Tag: M.W=250-300

Samath, Sheik A. published the artcileSubstitutions of coordinated salicylaldehyde and its Schiff bases, Safety of 4,5-Dibromo-2-hydroxybenzaldehyde, the main research area is cobalt salicylaldehyde Schiff brominating agent reaction; copper salicylaldehyde Schiff brominating agent reaction; salicylaldehyde Schiff cobalt copper brominating agent; bromination cobalt copper salicylaldehyde Schiff; cyano substitution cobalt copper salicylaldehyde Schiff; succinimido substitution cobalt copper salicylaldehyde Schiff.

Several bis/tris-salicylaldehyde, salicylaldimine and salicylethylenediimine chelates of Co(III), Cr(III), Co(II), Ni(II) and Cu(II) readily react with various brominating agents and undergo α-bromo/cyano/succinimido substitution, with or without accompanying Br substitution of the aryl ring. The selectivity of these reactions on the metal-coordinated salicylaldehyde derivatives allows the preparation in 5-80% yield of hitherto unreported specific α-bromo products. Data are presented for several reactions with Co and Cu complexes. The substituted organic compounds could be isolated by demetalation of the chelate products.

Transition Metal Chemistry (Dordrecht, Netherlands) published new progress about Bromination. 156089-67-7 belongs to class bromides-buliding-blocks, name is 4,5-Dibromo-2-hydroxybenzaldehyde, and the molecular formula is C7H4Br2O2, Safety of 4,5-Dibromo-2-hydroxybenzaldehyde.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jain, Kiran published the artcileReaction of 2-mercapto-4-chloro-6-bromobenzimidazole with chloroacetic acid, α-halogenoketones and alkyl bromides, Recommanded Product: 4-Bromo-2-chloro-6-nitroaniline, the main research area is bromochlorobenzimidazolethioacetophenone cyclization regiochem; thiazolobenzimidazolone preparation fungicide bactericide; thiazolobenzimidazole preparation fungicide bactericide; thiazinobenzimidazole preparation fungicide bactericide; fungicide bromochlorothiazolobenzimidazolone bromochlorothiazolobenzimidazole; bactericide bromochlorothiazolobenzimidazolone bromochlorothiazolobenzimidazole; cyclocondensation mercaptochlorobromobenzimidazole dibromoalkane regiochem; cyclization bromochlorobenzimidazolethioacetate regiochemistry.

6-Bromo-8-chlorothiazolo[3,2-a]benzimidazol-3(2H)-one (I), 3-aryl-6-bromo-8-chlorothiazolo[3,2-a]benzimidazoles (II, R = Ph, p-MeC6H4), 2,3-dihydro-6-bromo-8-chloro-thiazolo[3,2-a]benzimidazole (III, n = 2) and 4H-2,3-dihydro-7-bromo-9-chloro[1,3]thiazino[3,2-a]benzimidazole (III, n = 3) were prepared to study the directive influence of Br and Cl on the cyclization of chlorobromobenzimidazoles IV. Cyclization of IV (R1 = CH2CO2H, CH2COPh, CH2COC6H4Me) gave I and II, resp. Similarly, cyclocondensation of IV (R1 = H) with Br(CH2)2Br and Br(CH2)3Br gave III. I, II and III (n = 2) had fungicidal and bactericidal activities at 1:500 dilution

Journal of the Indian Chemical Society published new progress about Cyclization. 34033-41-5 belongs to class bromides-buliding-blocks, name is 4-Bromo-2-chloro-6-nitroaniline, and the molecular formula is C6H4BrClN2O2, Recommanded Product: 4-Bromo-2-chloro-6-nitroaniline.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Seemaisamy, Revathi published the artcileAnti-microbial and anti-cancer activity of Aegle marmelos and gas chromatography coupled spectrometry analysis of their chemical constituents, Application In Synthesis of 55099-31-5, the main research area is Staphylococcus Bacillus Aegle breast cancer cell anticancer antimicrobial.

In this study, we investigated anti-cancer and antimicrobial activity of Aegle marmelos leaf extracts and their chem. profile characterized by gas chromatog. coupled mass spectrometry (GC-MS). A. marmelos leaves were extracted with acetone, methanol, ethanol, and chloroform. Presence of phenolic compounds was identified in these extracts by qual. anal. All the extracts were subjected for anti-bacterial activity against the different strains of bacteria (Staphylococcus aureus, Bacillus subtilis, Bacillus cereus, Bacillus ariyabattai, Bacillus megaterium, Pseudomonas putida, Klebsiella pneumonia, Serratia marcescens, and Escherichia coli). It is noteworthy that acetone extract elicited maximum growth inhibition on Serratia marcescens. Based on profound anti bacterial activity, acetone and methanol extract of A. marmelos were checked for cytotoxicity against MDA-MB-231, HEp-2 and vero cells. MDA-MB-231 cells were more sensitive to acetone extract of A. marmelos with an IC50 value of 79.62 μg/mL where as HEp-2 cells are more sensitive to methanol extract of A. marmelos with an IC50 value of 47.08 μg/mL. Vero cells withstand 24 h treatment of both extract, and it is evidenced that both acetone and methanol extract of A. marmelos exhibited chemo sensitive property towards cancer cells. GCMS anal. was performed to characterize the active principles of acetone and methanol extracts of A. marmelos. GC MS data revealed the presence of ten major components. Overall, both acetone and methanol extract of A. marmelos found to be promising anti antibacterial and anti-cancer agent however the active principle of these should be isolated and characterized before reaching a concrete scientific conclusion.

International Journal of Pharmaceutical Sciences and Research published new progress about Aegle marmelos. 55099-31-5 belongs to class bromides-buliding-blocks, name is Ethyl 10-bromodecanoate, and the molecular formula is C12H23BrO2, Application In Synthesis of 55099-31-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

LeMahieu, Ronald A. published the artcileSubstituted (aryloxy)alkanoic acids as antagonists of slow-reacting substance of anaphylaxis, Related Products of bromides-buliding-blocks, the main research area is aryloxyalkanoic acid preparation leukotriene antagonist activity; slow reacting substance anaphylaxis antagonist preparation; antiasthmatic aryloxyalkanoic acid preparation.

A series of aryloxyalkanoic acids [e.g., I, X = CH2)5, n = 3] containing the 4-acetyl-3-hydroxy-2-propylphenoxy moiety of the standard slow-reacting substances of anaphylaxis (SRS-A) antagonist, FPL-55712, was prepared Thus, dihydroxypropylacetophenone II (R = R1 = H) was successively alkylated by treatment with Br(CH2)3CO2Et and K2CO3 in DMF, followed by Br(CH2)5Br in Me2CO to give II [R = Br(CH2)5, R1 = EtO2C(CH2)3] which was treated with II (R = R1 = H) and K2CO3, and then NaOH in aqueous MeOH to give I [X = (CH2)5, n = 3]. The compounds were evaluated for their ability to antagonize SRS-A-induced contractions of guinea pig ilea and leukotriene E4-induced bronchoconstriction in the guinea pig. The results showed that the compounds were all less potent than FPL-55712 in vitro, yet surprisingly, most were more potent by the inhalation route of administration. Some of the most potent analogs were selected for further pharmacol. evaluation and exhibited selective antagonism of leukotrienes as compared with platelet activating factor or histamine. In comparison to FPL-55712, compounds I [X = (CH2)5 n = 1] and I [X = (CH2)3O(CH2)3, n = 3] were more potent against leukotriene E4 and (40- and 80-fold, resp.), leukotriene D4 (4- and 3-fold, resp.), and leukotriene C4 (27- and 20-fold, resp.) induced bronchoconstriction when tested by inhalation.

Journal of Medicinal Chemistry published new progress about Antiasthmatics. 58929-72-9 belongs to class bromides-buliding-blocks, name is 1-Bromo-3-(3-bromopropoxy)propane, and the molecular formula is C6H12Br2O, Related Products of bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhang, Beibei published the artcileSurface Functionalization of Zinc Oxide by Carboxyalkylphosphonic Acid Self-Assembled Monolayers, Quality Control of 55099-31-5, the main research area is carboxyalkylphosphonic acid self assembled monolayer zinc oxide antibody biosensor.

Two carboxyalkylphosphonic acids (HOOC(CH2)nP(O)(OH)2, n = 2 for 3-PPA and n = 9 for 10-PDA) were deposited onto 1-dimensional zinc oxide (ZnO) nanowires and bare ZnO wafers to form stable self-assembled monolayers (SAMs). The samples were systematically characterized using wettability, at. force microscopy (AFM), FTIR spectroscopy (FTIR), and XPS. 3-PPA was bound to the ZnO surfaces mainly through the CO2H headgroup, and 10-PDA formed self-assembled monolayers on the nanoscaled ZnO surface through the PO3H2 headgroups. To verify the potential use of the functionalized surfaces in the construction of biosensors or bioelectronics, IgG protein immobilization through SAM bridging was demonstrated. This work expands the application of phosphonic acid-based surface functionalization on sensing and optoelectronic devices.

Langmuir published new progress about Binding energy. 55099-31-5 belongs to class bromides-buliding-blocks, name is Ethyl 10-bromodecanoate, and the molecular formula is C12H23BrO2, Quality Control of 55099-31-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lalitha, R. published the artcilePhytochemical analysis of Scinaia bengalica by GC-MS, Product Details of C12H23BrO2, the main research area is Scinaia oleic octanoic acid calcitriol hexadecanol.

Marine red algae consist of various medicinal activities. Marine sources are more active than the other natural sources. One of the most important red algae is Scinaia Bengalica(SB)known for its phytochem. anal. by GC-MS revealed 19 chem. constituents. SB consist major constituents like oleic acid, octanoic acid, 2 hexyl-1-octanol,hexadecanol, calcitriol, bromine compounds

International Journal of ChemTech Research published new progress about Phytochemicals. 55099-31-5 belongs to class bromides-buliding-blocks, name is Ethyl 10-bromodecanoate, and the molecular formula is C12H23BrO2, Product Details of C12H23BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Baragana, Beatriz published the artcileDiscovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy, Product Details of C11H13BrFNO, the main research area is quinoline carboxamide derivative preparation malaria translation elongation factor.

The antiplasmodial activity, DMPK properties, and efficacy of a series of quinoline-4-carboxamides are described. This series was identified from a phenotypic screen against the blood stage of Plasmodium falciparum (3D7) and displayed moderate potency but with suboptimal physicochem. properties and poor microsomal stability. The screening hit (1, EC50 = 120 nM) was optimized to lead mols. with low nanomolar in vitro potency. Improvement of the pharmacokinetic profile led to several compounds showing excellent oral efficacy in the P. berghei malaria mouse model with ED90 values below 1 mg/kg when dosed orally for 4 days. The favorable potency, selectivity, DMPK properties, and efficacy coupled with a novel mechanism of action, inhibition of translation elongation factor 2 (PfEF2), led to progression of 2 (DDD107498) to preclin. development.

Journal of Medicinal Chemistry published new progress about Antimalarials. 338454-98-1 belongs to class bromides-buliding-blocks, name is 4-(4-Bromo-2-fluorobenzyl)morpholine, and the molecular formula is C11H13BrFNO, Product Details of C11H13BrFNO.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Jaradat, Nidal published the artcileIsolation, identification, and antimycotic activity of plumbagin from Plumbago europaea L. roots, leaves and stems, Formula: C12H23BrO2, the main research area is Plumbago root leaf stem plumbagin antimycotic.

Plumbago europaea L. is a plant utilized in Palestinian ethnomedicine for the treatment of various dermatol. diseases. The current investigation was designed to isolate plumbagin from P. europaea leaves, roots and for the first time from the stems. Moreover, it aimed to evaluate the antimycotic activity against three human fungal pathogens causing dermatophytosis, also against an animal fungal pathogen. The qual. anal. of plumbagin from the leaves, stems, and roots was conducted using HPLC and spectrophotometer techniques, while the structure of plumbagin was established utilizing Proton and Carbon-13 NMR (NMR) and IR (IR) techniques. The entire plant constituents were determined by GC-MS. Moreover, the antimycotic activity against Ascosphaera apis, Microsporum canis, Trichophyton rubrum, and Trichophyton mentagrophytes was assessed utilizing the poison food technique method. The percentage of plumbagin recorded in the leaves, stems, and roots was found to be 0.51±0.001%, 0.16±0.001%, and 1.65±0.015%, resp. The GC-MS examination declared the presence of 59 mols. in the plant extract The plant extract and pure plumbagin exhibited complete inhibition against all tested dermatophytes at 6.0mg/mL for the extracts and 0.2mg/mL for plumbagin. P. europaea root is the best source of plumbagin and the plant extract could represent a potential drug candidate for the treatment of dermatophytosis infections. Further studies required to design suitable dosage forms from the natural P. europaea root extracts or plumbagin alone, to be utilized for the treatment of dermatol. and veterinary ailments.

Pakistan Journal of Pharmaceutical Sciences published new progress about Ascosphaera apis. 55099-31-5 belongs to class bromides-buliding-blocks, name is Ethyl 10-bromodecanoate, and the molecular formula is C12H23BrO2, Formula: C12H23BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Braeu, Elmar published the artcileOn heterocyclic systems containing bismuth(III). 2. Eight-membered heterocycles Cl/Br/I-M(CH2CH2CH2)2X with Lewis acidic group 15 atoms M = As, Sb, Bi and donor atoms X = NR, S: a contribution to the value of the electronegativity of bismuth(III), Computed Properties of 58929-72-9, the main research area is Pauling electronegativity Group VA element; Group VA element heterocycle transannular interaction; crystal structure antimony nitrogen heterocycle; mol structure antimony nitrogen heterocycle; metallocane.

Paths to the ligands (XCH2CH2CH2)2Z [X = Cl, Br; Z = NR (R = Me, PhCH2, CHMe2, iso-Bu), O, S, Se], to the diGrignard reagents (XMgCH2CH2CH2)2Z (same X, Z), and to the eight-membered Group 15 heterocycles XM(CH2CH2CH2)2Z [I; X = Cl, Br, iodo; M = As, Sb, Bi; Z = NR (R = Me PhCH2, iso-Bu), S] are given. 13C-NMR, IR and Raman spectra are discussed; for the compound ClSb(CH2CH2CH2)2NMe the crystal structure anal. is given: the antimony atom is clearly Lewis acidic with ψ-trigonal-bipyramidal coordination and a transannular Sb…N interaction of 2.385(2)Å. For such a configuration the values of the 13C-NMR chem. shifts of the α-CH2-groups (e.g. ClM(αCH2CH2CH2)2NMe (M = As, Sb, Bi) 34.6, 25.9, 46.6 ppm) display clearly a sequence N > Bi > P ≈ As > Sb for the Pauling electronegativities of the group 15 elements: a value as high as 2.3 for bismuth is suggested.

Polyhedron published new progress about Crystal structure. 58929-72-9 belongs to class bromides-buliding-blocks, name is 1-Bromo-3-(3-bromopropoxy)propane, and the molecular formula is C6H12Br2O, Computed Properties of 58929-72-9.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Cui, Pei H. published the artcileAntiproliferative and Antimigratory Actions of Synthetic Long Chain n-3 Monounsaturated Fatty Acids in Breast Cancer Cells That Overexpress Cyclooxygenase-2, Application In Synthesis of 55099-31-5, the main research area is antitumor antimetastatic monounsaturated fatty acid preparation breast cancer; structure activity antitumor monounsaturated fatty acid preparation breast cancer.

Cyclooxygenase-2 (COX-2) is overexpressed in many human cancers and converts the n-6 polyunsaturated fatty acid (PUFA) arachidonic acid to prostaglandin E2 (PGE2), which drives tumorigenesis; in contrast, n-3 PUFA inhibit tumorigenesis. We tested the hypothesis that these antitumor actions of n-3 PUFA may involve the n-3 olefinic bond. n-3 Monounsaturated fatty acids (MUFAs) of chain length C16-C22 were synthesized and evaluated in MDA-MB-468 breast cancer cells that stably overexpressed COX-2 (MDA-COX-2 cells). Longer chain (C19-C22) n-3 MUFAs inhibited proliferation, activated apoptosis, decreased PGE2 formation, and decreased cell invasion; C16-C18 analogs were less active. Mol. modeling showed that interactions of Arg120, Tyr355, and several hydrophobic amino acid residues in the COX-2 active site with C19-C22 MUFA analogs were favored. Thus, longer-chain n-3 MUFAs may be prototypes of novel anticancer agents that decrease the formation of PGE2 in tumor cells that contain high levels of COX-2.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 55099-31-5 belongs to class bromides-buliding-blocks, name is Ethyl 10-bromodecanoate, and the molecular formula is C12H23BrO2, Application In Synthesis of 55099-31-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary