Tag: M.W=250-300

Elgendy, Bahaa published the artcileSynthesis and structure activity relationship of the first class of LXR inverse agonists, HPLC of Formula: 1997-80-4, the publication is Bioorganic Chemistry (2022), 105540, database is CAplus and MEDLINE.

Liver X Receptors (LXRs) are members of the nuclear receptor family, and they play significant role in lipid and cholesterol metabolism Moreover, they are key regulators of several inflammatory pathways. Pharmacol. modulation of LXRs holds great potential in treatment of metabolic diseases, neurodegenerative diseases, and cancer. We were the first group to identify LXR inverse agonists SR9238 and SR9243 and demonstrate their potential utility in treating liver diseases and cancer. Here, we present the results of structure-activity relationship (SAR) studies, based around SR9238 and SR9243. This study led to identification of I, II, III and IV which were more potent inverse agonists than SR9238 and SR9243 and inhibited expression of the fatty acid synthase gene in DU145 cells. We previously demonstrated that inhibition of FASN is correlated to the anticancer activity of SR9243 and this suggests that new inverse agonists have great potential as anticancer agents. We identified compounds with distinct selectivity toward both LXR isoforms, which can be excellent tools to study the pharmacol. of both isoforms. We employed mol. dynamic (MD) simulations to better understand the mol. mechanism underlying inverse agonist activity and to guide our future design.

Bioorganic Chemistry published new progress about 1997-80-4. 1997-80-4 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Benzene, name is 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene, and the molecular formula is C9H8BrF3, HPLC of Formula: 1997-80-4.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wu, Shaoxiang published the artcileThe enantioselective trifluoromethylation of aromatic aldehydes by quaternary ammonium bromide and (IPr)CuF at low catalyst loading, HPLC of Formula: 76283-09-5, the publication is Journal of Fluorine Chemistry (2013), 19-29, database is CAplus.

A general catalytic enantioselective trifluoromethylation of aromatic aldehydes using (IPr)CuF and quinidine-derived quaternary ammonium salt as catalysts has been developed. A wide range of aromatic aldehydes are converted to the corresponding products in up to 92% yield and 81% ee at 2 mol% of catalyst loading.

Journal of Fluorine Chemistry published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C13H19Br2ClN2O, HPLC of Formula: 76283-09-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Mei, Wenwen published the artcileSynthesis and protein-tyrosine phosphatase 1B inhibitory activity evaluation of indolepropyl based 1,3,4-oxadiazole derivatives, Recommanded Product: 4-Bromo-1-(bromomethyl)-2-fluorobenzene, the publication is Youji Huaxue (2016), 36(3), 533-539, database is CAplus.

A series of indolepropyl based 1,3,4-oxadiazole derivatives were synthesized by esterification, hydrazidation, cyclization and substitution using indolebutyric acid as starting material. The inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was evaluated. The results indicated that five compounds displayed obviously inhibitory effect against PTP1B in vitro, for instance, compound 5g exhibited the strongest PTP1B inhibitory activity with an IC₅₀ value of 6.74 μg·mL^-1. It was the first example of indolealkyl based oxadiazole derivatives showing PTP1B inhibitory activity.

Youji Huaxue published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Recommanded Product: 4-Bromo-1-(bromomethyl)-2-fluorobenzene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Bicciocchi, Erika published the artcileAn Alternating Donor-Acceptor Conjugated Polymer Based on Benzodithiophene and [3,4-c]pyrrole-4,6-dione: Synthesis, Characterization, and Application in Photovoltaic Devices, HPLC of Formula: 303734-52-3, the publication is Australian Journal of Chemistry (2015), 68(11), 1773-1782, database is CAplus.

The synthesis is described of a new alternating donor-acceptor semiconducting polymer based on an N-octylthieno[3,4-c]pyrrole-4,6-dione building block together with a newly designed 2,3-bis(2-ethylhexyl)thiophenylethynyl substituted benzodithiophene (BDT). The introduction of electron-rich thiophene units to BDT raises the HOMO level of the conjugated polymer and the concomitant reduction of the bandgap enhances the harvesting of solar radiation. This modification also introduces less sterically demanding triple bonds, thereby potentially enabling more favorable mol. interactions and an extra dimension of conjugation perpendicular to the main polymer chain. The optoelectronic properties of this new conjugated polymer were evaluated using UV-visible absorption and fluorescence spectroscopy, photoelectron spectroscopy in air, photo-induced charge extraction by linearly increasing voltage (Photo-CELIV), and d. functional theory calculations The polymer absorbs broadly in the wavelength range 300-700 nm in solution and the solid state. The estimated HOMO and LUMO levels of -5.4 and -3.6eV, resp., correspond to a bandgap of 1.8eV. Photovoltaic devices fabricated using the polymer as the active layer displayed power conversion efficiencies (PCEs) of up to 1%. Photo-CELIV results provide evidence that rapid recombination and poor charge mobility are likely contributing factors to the relatively low PCE values observed

Australian Journal of Chemistry published new progress about 303734-52-3. 303734-52-3 belongs to bromides-buliding-blocks, auxiliary class Thiophene,Bromide, name is 2-Bromo-3-(2-ethylhexyl)thiophene, and the molecular formula is C12H19BrS, HPLC of Formula: 303734-52-3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Chang, Suae-Chen published the artcileAttempt to observe neighboring group participation in hydrogen abstraction from β-(substituted phenyl)-ethyl bromides, Safety of 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene, the publication is Journal of Organic Chemistry (1975), 40(25), 3800-1, database is CAplus.

A series of β-(substituted phenyl)-ethyl bromides are reacted with bromotrichloromethane at 70°. Benzylic hydrogen abstraction comprises the only reaction. The exptl. ρ value for this process is -0.83 ± 0.02. A ρ value is calculated to have the range of -0.84 to -0.90. The negligible difference between these two ρ values is indicative of no anchimeric assistance in this reaction by the neighboring bromine atom under the conditions utilized.

Journal of Organic Chemistry published new progress about 1997-80-4. 1997-80-4 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Benzene, name is 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene, and the molecular formula is C9H8BrF3, Safety of 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Rakowitz, D. published the artcileN-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids as aldose reductase inhibitors, Computed Properties of 76283-09-5, the publication is Pharmazie (2007), 62(8), 636-637, database is CAplus and MEDLINE.

Novel N-substituted tetrahydro-2,4-dioxoquinazolin-1-yl acetic acids characterized by formal replacement of the substituted benzyl moiety by cyclohexylmethyl and n-heptyl residues, resp., were synthesized and evaluated as aldose reductase inhibitors.

Pharmazie published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Computed Properties of 76283-09-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Rakowitz, Dietmar published the artcileSynthesis of novel phenylacetic acid derivatives with halogenated benzyl subunit and evaluation as aldose reductase inhibitors, COA of Formula: C7H5Br2F, the publication is European Journal of Pharmaceutical Sciences (2006), 27(2-3), 188-193, database is CAplus and MEDLINE.

In the course of our ongoing studies several substituted benzyloxyphenylacetic acids were prepared Comparison of their aldose reductase inhibition with the biol. activity obtained for recently evaluated benzoic acid analogs revealed the critical role of a methylene spacer between the aromatic core and the acidic function. Starting from the most potent derivative (i.e. 5d, IC₅₀ = 20.9 μM) further structural modifications were performed and their influence on the inhibitory effect was established.

European Journal of Pharmaceutical Sciences published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, COA of Formula: C7H5Br2F.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lee, Jungho published the artcileInsights into constitutional isomeric effects on donor-acceptor intermolecular arrangements in non-fullerene organic solar cells, COA of Formula: C7H5Br2F, the publication is Journal of Materials Chemistry A: Materials for Energy and Sustainability (2019), 7(31), 18468-18479, database is CAplus.

Donor-acceptor intermol. interactions and/or arrangements are key factors determining the performance of organic solar cells (OSCs). Herein, two ITIC-based isomeric acceptors (o-F-ITIC and m-F-ITIC) with fluorine atoms at ortho and meta positions within the side chains were developed. The developed acceptors showed different interactions and/or arrangements with the donor counterpart (PBDB-T), which caused a significant variation in the power conversion efficiency (PCE) of OSCs. The PCE of the PBDB-T:o-F-ITIC device was 11.11% vs. 8.90% of the PBDB-T:m-F-ITIC device. A detailed theor. anal. of the intermol. complexes formed between F-ITICs and PBDB-T allows a determination of how the two isomeric acceptors interact differently with PBDB-T. Relative to PBDB-T:m-F-ITIC with a preferential DCI-BDD complex, PBDB-T:o-F-ITIC showed a closer donor-acceptor interaction, with a tightly packed parallel-like DCI-BDT complex, resulting in larger interfacial areas. These behavioral characteristics explain in detail the exptl. results obtained from the comparison of the two blend systems relating to elec. and morphol. properties. Moreover, transient absorption spectroscopy of PBDB-T:o-F-ITIC revealed superior hole/electron transfer and separation processes, providing further evidence of the presence of beneficial intermol. complexes. This study facilitates the understanding of the role of constitutional isomerism both in intermol. interactions and in promoting the development of high-performance OSCs.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, COA of Formula: C7H5Br2F.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Mercanton, Roger published the artcileBromonaphthalenesulfonic acids, Category: bromides-buliding-blocks, the publication is Helvetica Chimica Acta (1945), 533-9, database is CAplus.

4-Amino-2-naphthalenesulfonic acid gives by the Sandmeyer reaction 71% Na 4-bromo-2-naphthalenesulfonate (I) (Ag salt, 86% yield, Me ester m. 132° (all m.ps. corrected), Et ester m. 90°, acid chloride m. 112.5°, amide m. 183-5°, anilide m. 172°). Similarly is obtained 74% Na 5-bromo-2-naphthalenesulfonate (II) (Ag salt, 96% yield, Me ester m. 110°, Et ester m. 125°, acid chloride m. 100°, amide m. 225°, anilide m. 207.5°). All derivatives of II are less soluble than those of I. The reaction gives 61% K 8-bromo-2-naphthalenesulfonate (III) (Ag salt, 88% yield, Me ester m. 97°, Et ester m. 92.5°, acid chloride m. 120-1.5°, amide m. 193°, anilide m. 170°), and 70% K 2-bromo-1-naphthalenesulfonate (IV) (Ag salt, 87% yield, Me ester m. 93°, Et ester m. 65.5°, acid chloride m. 98°, amide m. 145°, anilide m. 144°). Treatment of the acid chlorides with NaHSO₃ and NaOH gives bromonaphthalenesulfinic acids which with HgCl₂ form bromonaphthylmercuric chlorides. When these are refluxed with Br and KBr in EtOH they form dibromonaphthalenes, I giving the 1,3-, II the 1,6-, III the 1,7-, and IV the 1,2-dibromides.

Helvetica Chimica Acta published new progress about 52358-73-3. 52358-73-3 belongs to bromides-buliding-blocks, auxiliary class Bromide,Naphthalene, name is 1,3-Dibromonaphthalene, and the molecular formula is C10H6Br2, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wang, Wei published the artcileBuilding fluorescent sensors by template polymerization: the preparation of a fluorescent sensor for D-fructose, Application In Synthesis of 166821-88-1, the publication is Organic Letters (1999), 1(8), 1209-1212, database is CAplus and MEDLINE.

The application of mol. imprinting in making fluorescent sensors was hampered by the lack of suitable fluorescent tags, which would respond to the binding event with significant fluorescence intensity changes. The authors have designed and synthesized a fluorescent monomer which allows for the preparation of fluorescent sensors of cis diols using mol. imprinting methods. This monomer was used for the preparation of sensitive fluorescent sensors for D-fructose.

Organic Letters published new progress about 166821-88-1. 166821-88-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester, name is 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C7H8BFO2, Application In Synthesis of 166821-88-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary