Tag: M.W=250-300

Li, Hao-Chun published the artcileColor tuning and highly efficient blue emitters of finite diphenylamino-containing oligo(arylenevinylene) derivatives using fluoro substituents, Recommanded Product: 4-Bromo-1-(bromomethyl)-2-fluorobenzene, the publication is Advanced Functional Materials (2007), 17(4), 520-530, database is CAplus.

New fluoro derivatives of Ph₂N-containing (Ph: phenyl) oligo(arylenevinylene) derivatives were prepared by using double Heck-coupling reactions or Horner-Wadsworth-Emmons reactions. These oligomers are highly fluorescent (fluorescence quantum yields Φ = 0.93-0.68) with emissions in a broad wavelength region (448-579 nm), depending on the position of the fluoro substituents. The highest occupied and LUMO (HOMO-LUMO) energy levels of these oligomers were characterized by electrochem. and UV spectroscopy. The effects of the fluoro substituents on the energy levels are rationalized with HOMO-LUMO simulations. In a classical organic light emitting diode (OLED), one representative (5a) shows a remarkable external quantum efficiency value (η_ext = 4.87 %) at J = 20 mA cm^-2; the maximum brightness at 10.2 V is 22,506 cd m^-2 (λ = 458 nm; Commission Internationale de l’Eclairage (CIE) coordinates x = 0.14, y = 0.14) with a full width at half-maximum of 54 nm, demonstrating the superiority of these fluoro-containing oligomers in OLED devices.

Advanced Functional Materials published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Recommanded Product: 4-Bromo-1-(bromomethyl)-2-fluorobenzene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Li, Hui published the artcileAllosteric Inhibitors of Hepatitis C Polymerase: Discovery of Potent and Orally Bioavailable Carbon-Linked Dihydropyrones, Product Details of C7H5Br2F, the publication is Journal of Medicinal Chemistry (2007), 50(17), 3969-3972, database is CAplus and MEDLINE.

The discovery and optimization of a novel class of carbon-linked dihydropyrones as allosteric HCV NS5B polymerase inhibitors are presented. Replacement of the sulfur linker atom with carbon reduced compound acidity and greatly increased cell permeation. Further structure-activity relationship (SAR) studies led to the identification of compounds, exemplified by (I) and (II), with significantly improved antiviral activities in the cell-based replicon assay and favorable pharmacokinetic profiles.

Journal of Medicinal Chemistry published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Product Details of C7H5Br2F.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhang, Wen-Jin published the artcileSynthesis and identification of quinoline derivatives as topoisomerase I inhibitors with potent antipsoriasis activity in an animal model, Category: bromides-buliding-blocks, the publication is Bioorganic Chemistry (2019), 102899, database is CAplus and MEDLINE.

Psoriasis is a chronic inflammatory and immune-mediated skin disease. Although certain agents have shown clin. success in treating psoriasis, development of safe and effective strategies for the treatment of this condition remains important. Research suggests that DNA topoisomerase I (Topo I) inhibitors may have potent psoriasis-ameliorating effects. Here, 25 quinoline derivatives were synthesized and identified as Topo I inhibitors. These compounds inhibited the 12-O-tetradecanoylphorbol-13-acetate-induced mouse ear inflammation. The most potent analogs, 5i and 5l, suppressed the expression of inflammatory cytokines in lipopolysaccharide-stimulated HaCaT cells. Addnl., the lead compounds significantly improved imiquimod-induced psoriasis-like inflammation in mice. Moreover, the expression levels of cytokines and inflammatory mediators, such as interleukin (IL)-17A, IL-22, IL-23, nuclear factor-κB subunit p65, tumor necrosis factor-α, and interferon-γ, were dramatically inhibited in the dorsal skin of 5i- and 5l-treated mice. These findings indicate that the inhibition of Topo I activity may potentially be an effective strategy for psoriasis treatment.

Bioorganic Chemistry published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C42H63O3P, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lu, Wenqing published the artcileIridium(I)-catalyzed deoxgenation of fluoroalkylsulfoxides with dimethyl diazomalonate to access fluoroalkylthioethers, Formula: C8H6BrF3S, the publication is Chinese Chemical Letters (2022), 33(11), 4865-4869, database is CAplus.

A new method for the preparation of trifluoromethylthioethers RSCF₃ [R = Ph, 4-BrC₆H₄, 4-MeOC₆H₄, etc.]/difluoromethylthioethers RCF₂H [R = 4-O₂NC₆H₄, 4-BrC₆H₄, 3-ClC₆H₄, etc.] via iridium(I)-catalyzed deoxgenation of fluoroalkylsulfoxides with di-Me diazomalonate was developed. In the reaction system, di-Me diazomalonate was used as reducing reagent and the corresponding fluoroalkylthioethers were produced through oxygen atom transfer from fluoroalkylsulfoxides to diazomalonate. The protocol featuring effective oxygen atom transfer, mild reaction conditions and good functional groups tolerance offered an alternative strategy for the synthesis of fluoroalkylthioethers.

Chinese Chemical Letters published new progress about 21101-63-3. 21101-63-3 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,sulfides,Benzyl bromide,Benzene, name is (4-(Bromomethyl)phenyl)(trifluoromethyl)sulfane, and the molecular formula is C8H6BrF3S, Formula: C8H6BrF3S.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wang, Yaping published the artcileOne-Pot Double Benzylation of 2-Substituted Pyridines using Palladium-Catalyzed Decarboxylative Coupling of sp² and sp³ Carbons, Related Products of bromides-buliding-blocks, the publication is Advanced Synthesis & Catalysis (2014), 356(16), 3307-3313, database is CAplus.

An efficient and practical decarboxylative double benzylation method for various 2-picolinic acids has been established by using a bimetallic catalytic system of palladium(II) chloride (PdCl₂) and silver(I) oxide (Ag₂O), which offered a variety of diarylmethane derivatives e.g., I, with moderate to good yields.

Advanced Synthesis & Catalysis published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C15H14Cl2S2, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wang, Yan-en published the artcileSynthesis of Bisboronic Acids and Their Selective Recognition of Sialyl Lewis X Antigen, Category: bromides-buliding-blocks, the publication is Chemical Research in Chinese Universities (2018), 34(3), 415-422, database is CAplus.

The development of sensors that recognize Lewis oligosaccharides can help the diagnosis and early detection of cancer. Herein, authors reported the design and synthesis of a series of anthracene-based bisboronic acids (9a–9e) with different N-substituents near the boronic acid unit. Among them, compound 9a could recognize sialyl Lewis X(sLe^x) with selectivity over other Lewis sugars, and could significantly stain sLe^x-expressing HEPG2 cells with selectivity over the range of 0.1-10 μmol/L. Compound 9a possibly has two properly positioned boronic acids caused by the steric hindrance by the near N-benzyl substituent group, which empower its sLe^x selectivity and higher binding affinity.

Chemical Research in Chinese Universities published new progress about 166821-88-1. 166821-88-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester, name is 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C15H21BO2, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Ding, Xiao published the artcileDe Novo Design, Synthesis and Evaluation of Benzylpiperazine Derivatives as Highly Selective Binders of Mcl-1, Recommanded Product: 4-Bromo-1-(bromomethyl)-2-fluorobenzene, the publication is ChemMedChem (2013), 8(12), 1986-2014, database is CAplus and MEDLINE.

Considerable efforts have been made towards the development of small-mol. inhibitors of antiapoptotic B-cell lymphoma 2 (Bcl-2) family proteins (such as Bcl-2, Bcl-x_L, and Mcl-1) as a new class of anticancer therapies. Unlike general inhibitors of the entire family, selective inhibitors of each member protein can hopefully reduce the adverse side effects in chemotherapy treatments of cancers overexpressing different Bcl-2 family proteins. In this study, we designed four series of benzylpiperazine derivatives as plausible Bcl-2 inhibitors based on the outcomes of a computational algorithm. A total of 81 compounds were synthesized, and their binding affinities to Bcl-2, Bcl-x_L, and Mcl-1 measured. Encouragingly, 22 compounds exhibited binding affinities in the micromolar range (K_i<20 μM) to at least one target protein. Moreover, some compounds were observed to be highly selective binders to Mcl-1 with no detectable binding to Bcl-2 or Bcl-x_L, among which the most potent one, I, has a K_i value of 0.18 μM for Mcl-1. Binding modes of four selected compounds to Mcl-1 and Bcl-x_L were derived through mol. docking and mol. dynamics simulations. It seems that the binding affinity and selectivity of these compounds can be reasonably interpreted with these models. Our study demonstrated the possibility for obtaining selective Mcl-1 inhibitors with relatively simple chem. scaffolds. The active compounds identified by us could be used as lead compounds for developing even more potent selective Mcl-1 inhibitors with potential pharmaceutical applications.

ChemMedChem published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Recommanded Product: 4-Bromo-1-(bromomethyl)-2-fluorobenzene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Yang, Wu published the artcileLewis acid-assisted Ir(III) reductive elimination enables construction of seven-membered-ring sulfoxides, Safety of (4-(Bromomethyl)phenyl)(trifluoromethyl)sulfane, the publication is Chemical Science (2020), 11(37), 10149-10158, database is CAplus and MEDLINE.

Iridium has played an important role in the evolution of C-H activation chem. over the last half century owing to its high reactivity towards stoichiometric C-H bond cleavage; however, the use of Ir(III) complexes in catalytic C-H functionalization/C-C bond formation appears to have fallen off significantly. The main problem lies in the reductive elimination step, as iridium has a tendency to form stable and catalytically inactive Ir(III) species. Herein, with a rationally designed Lewis acid assisted oxidatively induced strategy, the sluggish Ir(III) reductive elimination is successfully facilitated, enabling the facile C-C bond formation. The X-ray crystal structure of a silver salt adduct of iridacycle and DFT calculations demonstrate that the sulfoxide group acts as a key bridge connecting the Ir(III) metal center with the silver Lewis acid, which facilitates the reductive elimination of the Ir(III) metallacycle. Further identification of oxidants was carried out by performing stoichiometric reactions, which enables the development of catalytic construction of various highly functionalized seven-membered-ring sulfoxides e.g., 5,7-dihydrodibenzo[c,e]thiepine 6-oxide, that are of great interest in medicinal chem. and materials science.

Chemical Science published new progress about 21101-63-3. 21101-63-3 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,sulfides,Benzyl bromide,Benzene, name is (4-(Bromomethyl)phenyl)(trifluoromethyl)sulfane, and the molecular formula is C23H20BN, Safety of (4-(Bromomethyl)phenyl)(trifluoromethyl)sulfane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Gruetzmacher, Hans F. published the artcileMass spectrometry of unstable organic molecules. IX. Evidence for isomeric dehydronaphthalenes from pyrolysis-mass spectrometry, Application of 1,3-Dibromonaphthalene, the publication is Justus Liebigs Annalen der Chemie (1975), 2023-32, database is CAplus.

Thermal fragmentations of substituted naphthalenes (e.g. I; R,R1 = Br; R,R1 = NO2, R = NO2, R1 = iodo; II; R,R1 = Br; R,R1 = NO2) were examined via pyrolysis mass spectrometry. 1,4- And 1,3-disubstituted naphthalenes produce o-diethynylbenzene (ionization potential = 8.96 ± 0.05 eV); the other disubstituted naphthalenes produce dehydronaphthalenes. The ionization potentials of the dehydronaphthalenes were determined

Justus Liebigs Annalen der Chemie published new progress about 52358-73-3. 52358-73-3 belongs to bromides-buliding-blocks, auxiliary class Bromide,Naphthalene, name is 1,3-Dibromonaphthalene, and the molecular formula is C10H6Br2, Application of 1,3-Dibromonaphthalene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Nykaza, Trevor V. published the artcileP^III/P^V=O Catalyzed Cascade Synthesis of N-Functionalized Azaheterocycles, Quality Control of 189748-25-2, the publication is Angewandte Chemie, International Edition (2020), 59(11), 4505-4510, database is CAplus and MEDLINE.

An organocatalytic method for the modular synthesis of diverse N-aryl and N-alkyl azaheterocycles (indoles, oxindoles, benzimidazoles, and quinoxalinediones) is reported. The method employs a small-ring organophosphorus-based catalyst (1,2,2,3,4,4-hexamethylphosphetane P-oxide) and a hydrosilane reductant to drive the conversion of ortho-functionalized nitroarenes into azaheterocycles through sequential intermol. reductive C-N cross coupling with boronic acids, followed by intramol. cyclization. This method enables the rapid construction of azaheterocycles from readily available building blocks, including a regiospecific approach to N-substituted benzimidazoles and quinoxalinediones.

Angewandte Chemie, International Edition published new progress about 189748-25-2. 189748-25-2 belongs to bromides-buliding-blocks, auxiliary class Bromide,Nitro Compound,Benzene,Ester, name is Methyl 2-(5-bromo-2-nitrophenyl)acetate, and the molecular formula is C9H8BrNO4, Quality Control of 189748-25-2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary