M.W=250-300 Archives - Page 33 of 46 - Bromides-buliding-blocks

Shaik, Mahammad Sadik team published research in Journal of Heterocyclic Chemistry in 2021 | 90-59-5

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

3,5-Dibromosalicylaldehyde, also known as 3,5-Dibromosalicylaldehyde, is a useful research compound. Its molecular formula is C7H4Br2O2 and its molecular weight is 279.91 g/mol. The purity is usually 95%.

3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes. 3,5-Dibromosalicylaldehyde can be used in the synthesis of Schiff base and can be used as reactant for synthesis of Schiff base ligands which forms mononuclear complexes with copper(II), nickel(II), zinc(II) and cobalt(II).

3,5-Dibromosalicylaldehyde is a copper complex that has been synthesized from 3,5-dibromosalicylaldehyde and copper chloride. FTIR spectroscopy revealed that the coordination geometry of the copper complex is octahedral with two nitrogen atoms in the equatorial plane. The presence of hydrogen bonding interactions was confirmed by homologous protein adsorption experiments. This chemical structure was determined using X-ray crystallography and fluorescence probe experiments. The copper complex showed high affinity for malonic acid, which is an ester hydrochloride. The molecular mechanism of this interaction is based on adsorption, which occurs through hydrogen bonding interactions and hydrophobic interactions. Structural analysis revealed that the polymeric matrix consists of a three-dimensional network of crosslinked chains, while FTIR analysis indicated a possible disulfide bond between two cysteine residues., Category: bromides-buliding-blocks

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Category: bromides-buliding-blocks.

Shaik, Mahammad Sadik;Nadiveedhi, Maheshwara Reddy;Gundluru, Mohan;Narreddy, Ananda Kumar Reddy;Thathireddy, Krishna Reddy;Ramakrishna, Ranjani;Cirandur, Suresh Reddy research published 《 2-Amino-3-cyano-4H-chromene-4-ylphosphonates as potential antiviral agents: Synthesis, in ovo and in silico approach》, the research content is summarized as follows. A simplistic synthetic procedure for the synthesis of structurally diversified 2-amino-3-cyano-4H-chromene-4-ylphosphonates were developed by the treatment of substituted salicylaldehydes, malononitrile, and dialkyl phosphite in presence of Cu(OAc)₂ catalyst at room temperature and neat conditions. The synthesized compounds were tested for their antiviral assay. Among all, the compounds three have shown good in ovo antiviral activity against New castle disease virus (NDV) at a concentration of 150μg/mL. The remarkable reduction in NDV virus population in embryos treated with title compounds in a dose dependent manner, indicated that the synthesized compounds are extreme by toxic to the NDV virus. The title compounds were also docked against hemagglutinin neuraminidase enzyme and the more bioactive compound showed highest docking score than the standard antiviral drug taribavirin while two compounds have the same docking score as that of the standard

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Shaik, Yasmin Haroon team published research in Synthetic Communications in 2022 | 90-59-5

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde, Computed Properties of 90-59-5

Shaik, Yasmin Haroon;Chintha, Venkataramaiah;Gundluru, Mohan;Sarva, Santhisudha;Cirandur, Suresh Reddy research published 《 An efficient nano-FGT catalyzed green synthesis of α-aminophosphonates and evaluation of their antioxidant, anti-inflammatory activity and molecular docking studies》, the research content is summarized as follows. A green and efficient one-pot has been developed for the synthesis of a series of new diethyl-(((2,3-dihydrobenzo[b][1,4]dioxin-6yl)amino) (substituted phenyl)methyl) phosphonates (4a–4k) by the Kabachinik-Fields reaction of 2,3-dihydrobenzo[b][1,4]dioxin-6-amine (2a-2k) with various substituted aldehydes (2a–2k) and di-Et phosphite (3) using nano ferrite supported glutathione (nano FGT) as catalyst under microwave irradiation and solvent free conditions. The synthesized compounds were evaluated for their antioxidant (DPPH & FRAP) and anti-inflammatory activity studies. Compounds 4b (naphthyl) and 4k (9-anthracenyl) 4k showed highest antioxidant activity than that of standard ascorbic acid in DPPH method. Whereas compounds 4f (3-nitrophenyl), 4h -phenoxyphenyl and 4k (9-anthracenyl) exhibited low IC₅₀ values than that of standard ascorbic acid in and in Ferric Reducing Antioxidant Power (FRAP) studies. Compounds 4a, 4b, 4h, 4i and 4k have shown strong anti-inflammatory activity against LPS induced cell death in RAW 264.7 cell lines. Mol. docking studies were also carried out against COX-2 showed high binding energies that are in support of their high anti-inflammatory activity. Being the most bioactive compound (4k) stands as promising next future anti-oxidant and anti-inflammatory agent.

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Saroya, Sonia team published research in Research on Chemical Intermediates in 2022 | 90-59-5

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Organic compounds having carbon bonded to bromine are called organic bromides. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. Product Details of C7H4Br2O2.

Saroya, Sonia;Asija, Sonika;Deswal, Yogesh;Kumar, Naresh;Kumar, Ashwani research published 《 Synthesis, spectral studies, in vitro antimicrobial activity and molecular docking studies of organotin(IV) complexes derived from tridentate Schiff base ligands》, the research content is summarized as follows. In this work, diorganotin complexes of Schiff base ligands, R₂SnL I (R = Bu, Me, Ph; R¹, R² = H, CO₂Me; R³, R⁴ = H, Br, OEt), were synthesized. Schiff base ligands were obtained by the condensation of Me 3-amino-4-hydroxybenzoate and Me 4-amino-3-hydroxybenzoate with salicylaldehyde derivatives in equimolar ratio. The structure of all synthesized compounds were confirmed by several spectroscopic techniques like elemental anal., FT-IR, multinuclear (¹H, ¹³C, and ¹¹⁹Sn) NMR and mass spectrometry. From the spectroscopic data, it was found that the Schiff base ligands are coordinated to tin atom through -ONO donor atoms and tin atom exhibits pentacoordinated geometry in all complexes. The synthesized compounds were assessed for their in vitro antimicrobial potential against four bacterial and two fungal strains. Mol. docking studies of the most potent compound 9 was performed with enzyme 3-oxoacyl-[acyl-carrier-protein] synthase 2 (FabF) of Escherichia coli and sterol 14-alpha demethylase of C. albicans to study their interactions.

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Satheeshkumar, K. team published research in Inorganic Chemistry Communications in 2022 | 90-59-5

Related Products of 90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Dehydrobromination, Grignard reactions, reductive coupling, Wittig reaction, and several nucleophilic substitution reactions are some of the principal reactions which involve organic bromides. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Organic compounds having carbon bonded to bromine are called organic bromides. Related Products of 90-59-5.

Satheeshkumar, K.;Saravana Kumar, P.;Shanmugapriya, R.;Nandhini, C.;Vennila, K. N.;Elango, Kuppanagounder P. research published 《 An easy to make Hg(II) complex as a selective and sensitive fluorescent turn-on chemosensor for iodide in an aqueous solution based on metal ion displacement mechanism》, the research content is summarized as follows. A simple Schiff base ligand (L) bearing 3,5-dibromo-2-hyrdoxybenzaldehyde fluorophore moiety has rationally been designed, synthesized and characterized. The Hg(II) complex of L was synthesized by simply stirring a mixture of L and HgCl₂ in ethanol at RT and the resultant non-fluorescent complex HgL is found to detect iodide ion selectively, with a turn-on fluorescence in H₂O:DMSO (1:1 volume/volume) medium. The detection of iodide was performed via the metal ion displacement mechanism with a 1:2 (Probe:Iodide) stoichiometry and binding constant of 1.51 × 10⁴ M^-1. Novel HgL complex showed rapid response towards iodide ion with a limit of detection (LOD) as low as 60 nM. Moreover, the sensing mechanism of iodide by the complex is theor. supported by d. functional theory (DFT) and time dependent d. functional theory (TD-DFT) calculations In addition, estimation of iodide in real water samples, table salt and urine sample demonstrate the practical value of the probe.

Related Products of 90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rudbari, Hadi Amiri team published research in Dalton Transactions in 2022 | 90-59-5

Electric Literature of 90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Electric Literature of 90-59-5.

Rudbari, Hadi Amiri;Saadati, Arezoo;Aryaeifar, Mahnaz;Blacque, Olivier;Correia, Isabel;Islam, Mohammad Khairul;Woschko, Dennis;Janiak, Christoph;Enamullah, Mohammed research published 《 Pseudotetrahedral Zn(II)-(R or S)-dihalogen-salicylaldiminato complexes with Λ- or Δ-chirality induction at-metal》, the research content is summarized as follows. Reactions of enantiopure (S or R)-N-1-(phenyl)ethyl-2,4-X¹,X²-salicylaldimine (S-H or R-H; X¹, X² = dihalogen) with Zn(II)-nitrate give bis[(S or R)-N-1-(phenyl)ethyl-2,4-X¹,X²-salicylaldiminato-κ²N,O]-Zn(II), (Δ-ZnS or Λ-ZnR) with Δ/Λ-chirality induction at-metal in the C₂-sym. mols. EI-mass spectra show parent ion peaks. X-ray structures indicate that two phenolate-O and two imine-N atoms from two mols. of the Schiff bases coordinate to the Zn(II) ion in a pseudotetrahedral geometry. Structural analyses give evidence that the S- or R-ligand chirality gives only one diastereomer Δ-ZnS or Λ-ZnR in an enantiopure crystal. Gas-phase optimized structures suggest that the Δ-ZnS or Λ-ZnR diastereomers are slightly more stable than Λ-ZnS or Δ-ZnR by 1-2 kcal mol^-1. The intramol. interactions were analyzed with the Independent Gradient Model (IGM) using the program Multiwfn on the optimized structures and also indicate the diastereomeric preference of Δ-ZnS1 over Λ-ZnS1 (or Λ-ZnR1 over Δ-ZnR1). Variable time and temperature ¹H NMR spectra support the presence of only one diastereomer Λ-ZnR or Δ-ZnS in the bulk samples, backed by the simulated spectra which exhibit no diastereomerization in solution In contrast, the reported Zn(II)-(R or S)-salicylaldiminato/naphthaldiminato complexes show a diastereomeric mixture of both Δ- and Λ-forms and a Δ ⇄ Λ equilibrium in solution Electronic CD (ECD) spectra in solution display expected mirror-image relations for the (S or R)-Schiff base ligands and the (S or R)-ligated complexes. Combined analyses of exptl. and simulated ECD spectra further support the notion of diastereomeric excess of Δ-ZnS or Λ-ZnR in solution The overall results thus suggest the preservation of chirality at-Zn induced by S- or R-ligands in a solid or solution Supramol. packing analyses explore different kinds of intermol. interactions with the strongest one for X···O. Only the halogen atom in the para position is involved in these interactions with Br···O > Cl···O. Hirshfeld surface analyses also support these interactions between two mols. at a distance shorter than the sum of the van der Wall radii. Comparison of the exptl. and simulated PXRD patterns from the single-crystal x-ray structures shows a good matching and confirms the phase purity of the bulk samples.

Electric Literature of 90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rudbari, Hadi Amiri team published research in New Journal of Chemistry in 2022 | 90-59-5

SDS of cas: 90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Rudbari, Hadi Amiri;Kordestani, Nazanin;Cuevas-Vicario, Jose V.;Zhou, Min;Efferth, Thomas;Correia, Isabel;Schirmeister, Tanja;Barthels, Fabian;Enamullah, Mohammed;Fernandes, Alexandra R.;Micale, Nicola research published 《 Investigation of the influence of chirality and halogen atoms on the anticancer activity of enantiopure palladium(II) complexes derived from chiral amino-alcohol Schiff bases and 2-picolylamine》, the research content is summarized as follows. In continuation of authors work on the synthesis of heteroleptic enantiopure Pd(II)-complexes, four mixed-ligand enantiomeric pairs of Pd(II) complexes (J1–J8), [Pd(pic) (R or S)-N-(2,3-dihydroxypropyl)-3,5-X₁,X₂-salicylaldimines]NO₃, (pic = 2-picolylamine; X₁ = X₂ = Cl, Br, I; X₁/X₂ = Br/Cl), were synthesized by the reaction of enantiopure halogen-substituted Schiff bases (R or S)-N-(2,3-dihydroxypropyl)-3,5-X₁,X₂-salicylaldimines with [Pd(pic)Cl₂] and obtained as yellow precipitates The composition and structure of the complexes were confirmed by elemental analyses, NMR (¹H and ¹³C), FT-IR spectroscopy and theor. calculations The NMR data confirmed the stability of these complexes in DMSO. The electronic structure of the reported complexes was investigated using UV-Vis absorption and electronic CD (ECD) spectroscopy. The antiproliferative activity of the newly synthesized metal complexes was evaluated against CCRF-CEM acute lymphocytic leukemia cells and their multidrug-resistant CEM/ADR5000 subline showing IC₅₀ values in the low-micromolar range. The two most active compounds (J4 and J6) in the assays above were selected for further biol. testing, i.e. cell cycle analyses, apoptosis detection and ability to inhibit the chymotrypsin-like activity of the 20S human proteasome. Both compounds arrested the G2/M cell cycle phase in a concentration-dependent manner without inducing significant apoptosis and inhibited the above-mentioned proteolytic activity of the proteasome in the low-micromolar range.

SDS of cas: 90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ryzhkov, Fedor V. team published research in Journal of Heterocyclic Chemistry in 2021 | 90-59-5

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Application of C7H4Br2O2.

Ryzhkov, Fedor V.;Elinson, Michail N.;Ryzhkova, Yuliya E.;Vereshchagin, Anatoly N.;Korolev, Victor A.;Egorov, Mikhail P. research published 《 Pseudo-four-component synthesis and in silico studies of 5-(5-hydroxy-3-methyl-1H-pyrazol-4-yl)-substituted 5H-chromeno[2,3-b]pyridines》, the research content is summarized as follows. A new pseudo-four-component synthetic approach to 5-(5-hydroxy-3-methyl-1H-pyrazol-4-yl)-substituted 5H-chromeno[2,3-b]pyridines I [R¹ = H, OEt, Br, I; R² = H, OH; R³ = H, Br, I, NO₂; R⁴ = H, Ph; R⁵ = H; R³R⁵ = CH=CH-CH=CH] with 68%-95% yields was reported. This multicomponent reaction opened an efficient and convenient way to substituted 5H-chromeno[2,3-b]pyridines I, which were promising compounds in medicinal chem. and for the treatment of lung cancer through inhibition of aldo-keto reductase 1B10. A new consensus approach of mol. docking and mol. dynamics was applied for the investigation of interaction of synthesized 5H-chromeno[2,3-b]pyridines I and aldo-keto reductase 1B10.

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Ren, Nan team published research in Journal of Organic Chemistry in 2021 | 90-59-5

Recommanded Product: 3,5-Dibromo-2-hydroxybenzaldehyde, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 90-59-5, formula is C7H4Br2O2, The most pervasive is the naturally produced bromomethane. Recommanded Product: 3,5-Dibromo-2-hydroxybenzaldehyde

Ren, Nan;Zhang, Lingfeng;Hu, Yijie;Wang, Xiaoli;Deng, Zhen;Chen, Jie;Deng, Hongmei;Zhang, Hui;Tang, Xiao-Jun;Cao, Weiguo research published 《 Perfluoroalkyl-Promoted Synthesis of Perfluoroalkylated Pyrrolidine-Fused Coumarins with Methyl β-Perfluoroalkylpropionates》, the research content is summarized as follows. Employing the Me β-perfluoroalkylpropionate as the Michael acceptor, an efficient approach for the synthesis of perfluoroalkylated pyrrolidine-fused coumarins has been achieved. A tandem reaction involving [3 + 2] cycloaddition and intramol. transesterification was proposed for the mechanism. The enhanced electrophilicity resulting from the strong electron-withdrawing ability of the perfluoroalkyl group was crucial for this tandem reaction.

Recommanded Product: 3,5-Dibromo-2-hydroxybenzaldehyde, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rajnak, Cyril team published research in Dalton Transactions in 2021 | 90-59-5

Product Details of C7H4Br2O2, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Rajnak, Cyril;Micova, Romana;Moncol, Jan;Dlhan, Lubor;Kruger, Christoph;Renz, Franz;Boca, Roman research published 《 Spin-crossover in an iron(III) complex showing a broad thermal hysteresis》, the research content is summarized as follows. A pentadentate Schiff-base ligand ^3,5Cl-L^2- and NCSe^– form an iron(III) mononuclear complex [Fe(^3,5Cl-L)(NCSe)], which shows a thermally induced spin crossover with a broad hysteresis width of 24 K between 123 K (warming) and 99 K (cooling). Analogous complexes of the [Fe(^3,5X-L)(Y)] type, where X = Cl or Br and Y = Cl^–, N₃^–, NCS^–, and NCSe^–, are high-spin over the whole temperature interval.

Product Details of C7H4Br2O2, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Rambabu, Aveli team published research in Journal of Molecular Structure in 2021 | 90-59-5

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Rambabu, Aveli;Daravath, Sreenu;Shankar, Dasari Shiva;Shivaraj research published 《 DNA-binding, -cleavage and antimicrobial investigation on mononuclear Cu(II) Schiff base complexes originated from Riluzole》, the research content is summarized as follows. Two mononuclear metal complexes, [Cu(L₁)₂] (1) and [Cu(L₂)₂] (2) of the resp. Schiff bases, HL₁ = 2-((E)-(6-(trifluoromethoxy)benzo[d]thiazol-2-ylimino)methyl)-4-methoxyphenol and HL₂ = 2-((E)-(6-(trifluoromethoxy)benzo[d]thiazol-2-ylimino)methyl)-4,6-dibromophenol were synthesized and well characterized by anal. and various spectroscopic techniques like elemental anal., NMR, mass spectrometry, IR, UV, ESR and thermogravimetric analyses. These spectral studies gave a square planar geometry for both the complexes. These complexes underwent DNA investigation against calf thymus DNA and supercoiled pBR322 DNA. The complexes bound the DNA through an intercalation mode and the binding affinity order follows as 1 > 2 > HL₂ > HL₁. Both complexes show good cleavage ability against double-stranded pBR322 DNA under oxidative and photolytic conditions. In vitro antimicrobial study resulted in both complexes have shown marked biocidal potential compared to resp. free ligands.

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary