Tag: M.W=250-300

Tlach, Brian C. published the artcileEffect of Extended Conjugation on the Optoelectronic Properties of Benzo[1,2-d:4,5-d’]bisoxazole Polymers, SDS of cas: 303734-52-3, the publication is Australian Journal of Chemistry (2014), 67(5), 711-721, database is CAplus.

Four copolymers comprising benzo[1,2-d:4,5-d’]bisoxazole (BBO) and benzo[1,2-b:4,5-b’]dithiophene (BDT) bearing phenylethynyl substituents on either the BBO, BDT moieties or both units were synthesized and the influence of two-dimensional conjugation on their optoelectronic properties investigated. Extending conjugation along the BBO resulted in a 0.5eV decrease in the LUMO level, whereas the HOMO level was raised by 0.2eV. Extending conjugation across the BDT moiety in also resulted in a 0.5eV decrease in the LUMO level, however, the effect was negligible on the HOMO level. Thus, cross-conjugation can be used to independently tune the LUMO level within these systems.

Australian Journal of Chemistry published new progress about 303734-52-3. 303734-52-3 belongs to bromides-buliding-blocks, auxiliary class Thiophene,Bromide, name is 2-Bromo-3-(2-ethylhexyl)thiophene, and the molecular formula is C5H10Cl3O3P, SDS of cas: 303734-52-3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Milne, Kirsty published the artcileA fragment-like approach to PYCR1 inhibition, Related Products of bromides-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2019), 29(18), 2626-2631, database is CAplus and MEDLINE.

Pyrroline-5-carboxylate reductase 1 (PYCR1) is the final enzyme involved in the biosynthesis of proline and has been found to be upregulated in various forms of cancer. Due to the role of proline in maintaining the redox balance of cells and preventing apoptosis, PYCR1 is emerging as an attractive oncol. target. Previous PYCR1 knockout studies led to a reduction in tumor growth. Accordingly, a small mol. inhibitor of PYCR1 could lead to new treatments for cancer, and a focused screening effort identified pargyline as a fragment-like hit. Herein the design and synthesis of the first tool compounds as PYCR1 inhibitors, derived from pargyline, which were assayed to assess their ability to attenuate the production of proline, are reported. Structural activity studies have revealed the key determinants of activity, with the most potent compound, 4-bromobenzyl(propargyl)methylamine, showing improved activity in vitro in enzyme (IC₅₀ = 8.8μM) and pathway relevant effects in cell-based assays.

Bioorganic & Medicinal Chemistry Letters published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Xiang, Panjie published the artcileDirect benzylation reactions from benzyl halides enabled by transition-metal-free photocatalysis, SDS of cas: 76283-09-5, the publication is Chinese Chemical Letters (2022), 33(12), 5074-5079, database is CAplus.

An SN²-based photochem. strategy using dithiocarbamate anion as catalyst was developed for the activation of benzyl halides, which are extremely challenging to be applied as radical precursors in visible light photocatalysis. With this transition-metal-free and oxidant-free protocol, the benzylation (or cyanomethylation) of various heterocycles including quinoxalin-2(1H)-ones, coumarin, 2-phenyl-2H-indazole, 1-methyl-5-phenylpyrazin-2(1H)-one, 1-(fluoromethyl)cinnolin-4(1H)-one, and 2,4-dibenzyl-1,2,4-triazine-3,5(2H,4H)-dione could be realized (46 examples, up to 98% yield). Importantly, some biol. relevant 3-benzylquinoxalin-2(1H)-ones were also be synthesized under mild conditions.

Chinese Chemical Letters published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C13H18N2, SDS of cas: 76283-09-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Obreque-Balboa, Jose Esteban published the artcileFlavonoid derivatives as selective ABCC1 modulators: Synthesis and functional characterization, HPLC of Formula: 21101-63-3, the publication is European Journal of Medicinal Chemistry (2016), 124-133, database is CAplus and MEDLINE.

A series of chromones, bearing substituted amino groups or N-substituted carboxamide moieties in position 2, was synthesized and characterized in cellular assays for modulation of the ABC transporters ABCC1 (MDCKII-MRP1 cells), ABCB1 (Kb-V1 cells) and ABCG2 (MCF-7/Topo cells). The most potent ABCC1 modulators identified among these flavonoid-type compounds were comparable to the reference compound reversan regarding potency, but superior in terms of selectivity concerning ABCB1 and ABCG2 (2-[4-(Benzo[c][1,2,5]oxadiazol-5-ylmethyl)piperazin-1-yl]-5,7-dimethoxy-4H-chromen-4-one: ABCC1, IC₅₀ 11.3 μM; inactive at ABCB1 and ABCG2). This compound was as effective as reversan in reverting ABCC1-mediated resistance to cytostatics in MDCKII-MRP1 cells and proved to be stable in mouse plasma and cell culture medium. Modulators, such 2-[4-(Benzo[c][1,2,5]oxadiazol-5-ylmethyl)piperazin-1-yl]-5,7-dimethoxy-4H-chromen-4-one, were of potential value as pharmacol. tools for the investigation of the (patho)physiol. role of ABCC1.

European Journal of Medicinal Chemistry published new progress about 21101-63-3. 21101-63-3 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,sulfides,Benzyl bromide,Benzene, name is (4-(Bromomethyl)phenyl)(trifluoromethyl)sulfane, and the molecular formula is C8H6BrF3S, HPLC of Formula: 21101-63-3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Dastan, Arif published the artcileBromination of naphthalene and derivatives: high temperature bromination. XI, Recommanded Product: 1,3-Dibromonaphthalene, the publication is Tetrahedron (1999), 55(44), 12853-12864, database is CAplus.

Thermal bromination and photobromination of naphthalenes have been studied. Several hexabromo- and tetrabromotetralin derivatives have been obtained as the major products, besides bromonaphthalene derivatives Base-promoted elimination reactions provided di-, tri-, and tetrabromonaphthalenes. A convenient method was developed for the synthesis of 1,3-dibromonaphthalene starting from I. The structures of these products were determined by ¹H- and ¹³C-NMR data and x-ray structural anal.

Tetrahedron published new progress about 52358-73-3. 52358-73-3 belongs to bromides-buliding-blocks, auxiliary class Bromide,Naphthalene, name is 1,3-Dibromonaphthalene, and the molecular formula is C10H6Br2, Recommanded Product: 1,3-Dibromonaphthalene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhang, Yue published the artcileSynthesis of All-Conjugated Diblock Copolymers by Quasi-Living Polymerization and Observation of Their Microphase Separation, Application In Synthesis of 303734-52-3, the publication is Journal of the American Chemical Society (2008), 130(25), 7812-7813, database is CAplus and MEDLINE.

We designed and synthesized the all-conjugated diblock copolymers poly(3-hexylthiophene-block-3-(2-ethylhexyl)thiophene)s (P(3HT-b-3EHT)s) via a modified Grignard metathesis (GRIM), a type of quasi-living polymerization, and studied their microphase-separated structures. The P(3HT-b-3EHT)s synthesized had well-controlled mol. weights and very narrow polydispersity indexes (PDIs), which demonstrates the usefulness of GRIM polymerization for the synthesis of semiconducting block copolymers. P(3HT-b-3EHT)s self-organized to form clear microphase-separated patterns upon thermal treatment, as observed by AFM. Interestingly, the enhancement of the interchain interaction of the P3HT segments compared with the P3HT homopolymer was clearly observed from the UV-vis spectra, despite the fact that the amount of crystalline P3HT fraction was reduced to 83% of the total polymer amount in P(3HT-b-3EHT). It is suggested that the relatively unconstrained, amorphous segments of P3EHT can enhance the crystallization of P3HT segments to form an ordered self-organized nanostructure.

Journal of the American Chemical Society published new progress about 303734-52-3. 303734-52-3 belongs to bromides-buliding-blocks, auxiliary class Thiophene,Bromide, name is 2-Bromo-3-(2-ethylhexyl)thiophene, and the molecular formula is C42H63O3P, Application In Synthesis of 303734-52-3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Fuji, Kanta published the artcileMurahashi Coupling Polymerization: Nickel(II)-N-Heterocyclic Carbene Complex-Catalyzed Polycondensation of Organolithium Species of (Hetero)arenes, Related Products of bromides-buliding-blocks, the publication is Journal of the American Chemical Society (2013), 135(33), 12208-12211, database is CAplus and MEDLINE.

Revisiting Murahashi coupling, we found that it effectively allows polymerization of lithiated (hetero)arenes by nickel(II)-catalyzed polycondensation. Deprotonative polymerization of 2-chloro-3-substituted thiophene with n-butyllithium gave head-to-tail-type poly(3-substituted thiophene). Poly(1,4-arylene)s were obtained by the reaction of the corresponding dibromides through lithium-bromine exchange. A lithiated thiophene derivative obtained via deprotonative halogen dance also underwent polymerization to afford a bromo-substituted polythiophene.

Journal of the American Chemical Society published new progress about 303734-52-3. 303734-52-3 belongs to bromides-buliding-blocks, auxiliary class Thiophene,Bromide, name is 2-Bromo-3-(2-ethylhexyl)thiophene, and the molecular formula is C12H19BrS, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Nakamura, Karin published the artcileFacile preparation of poly(3-substituted thiophene) block copolymers by nickel-catalyzed deprotonative polycondensation without external generation of thiophene organometallic species, HPLC of Formula: 303734-52-3, the publication is Chemistry Letters (2013), 42(10), 1200-1202, database is CAplus.

Thiophene-based block copolymers are synthesized by addition of bromothiophene and the Knochel-Hauser base (TMPMgCl.LiCl). Ni-catalyzed deprotonative C-H coupling polycondensation of 3-substituted-thiophenes gives head-to-tail-type poly(3-substituted thiophen-2,5-diyl) bearing Ni at the polymer end. Block copolymers of thiophene derivatives are obtained by successive addition of 2-bromo-3-alkylthiophene and Mg amide to a living polythiophene end. The use of Ni catalyst bearing an o-tolyl group gives the tolyl-group-terminated thiophene diblock copolymers in high efficiency. Triblock copolymer is also synthesized by the iterative addition of bromothiophene and TMPMgCl.LiCl.

Chemistry Letters published new progress about 303734-52-3. 303734-52-3 belongs to bromides-buliding-blocks, auxiliary class Thiophene,Bromide, name is 2-Bromo-3-(2-ethylhexyl)thiophene, and the molecular formula is C12H19BrS, HPLC of Formula: 303734-52-3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Norrild, Jens Chr. published the artcileDesign, synthesis and structure of new potential electrochemically active boronic acid-based glucose sensors, Computed Properties of 166821-88-1, the publication is Journal of the Chemical Society, Perkin Transactions 2 (2002), 303-311, database is CAplus.

In the authors’ studies on new boronic acid based carbohydrate sensors three new boronic acids (2-FcCH₂NMeCH₂C₆H₄B(OH)₂ (3), 1,2-(2-(HO)₂BC₆H₄CH₂NMeCH₂)₂ferrocene (7) and 1,1′-(2-(HO)₂BC₆H₄CH₂NMeCH₂)₂ferrocene (11)) containing a ferrocene moiety were synthesized. Their design includes an intramol. B-N bonding motif to facilitate binding at physiol. pH. The authors report the synthesis of the compounds and studies on glucose complexation as studied by ¹³C NMR spectroscopy. The crystal structure of 2,4,6-tris[2-(N-ferrocenylmethyl-N-methylaminomethyl)phenyl]boroxin (13) (boroxin of boronic acid 3) (boroxin = cyclotriboroxane) was obtained and compared with structures obtained of 2,4,6-tris[2-(N,N-dimethylaminomethyl)phenyl]boroxin (14) and 2-(2-(dimethylaminomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane (15). The structure of 13 shows the existence of intramol. B-N bonds in the solid phase.

Journal of the Chemical Society, Perkin Transactions 2 published new progress about 166821-88-1. 166821-88-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester, name is 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C12H16BBrO2, Computed Properties of 166821-88-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Guelak, Samet published the artcileHighly chemoselective cobalt-catalyzed biaryl coupling reactions, Synthetic Route of 76283-09-5, the publication is Chemical Science (2013), 4(2), 776-784, database is CAplus.

A practical cobalt-catalyzed hetero-biaryl coupling reaction between aryl chlorides and arylmagnesium halides with unprecedented selectivity has been developed. The protocol utilizes 1 mol% of cheap Co(acac)₃ as pre-catalyst and effects clean reactions of deactivated chlorostyrenes with only 1.1 equivalent of the Grignard reagent under mild conditions (30°, 5-30 min). Highly chemoselective reactions were realized even in the presence of activated bromoarenes. The olefin substituent facilitates the activation of the C-Cl bond by coordination to the catalyst. Kinetic studies indicate the operation of an arylcobaltate(i) catalyst species. Catalyst formation during the induction period was studied in the presence of cobalt(iii), (i), and (-i) pre-catalysts.

Chemical Science published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Synthetic Route of 76283-09-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary