Tag: M.W=250-300

Aimi, Takahiro published the artcileNucleophilic transformations of azido-containing carbonyl compounds via protection of the azido group, Related Products of bromides-buliding-blocks, the main research area is azido alc preparation; carbonyl compound azido nucleophile nucleophilic transformation.

Nucleophilic transformations of azido-containing carbonyl compounds, e.g., 4-(4-azidophenyl)benzaldehyde are discussed. The phosphazide formation from azides and di(tert-butyl)(4-(dimethylamino)phenyl)phosphine (Amphos) enabled transformations of carbonyl groups with nucleophiles such as lithium aluminum hydride and organometallic reagents RMgX (R = Et, Ph, 2-thienyl, etc.; X = Cl, Br). The good stability of the phosphazide moiety allowed to perform consecutive transformations of a diazide like 3-azido-5-(azidomethyl)benzaldehyde through triazole I formation and the Grignard reaction.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 55099-31-5 belongs to class bromides-buliding-blocks, name is Ethyl 10-bromodecanoate, and the molecular formula is C12H23BrO2, Related Products of bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Leyva-Perez, Antonio published the artcileOxyhalogenation of Activated Arenes with Nanocrystalline Ceria, Name: 1-Bromo-3-(3-bromopropoxy)propane, the main research area is nanocrystalline ceria oxyhalogenation activated arene.

Arenes can be chlorinated, brominated, and iodinated in the presence of CeO2 nanoparticles under aerobic conditions. In a biomimetic approach, active electrophilic halogen species are generated from either organic or inorganic halogen compounds and are trapped by arenes. This C-H transformation can be applied to the synthesis of naturally occurring products.

ACS Catalysis published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 58929-72-9 belongs to class bromides-buliding-blocks, name is 1-Bromo-3-(3-bromopropoxy)propane, and the molecular formula is C6H12Br2O, Name: 1-Bromo-3-(3-bromopropoxy)propane.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Gao, Guangpeng published the artcileEnantiomeric discrimination of α-hydroxy acids and N-Ts-α-amino acids by 1H NMR spectroscopy, Category: bromides-buliding-blocks, the main research area is hydroxy acid enantiomeric discrimination proton NMR spectroscopy; protected amino acid enantiomeric discrimination proton NMR spectroscopy; chiral solvating agent amino amido phenolic hydroxy group containing.

A new kind of chiral compounds with multiple amino, amido and phenolic hydroxy groups was synthesized from D-phenylalanine and D-phenylglycine, resp. The enantiomeric discriminations of α-hydroxy acids and N-Ts-α-amino acids were finished in the presence of the above chiral compounds as chiral solvating agents by 1H NMR spectroscopy. The chiral compounds are highly effective and practical chiral solvating agents towards α-hydroxy acids and N-Ts-α-amino acids.

Tetrahedron Letters published new progress about Amino acids, N-protected Role: ANT (Analyte), ANST (Analytical Study). 156089-67-7 belongs to class bromides-buliding-blocks, name is 4,5-Dibromo-2-hydroxybenzaldehyde, and the molecular formula is C7H4Br2O2, Category: bromides-buliding-blocks.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Lalitha, R. published the artcilePhytochemical analysis of Scinaia bengalica by GCMS, COA of Formula: C12H23BrO2, the main research area is Scinaia marine extract phytochem GCMS.

Marine red algae consist of various medicinal activities. Marine sources are more active than the other natural sources. One of the most important red algae is Scinaia Bengalica (SB) known for its phytochem. anal. by GC-MS revealed 19 chem. constituents. SB consist major constituents like oleic acid, octanoic acid, 2 hexyl-1-octanol,hexadecanol, calcitriol, bromine compounds

International Journal of MediPharm Research published new progress about High resolution gas chromatography-high resolution mass spectrometry. 55099-31-5 belongs to class bromides-buliding-blocks, name is Ethyl 10-bromodecanoate, and the molecular formula is C12H23BrO2, COA of Formula: C12H23BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Zhai, Shiyang published the artcileDesign, synthesis and biological evaluation of novel hybrids targeting mTOR and HDACs for potential treatment of hepatocellular carcinoma, Formula: C12H23BrO2, the main research area is hepatocellular carcinoma mTOR HDAC1 antiproliferative drug deign mol docking; HDACs; Hepatocellular carcinoma; Hybrids; mTOR.

Hepatocellular carcinoma (HCC) is a major contributor to global cancer incidence and mortality. Many pathways are involved in the development of HCC and various proteins including mTOR and HDACs have been identified as potential drug targets for HCC treatment. In the present study, two series of novel hybrid mols. targeting mTOR and HDACs were designed and synthesized based on parent inhibitors (MLN0128 and PP121 for mTOR, SAHA for HDACs) by using a fusion-type mol. hybridization strategy. In vitro antiproliferative assays demonstrated that these novel hybrids with suitable linker lengths exhibited broad cytotoxicity against various cancer cell lines, with significant activity against HepG2 cells. Notably, DI06, an MLN0128-based hybrid, exhibited antiproliferative activity against HepG2 cells with an IC50 value of 1.61μM, which was comparable to those of both parent drugs (MLN0128, IC50 = 2.13μM and SAHA, IC50 = 2.26μM). In vitro enzyme inhibition assays indicated that DI06, DI07 and DI17 (PP121-based hybrid) exhibited nanomolar inhibitory activity against mTOR kinase and HDACs (e.g., HDAC1, HDAC2, HDAC3, HADC6 and HADC8). Cellular studies and western blot analyses uncovered that in HepG2 cells, DI06 and DI17 induced cell apoptosis by targeting mTOR and HDACs, blocked the cell cycle at the G0/G1 phase and suppressed cell migration. The potential binding modes of the hybrids (DI06 and DI17) with mTOR and HDACs were investigated by mol. docking. DI06 displayed better stability in rat liver microsomes than DI07 and DI17. Collectively, DI06 as a novel mTOR and HDACs inhibitor presented here warrants further investigation as a potential treatment of HCC.

European Journal of Medicinal Chemistry published new progress about Acetylation. 55099-31-5 belongs to class bromides-buliding-blocks, name is Ethyl 10-bromodecanoate, and the molecular formula is C12H23BrO2, Formula: C12H23BrO2.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Fu, Rugang published the artcileDirect Synthesis of 3-Coumaranones with Calcium Carbide as an Acetylene Source, HPLC of Formula: 156089-67-7, the main research area is salicylaldehyde calcium carbide one pot cycloaddition reaction; methyl vinylbenzofuranone preparation.

A synthesis method for the construction of 3-coumaranones from the reaction of two mols., calcium carbide and salicylaldehydes was reported. Various 2-methyl-2-vinylbenzofuran-3(2H)-ones was obtained in moderate yields in the absence of a metal catalyst. This involved widely available starting materials, an inexpensive and easy-to-handle alkyne source, and a cost-efficient route. The reaction mechanism was verified by d. functional theory calculations of possible intermediates and corresponding transition states.

Organic Letters published new progress about Cycloaddition reaction. 156089-67-7 belongs to class bromides-buliding-blocks, name is 4,5-Dibromo-2-hydroxybenzaldehyde, and the molecular formula is C7H4Br2O2, HPLC of Formula: 156089-67-7.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde, Application In Synthesis of 90-59-5

Zianna, Ariadni;Geromichalou, Elena;Geromichalos, George;Fiotaki, Augusta-Maria;Hatzidimitriou, Antonios G.;Kalogiannis, Stavros;Psomas, George research published 《 Zinc(II) complexes of 3,5-dibromo-salicylaldehyde and α-diimines: Synthesis, characterization and in vitro and in silico biological profile》, the research content is summarized as follows. The synthesis of five neutral zinc(II) complexes of 3,5-dibromo-salicyladehyde (3,5-diBr-saloH) in the presence of nitrogen-donor co-ligands 2,2′-bipyridine (bipy), 1,10-phenanthroline (phen), 2,9-dimethyl-1,10-phenanthroline (neoc), or 2,2′-bipyridylamine (bipyam) was undertaken and complexes [Zn(3,5-diBr-salo)₂(H₂O)₂] (1), [Zn(3,5-diBr-salo)₂(bipy)] (2), [Zn(3,5-diBr-salo)₂(phen)]^.3,5-diBr-saloH (3), [Zn(3,5-diBr-salo)₂(neoc)] (4) and [Zn(3,5-diBr-salo)₂(bipyam)] (5) were characterized by various techniques. The crystal structures of complexes 3 and 5 were determined by x-ray crystallog., revealing the coexistence of two different coordination modes of 3,5-diBr-salo^– ligands. The new complexes show selective in vitro antibacterial activity against two Gram-pos. and two Gram-neg. bacterial strains. The complexes may scavenge 1,1-diphenyl-picrylhydrazyl and 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonic acid) radicals and reduce H₂O₂. The complexes may intercalate in-between the calf-thymus DNA-bases and have exhibited low-to-moderate ability to cleave supercoiled circular pBR322 plasmid DNA. The complexes may bind tightly and reversibly to bovine and human serum albumins. In order to explain the in vitro activity of the compounds, mol. docking studies were adopted on the crystal structure of calf-thymus DNA, human and bovine serum albumin, Escherichia coli and Staphylococcus aureus DNA-gyrase, 5-lipoxygenase, and 5-lipoxygenase activating protein. The employed in silico studies aimed to explore the ability of the compounds to bind to these target biomacromols., establishing a possible mechanism of action and were in accordance with the in vitro studies.

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

3,5-Dibromosalicylaldehyde, also known as 3,5-Dibromosalicylaldehyde, is a useful research compound. Its molecular formula is C7H4Br2O2 and its molecular weight is 279.91 g/mol. The purity is usually 95%.

3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes. 3,5-Dibromosalicylaldehyde can be used in the synthesis of Schiff base and can be used as reactant for synthesis of Schiff base ligands which forms mononuclear complexes with copper(II), nickel(II), zinc(II) and cobalt(II).

3,5-Dibromosalicylaldehyde is a copper complex that has been synthesized from 3,5-dibromosalicylaldehyde and copper chloride. FTIR spectroscopy revealed that the coordination geometry of the copper complex is octahedral with two nitrogen atoms in the equatorial plane. The presence of hydrogen bonding interactions was confirmed by homologous protein adsorption experiments. This chemical structure was determined using X-ray crystallography and fluorescence probe experiments. The copper complex showed high affinity for malonic acid, which is an ester hydrochloride. The molecular mechanism of this interaction is based on adsorption, which occurs through hydrogen bonding interactions and hydrophobic interactions. Structural analysis revealed that the polymeric matrix consists of a three-dimensional network of crosslinked chains, while FTIR analysis indicated a possible disulfide bond between two cysteine residues., Application In Synthesis of 90-59-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Application In Synthesis of 90-59-5.

Zinnatullin, R. G.;Nikitina, K. A.;Badeeva, E. K.;Metlushka, K. E. research published 《 New chiral 1,4,2-oxazaphosphorinanes bearing a free hydroxy group》, the research content is summarized as follows. Abstract: New chiral 3-aryl-2-hydroxy-2-oxo-5-R-1,4,2-oxazaphosphorinanes were obtained by a three-step one-pot synthesis, which included the preparation of imines from enantiopure (2R)-2-aminoalkan-1-ols, their phosphonylation and subsequent dealkylation of the P(O)OEt-fragment. The major diastereomers of the compounds obtained were found to have the (3R,5R)-configuration.

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

3,5-Dibromosalicylaldehyde, also known as 3,5-Dibromosalicylaldehyde, is a useful research compound. Its molecular formula is C7H4Br2O2 and its molecular weight is 279.91 g/mol. The purity is usually 95%.

3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes. 3,5-Dibromosalicylaldehyde can be used in the synthesis of Schiff base and can be used as reactant for synthesis of Schiff base ligands which forms mononuclear complexes with copper(II), nickel(II), zinc(II) and cobalt(II).

3,5-Dibromosalicylaldehyde is a copper complex that has been synthesized from 3,5-dibromosalicylaldehyde and copper chloride. FTIR spectroscopy revealed that the coordination geometry of the copper complex is octahedral with two nitrogen atoms in the equatorial plane. The presence of hydrogen bonding interactions was confirmed by homologous protein adsorption experiments. This chemical structure was determined using X-ray crystallography and fluorescence probe experiments. The copper complex showed high affinity for malonic acid, which is an ester hydrochloride. The molecular mechanism of this interaction is based on adsorption, which occurs through hydrogen bonding interactions and hydrophobic interactions. Structural analysis revealed that the polymeric matrix consists of a three-dimensional network of crosslinked chains, while FTIR analysis indicated a possible disulfide bond between two cysteine residues., Application In Synthesis of 90-59-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Computed Properties of 90-59-5.

Zou, Dong-Hui;Liang, Min;Chen, Wei research published 《 Synthesis, X-ray crystal structures and catalytic epoxidation of oxidovanadium(V) complexes with aroylhydrazone and ethyl maltolate ligands》, the research content is summarized as follows. Two oxidovanadium(V) complexes, [VOL¹L] (1) and [VOL²L] (2) (L = Et maltolate), derived from the aroylhydrazones 4-bromo-N′-(2-hydroxy-5-methylbenzylidene)benzohydrazide (H₂L¹) and N′-(3,5-dibromo-2-hydroxybenzylidene)-4-methoxybenzohydrazide (H₂L²), resp., have been synthesized and characterized by elemental anal., IR and electronic spectroscopy. Structures of the complexes were further confirmed by single crystal X-ray determination The V atoms in the complexes are coordinated by the ONO donor atoms of the aroylhydrazone ligand, OO donor atoms of the Et maltolate ligand, and one oxido O atom, forming octahedral coordination. The complexes function as effective olefin epoxidation catalysts with hydrogen peroxide as terminal oxidant and sodium hydrogen carbonate as a co-catalyst.

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

3,5-Dibromosalicylaldehyde, also known as 3,5-Dibromosalicylaldehyde, is a useful research compound. Its molecular formula is C7H4Br2O2 and its molecular weight is 279.91 g/mol. The purity is usually 95%.

3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes. 3,5-Dibromosalicylaldehyde can be used in the synthesis of Schiff base and can be used as reactant for synthesis of Schiff base ligands which forms mononuclear complexes with copper(II), nickel(II), zinc(II) and cobalt(II).

3,5-Dibromosalicylaldehyde is a copper complex that has been synthesized from 3,5-dibromosalicylaldehyde and copper chloride. FTIR spectroscopy revealed that the coordination geometry of the copper complex is octahedral with two nitrogen atoms in the equatorial plane. The presence of hydrogen bonding interactions was confirmed by homologous protein adsorption experiments. This chemical structure was determined using X-ray crystallography and fluorescence probe experiments. The copper complex showed high affinity for malonic acid, which is an ester hydrochloride. The molecular mechanism of this interaction is based on adsorption, which occurs through hydrogen bonding interactions and hydrophobic interactions. Structural analysis revealed that the polymeric matrix consists of a three-dimensional network of crosslinked chains, while FTIR analysis indicated a possible disulfide bond between two cysteine residues., Computed Properties of 90-59-5

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 90-59-5, formula is C7H4Br2O2, The most pervasive is the naturally produced bromomethane. Safety of 3,5-Dibromo-2-hydroxybenzaldehyde

Zhou, Yan;Zhou, Zebiao;Liu, Siqi;Cai, Mingzhong research published 《 Recyclable palladium-catalyzed cyclocarbonylation between benzyl chlorides and salicylic aldehydes towards coumarins》, the research content is summarized as follows. A novel and practical route to coumarin derivatives was developed via the heterogeneous Pd-catalyzed carbonylative reaction and subsequent intramol. condensation process starting from com. easily available benzyl chlorides and salicylic aldehydes. Reactions were performed in the existence of 2 mol% of an SBA-15-immobilized bidentate phosphine palladium complex [SBA-15-P,P-PdCl2] in dioxane at 110°C with Et₃N as base under 10 bar of CO to afford a wide range of coumarin derivatives mostly with good to high yields. Importantly, this new heterogenized palladium complex was easy to recover via filtration of the reaction mixture, and was recyclable up to 8 times without apparent drop in its catalytic performance.

Safety of 3,5-Dibromo-2-hydroxybenzaldehyde, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

3,5-Dibromosalicylaldehyde, also known as 3,5-Dibromosalicylaldehyde, is a useful research compound. Its molecular formula is C7H4Br2O2 and its molecular weight is 279.91 g/mol. The purity is usually 95%.

3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes. 3,5-Dibromosalicylaldehyde can be used in the synthesis of Schiff base and can be used as reactant for synthesis of Schiff base ligands which forms mononuclear complexes with copper(II), nickel(II), zinc(II) and cobalt(II).

3,5-Dibromosalicylaldehyde is a copper complex that has been synthesized from 3,5-dibromosalicylaldehyde and copper chloride. FTIR spectroscopy revealed that the coordination geometry of the copper complex is octahedral with two nitrogen atoms in the equatorial plane. The presence of hydrogen bonding interactions was confirmed by homologous protein adsorption experiments. This chemical structure was determined using X-ray crystallography and fluorescence probe experiments. The copper complex showed high affinity for malonic acid, which is an ester hydrochloride. The molecular mechanism of this interaction is based on adsorption, which occurs through hydrogen bonding interactions and hydrophobic interactions. Structural analysis revealed that the polymeric matrix consists of a three-dimensional network of crosslinked chains, while FTIR analysis indicated a possible disulfide bond between two cysteine residues., 90-59-5.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary