M.W=250-300 Archives - Page 36 of 46 - Bromides-buliding-blocks

Kordestani, Nazanin team published research in New Journal of Chemistry in 2021 | 90-59-5

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

3,5-Dibromosalicylaldehyde, also known as 3,5-Dibromosalicylaldehyde, is a useful research compound. Its molecular formula is C7H4Br2O2 and its molecular weight is 279.91 g/mol. The purity is usually 95%.

3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes. 3,5-Dibromosalicylaldehyde can be used in the synthesis of Schiff base and can be used as reactant for synthesis of Schiff base ligands which forms mononuclear complexes with copper(II), nickel(II), zinc(II) and cobalt(II).

3,5-Dibromosalicylaldehyde is a copper complex that has been synthesized from 3,5-dibromosalicylaldehyde and copper chloride. FTIR spectroscopy revealed that the coordination geometry of the copper complex is octahedral with two nitrogen atoms in the equatorial plane. The presence of hydrogen bonding interactions was confirmed by homologous protein adsorption experiments. This chemical structure was determined using X-ray crystallography and fluorescence probe experiments. The copper complex showed high affinity for malonic acid, which is an ester hydrochloride. The molecular mechanism of this interaction is based on adsorption, which occurs through hydrogen bonding interactions and hydrophobic interactions. Structural analysis revealed that the polymeric matrix consists of a three-dimensional network of crosslinked chains, while FTIR analysis indicated a possible disulfide bond between two cysteine residues., Computed Properties of 90-59-5

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde, Computed Properties of 90-59-5

Kordestani, Nazanin;Amiri Rudbari, Hadi;Correia, Isabel;Valente, Andreia;Corte-Real, Leonor;Islam, Mohammad Khairul;Micale, Nicola;Braun, Jason D.;Herbert, David E.;Tumanov, Nikolay;Wouters, Johan;Enamullah, Mohammed research published 《 Heteroleptic enantiopure Pd(II)-complexes derived from halogen-substituted Schiff bases and 2-picolylamine: synthesis, experimental and computational characterization and investigation of the influence of chirality and halogen atoms on the anticancer activity》, the research content is summarized as follows. Seven enantiomeric pairs of palladium complexes, [Pd(pic)(R or S)-N-1-(phenyl)ethyl-2,4-X₁,X₂-salicylaldiminate]NO₃, [Pd(pic)(R or S)]NO₃ (X₁ = X₂ = Cl, Br, I, H; X₁/X₂ = Br/Cl), were synthesized by the reaction of enantiopure halogen-substituted Schiff bases (R or S)-N-1-(phenyl)ethyl-2,4-X₁,X₂-salicylaldimine with [Pd(pic)Cl₂] (pic = 2-picolylamine). The composition and structure of the complexes were confirmed by FT-IR, ¹H NMR and ¹³C NMR spectroscopy, elemental anal. and x-ray crystallog. The electronic structure of the reported complexes was investigated using UV-vis absorption and electronic CD (ECD) spectroscopy, complemented by DFT/TDDFT modeling. To investigate the effect of chirality and different halogen substituents on the anticancer activity of the complexes, the cytotoxic activity of all fourteen complexes was tested in the human breast cancer cell lines MDA-MB-231 and MCF-7 at 24 h using the colorimetric MTT assay. Also, the cell death mechanism was assessed using the annexin V/propidium iodide (AV/PI) cytometry-based assay.

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kumar Saini, Manoj team published research in Advanced Synthesis & Catalysis in 2022 | 90-59-5

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Vinyl bromides undergo the Heck reaction, which involves C-C coupling with alkene to give substituted alkenes. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Methyl bromide is a precursor in the manufacture of several chemicals and is employed as a soil sterilant, mainly for seed production. Category: bromides-buliding-blocks.

Kumar Saini, Manoj;Kant Verma, Shashi;Basak, Ashok K. research published 《 Catalytic Cycloisomerization of Enyne Diesters Derived From 2-Propargyloxyarylaldehydes》, the research content is summarized as follows. A catalytic cycloisomerization of enyne diesters derived from 2-propargyloxyarylaldehydes is described. The cycloisomerization, catalyzed by 10 mol% In(OTf)₃, provides access to 2H-chromenes bearing di-Et 2-(hetero)arylidene malonates at 3-position. This enyne metathesis-type reaction is also useful for the synthesis of thia-, aza- and quinoline analogs of the 3-substituted 2H-chromenes. DDQ mediated oxidative C-N bond formation and further synthetic manipulation enables the conversion of 3-substituted 2H-chromene into chromene-fused mol. scaffold. Pd(0)-catalyzed intramol. Heck reaction on suitably substituted 2H-chromene provides indene-based mol. scaffold.

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kesharwani, Neha team published research in Catalysis Letters in 2021 | 90-59-5

Safety of 3,5-Dibromo-2-hydroxybenzaldehyde, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Organic bromides such as alkyl bromides are used as fumigants in agriculture to control insects. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Ethylene bromide is one of the commercially important organic bromides which are the component of leaded gasoline. Safety of 3,5-Dibromo-2-hydroxybenzaldehyde.

Kesharwani, Neha;Chaudhary, Nikita;Haldar, Chanchal research published 《 Heterogeneous Catalytic Oxidative Bromination and Oxidation of Thioethers By Vanadium(IV) Oxido Complex of Benzoylacetone and Effect of Solid Supports》, the research content is summarized as follows. Vanadium(IV) oxido complex of 1-Phenyl-1,3-butanedione [V^IVO(bzac)₂] (1) was prepared, characterized, and heterogenized onto APTMS modified graphene oxide, as well as imidazole modified polystyrene beads. Graphene oxide supported complex GO-APTMS-[V^IVO(bzac)₂] (2) and polymer anchored complex PS-i.m.-[V^IVO(bzac)₂] (3) were used for the oxidative bromination of a number of small organic mols. and oxidation of a series of thioethers. Both 2 and 3 evolve as excellent heterogeneous catalysts. The nature of solid support does not impact substrate conversion (%) during the oxidative bromination of salicylaldehyde, phenol, or styrene, whereas it influences the substrate conversion (%) as well as the product selectivity (%) during the oxidation of thioethers.

Safety of 3,5-Dibromo-2-hydroxybenzaldehyde, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kilic, Ahmet team published research in Journal of Organometallic Chemistry in 2022 | 90-59-5

COA of Formula: C7H4Br2O2, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Kilic, Ahmet;Soylemez, Rahime;Okumus, Veysi research published 《 Design, spectroscopic properties and effects of novel catechol spiroborates derived from Schiff bases in the antioxidant, antibacterial and DNA binding activity》, the research content is summarized as follows. Novel catechol spiroborates (L_(1-5)B) were prepared from the reaction of the corresponding Schiff base (L_(1-5)H) ligands, boric acid, and 3,5-di-tert-Bu catechol under favorable reaction conditions. The synthesized all compounds were characterized by NMR spectra, FT-IR spectra, UV-Vis spectra, LC-MS/MS spectra, fluorescence spectra, elemental anal. as well as the m.p. The optical properties of the Schiff base ligands and catechol spiroborates were investigated using – and fluorescence spectra in the C₂H₅OH. The antioxidant activities of newly synthesized Schiff base ligands and their catechol spiroborates were investigated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging ability and reducing power ability. Among the synthesized catechol spiroborates, (L₂B) exhibited the maximum radical scavenging (91.5 ± 2.11%) and reducing power activity (0.654±0.015) at a concentration of 200.0μg/mL. Antibacterial activity was determined using 3 Gram pos. and 2 Gram neg. bacteria by disk diffusion method. Schiff base (L₂H) was found to be effective against all test bacteria used. Besides, the DNA binding activity of the catechol spiroborates was determined using Calf Thymus DNA, and the DNA cleavage activity was determined using pBR-322 plasmid DNA by agarose gel electrophoresis method.

COA of Formula: C7H4Br2O2, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kleinmans, Roman team published research in Nature (London, United Kingdom) in 2022 | 90-59-5

Safety of 3,5-Dibromo-2-hydroxybenzaldehyde, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 90-59-5, formula is C7H4Br2O2, The most pervasive is the naturally produced bromomethane. Safety of 3,5-Dibromo-2-hydroxybenzaldehyde

Kleinmans, Roman;Pinkert, Tobias;Dutta, Subhabrata;Paulisch, Tiffany O.;Keum, Hyeyun;Daniliuc, Constantin G.;Glorius, Frank research published 《 Intermolecular [2π+2σ]-photocycloaddition enabled by triplet energy transfer》, the research content is summarized as follows. For more than one century, photochem. [2+2]-cycloadditions have been used by synthetic chemists to make cyclobutanes, four-membered carbon-based rings. In this reaction, typically two olefin subunits (two π-electrons per olefin) cyclize to form two new C-C σ-bonds. Although the development of photochem. [2+2]-cycloadditions has made enormous progress within the last century, research has been focused on such [2π+2π]-systems, in which two π-bonds are converted into two new σ-bonds. Here an intermol. [2+2]-photocycloaddition that uses bicyclo[1.1.0]butanes as 2σ-electron reactants was reported. This strain-release-driven [2π+2σ]-photocycloaddition reaction was realized by visible-light-mediated triplet energy transfer catalysis. A simple, modular and diastereoselective synthesis of bicyclo[2.1.1]hexanes from heterocyclic olefin coupling partners, namely coumarins, flavones and indoles, is disclosed. Given the increasing importance of bicyclo[2.1.1]hexanes as bioisosteres-groups that convey similar biol. properties to those they replace-in pharmaceutical research and considering their limited access, there remains a need for new synthetic methodologies. Applying this strategy enabled to extend the intermol. [2+2]-photocycloadditions to σ-bonds and provides previously inaccessible structural motifs.

Safety of 3,5-Dibromo-2-hydroxybenzaldehyde, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kolodziej, Beata team published research in Journal of Molecular Structure in 2022 | 90-59-5

Formula: C7H4Br2O2, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Kolodziej, Beata;Duran, Burcu;Morawiak, Maja;Schilf, Wojciech research published 《 Unusual products of reaction between aminoisoxazoles and aromatic aldehydes》, the research content is summarized as follows. In this work, the results of research (NMR, ATR-FTIR, UV-Vis, and X-ray) of products obtained in the reaction of 5-methyl-3-aminoisoxazole (3AMI) or 3-methyl-5-aminoisoxazole (5AMI) with 17 different aldehydes was presented. Based on the results, it was proved that this simple and well-known reaction does not always lead to the obtaining of typical products. In addition, a discussion on tautomeric forms preferred by the investigated o-hydroxy imine compounds in solution and in the solid state was presented. Knowledge of the tautomeric form which given Schiff base exists in the solution and in the solid state is very important in the development of medicine and pharmacy as well as coordination chem.

Formula: C7H4Br2O2, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Karim, Suhana team published research in Applied Organometallic Chemistry in 2022 | 90-59-5

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

A variety of minor organobromine compounds are found in nature, but none are biosynthesized or required by mammals. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Organobromine compounds have fallen under increased scrutiny for their environmental impact., Recommanded Product: 3,5-Dibromo-2-hydroxybenzaldehyde.

Karim, Suhana;Dasgupta, Sanchari;Parveen, Rumana;Biswas, Subhendu;Das, Debasis research published 《 A mechanistic approach for in-vitro anticancer activity via nucleic acid fragmentation by copper(II) complex anchored on MCM-41》, the research content is summarized as follows. Three new mononuclear copper Schiff base complexes, namely, ([Cu(L1)Cl]·CH₃CN (HmC_1), [Cu(L2)Cl]·CH₃CN (HmC_2) and [Cu(L3)Cl]·CH₃CN (HmC_3) derived from ONO donor tridentate ligands HL1, HL2 and HL3, resp.), have been synthesized to check their efficacy as target-specific next-generation anticancer therapeutics. All the HmCs have been characterized by using various physicochem. techniques (i.e., single-crystal X-ray anal., Fourier transform IR [FT-IR] spectroscopy and elemental anal.). Among the synthesized Schiff base complexes, HmC_3 was turned out to be most effective in killing cancer cell carried out on cultured human breast cancer cell line (MDA-MB-231) and human lung carcinoma cell line (A549). Finally, in order to improve the cellular permeability, particle size of HmC_3 was scaling down to nano-regime by immobilizing it onto a suitable matrix MCM-41@APTES (MCM-41 = Mobil Composition of Matter Number 41 and APTES = 3-aminopropyltriethoxysilane) to generate MCM-41@APTES@HmC_3 (MCM-41@APTES@HmC_3 = HtC_3). Field-emission scanning electron microscope (FESEM) and dynamic light scattering (DLS) study revealed the particle size of the synthesized HtC_3 nano-composite was within nano-regime and therefore could be further effective for biomedical applications. Furthermore, HtC_3 displayed better cancer cell killing property. To get insight into the mechanism of action of HtC_3, Annexin V-FITC/PI anal. and TUNEL assay revealed that DNA damage phenomenon is accompanied with changes in cellular morphol. leading to cell apoptosis. Cell migration assay on MDA-MB-231 cell with HtC_3 exposed the effectiveness of HtC_3 in arresting cancer cell migration. Therefore, all the in-vitro studies demonstrated that the immobilization of the copper Schiff base complex onto a suitable matrix increased its efficiency and becomes a promising anticancer nano-therapeutic agent.

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kaya, Yeliz team published research in Journal of Molecular Structure in 2021 | 90-59-5

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Kaya, Yeliz;Ercag, Ayse;Serdaroglu, Goncagul;Kaya, Savas;Grillo, Igor Barden;Rocha, Gerd Bruno research published 《 Synthesis, spectroscopic characterization, DFT calculations and molecular docking studies of new unsymmetric bishydrazone derivatives》, the research content is summarized as follows. Three unsym. isatin bishydrazone compounds I [R¹ = R² = Cl; R¹ = Br, R² = Cl; R¹ = R² = Br] were synthesized by the condensation of 3,5-dichloro-salicylaldehyde, 3-bromo-5-chloro-salicylaldehyde and 3,5-dibromo-salicylaldehyde with isatin monohydrazone, resp. The synthesized compounds I were characterized by elemental anal., ¹H-NMR, FT-IR, UV-Vis spectroscopy and mass spectrometry technique. For studied mols. I, chem. parameters like frontier orbital energies, energy gap, electronegativity, chem. potential, chem. hardness, softness, electrophilicity, nucleophilicity, electrodonating power, electroaccepting power, polarizability and dipole moment were calculated and discussed. Investigating the validity of well-known electronic structure principles like maximum hardness, min. polarizability and min. electrophilicity principles in the study, it was determined which compound is more stable compared to others. A software having PRIMorDIA name was developed to explore reactivity and electronic structure in large biomols. by some of the authors of this paper. Mol. docking studies for these synthesized mols. I were performed using PRIMorDIA software. Considering the intramol. interactions, NBO analyzes of three bishydrazone derivatives I were conducted to evaluate the chem. behavior.

90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kaya, Yeliz team published research in Polyhedron in 2021 | 90-59-5

HPLC of Formula: 90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Kaya, Yeliz;Ercag, Ayse;Uguz, Ozlem;Koca, Atif;Zorlu, Yunus;Hacioglu, Mayram;Seher Birteksoz Tan, Ayse research published 《 New asymmetric bisthiocarbohydrazones and their mixed ligand nickel(II) complexes: Synthesis, characterization, crystal structure, electrochemical-spectroelectrochemical property, antimicrobial and antioxidant activity》, the research content is summarized as follows. New asym. isatin bisthiocarbohydrazone ligands were synthesized by the condensation of 3,5-dibromosalicylaldehyde, 3,5-dichlorosalicylaldehyde and 3-bromo-5-chlorosalicylaldehyde with isatin monothiocarbohydrazone. New mixed ligand Ni(II) complexes were synthesized from these ligands using triphenylphosphine (PPh₃) as a secondary ligand. The synthesized ligands and complexes were characterized by elemental anal., FTIR, ¹H NMR, UV-visible spectroscopy and mass spectrometry techniques, along with conductivity measurements. The ligands bind to the Ni(II) ion as ONS donors. The fourth coordination site is completed by the secondary ligand PPh₃. The single crystal structures of one ligand and one complex were also resolved by x-ray crystallog. The electrochem. responses of the ligands and their complexes were determined and the results were evaluated to illustrate the influence of the substitution of different groups on the ligands. While the free ligands only give one oxidation peak, two oxidation peaks are observed for the Ni(II) complexes. Complexation of the ligands with the Ni(II) ion considerably affected the in-situ spectroelectrochem. responses of the ligands. Finally, the in vitro antioxidant and antimicrobial activities of the synthesized compounds were determined

HPLC of Formula: 90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Kandula, Madhu Kumar Reddy team published research in Journal of Heterocyclic Chemistry in 2021 | 90-59-5

SDS of cas: 90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Organic compounds having carbon bonded to bromine are called organic bromides. 90-59-5, formula is C7H4Br2O2, Name is 3,5-Dibromo-2-hydroxybenzaldehyde. Depending on the type of carbon to which the bromine is bonded, organic bromide could be alkyl, alkenyl, alkynyl, or aryl. SDS of cas: 90-59-5.

Kandula, Madhu Kumar Reddy;Gundluru, Mohan;Nemallapudi, Bakthavatchala Reddy;Gundala, Sravya;Kotha, Peddanna;Zyryanov, Grigory V.;Chadive, Sridevi;Cirandur, Suresh Reddy research published 《 Synthesis, antioxidant activity, and α-glucosidase enzyme inhibition of α-aminophosphonate derivatives bearing piperazine-1,2,3-triazole moiety》, the research content is summarized as follows. A novel series of piperazine-1,2,3-triazole bearing di-Me ((2-(4-((1H-1,2,3-triazole-4-yl)methyl)piperazin-1-yl)ethylamino)(2-hydroxyaryl)methyl)phosphonate derivatives have been prepared via copper-catalyzed azide-alkyne 1,3-dipolar cycloaddition (CuAAC) (Click Reaction) and Schiff base reactions. The synthesized compounds were confirmed by spectral characterization (¹H, ¹³C and ³¹P NMR, and mass). The title compounds were evaluated for in vitro alpha glucosidase enzyme inhibition and in vitro antioxidant activity using DPPH and H₂O₂ methods.

SDS of cas: 90-59-5, 3,5-Dibromosalicylaldehyde reacts with alkyl cyanoacetates in the presence of ammonium acetate to yield 4H- chromenes.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary