Tag: M.W=200-300

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52723-82-7, name is 4-Bromo-5-fluoro-2-methylaniline, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 52723-82-7

EXAMPLE 47 4-Amino-2-fluoro-5-methylbenzonitrile Using the method of Example 15, 4-bromo-3-fluoro-6-methylaniline is converted into the title compound.

According to the analysis of related databases, 52723-82-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; American Cyanamid Company; US4863959; (1989); A;,
Bromide – Wikipedia,
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337915-79-4, name is 5-Bromo-N1-methylbenzene-1,2-diamine, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. SDS of cas: 337915-79-4

Example 62 4- ( ( 4-Chlorobenzyl) oxy) -1- (2- (2, 2-difluorocyclopropyl) -1- methyl-lH-benzimidazol-6-yl ) pyridin-2 (1H) -one A) 6-Bromo-2- (2, 2-difluorocyclopropyl) -1-methyl-lH- benzimidazole A. mixture of 5-bromo-N1-methylbenzene-l, 2-diamine (300 mg) , HATU (567 mg) , N, N-diisopropylethylamine (0.255 ml), 2,2- difluorocyclopropanecarboxylic acid (182 mg) and DMF (10 ml) was stirred at room temperature for 1 h. The mixture was quenched with water and extracted with EtOAc. The organic layer was separated, washed with water and brine, dried over MgS04, passed through NH silica gel pad and concentrated in vacuo. The precipitate was washed with IPE/hexane, collected by filtration and dried in vacuo to give the title compound (255 mg) as a yellow solid. MS (ESI+) : [M+H]+ 288.9.

The synthetic route of 337915-79-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; KASAI, Shizuo; IGAWA, Hideyuki; TAKAHASHI, Masashi; MAEKAWA, Tsuyoshi; KAKEGAWA, Keiko; YASUMA, Tsuneo; KINA, Asato; AIDA, Jumpei; KHAMRAI, Uttam; KUNDU, Mrinalkanti; WO2013/105676; (2013); A1;,
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Related Products of 176317-02-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 176317-02-5, name is 1-Bromo-2,3,4-trifluorobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step 1: 5-bromo-2,3,4-trifluorobenzoic acid To a solution of diisopropylamine (10.14 g, 100.20 mmol) in THF (100 mL) was added n-BuLi (40.08 mL, 2.5 M in hexane, 100.20 mmol) at -78 C. under nitrogen atmosphere. The stirring was maintained at this temperature for 1 h. Then a solution of 1-bromo-2,3,4-trifluorobenzene (17.62 g, 83.50 mmol) in THF (120 mL) was added. After stirring for 1 h at -78 C., the mixture was transferred to a bottle with dry ice. The mixture was stirred overnight at room temperature. The reaction was quenched with 10% aqueous HCl and pH was adjusted to 1-2. The mixture was extracted with ethyl acetate (100 mL*3). The combined organic extracts were washed with water (100 mL) and brine (100 mL) sequentially, dried over Na2SO4, filtered and concentrated under reduced pressure to afford the desired product (20.12 g, 94.5% yield). 1H NMR (400 MHz, DMSO-d6): delta 13.95 (s, 1H), 7.97 (m, 1H).

The synthetic route of 1-Bromo-2,3,4-trifluorobenzene has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TIANJIN BINJIANG PHARMA, INC.; Tian, Hongqi; Ji, Conghui; Liu, Chunlei; Kong, Li; Cheng, Ying; Huang, Gongchao; US2014/371278; (2014); A1;,
Bromide – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6274-57-3, name is 1-(4-Bromophenyl)-N,N-dimethylmethanamine, A new synthetic method of this compound is introduced below., Recommanded Product: 1-(4-Bromophenyl)-N,N-dimethylmethanamine

To a 1 L round bottom flask with a stir bar, reflux condenser and gas inlet containing [4-bromophenyl)methyl]dimethyl amine (55 mmol, 11.8 g) in glyme (300 mL) and water (30 mL) was added 3-aminophenyl boronic acid hydrate (110 mmol, 17g), (Ph3P)2PdCI2 (2.75 mmol, 1.93 g) and sodium carbonate (165 mmol, 17.5 g). The reaction was stirred at reflux under nitrogen until LC-MS analysis indicated consumption of starting material. The reaction mixture was partitioned between diethyl ether and water. The organic layer was washed with brine, dried (Na2SO4), filtered, and concentrated to give an oil. The oil was slurried in Et2O and acidified with 1N HCI in Et2O to give the HCI salt of the product as a precipitate (12 g, 73%). 1H NMR (300 MHz, DMSO-d6) delta ppm 8.15 (br s, 2H), 7.58 (d, 1 H, J = 7.3), 7.52 (d, 1H, J = 1.8), 7.34 (t, 1 H, J = 7.7), 7.22 (m, 2H)1 7.06 (m, 2H), 6.79 (d, 1H, J = 7.8), 4.32 (s, 2H), 2.73 (s, 6H)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2007/18941; (2007); A2;,
Bromide – Wikipedia,
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Synthetic Route of 69272-50-0, The chemical industry reduces the impact on the environment during synthesis 69272-50-0, name is 3,6-Dibromobenzene-1,2-diamine, I believe this compound will play a more active role in future production and life.

In a dry 100 mL flask, compound 1 (0.59 g, 2 mmol) and NaBH4 (0.76 g, 20 mmol) were mixed inethanol (40 mL) for 1 h at RT, and then refluxed for 4 h under a nitrogen atmosphere. After coolingto RT, water was added and filtered. The residue was dried in vacuum. Then the crude product andsodium acetate (0.33 g, 4 mmol) were added to a solution of benzil (0.42 g, 2 mmol) in anhydrousethanol (30 mL) under a nitrogen atmosphere. The mixture was refluxed for 24 h. After cooling to RT,the solvent was removed under reduced pressure and the residue was purified by silica gel columnchromatography (eluent: n-hexane:CH2Cl2 = 4:1) to give a pale yellow solid (yield 72.0%, 0.75 g).1H-NMR (400 MHz, CDCl3,delta ): 7.91(s, 2H), 7.65-7.66(m, 4H), 7.34-7.41(m, 6H). 13C-NMR (100 MHz,CDCl3,delta ): 154.15, 139.36, 137.95, 133.10, 130.26, 129.59, 128.38, 123.74.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,6-Dibromobenzene-1,2-diamine, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Wu, Zhonglian; Jiang, Huanxiang; Wang, Xingzhu; Yan, Lei; Zeng, Wei; Wu, Xiu-Gang; Zhuang, Haiyu; Zhu, Wen; Yang, Renqiang; Molecules; vol. 24; 1; (2019);,
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608-30-0, name is 2,6-Dibromoaniline, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 2,6-Dibromoaniline

Example 15 In this example, formation of 2,6,2″,6″-tetramethoxy-[1,1′;3′,1″]terphenyl-2′-ylamine is shown. 25.0 g (0.137 mol) of 2,6-dimethoxyphenylboronic acid, 11.41 g (0.046 mol) of 2,6-dibromo-phenylamine, 54.00 g (0.166 mol) of cesium carbonate, 0.62 g (0.000677 mol) of tris(dibenzylideneacetone)dipalladium (0), 0.38 g (0.00163 mol) of di-tert-butyl-trimethylsilanylmethyl-phosphine and 125 ml of dioxane were stirred at room temperature for 12 hours. The reaction mixture was filtered and the solvent was removed under vacuum. The resulting mixture was recrystallized from methylene chloride. Yield of 2,6,2″,6″-tetramethoxy-[1,1′;3′,1″]terphenyl-2′-ylamine was 12.21 g (73%) with m.p. 177.77 C. 1H NMR (CDCl3) 3.95 (s, 12H, MeO), 4.10 (s, 2H, NH2), 6.85-7.60 (m, arom. 9H).Anal. Calcd. for C22H23NO4: C, 72.31; H, 6.34; N, 3.83. Found: C, 72.13; H, 6.28; N, 3.02. GC/MS MW is 365. The structure was confirmed by X-ray analysis.

The synthetic route of 608-30-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Ionkin, Alex Sergey; US2006/281923; (2006); A1;,
Bromide – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1435-52-5, name is 1,4-Dibromo-2-fluorobenzene, A new synthetic method of this compound is introduced below., name: 1,4-Dibromo-2-fluorobenzene

General procedure: 6.19 1-Bromo-4(4′-vinylphenyl)-2-fluorobenzene (8e): Starting with 6 (100 mg, 0.39 mmol), Cs2CO3 (190 mg, 0.50 mmol), Pd(PPh3)4 (3 molpercent), 4-vinylphenylboronic acid (57 mg, 0.39 mmol) and 1,4-dioxane (4 mL), 8e was isolated as a colorless solid (49 mg, 45percent). Mp 338-340 °C. 1H NMR (300 MHz, CDCl3): delta = 5.03 (d, J = 2.3 Hz, 1H, CH), 5.58 (d, J = 4.3 Hz, 1H, CH), 6.52 (q, J = 3.7 Hz, 1H, CH), 7.00-7.13 (m, 3H, ArH), 7.23-7.35 (m, 4H, ArH). 13C NMR (75.46 MHz, CDCl3): delta = 114.5 (CH), 114.9 (CH), 123.5 (d, J = 4.3 Hz, CH), 126.4 (CH), 126.8 (CH), 126.9 (CH), 128.9 (d, J = 3.2 Hz, CH), 133.7 (CH), 136.1 (CH), 136.3 (d, J = 19.6 Hz, C), 137.5 (C), 137.6 (d, J = 2.4 Hz, C), 142.1 (d, J = 7.4 Hz, C), 159.4 (d, JCF = 243.3 Hz, CF). 19F NMR (282.4 MHz, CDCl3): delta = -107.1 (CF). IR (ATR, cm-1): , 2852 (w), 2368 (w), 2165 (w), 2046 (w), 1977 (w), 1711 (m), 1605 (w), 1573 (w), 1521 (w), 1486 (w), 1432 (w), 1359 (m), 1301 (w), 1219 (m), 1186 (w), 1116 (w), 1090 (w), 1006 (w), 989 (w), 905 (w), 878 (w), 814 (m), 771 (w), 721 (w), 668 (w), 622 (w), 578 (w), 529 (w). MS (EI, 70 eV); m/z (percent) = 278 (96) (81Br) [M]+, 276 (100), 277 (18), 196 (41), 170 (14), 158. HRMS (EI) calcd. for C14H1081BrF [M]+: 277.99240; found 277.99241.

The synthetic route of 1435-52-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Sharif, Muhammad; Maalik, Aneela; Reimann, Sebastian; Feist, Holger; Iqbal, Jamshed; Patonay, Tama?s; Villinger, Alexander; Langer, Peter; Journal of Fluorine Chemistry; vol. 146; (2013); p. 19 – 36;,
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Electric Literature of 68322-84-9, The chemical industry reduces the impact on the environment during synthesis 68322-84-9, name is 2-Bromo-1-fluoro-4-(trifluoromethyl)benzene, I believe this compound will play a more active role in future production and life.

A mixture of [3,5-biotas(tnfluoromethyl)benzyl]-((3S,5R)-5-ethyl-pyrroliotadiotan-3-yl)-[5-(1-methyl- 1 H-pyrazol-4-yl)-py?miotadiotan-2-yl]-amiotane (45 mg, 0 27 mmol), 2-chloro-5-triotafluoromethyl- py?dine (196 mg, 0 81 mmol) and K2CO3 (11 1 mg, 0 81 mmol) in THF (2 0 ml_) in a sealed tube is stirred at 120 C for 2 hours The mixture is concentrated under reduced pressure The obtained residue is purified by silica gel column chromatography (eluent hexane / EtOAc) to give (3,5-biotas-t?fluoromethyl-benzyl)-[(3S,5R)-1-(2-bromo-4-triotafluoromethyl-phenyl)- 5-ethyl-pyrroliotadiotan-3-y.]-[5-(1 -methyl-1 H-pyrazol-4-yl)-py?miotadiotan-2-yl]-amiotane as a colorless oil (36 mg, 18%) 1 H NMR (400 MHz, chloroform-d) delta ppm 0 81 (t, 3H), 1 31 -1 35 (m, 1 H) 1 63-1 69 (m, 1 H),1 74 (q, 1 H), 2 40-2 43 (m, 1 H), 3 20 (dd, 1 H), 3 76-3 83 (m, 1 H) 3 88 (dd, 1 H), 3 95 (s, 3H), 5 02 (d, 1 H), 5 16 (d, 2H), 5 45-5 50 (m, 1 H), 6 98 (d, 1 H), 7 46 (dd, 1 H), 7 52 (s, 1 H), 7 66 (s, 1 H), 7 72 (s, 2H), 7 75 (d, 2H), 8 42 (s, 2H) ESI-MS m/z 722 [M+1]+, Retention time2 48 mm (condition A)

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-1-fluoro-4-(trifluoromethyl)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; WO2009/71509; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 28342-75-8,Some common heterocyclic compound, 28342-75-8, name is 1,5-Dibromo-2,4-difluorobenzene, molecular formula is C6H2Br2F2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1,5-dibromo-2,4-difluorobenzene(30 g, 110.3 mmol)And cyanocopper(22.7 g, 253.7 mmol)After dissolving in DMF (120 ml), it was made into nitrogen atmosphere, and the temperature was raised, and the mixture was refluxed with stirring for 17 hours.The reaction solution was extracted with MC and then subjected to column chromatography using an ethyl acetate / hexane mixed solvent as eluent to obtain 6.0 g of Intermediate 1.

The synthetic route of 28342-75-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Cheil Industries Co., Ltd.; Dankook University Academic Cooperation; Lee, Sang Sin; Yu, Uhn Sun; Lee, Jun Yeop; Jo, Yong Ju; Choe, Yun Ho; (26 pag.)KR2016/331; (2016); A;,
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Electric Literature of 58971-11-2, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 58971-11-2, name is 3-Bromophenethylamine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

o a solution of 2-bromophenethyl amine (2.0 g, 0.01 mol) in acetonitrile at room temperature was added di-tert-butyl dicarbonate (2.1 g, 0.01 mol) in one portion. After stirring at room temperature for 72 hr the reaction mixture was concentrated in vacuo and the residue was dissolved in ethyl acetate. The solution was washed with brine, dried (Na2SO4), filtered and concentrated in vacuo to give 1,1-dimethylethyl[2-(3-bromophenyl)ethyl]carbamate as a yellow oil.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Bromophenethylamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SMITHKLINE BEECHAM CORP; COWAN, D. J; LARKIN, A. L.; ZHANG, CUNYU; MUSSO, D. L.; GREEN, G. M.; CADILLA, R.; SPEARING, P.K.; BISHOP, M. J.; SPEAKE, J. D.; (219 pag.)CN102516115; (2016); B;,
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