Tag: M.W=250-300

Hi, Jianxing published the artcileResearch on synthesis of chiral quinine quaternary ammonium ligand and its catalyzing activity for Darzens reaction, Name: 4-Bromo-1-(bromomethyl)-2-fluorobenzene, the publication is Guangdong Huagong (2013), 40(7), 27-29, 31, database is CAplus.

Through quaternization reaction of a series of halogenated hydrocarbons and quinine alkali, a series of chiral quinine quaternary ammonium salt ligands were generated with quinine as base matrix and its synthesized ligand structure was confirmed by ¹H-NMR, IR and MS. And catalytic performance of ligands in Darzens condensation reaction between 2-chloroacetophenone and benzaldehyde in the asym. catalytic condition was investigated, implying that the chiral catalytic properties were associated with the steric size of substituents. And the best enantioselectivity of 46% was obtained.

Guangdong Huagong published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Name: 4-Bromo-1-(bromomethyl)-2-fluorobenzene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Amsharov, K. Yu. published the artcileFormation of fullerenes by pyrolysis of 1,2′-binaphthyl and 1,3-oligonaphthylene, HPLC of Formula: 52358-73-3, the publication is Carbon (2007), 45(2), 337-343, database is CAplus.

High-temperature pyrolysis of two fullerene precursors, 1,2′-binaphthyl and 1,3-oligonaphthyl, has been investigated. An oligomer of naphthalene with the appropriate orientation of fragments, which contains all 60 carbon atoms, 12 of 20 six-membered rings and 71 of 90 carbon-carbon bonds required to form the C₆₀ fullerene cage was synthesized in a three-step synthesis from naphthalene. The formation of fullerene during pyrolysis was confirmed by MALDI-TOF and HPLC anal. of the toluene extract obtained from the raw soot. It was found that the toluene extract contains free C₆₀ fullerene but the main share of fullerenes exists in the form of their derivatives The yield of free C₆₀ was estimated as 0.1% by HPLC but the overall yield of C₆₀ seems to be higher and was estimated as ≈1%.

Carbon published new progress about 52358-73-3. 52358-73-3 belongs to bromides-buliding-blocks, auxiliary class Bromide,Naphthalene, name is 1,3-Dibromonaphthalene, and the molecular formula is C10H6Br2, HPLC of Formula: 52358-73-3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Barnych, Bogdan published the artcileDevelopment of potent inhibitors of the human microsomal epoxide hydrolase, Name: 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene, the publication is European Journal of Medicinal Chemistry (2020), 112206, database is CAplus and MEDLINE.

Microsomal epoxide hydrolase (mEH) hydrolyzes a wide range of epoxide containing mols. Although involved in the metabolism of xenobiotics, recent studies associate mEH with the onset and development of certain disease conditions. This phenomenon is partially attributed to the significant role mEH plays in hydrolyzing endogenous lipid mediators, suggesting more complex and extensive physiol. functions. In order to obtain pharmacol. tools to further study the biol. and therapeutic potential of this enzyme target, we describe the development of highly potent 2-alkylthio acetamide inhibitors of the human mEH with IC₅₀ values in the low nanomolar range. These are around 2 orders of magnitude more potent than previously obtained primary amine, amide and urea-based mEH inhibitors. Exptl. assay results and rationalization of binding through docking calculations of inhibitors to a mEH homol. model indicate that an amide connected to an alkyl side chain and a benzyl-thio function as key pharmacophore units.

European Journal of Medicinal Chemistry published new progress about 1997-80-4. 1997-80-4 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Benzene, name is 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene, and the molecular formula is C9H8BrF3, Name: 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wibaut, J. P. published the artcileEffect of temperatures and catalysts on the bromination of naphthalene; the α-bromonaphthalene ⇄ β-bromonaphthalene equilibrium, Quality Control of 52358-73-3, the publication is Proceedings of the Koninklijke Nederlandse Akademie van Wetenschappen (1948), 776-86, database is CAplus.

The content of β-monobromonaphthalene increases slowly with temperature of reaction over the range 85° to 215° according to ln(Cα/Cβ) = (Εβ – Εα)/RT where Ε is the energy of activation of the bromination reaction. Εβ – Εα = 2498 cal./mol. in agreement with exptl. results of Suyver and Wibaut. (C.A. 40, 3428). Catalysts (FeCl₃ or FeBr₃) cause an increase in amount of β-mono-, di-, and tribrominated products. Uncatalyzed: about 3-8% β in a yield of 50-60% C₁₀H₇Br over the range 85-215° is obtained; catalyzed: about 22 to 48% β in a yield of 37-42% C₁₀H₇Br. The yield is affected greatly by reaction time, etc. Either α- or β-C₁₀H₇Br in contact with FeCl₃ or FeBr₃ at 150° gives the same equilibrium mixture of 40% α and 60% β. No such conversion occurs in the absence of catalyst. Equilibrium mixtures contain 63.1% β at 100°, 62.3% β at 150°, 60.4% β at 200°, and 58.8% β at 250°. ΔH conversion α ⇄ β is calculated as -500 ± 130 cal./mol. 1,2-, 1,3-, and 1,6-Dibromonaphthalene +HBr + FeCl₃ at 150° → 56% β- and 44% α-C₁₀H₇Br + Br₂. An ionic mechanism is proposed, although wave-mech. calculations are discussed which support either ionic or free-radical mechanisms. Catalyzed vapor-phase bromination of C₁₀H₈ yields 55.35% (calculated on Br) C₁₀H₇Br in range 250°. The kinetics and mechanism of this reaction are discussed. Again either α- or β-C₁₀H₇Br passed over a catalyst in gas phase yields an equilibrium mixture of about 60% β and 40% α.

Proceedings of the Koninklijke Nederlandse Akademie van Wetenschappen published new progress about 52358-73-3. 52358-73-3 belongs to bromides-buliding-blocks, auxiliary class Bromide,Naphthalene, name is 1,3-Dibromonaphthalene, and the molecular formula is C4H10O2, Quality Control of 52358-73-3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Patterson, Steven published the artcileFluorescence sensing of a ribonucleoside 5′-triphosphate, Product Details of C12H16BBrO2, the publication is Tetrahedron Letters (1997), 38(36), 6323-6326, database is CAplus.

Conjugation of a fluorescent saccharide sensor to poly(allylamine) produces a sensing compound with selectivity for ribonucleoside 5′-triphosphate. An association constant (log K_a) of 5.6 was determined for UTP in pH 7.3 phosphate solution (15 mM, 298 K), whereas log K_a was less than 2 for uridine, UMP, and UDP.

Tetrahedron Letters published new progress about 166821-88-1. 166821-88-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester, name is 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C12H16BBrO2, Product Details of C12H16BBrO2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Choi, Min Hee published the artcileEffect of side chains on solubility and morphology of poly(benzodithiohene-alt-alkylbithiophene) in organic photovoltaics, Recommanded Product: 2-Bromo-3-(2-ethylhexyl)thiophene, the publication is Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) (2015), 120-128, database is CAplus.

It was reported that the side chains play especially an important role in enhancing phys. properties and energy levels. Polythiophene based on benzodithiophene has excellent carrier mobility, but high HOMO level. We synthesized polythiophenes, PBDTBiTh(2EH) and PBDTBiTh(12C), were polymerized using the Stille coupling reaction and had thiophene with a 2-ethylhexyl or n-dodecyl side chain. Upon introducing the 2-ethylhexyl side chain, the absorption coefficients of the monomers and polymers were enhanced. Also, the edge-on orientation was fortified and the HOMO level was decreased to -5.37 eV. PBDTBiTh(2EH) showed a power conversion efficiency (PCE) of 2.1%, which was double that of PBDTBiTh(12C).

Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) published new progress about 303734-52-3. 303734-52-3 belongs to bromides-buliding-blocks, auxiliary class Thiophene,Bromide, name is 2-Bromo-3-(2-ethylhexyl)thiophene, and the molecular formula is C12H19BrS, Recommanded Product: 2-Bromo-3-(2-ethylhexyl)thiophene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Pokorny, Jan published the artcileSubstituted dienes prepared from betulinic acid – Synthesis, cytotoxicity, mechanism of action, and pharmacological parameters, Application In Synthesis of 76283-09-5, the publication is European Journal of Medicinal Chemistry (2021), 113706, database is CAplus and MEDLINE.

A set of new substituted dienes were synthesized from betulinic acid by its oxidation to 30-oxobetulinic acid followed by the Wittig reaction. Cytotoxicity of all compounds was tested in vitro in eight cancer cell lines and two noncancer fibroblasts. Almost all dienes were more cytotoxic than betulinic acid. Four compounds had IC₅₀ below 5μmol/L; I and II were selected for studies of the mechanism of action. Cell cycle anal. revealed an increase in the number of apoptotic cells at 5 x IC₅₀ concentration, where activation of irreversible changes leading to cell death can be expected. Both I and II led to the accumulation of cells in the G0/G1 phase with partial inhibition of DNA/RNA synthesis at 1 x IC₅₀ and almost complete inhibition at 5 x IC₅₀. Interestingly, compound II at 5 x IC₅₀ caused the accumulation of cells in the S phase. Higher concentrations of tested drugs probably inhibit more off-targets than lower concentrations Mechanisms disrupting cellular metabolism can induce the accumulation of cells in the S phase. Both compounds I and II trigger selective apoptosis in cancer cells via intrinsic pathway, which we have demonstrated by changes in the expression of the crucial apoptosis-related protein. Pharmacol. parameters of derivative I were superior to II, therefore I was the finally selected candidate for the development of anticancer drug.

European Journal of Medicinal Chemistry published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Application In Synthesis of 76283-09-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Suzuki, Takayoshi published the artcileRapid Discovery of Highly Potent and Selective Inhibitors of Histone Deacetylase 8 Using Click Chemistry to Generate Candidate Libraries, Application In Synthesis of 1997-80-4, the publication is Journal of Medicinal Chemistry (2012), 55(22), 9562-9575, database is CAplus and MEDLINE.

To find HDAC8-selective inhibitors, we designed a library of HDAC inhibitor candidates, each containing a zinc-binding group that coordinates with the active-site zinc ion, linked via a triazole moiety to a capping structure that interacts with residues on the rim of the active site. These compounds were synthesized by using click chem. Screening identified HDAC8-selective inhibitors including (I) (IC₅₀ = 0.070 μM), which was more potent than PCI-34058 (IC₅₀ = 0.31 μM), a known HDAC8 inhibitor. Mol. modeling suggested that the phenylthiomethyl group of I binds to a unique hydrophobic pocket of HDAC8, and the orientation of the phenylthiomethyl and hydroxamate moieties (fixed by the triazole moiety) is important for the potency and selectivity. The inhibitors caused selective acetylation of cohesin in cells and exerted growth-inhibitory effects on T-cell lymphoma and neuroblastoma cells (GI₅₀ = 3-80 μM). These findings suggest that HDAC8-selective inhibitors have potential as anticancer agents.

Journal of Medicinal Chemistry published new progress about 1997-80-4. 1997-80-4 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Benzene, name is 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene, and the molecular formula is C9H9BrO2, Application In Synthesis of 1997-80-4.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Nguyen, Quyen published the artcileIron(II) bromide-catalyzed intramolecular C-H bond amination [1,2]-shift tandem reactions of aryl azides, Product Details of C9H8BrNO4, the publication is Journal of the American Chemical Society (2013), 135(2), 620-623, database is CAplus and MEDLINE.

Iron(II) bromide catalyzes the transformation of ortho-substituted aryl azides into 2,3-disubstituted indoles through a tandem ethereal C-H bond amination [1,2]-shift reaction. The preference for the 1,2-shift component of the tandem reaction was established to be Me < 1° < 2° < Ph.

Journal of the American Chemical Society published new progress about 189748-25-2. 189748-25-2 belongs to bromides-buliding-blocks, auxiliary class Bromide,Nitro Compound,Benzene,Ester, name is Methyl 2-(5-bromo-2-nitrophenyl)acetate, and the molecular formula is C9H8BrNO4, Product Details of C9H8BrNO4.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Akkuratov, Alexander V. published the artcileDesign of novel thiazolothiazole-containing conjugated polymers for organic solar cells and modules, Application In Synthesis of 303734-52-3, the publication is Solar Energy (2020), 605-611, database is CAplus.

One of the major challenges in the field of organic photovoltaics is associated with high-throughput manufacturing of efficient and stable organic solar cells. Practical realization of technologies for production of large-area organic solar cells requires the development of novel materials with a defined combination of properties ensuring sufficient reliability and scalability of the process in addition to good efficiency and operation stability of the devices. In this work, we designed two novel polymers comprising thiazolothiazole units and investigated their performance as absorber materials for organic solar cells and modules. Optimized small-area solar cells based on P1/[70]PCBM ([6,6]-phenyl-C71-butyric acid Me ester) blends exhibited promising power conversion efficiency (PCE) of 7.5%, while larger area modules fabricated using slot die coating showed encouraging PCE of 4.2%. Addnl., the fabricated devices showed promising outdoor stability maintaining 60-70% of the initial efficiency after 20 sun days being exposed to natural sunlight at the Negev desert. The obtained results feature the designed polymer P1 as a promising absorber material for a large-scale production of organic solar cells under ambient conditions.

Solar Energy published new progress about 303734-52-3. 303734-52-3 belongs to bromides-buliding-blocks, auxiliary class Thiophene,Bromide, name is 2-Bromo-3-(2-ethylhexyl)thiophene, and the molecular formula is C12H19BrS, Application In Synthesis of 303734-52-3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary