang, Feifei; Li, Jingjie; Wang, Peng; Zhou, Wenbo; Qin, Liwen; Li, Yunqi; Luo, Jian; Yi, Zhengfang; Liu, Mingyao; Chen, Yihua; European Journal of Medicinal Chemistry; vol. 80; (2014); p. 340 – 351;,
Bromide – Wikipedia,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 50548-45-3 as follows. Application In Synthesis of 1-Bromodibenzo[b,d]furan

180 g (728 mmol) of 1-bromodibenzofuran are dissolved in 1500 ml of dry THF and cooled to -78°C. 305 ml (764 mmol I 2.5 M in hexane) of n-butyllithium are added over the course of about 5 mm. at this temperature, and the mixture is subsequently stirred at -78°C for a further 2.5 h. 151 g (1456 mmol) of trimethyl borate are added as rapidly as possible at this temperature, and the reaction is slowly allowed to come to room temperature(about 18 h). The reaction solution is washed with water, and the solid which has precipitated out and the organic phase are dried azeotropically with toluene. The crude product is washed by stirring with toluene/methylene chloride at about 40°C and filtered off with suction. Yield: 146 g (690 mmol),95percent of theory.

According to the analysis of related databases, 50548-45-3, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MERCK PATENT GMBH; PARHAM, Amir Hossain; JATSCH, Anja; EBERLE, Thomas; GROSSMANN, Tobias; KROEBER, Jonas Valentin; DOBELMANN-MARA, Lars; (100 pag.)WO2016/198144; (2016); A1;,
Bromide – Wikipedia,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 73918-56-6, name is 2-(4-Bromophenyl)ethanamine, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 73918-56-6

General procedure: To compound 5, 6 or 7 (1 equiv) and the appropriate alkylamine(1.3 equiv) in anhydrous DMF (10 mL/mmol) were added DIEA (3equiv) and PyBOP (1 equiv), and the reaction mixturewas stirred atroom temperature under argon. When the reaction was complete(2 h – 4 h), the solvents were removed under reduced pressure togive a residue that was taken up in CH2Cl2. The solution waswashed with saturated aqueous NaHCO3, then water. The organiclayer was dried over Na2SO4 and then evaporated in vacuo. Purificationby flash chromatography afforded the corresponding amidederivatives 8, 9 or 10 (yield: 40-76%).

According to the analysis of related databases, 73918-56-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Paoletti, Julie; Assairi, Liliane; Gelin, Muriel; Huteau, Valerie; Nahori, Marie-Anne; Dussurget, Olivier; Labesse, Gilles; Pochet, Sylvie; European Journal of Medicinal Chemistry; vol. 124; (2016); p. 1041 – 1056;,
Bromide – Wikipedia,
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Synthetic Route of 937046-98-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 937046-98-5, name is 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 7-bromopyrrolo[2,1-f][1,2,4]triazin- 4-amine (250 mg, 1.174 mmol), (S)-1-tert-butyl 2-methyl 4-(4,4,5,5-tetramethyl-1,3,2- dioxaborolan-2-yl)-1H-pyrrole-1,2(2H,5H)-dicarboxylate (912 mg, 2.58 mmol) and potassium phosphate tribasic (2 M in water) (1760 mul, 3.52 mmol) in DMF (6593 mul) was sparged with nitrogen for 5 min. PdCl2(dppf)-CH2Cl2 adduct (96 mg, 0.117 mmol) was added to the reaction mixture which was sparged with nitrogen for an additional 5 min. The mixture was brought to 100 C and stirred for 30 min. The reaction mixture was then diluted with EtOAc, washed with water, brine, dried over MgSO4, filtered and concentrated in vacuo. Purification by flash chromatography (Silica, 40g, 40 – 70% EtOAc/Hexanes) gave (S)-1-tert-butyl 2-methyl 4-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7- yl)-1H-pyrrole-1,2(2H,5H)-dicarboxylate (165 mg, 0.459 mmol, 39.1 % yield). (0757) MS ESI (m/z) 360.1 (M+H)

The synthetic route of 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WATTERSON, Scott Hunter; ANDAPPAN MURUGAIAH SUBBAIAH, Murugaiah; DZIERBA, Carolyn Diane; GONG, Hua; GUERNON, Jason M.; GUO, Junqing; HART, Amy C.; LUO, Guanglin; MACOR, John E.; PITTS, William J.; SHI, Jianliang; VENABLES, Brian Lee; WEIGELT, Carolyn A.; WU, Yong-Jin; ZHENG, Zhizhen Barbara; SIT, Sing-Yuen; CHEN, Jie; (810 pag.)WO2019/147782; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4549-33-1, name is 1,9-Dibromononane, A new synthetic method of this compound is introduced below., Recommanded Product: 4549-33-1

General procedure: To a stirred solution of monovalent beta-carbolines 1-17 (2.0 mmol) in anhydrous DMF (30 ml) was added 60% NaH (0.4 g, 10 mmol). After stirring for 20 min at room temperature, the appropriate dibromoalkane (1.0 mmol) was added. And then the reaction mixture was stirred at room temperature for 8-20 h. After completion of the reaction as indicated by TLC, the solution was poured into ice-water and extracted with CH2Cl2. The combined organic layer was washed with water and brine, dried over anhydrous Na2SO4, filtered and evaporated in vacuum. The residue was purified by column chromatography with CH2Cl2/MeOH (50:1) to successfully afford the desirable target products.

The synthetic route of 4549-33-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Shi, Buxi; Cao, Rihui; Fan, Wenxi; Guo, Liang; Ma, Qin; Chen, Xuemei; Zhang, Guoxian; Qiu, Liqin; Song, Huacan; European Journal of Medicinal Chemistry; vol. 60; (2013); p. 10 – 22;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 13633-25-5, A common heterocyclic compound, 13633-25-5, name is 1-Bromo-4-phenylbutane, molecular formula is C10H13Br, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3) 0.24 g (10 mmol) of sodium hydride and 15 ml of N, N-dimethylformamide were added to a 50 ml round bottom flask at room temperatureStir for 10 minutes,Then, 2.5 g (10 mmol) of compound 2 and 10 mmol of 1-bromo-4-phenylbutane were added and subjected to thin layer chromatography to the end of the reaction. The reaction solution was then poured into 500 ml of ice water, extracted three times with 100 ml of ethyl acetate,The organic phase was combined and the solvent was evaporated to dryness. The resulting residue was purified by silica gel column chromatography (V dichloromethane: V methanol = 100: 1) to give Compound 3 (3.1 g, yield 82%).

The synthetic route of 13633-25-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Guangxi Normal University; Chen Zhenfeng; Liang Hong; Liu Yancheng; Lu Xing; Li Liangping; (13 pag.)CN106478690; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 13633-25-5, The chemical industry reduces the impact on the environment during synthesis 13633-25-5, name is 1-Bromo-4-phenylbutane, I believe this compound will play a more active role in future production and life.

General procedure: A mixture of the amine 9, alkyl bromide (1.2 equiv) and NaHCO3 (2 equiv) in DMF (20mL) was heated at 50C for 20h. After cooling to room temperature, the reaction mixture was poured into ice- H2O, and the product was extracted with Et2O. The ethereal extracts were washed with saturated NH4Cl solution, dried over Na2SO4, and the solvent was removed in vacuo to afford an oil. The crude oil was subjected to flash chromatography on silica gel using 75% EtOAc in hexanes as the eluent to give the 10-12 as solids.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Bromo-4-phenylbutane, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Iyer, Malliga R.; Rothman, Richard B.; Dersch, Christina M.; Jacobson, Arthur E.; Rice, Kenner C.; European Journal of Medicinal Chemistry; vol. 92; (2015); p. 531 – 539;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 75024-22-5, These common heterocyclic compound, 75024-22-5, name is 1,4-Dibromo-2,3-dimethylbenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Add 6.3 mmol to a 100 ml three-necked flask under N2 protection.1,4-Dibromo-2,3-dimethylbenzene, 14.1 mmol 4-methylphenylboronic acid, 25.6 mmol sodium carbonate, 0.2 mmol tetrakistriphenylphosphine palladium, 30 ml toluene, 6 ml deionized water, and then replaced with nitrogen Three times, then heated to 90 C with an oil bath under magnetic stirring for 6 h. After the reaction,After washing with water, extracting, drying, and removing the organic solvent under reduced pressure,The product was isolated by column chromatography (petroleum ether) in a yield of 85%.Then 1.75 mmol of the obtained product, 42 mmol of potassium permanganate, 10 ml of pyridine,12 ml of distilled water was added to a 100 ml three-necked flask, and then heated to 100 C with an oil bath under magnetic stirring, and the reaction was refluxed for 15 hours. After the reaction was completed, the organic solvent was depressurized under reduced pressure, and then water was added thereto. After ultrasonic etching, MnO 2 was filtered through celite. Add hydrochloric acid to adjust the pH to 1 to precipitate largeThe white powder was collected, collected by centrifugation and dried to give a polycarboxylic acid product with a yield of 97%.Finally, 1.98 mmol of the tetracarboxylic acid product, 4 mmol of hydroxylamine hydrochloride, and 10 ml of pyridine were placed in a 50 ml single-necked flask, and heated to 90 C with an oil bath under magnetic stirring for 6 h.After the reaction, the organic solvent is depressurized under reduced pressure, then ultrasonically diluted with dilute hydrochloric acid, collected by centrifugation and dried to obtain an off-white product: an organic ligand based on NHPI functionalized polycarboxylic acid (a)The yield was 96%.

The synthetic route of 75024-22-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Tongji University; Li Liangchun; Liang Gan; Sun Chengmei; (12 pag.)CN109608381; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary