Tag: M.W=300-400

Related Products of 1295502-53-2, A common heterocyclic compound, 1295502-53-2, name is 4,7-Dibromo-5,6-difluorobenzo[c][1,2,5]thiadiazole, molecular formula is C6Br2F2N2S, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A 100 mLthree-neck round-bottom flask was added with 4-nitro-N-phenyl-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)aniline(1.2 mmol, 0.5 g), 4,7-dibromo-5,6-difluorobenzo[c] [1,2,5]thiadiazole(0.5 mmol, 0.17 g), potassium carbonate (2.17 mmol, 0.3 g),toluene (20 mL), H2O (20 mL) and ethanol (8 mL). Under N2 protection,tetrakis (triphenylphosphine) palladium (0.04 mmol,47 mg) was added quickly to the mixture. The reactionwas refluxedat 70 C for 24 h and then water was added. The water phase wasextracted with ethyl acetate before the organic phase was washedwith water and brine. The solvent was removed under reducedpressure after the extract dried over sodium sulfate. Purificationwas done by column chromatography on silica gel usingdichloromethane-petroleum ether as eluent. Yellow solidNTPA2BTF2 was produced (0.20 g, 53%). 1H NMR (400 MHz, DMSO) delta (ppm): 8.15 (d, J 8.9 Hz, 4H), 7.90 (d, J 8.0 Hz, 4H), 7.52 (t,J 7.5 Hz, 4H), 7.44 (d, J 8.2 Hz, 4H), 7.34 (d, J 7.7 Hz, 6H), 6.99(d, J 8.9 Hz, 4H).

The synthetic route of 1295502-53-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Bao, Qing; Li, Hua; Li, Yang; He, Jinghui; Xu, Qingfeng; Li, Najun; Chen, Dongyun; Wang, Lihua; Lu, Jianmei; Dyes and Pigments; vol. 130; (2016); p. 306 – 313;,
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Synthetic Route of 24468-88-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 24468-88-0, name is N-Benzyl-2-bromo-N-(2-bromoethyl)ethanamine belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a solution of compound 1-2 (2.56 g, 14.34 mmol) and compound 32-1 (6.905 g, 21.51 mmol) in DMF (15mL) under N2 was added NaH (1.434g, 35.85 mmol, 60% dispersed in Mineral oil). The mixture was stirred at 50 C for18 hours, cooled to rt, and quenched with water (20 mL). The mixture was extracted with EtOAc (150 mL x 3). Thecombined organic phases were washed with water, dried over anhydrous Na2SO4 and concentrated in vacuo. Theresidue was purified by silica gel column chromatography (hexane/EtOAc (v/v) = 8/1) to give the title compound 32-2(0.752 g, 14.9%). The compound was characterized by the following spectroscopic data:MS-ESI: m/z 352.1 [M+H]+; and1H NMR (400 MHz, CDCl3): delta 7.63-7.56 (m, 1H), 7.41-7.22 (m, 6H), 3.82 (d, 6H), 3.56 (s, 2H), 3.03 (s, 2H), 2.98-2.89(m, 2H), 2.24-2.00 (m, 4H), 1.37 (d, J = 11.8 Hz, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, N-Benzyl-2-bromo-N-(2-bromoethyl)ethanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Sunshine Lake Pharma Co., Ltd.; ZHANG, Jiancun; ZHANG, Yingjun; XIE, Hongming; REN, Qingyun; LUO, Huichao; YU, Tianzhu; TAN, Yumei; EP2730572; (2015); B1;,
Bromide – Wikipedia,
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Synthetic Route of 615-54-3, A common heterocyclic compound, 615-54-3, name is 1,2,4-Tribromobenzene, molecular formula is C6H3Br3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1,3,4-bromobenzene (3.12g, 0.01mol) and 2,4,5-tribromophenol (11.47g, 0.035mol) was stirred in a beaker and mix, 110g montmorillonite was added, stirring again mixed after homogenization dedicated microwave reaction flask was transferred to, the reaction was heated under microwave 300w 60min, cooled. 100mL washing liquid collected after the reaction was washed with petroleum ether, evaporated under reduced pressure to give a black oil by column chromatography, to give 4.40 g of a white solid, 69% yield.

The synthetic route of 615-54-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shandong Analysis Beta Center; Ji Wenhua; Chen Xiangfeng; Zhao Rusong; Gao Qianshan; Geng Yanling; Wang Xiao; (9 pag.)CN104860799; (2016); B;,
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Some common heterocyclic compound, 20191-76-8, name is 2,4-Dibromonaphthalen-1-amine, molecular formula is C10H7Br2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C10H7Br2N

52.0 g (172 mmol) of 48-4, 12.1 g (17 mmol) of Pd (dppf) Cl2,63.2 g (518 mmol) of phenylboronic acid, 119.4 g (863 mmol) of K2CO3,The EtOH / H2O mixture was refluxed at 80C for 6 hours. After the temperature was lowered and the mixture was extracted with MC / H2O, the organic layer was dried over MgSO4.After concentration, the product was purified by column chromatography (SiO2, hexane: MC = 1: 2)To thereby obtain objective compound 48-3 (42.0 g, 82%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 20191-76-8, its application will become more common.

Reference:
Patent; HEESUNG MAT LTD; Hui Sanctum Jae Co., Ltd.; JUNG YU JUN; Jeong Yu-jun; DONG GWANG IL; Dong Gwang-il; KIM YONG WOO; Kim Yong-u; CHOI JIN SEOK; Choi Jin-seok; CHOI DAE HYUK; Choi Dae-hyeok; LEE JOO DONG; Lee Ju-dong; (34 pag.)KR2018/72058; (2018); A;,
Bromide – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4101-68-2, name is 1,10-Dibromodecan, A new synthetic method of this compound is introduced below., Quality Control of 1,10-Dibromodecan

Tempol (0.01 mol) was added to a three-neck flask containing 100 ml dry benzene that is maintained at nitrogen atmosphere. To the flask, sodium hydride (0.015 mol) was added and kept refluxed for 24 hrs. The flask was cooled in ice bath and added 1,10-dibromodecane (0.02 mol) in one portion. The refluxing was then resumed for another 72 hrs. The contents of the flask was cooled in ice bath and added 25 ml water and transferred to a separatory funnel. The red upper benzene layer was separated , dried over anhydrous magnesium sulfate and solvent removed by rotory evaporation to get a red oil. The oil was purified by column chromatography on silica gel 60. The material was added to the column and eluted first with about 150 ml hexane that removed the excess of dibromodecane. The desired bromodecanoyl ether of Tempol was eluted with a mixture of hexane and ether (90:10). The red eluate was collected and was found to be pure on thin layer chromatography plates developed using the same solvent mixture. The yield was 0.008 mol (80%).

The synthetic route of 4101-68-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; COLBY PHARMACEUTICAL COMPANY; MEDICAL COLLEGE OF WISCONSIN, INC.; US2011/59922; (2011); A1;,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2789-89-1 as follows. COA of Formula: C14H8Br2

General procedure: The photocatalyst [Ir(dF-CF3-ppy)2(dtbpy)]PF6 (PC-1) (11.2 mg, 0.01 mmol, 2.0 mol%) wasadded to an oven-dried Schlenk tube containing a magnetic stirring bar and anhydrous ethylacetate (2.5 mL, 0.2 M) was added under argon. In the absence of light, the enone (0.5 mmol,1.0 equiv) and the alkyne (1.0 mmol, 2.0 equiv) were added under an argon stream. Theresulting solution was degassed using three freeze-pump-thaw cycles and the tube was finallybackfilled with argon. The reaction mixture was allowed to stir at room temperature for 24 hunder irradiation with visible light from two 30 W Kessil LEDs (lambdamax = 455 nm, see chapter 1.2).The solvent was evaporated and the crude reaction products were purified by columnchromatography over silica gel (dry load of crude material, pentane/EtOAc or pentane/diethylether mixtures as eluent) to afford products 6a-6e, 9a-9e and 10.

According to the analysis of related databases, 2789-89-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Strieth-Kalthoff; Henkel, Christian; Teders, Michael; Kahnt, Axel; Knolle, Wolfgang; Gomez-Suarez, Adrian; Dirian, Konstantin; Alex, Wiebke; Bergander; Daniliuc, Constantin G.; Abel; Guldi, Dirk M.; Glorius; Chem; vol. 5; 8; (2019); p. 2183 – 2194;,
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Application of 201138-91-2, The chemical industry reduces the impact on the environment during synthesis 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan, I believe this compound will play a more active role in future production and life.

General procedure: The triolborate, dibromides (0.2 mmol), and palladium acetate (10 mol %) were placed in a flask under an atmosphere of nitrogen. DMF/H2O (4/1; 10 mL) was added, and the reaction mixture was stirred at room temperature for 16 h. The mixture was extracted with dichloromethane, dried over MgSO4, and then purified by chromatography on sili

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4,6-Dibromodibenzo[b,d]furan, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Li, Gao-Qiang; Yamamoto, Yasunori; Miyaura, Norio; Tetrahedron; vol. 67; 36; (2011); p. 6804 – 6811;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 401-84-3, A common heterocyclic compound, 401-84-3, name is 1,3-Dibromo-5-(trifluoromethyl)benzene, molecular formula is C7H3Br2F3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A vial was charged with N-(2,4-dimethoxybenzyl)-l-methyl-3-(4,4,5,5- tetramethyl-l,3,2-dioxaborolan-2-yl)-N-(l,2,4-thiadiazol-5-yl)-lH-indole-6-sulfonamide (0.200 g, 0.351 mmol), potassium phosphate (0.260 g, 1.227 mmol), and PdCi2(dppf)- CH2C12 (0.029 g, 0.035 mmol). DMF (0.150 mL) was added, followed by 1,3-dibromo- 5-(trifluoromethyl)benzene (0.166 ml, 1.052 mmol). The vial was flushed with argon, sealed, and stirred at 85 C for two hours. The reaction was diluted with ethyl acetate and washed with water. The aqueous layer was extracted with ethyl acetate, and the combined organic layers were washed with brine, dried with sodium sulfate, filtered, and concentrated. The material was purified via column chromatography (silica gel, gradient elution 0 to 75% EtOAc:Hexane) to afford 3-(3-bromo-5-(trifluoromethyl)phenyl)-N- (2,4-dimethoxybenzyl)- 1 -methyl-N-( 1 ,2,4-thiadiazol-5-yl)- 1 H-indole-6-sulfonamide (.081 g, 0.121 mmol, 34.6 % yield) as a white solid, m/z (ESI) 668.0 (M+H)+.

The synthetic route of 401-84-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; DINEEN, Thomas; MARX, Isaac, E.; NGUYEN, Hanh, Nho; WEISS, Matthew; AMGEN INC.; WO2013/25883; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 43204-63-3, name is Bis(2-Bromoethyl)amine hydrobromide, This compound has unique chemical properties. The synthetic route is as follows., name: Bis(2-Bromoethyl)amine hydrobromide

PREPARATION 5 A mixture of 6-amino-8-methyl-3,4-dihydro-2(1H)-quinolinone (19.4 g), bis(2-bromoethyl)amine hydrobromide (41 g) and methanol (140 ml) was stirred for 13 hours at 64 C. After cooling, sodium carbonate (5.83 g) was added thereto and the mixture was stirred for 9 hours at 70 C. After cooling, the resulting precipitate was collected by filtration and the residue was washed with methanol to give 3,4-dihydro-8-methyl-6-(1-piperazinyl)-2(1H)-quinolinone hydrobromide (21.6 g). mp: >250 C. IR (Nujol): 1680, 1595 cm-1

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 43204-63-3.

Reference:
Patent; Fujisawa Pharmaceutical Co., Ltd.; US4988698; (1991); A;,
Bromide – Wikipedia,
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Synthetic Route of 88223-35-2, These common heterocyclic compound, 88223-35-2, name is 2-Bromo-9,9-dibutyl-9H-fluorene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

3 parts of 4-tert-butylaniline,8.9 parts of 2-bromo-9,9-dibutylfluorene,0.23 parts of palladium (II) acetate,1.9 parts of 2,2-bis (diphenylphosphino) -1,1′-binaphthyl and 2.9 parts of sodium tert-butoxide were added to 35 parts of toluene and reacted under heating reflux condition for 15 hours.The reaction mixture was added drop-Extraction with chloroform – water,After concentrating the chloroform phase,Separation by column chromatography (ethyl acetate – hexane)Purified,4 parts of a compound represented by the following formula (300) as a yellow solid.

The synthetic route of 88223-35-2 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nippon Kayaku Corporation; Satake, Masamitsu; (71 pag.)JP2016/196424; (2016); A;,
Bromide – Wikipedia,
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