Tag: M.W=200-300

Adding a certain compound to certain chemical reactions, such as: 1435-53-6, name is 2,4-Dibromo-1-fluorobenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1435-53-6, Computed Properties of C6H3Br2F

A 150 ml three-necked flask was charged with 0.01 mol of 2,4-dibromofluorobenzene, 0.011 mol of M1, 0.02 mol of sodium carbonate and 15 ml of ethylene glycol dimethyl ether, and was purged with nitrogen, heated to 190 C, and stirred for 24 hours. It was then cooled to room temperature, poured into a beaker, and stirred for 40 minutes by adding 40 ml of toluene and 40 ml of water. Filtration, the filtrate was rotary evaporated, and passed through a silica gel column to afford white intermediate 2a, purity 98.30%, yield 75.6%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,4-Dibromo-1-fluorobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Jiangsu March Optoelectric Technology Co., Ltd.; Ye Zhonghua; Li Chong; Zhang Zhaochao; Tang Dandan; (35 pag.)CN110272440; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 393-36-2, name is 4-Bromo-3-(trifluoromethyl)aniline, A new synthetic method of this compound is introduced below., COA of Formula: C7H5BrF3N

3-Trifluoro4-bromo-aniline (5 g, 20.8 mmoL) in MeOH (10 mL) and THF (10 mL) was treated with NIS (5.16 g, 22.9 mmoL) at room temperature. After 2 hours, the reaction was quenched with saturated Na2S2O3. The solvent was removed and the residue was partitioned between CH2Cl2 and water. The organic layer was washed with brine and dried over anhydrous Na2SO4, then concentrated to yield a crude white solid. The crude material was purified using column chromatography (silica gel, 3:1 hexanes: EtOAc as eluent) to yield the title compound as a white solid. 1H NMR (CDCl3, 400 MHz) delta 7.88 (s, 1H), 6.98 (s, 1H), 4.45-4.18 (br, 5 s, 2H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Lanter, James C.; Sui, Zhihua; Fiordeliso, James J.; Jiang, Weiqin; Zhang, Xuqing; US2005/250741; (2005); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 73918-56-6, name is 2-(4-Bromophenyl)ethanamine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 73918-56-6

Preparation XXIV Ethyl [2-(4-bromophenyl)ethyl]carbamate . A solution of 4-bromophenethylamine (10.0 g, 50 mmol) and triethylamine (5.3 g, 52.5 mmol) in dichloromethane (200 ml) at 0C is treated with ethyl chloroformate (5.69 g, 52.5 mmol). The resulting solution is stirred at 0C for one hour and washed with saturated aqueous NaHCO3 solution (50 ml). The organic phase is dried (MgSO4) and concentrated. An oil is obtained (12.3 g, 90%).

The synthetic route of 73918-56-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; WARNER-LAMBERT COMPANY; EP421436; (1991); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 2576-47-8,Some common heterocyclic compound, 2576-47-8, name is 2-Bromoethylamine hydrobromide, molecular formula is C2H7Br2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

2-Bromoethylamine hydrobromide (500 mg, 2.44 mmol) and sodium azide (475.9 mg, 7.32 mmol) were dissolved in water (2 mL). The solution was heated to 75 C, stirred for 21 h, cooled to 0 C, Potassium (800 mg) and diethyl ether (2 mL). Purified by chloroform-methanol (20:1) column chromatography2-azidoethylamine (171 mg, 82%).

The synthetic route of 2576-47-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; China Institute Of Forestry Forest Products Chemical Industry Institute; Nanjing Zhongsen Biological Technology Co., Ltd.; Wang Chengzhang; Qi Zhiwen; (7 pag.)CN109180594; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 102169-44-8, A common heterocyclic compound, 102169-44-8, name is 4-Bromo-5-methylbenzene-1,2-diamine, molecular formula is C7H9BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

4-bromo-5-methylbenzene-1,2-diamine (0.5 g, 2.3 mmol) and cyclopropanecarboxaldehyde (207 mg, 18 mmol) was dissolved in 7.5 ml of ethanol and cobalthydroxide (22 mg, 0.24 mmol) blended. The reaction mixture was stirred overnight, opened the lid, filtered and concentrated under reduced pressure to dryness. The residue was By chromatography were purified (2chiLabomatic HD-3000 spring via HPLC, Labomatic AS-3000> Knauer DAD 2600 5 Labomatic Labcol Vario 4000 Plus Chromatorex C18 10 micron 125 mm chi 30 mm +250 mm chi 50.8 mm; eluent A: water volume +0.2 /. Ammonia (32%), Eluent B: methanol, gradient: 0-12 min 70-100% B; flow rate: 100 ml / min). 184 mg (31% of the theoretical value) of this compound to produce the subject.

The synthetic route of 102169-44-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; ROEHN, ULRIKE; ELLERMANN, MANUEL; STRASSBURGER, JULIA; WENDT, ASTRID; ROEHRIG, SUSANNE; WEBSTER, ROBERTALAN; SCHMIDT, MARTINAVICTORIA; TERSTEEGEN, ADRIAN; BEYER, KRISTIN; SCHAEFER, MARTINA; BUCHMUELLER, ANJA; GERDES, CHRISTOPH; SPERZEL, MICHAEL; SANDMANN, STEFFEN; HEITMEIER, STEFAN; HILLISCH, ALEXANDER; ACKERSTAFF, JENS; TERJUNG, CARSTEN; (148 pag.)TW2016/5809; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

2862-39-7, name is 2-Bromo-N,N-dimethylethanamine hydrobromide, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C4H11Br2N

The product (60mg, 0.17mmol) in 127 cases of [0479] embodiment taken dissolved in N, N- dimethylformamide (DMF, IOmL) was added cesium carbonate (125mg, 0.38mmol) and N, N- dimethyl amine bromoethane hydrobromide (45mg, 0.19mmol), 50 C oil bath and the reaction overnight, TLC detection, the reaction was complete, water chestnut evaporated to dryness and dissolved. (/=15:1)-1 (3 (2-(-5 (34–2-49mg70%) Column chromatography (dichloromethane / methanol = 15: 1) to give the product -1 (3 (2- (dimethylamino) ethoxy) benzyl) -5- (3,4-dimethoxybenzyl) pyrrolidin-2-one (49mg, 70%).

The synthetic route of 2862-39-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Hu Youhong; Leng Ying; Duan Shudong; Huang Suling; (120 pag.)CN103626713; (2017); B;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 626-40-4, name is 3,5-Dibromoaniline, A new synthetic method of this compound is introduced below., Computed Properties of C6H5Br2N

This compound was preparedwithout the use of air and moisture sensitive protocol. Using a modifiedpreparation similar to that used by Kln and co-workers[1], aqueousformaldehyde (37%, 31.2 mL) was added to a stirring mixture of THF (300 mL)and 3M H2SO4 (84 mL) cooled to 0C in a 1 L long neck flat bottom flask. After stirring for 10minutes at 0C, 3,5 dibromoaniline (35.00 g, 139.5 mmol) dissolved in THF (75mL) was addeddropwise over 15 minutes. The solution was stirred for another 10 minutes at 0C. This mixturewas then stirred vigorously while NaBH4 (21.14 g, 558.8 mmol) was carefully added portionwiseover a period of 30 minutes at 0C. After stirring at room temperature for 2 hours the solutionwas filtered and the solid was washed with THF (30 mL). The filtrate was collected and allvolatiles were removed via rotary evaporation. The remaining residue was basified withsaturated aqueous NaHCO3 (500 mL) and extracted with dichloromethane (3 x 100 mL). Theorganic extracts were combined, washed with water (200 mL), dried with anhydrous MgSO4 andfiltered. All volatiles were removed from the filtrate via rotary evaporation and an orange-redsolid was obtained in 96 % yield (37.51 g, 134.5 mmol). Material was used without furtherpurification.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Smith, Joel D.; Chih, Edwina; Piers, Warren E.; Spasyuk, Denis M.; Polyhedron; vol. 155; (2018); p. 281 – 290;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 13194-73-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13194-73-5, name is 3,5-Dibromo-4-methylaniline, This compound has unique chemical properties. The synthetic route is as follows.

Example 26 1,3-Dibromo-2-methylbenzene A solution of (3,5-dibromo-4-methylphenyl)amine dissolved in water (80 mL) and concentrated HCl (7.5 mL) stirring for 20 min, then the mixture was cooled to 0~5 C., and a solution of NaNO2 (3.4 g/40 mL H2O) was added. The reaction mixture was stirred for 2 h at 0~5 C., then the suspension was added to a solution of hypophosphorous acid (50%, 27.9 g), and the mixture was cooled to 0 C. The mixture was stirred at room temperature overnight. Then it was extracted with CH2Cl2 (100 mL*2). The organic layer was washed with brine (30 mL) and dried over Na2SO4. After silica column chomatography, (eluted with petroleum ether), 3.57 g product was obtained, as a colorless liquid. 1H NMR (400 MHz, CDCl3) delta 2.57 (s, 3H), 6.89 (t, J=8.0 Hz, 1H), 7.50 (d, J=8.0 Hz, 2H).

The chemical industry reduces the impact on the environment during synthesis 3,5-Dibromo-4-methylaniline. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Glaxo Group Limited; US2009/203657; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 314084-61-2, name is 2-Bromo-1,3-diethyl-5-methylbenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 314084-61-2, Product Details of 314084-61-2

In a 250 mL four-necked reaction flask equipped with a stirrer, thermometer, condenser,32.0 g (0.2 mol)Diethyl malonate, 16 g (0.4 mol) of sodium hydroxide and 100 mL of N-methylpyrrolidone. (0.11111) 2,6-diethyl-4-methyl bromobenzene and 1.28 cuprous bromide were added to a solution of 120 to 130 C for 10 h. Cool, then remove the solvent under negative pressure at 0.095 MPa, 90 C, add 200 g of 7K, adjust the pH to 3 with hydrochloric acid, extract with 3 x 80 mL of ethyl acetate, wash with 3X, 150 mL water, 1 OmL was calcined and crystallized by filtration, washed with n-hexane to give 22.9 g of a pale yellow solid in 75% yield.sodium hydroxideDefinitions of sodium hydroxidenouna strongly alkaline white deliquescent compound used in many industrial processes, e.g., the manufacture of soap and paper.Primary alkaline batteries use sodium hydroxide or potassium hydroxide as the electrolyte.See alsosodium, hydroxideGoogle Translate for Business:Translator ToolkitWebsite Translator

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-1,3-diethyl-5-methylbenzene, and friends who are interested can also refer to it.

Reference:
Patent; Wuhan Institute of Technology; Liu Anchang; Dong Yuanhai; Yu Yu; Zheng Yiqian; Wang Yanlu; (10 pag.)CN106928253; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 156682-52-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 156682-52-9 name is 1,4-Dibromo-2,3-difluorobenzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Step 1 : Synthesis of 2,3-difiuoro-1 ,4-dibromo-5,6-dinitro-benzene 2,3-difluoro-1 ,4-dibromo-benzene as the starting raw material was synthesized according to prior methods (Dunn 2006). In a 250 ml flask, concentrated sulphuric acid (50 ml) was added and cooled to 0-5C in an ice water bath. Fuming nitric acid (50 ml) and 2,3-difluoro-1 ,4-dibromo-benzene (10 g, 36.8 mmol) were slowly added. Then, the flask was heated to 65C for 14 h. The mixture was then precipitated into ice water. The resulting yellow solid was filtered and purified by column chromatograph with a mixture of hexane and dichloromethane (1 :4 v/v) to afford 2,3-difluoro-1 ,4-dibromo-5,6-dinitro- benzene (3.5 g, 26%). H and 9F NMR spectra were as expected.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,4-Dibromo-2,3-difluorobenzene, and friends who are interested can also refer to it.

Reference:
Patent; NATIONAL RESEARCH COUNCIL OF CANADA; Ll, Zhao; DING, Jianfu; LU, Jianping; TAO, Ye; WO2011/60526; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary