Tag: M.W=300-350

Lee, Junghun published the artcileDiscovery of novel 4-aryl-thieno[1,4]diazepin-2-one derivatives targeting multiple protein kinases as anticancer agents, Name: 2,5-Dibromo-3,4-dinitrothiophene, the publication is Bioorganic & Medicinal Chemistry (2018), 26(8), 1628-1637, database is CAplus and MEDLINE.

A series of 4-aryl-thieno[1,4]diazepin-2-one were synthesized and evaluated for their antiproliferative activities against the A375P melanoma and U937 hematopoietic cell lines. Several compounds showed very potent antiproliferative activities toward both cell lines and the activities were better than that of sorafenib, the reference standard Derivatives were made as amide (8a-8i, 9a-9m) and urea (10a-10d, 11a-11d) with diverse hydrophobic moieties. One of the most potent inhibitor 10d, 1-(4-((4-ethylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(4-(2-oxo-2,3-dihydro-1H-thieno [3,4-b][1,4]diazepin-4-yl)phenyl)urea was found to be very potent inhibitor of multi-protein kinases including FMS kinase (IC₅₀=3.73nM) and is a promising candidate for further development in therapeutics for cancer.

Bioorganic & Medicinal Chemistry published new progress about 52431-30-8. 52431-30-8 belongs to bromides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 2,5-Dibromo-3,4-dinitrothiophene, and the molecular formula is C4Br2N2O4S, Name: 2,5-Dibromo-3,4-dinitrothiophene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lian, Zhe published the artcileSignificant enhancement of light-harvesting efficiency through the formation of [2]pseudorotaxane with γ-cyclodextrin based on a bolaamphiphile of salicylaldehyde azine moiety, Product Details of C13H17BrO3, the publication is Dyes and Pigments (2019), 475-480, database is CAplus.

In this work, we have designed and synthesized a bolaamphiphile of salicylaldehyde azine (BSA), which can form [2]pseudorotaxane with γ-cyclodextrin (BSA@γ-CD) in aqueous solution and exhibit remarkable enhancement of the fluorescence emission. Both BSA and BSA@γ-CD assembly can spontaneously form spherical aggregates in aqueous solution with diameter at about 30 nm and 20 nm, resp. By using BSA and BSA@γ-CD as energy donor and sulforhodamine 101 (SR101) as energy acceptor, we fabricated two artificial light-harvesting systems in aqueous solution Significantly, an efficient energy transfer process was revealed to occur between the BSA or BSA@γ-CD assembly and the loaded SR101 to obtain high energy transfer efficiency and antenna effect. More importantly, energy transfer efficiency and antenna effect can be greatly improved in these two systems only just by addition of γ-CD.

Dyes and Pigments published new progress about 1207448-58-5. 1207448-58-5 belongs to bromides-buliding-blocks, auxiliary class Bromide,Benzene,Phenol,Ether,Aldehyde, name is 4-((6-Bromohexyl)oxy)-2-hydroxybenzaldehyde, and the molecular formula is C13H17BrO3, Product Details of C13H17BrO3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Murad, Ary R. published the artcileCharacteristics of low band gap copolymers containing anthracene-benzothiadiazole dicarboxylic imide: synthesis, optical, electrochemical, thermal and structural studies, HPLC of Formula: 52431-30-8, the publication is Polymers (Basel, Switzerland) (2021), 13(1), 62, database is CAplus and MEDLINE.

Two novel low band gap donor-acceptor (D-A) copolymers, poly[9,10-bis(4-(dodecyloxy)phenyl)-2,6-anthracene-alt-5,5-(4′,7′-bis(2-thienyl)-2′,1′,3′-benzothiadiazole-N-5,6-(3,7-dimethyloctyl)dicarboxylic imide)] (PPADTBTDI-DMO) and poly[9,10-bis(4-(dodecyloxy)phenyl)-2,6-anthracene-alt-5,5-(4′,7′-bis(2-thienyl)-2′,1′,3′-benzothiadiazole-5,6-N-octyl-dicarboxylic imide)] (PPADTBTDI-8) were synthesized in the present work by copolymerising the bis-boronate ester of 9,10-phenylsubstituted anthracene flanked by thienyl groups as electron-donor units with benzothiadiazole dicarboxylic imide (BTDI) as electron-acceptor units. Both polymers were synthesized in good yields via Suzuki polymerization Two different solubilizing alkyl chains were anchored to the BTDI units in order to investigate the impact upon their solubilities, mol. weights, optical and electrochem. properties, structural properties and thermal stability of the resulting polymers. Both polymers have comparable mol. weights and have a low optical band gap (Eg) of 1.66 eV. The polymers have low-lying HOMO (HOMO) levels of about -5.5 eV as well as the similar LUMO (LUMO) energy levels of -3.56 eV. Thermogravimetric analyses (TGA) of PPADTBTDI-DMO and PPADTBTDI-8 did not prove instability with decomposition temperatures at 354 and 313°C, resp. Powder X-ray diffraction (XRD) studies have shown that both polymers have an amorphous nature in the solid state, which could be used as electrolytes in optoelectronic devices.

Polymers (Basel, Switzerland) published new progress about 52431-30-8. 52431-30-8 belongs to bromides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 2,5-Dibromo-3,4-dinitrothiophene, and the molecular formula is C4Br2N2O4S, HPLC of Formula: 52431-30-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Alghamdi, Abdulaziz Ali B. published the artcileSynthesis and characterization of novel thiophene and carbazole-based polymers – optical and electrochemical characterization, Computed Properties of 52431-30-8, the publication is International Journal of Electrochemical Science (2016), 11(6), 5111-5127, database is CAplus.

A donor/acceptor series of carbazole copolymers, composed of alternating 2,7-linked 3,6-difluoro-9-(1-octyl-nonyl)-carbazole units and bithiophene repeated units [P1], 5,7-bis(5-bromothiophen-2-yl)-2,3-bis(4-(2-ethylhexyloxy) phenyl) thieno[3,4-b]pyrazine repeated units [P2] and bithiophene mixed with 5,7-bis(5-bromothiophen-2-yl)-2,3-bis(4-(2-ethylhexyloxy) phenyl) thieno[3,4-b]pyrazine repeated units [P3] have been prepared following Suzuki polymerization procedures. The route of synthesis and characterization techniques of this novel class of materials, together with their photophys. and electrochem. properties are presented in this study. The polymers were characterized by 1H NMR, 13C NMR and Elemental Anal. Mol. weights were estimated using gel permeation chromatog. (GPC). The thermal stability behavior for polymers was investigated using thermogravimetric anal. (TGA) and differential scanning calorimetry (DSC). The electronic and photo-phys. properties were investigated by use of cyclic voltammetry (CV) and UV-Vis spectroscopy, resp.

International Journal of Electrochemical Science published new progress about 52431-30-8. 52431-30-8 belongs to bromides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 2,5-Dibromo-3,4-dinitrothiophene, and the molecular formula is C4Br2N2O4S, Computed Properties of 52431-30-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Murad, Ary R. published the artcileInfluence of fluorine substitution on the optical, thermal, electrochemical and structural properties of carbazole-benzothiadiazole dicarboxylic imide alternate copolymers, Name: 2,5-Dibromo-3,4-dinitrothiophene, the publication is Polymers (Basel, Switzerland) (2020), 12(12), 2910, database is CAplus and MEDLINE.

In this work four novel donor-acceptor copolymers, PCDTBTDI-DMO, PCDTBTDI-8, P2F-CDTBTDI-DMO and P2F-CDTBTDI-8, were designed and synthesized via Suzuki polymerization The first two copolymers consist of 2,7-carbazole flanked by thienyl moieties as the electron donor unit and benzothiadiazole dicarboxylic imide (BTDI) as electron acceptor units. In the structures of P2F-CDTBTDI-DMO and P2F-CDTBTDI-8 copolymers, two fluorine atoms were incorporated at 3,6-positions of 2,7-carbazole to investigate the impact of fluorine upon the optoelectronic, structural and thermal properties of the resulting polymers. P2F-CDTBTDI-8 possesses the highest number average mol. weight (Mn = 24,200 g mol-1) among all the polymers synthesized. PCDTBTDI-DMO and PCDTBTDI-8 show identical optical band gaps of 1.76 eV. However, the optical band gaps of fluorinated copolymers are slightly higher than non-fluorinated counterparts. All polymers have deep-lying HOMO (HOMO) levels. Changing the alkyl chain substituents on BTDI moieties from linear n-octyl to branched 3,7-dimethyloctyl groups as well as substituting the two hydrogen atoms at 3,6-positions of carbazole unit by fluorine atoms has negligible impact on the HOMO levels of the polymers. Similarly, the LUMO (LUMO) energy levels are almost comparable for all polymers. Thermogravimetric anal. (TGA) has shown that all polymers have good thermal stability and also confirmed that the fluorinated copolymers have higher thermal stability relative to those non-fluorinated analogs. Powder X-ray diffraction (XRD) studies proved that all polymers have an amorphous nature in the solid state.

Polymers (Basel, Switzerland) published new progress about 52431-30-8. 52431-30-8 belongs to bromides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 2,5-Dibromo-3,4-dinitrothiophene, and the molecular formula is C4Br2N2O4S, Name: 2,5-Dibromo-3,4-dinitrothiophene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Murad, Ary R. published the artcileFabrication of alternating copolymers based on cyclopentadithiophene-benzothiadiazole dicarboxylic imide with reduced optical band gap: synthesis, optical, electrochemical, thermal, and structural properties, Category: bromides-buliding-blocks, the publication is Polymers (Basel, Switzerland) (2021), 13(1), 63, database is CAplus and MEDLINE.

A series of alternating copolymers containing cyclopentadithiophene (CPDT) flanked by thienyl moieties as electron-donor units and benzothiadiazole dicarboxylic imide (BTDI) as electron-acceptor units were designed and synthesized for solar cell applications. Different solubilizing side chains, including 2-ethylhexyl chains and n-octyl chains were attached to CPDT units, whereas 3,7-dimethyloctyl chains and n-octyl chains were anchored to the BTDI moieties. The impact of these substituents on the solubilities, mol. weights, optical and electrochem. properties, and thermal and structural properties of the resulting polymers was investigated. PCPDTDTBTDI-EH, DMO was synthesized via Suzuki polymerization, whereas PCPDTDTBTDI-8, DMO, and PCPDTDTBTDI-EH, 8 were prepared through direct arylation polymerization PCPDTDTBTDI-8, DMO has the highest number average mol. weight (M_n = 17,400 g mol-1) among all polymers prepared The PCPDTDTBTDI-8, DMO and PCPDTDTBTDI-8, 8 which have n-octyl substituents on their CPDT units have comparable optical band gaps (E_g ∼ 1.3 eV), which are around 0.1 eV lower than PCPDTDTBTDI-EH, DMO analogs that have 2-ethylhexyl substituents on their CPDT units. The polymers have their HOMO levels between -5.10 and -5.22 eV with PCPDTDTBTDI-EH, DMO having the deepest HOMO (HOMO) energy level. The LUMO (LUMO) levels of the polymers are between -3.4 and -3.5 eV. All polymers exhibit good thermal stability with decomposition temperatures surpassing 350 °C. Powder X-ray diffraction (XRD) studies have shown that all polymers have the amorphous nature in solid state.

Polymers (Basel, Switzerland) published new progress about 52431-30-8. 52431-30-8 belongs to bromides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 2,5-Dibromo-3,4-dinitrothiophene, and the molecular formula is C4Br2N2O4S, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Chen, Chiu-Hsiang published the artcileSynthesis and Characterization of Bridged Bithiophene-Based Conjugated Polymers for Photovoltaic Applications: Acceptor Strength and Ternary Blends, Application In Synthesis of 52431-30-8, the publication is Macromolecules (Washington, DC, United States) (2010), 43(2), 697-708, database is CAplus.

Six of three-component donor-acceptor random copolymers P1-P6, symbolized as (thiophene donor)_m-(thiophene acceptor)_n, were rationally designed and successfully synthesized by the palladium-catalyzed Stille coupling. The 4H-cyclopenta[2,1-b:3,4-b’]dithiophene (CPDT) unit serves as the donor for P1-P4, while the benzothiadiazole (BT), quinoxaline (QU), dithienoquinoxaline, and thienopyrazine (TP) units are used as the acceptor for P1, P2, P3, and P4, resp. P5 and P6 are structurally analogous to P1 and P2 except for using the dithieno[3,2-b:2′,3′-d]silole (DTS) unit as the donor. Because the band gap lowering ability of the acceptor units in the polymer is in the order TP > BT > QU presumably due to the quinoid form population in the polymers, the optical band gaps can be well adjusted to be 1.2, 1.6, and 1.8 eV for P4, P1, and P2, resp. It is found that the two bridged bithiophene units, CPDT and DTS, have similar steric and electronic effects on the P1 and P5 as well as P2 and P6, resp., leading to comparable intrinsic properties and device performances. Bulk heterojunction photovoltaic cells based on ITO/PEDOT:PSS/polymer:PC₇₁BM/Ca/Al configuration were fabricated and characterized. Although P4 exhibits the lowest optical band gap, broadest absorption spectrum, and highest mobility, the too low-lying LUMO level hinders the efficient exciton dissociation, resulting in a low PCE of 0.7%. Compared with poly[2,6-(4,4-bis(2-ethylhexyl)-4H-cyclopenta[2,1-b;3,4-b’]dithiophene)-alt-4,7-(2,1,3-benzothiadiazole)] (PCPDTBT), random copolymer P1 shows more blue-shifted, broader absorption spectrum, comparable mobility, and a higher PCE of 2.0%. In view of the fact that P1 shows a higher band gap with strong absorption in visible region, while PCPDTBT has a lower band gap to mainly absorb NIR light, a BHJ device with the active layer containing ternary blend of PCPDTBT/P1/PC₇₁BM was investigated and achieved an enhanced PCE of 2.5%, which outperforms the devices based on the binary blending systems of PCPDTBT/PC₇₁BM (PCE = 1.4%) or P1/PC₇₁BM (PCE = 2.0%) under the identical conditions. Such an improvement is ascribed to the complementary absorption and compatible structure of P1 and PCPDTBT polymers.

Macromolecules (Washington, DC, United States) published new progress about 52431-30-8. 52431-30-8 belongs to bromides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 2,5-Dibromo-3,4-dinitrothiophene, and the molecular formula is C4Br2N2O4S, Application In Synthesis of 52431-30-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Gao, Juan published the artcileSynthesis, characterization and photovoltaic properties of conjugated copolymers based on 2-alkyl-thieno[3,4-b]imidazole, Formula: C4Br2N2O4S, the publication is Synthetic Metals (2012), 162(17-18), 1694-1700, database is CAplus.

A new acceptor unit, 2-alkyl-thieno[3,4-b]imidazole, was synthesized through an annulation reaction between a 3,4-diaminothiophene derivative and a carboxyl acid or an acyl chloride, and was used for developing donor-acceptor conjugated copolymers. Copolymerization of 2-alkyl-thieno[3,4-b]imidazole and benzo[1,2-b:3,4-b’]dithiophene (BDT) or dithieno[3,2-b:2′,3′-d]silole (DTS) afforded 6 new low bandgap polymers P1-P6. These polymers possess intensive absorption at 400-650 nm and the optical bandgaps are in the range of 1.69-1.88 eV. They were firstly applied in polymer solar cells and the best efficiency of 0.72% was obtained from P2/PC₇₁BM cells fabricated using a dip-coating method.

Synthetic Metals published new progress about 52431-30-8. 52431-30-8 belongs to bromides-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 2,5-Dibromo-3,4-dinitrothiophene, and the molecular formula is C4Br2N2O4S, Formula: C4Br2N2O4S.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Willmann, Michael published the artcileRadiosynthesis and Biological Evaluation of [¹⁸F]R91150, a Selective 5-HT_2A Receptor Antagonist for PET-Imaging, HPLC of Formula: 957061-13-1, the publication is ACS Medicinal Chemistry Letters (2021), 12(5), 738-744, database is CAplus and MEDLINE.

Serotonergic 5-HT_2A receptors in cortical and forebrain regions are an important substrate for the neuromodulatory actions of serotonin in the brain. They have been implicated in the etiol. of many neuropsychiatric disorders and serve as a target for antipsychotic, antidepressant, and anxiolytic drugs. Positron emission tomog. imaging using suitable radioligands can be applied for in vivo quantification of receptor densities and receptor occupancy for therapy evaluation. Recently, the radiosynthesis of the selective 5-HT_2AR antagonist [¹⁸F]R91150 was reported. However, the six-step radiosynthesis is cumbersome and time-consuming with low radiochem. yields (RCYs) of <5%. In this work, [¹⁸F]R91150 was prepared using late-stage Cu-mediated radiofluorination to simplify its synthesis. The detailed protocol enabled us to obtain RCYs of 14 ± 1%, and the total synthesis time was reduced to 60 min. In addition, autoradiog. studies with [¹⁸F]R91150 in rat brain slices revealed the typical uptake pattern of 5-HT_2A receptor ligands.

ACS Medicinal Chemistry Letters published new progress about 957061-13-1. 957061-13-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronate Esters, name is 2-(4-(3-Bromopropoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C18H15N3O3, HPLC of Formula: 957061-13-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Meyer, Franc published the artcileTuning the metal-metal separation in pyrazolate-based dinuclear complexes by the length of chelating side arms, Safety of Cobalt(II) dibromo(1,2-dimethoxyethane), the publication is Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry (1998), 207-214, database is CAplus.

Six dinuclear Co(II) complexes of pyrazolate ligands with multidentate chelating side arms {3,5-(R₂NCH₂)₂C₃N₂H₂; R₂N = [Me₂N(CH₂)₃]₂N (HL¹) or (Et₂NCH₂CH₂)₂N (HL²)} were prepared and characterized. The reaction of L¹ and L² with 2 equiv of [Co(MeCN)₆][BF₄]₂ and NaBPh₄ proceeds via the isolable compounds [Co₂L¹(BF₄)][BPh₄]₂ (1a) and [Co₂L²(BF₄)][BPh₄]₂ (2a) finally to afford dinuclear [Co₂L¹F][BPh₄]₂ (1b) and [Co₂L²(F)(H₂O)][BPh₄]₂ (2b), resp., where a fluoride was abstracted from the BF₄^– starting material in both cases. While the longer side arms in 1b allow for an exogenous bridging position of the fluoride, an addnl. H₂O mol. is incorporated in 2b to form an FHO(H) moiety with an unusually short F-H-O bridge between the two Co centers. Evidence is reported for the reversible extrusion of the H₂O mol. from 2b. Treatment of 2b with KBr or NaN₃ yielded the resp. bromo- and azido-bridged complexes [Co₂L²Br][BPh₄]₂ (3) and [Co₂L²(N₃)][BPh₄]₂ (4), where in the latter case the azide adopts a μ-1,3-bridging mode. The magnetic properties of 3 and 4 were studied in the temperature range 8-200 K. Complexes 1b, 2b·3MeCN, 3·0.25Et₂O and 4·Me₂CO were also characterized by x-ray crystallog.

Journal of the Chemical Society, Dalton Transactions: Inorganic Chemistry published new progress about 18346-57-1. 18346-57-1 belongs to bromides-buliding-blocks, auxiliary class Cobalt, name is Cobalt(II) dibromo(1,2-dimethoxyethane), and the molecular formula is C4H10Br2CoO2, Safety of Cobalt(II) dibromo(1,2-dimethoxyethane).

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary