Tag: M.W=300-400

Reference of 43204-63-3, A common heterocyclic compound, 43204-63-3, name is Bis(2-Bromoethyl)amine hydrobromide, molecular formula is C4H10Br3N, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 4: 5-Fluoro-2-(piperazin-1-yl)benzenesulfonamide A mixture of 2-amino-5-fluoro-benzenesulfonamide (950.00 mg, 4.99 mmol), 2-bromo-N-(2-bromoethyl) ethanamine hydrobromide (7.78 g, 24.95 mmol) and n-butyl alcohol (50.00 mL) was stirred at 120 C. for 24 h. The reaction mixture was allowed to cool to rt. Filtered and the filtrate was used for the next step directly. MS (EI+, m/z): 260.2 [M+H]+

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Navitor Pharmaceuticals, Inc.; O’Neill, David John; Saiah, Eddine; Kang, Seong Woo Anthony; Brearley, Andrew; Bentley, Jonathan; (519 pag.)US2018/127370; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, A new synthetic method of this compound is introduced below., Formula: C18H11BrO

A flask was charged with 3.4 g of N,N?-diphenylbenzidine, 6.8 g of the intermediate 3, 2.6 g of sodium t-butoxide (manufactured by Hiroshima Wako Co., Ltd.), 92 mg of tris(dibenzylideneacetone)-dipalladium (O) (manufactured by Aldrich Co., Ltd.), 42 mg of tri-t-butylphosphine and 100 mL of dehydrated toluene under argon flow to carry out reaction at 80° C. for 8 hours.After cooling down, 500 mL of water was added thereto, and the mixture was filtered through celite. The filtrate was extracted with toluene, and the extract was dried on anhydrous magnesium sulfate. This was concentrated under reduced pressure, and a crude product obtained was refined through a column and recrystallized from toluene. It was separated by filtration and then dried, whereby 4.1 g of a pale yellow powder was obtained.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Idemitsu Kosan Corporation; Yabunouchi, Nobuhiro; Inoue, Tetsuya; (38 pag.)KR101551591; (2015); B1;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 2789-89-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2789-89-1, name is 1,2-Bis(4-bromophenyl)ethyne belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: A 7 ml screw-cap tube, containing a magnetic stirring bar, was flame-dried undervacuum and filled with nitrogen after cooling to room temperature. To this tube wereadded tetraarylthiophene S-oxide 6 (0.03 mmol, 1.0 equiv.), diarylethyne 7 (0.06 mmol,2.0 equiv.) and mesitylene (200 mul) under a stream of nitrogen. The flask was heatedat 160 C for 48 h. After cooling the reaction mixture to room temperature, themixture was concentrated in vacuo and the residue was purified by preparativethin-layer chromatography to afford the corresponding HAB 9.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2-Bis(4-bromophenyl)ethyne, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Suzuki, Shin; Segawa, Yasutomo; Itami, Kenichiro; Yamaguchi, Junichiro; Nature Chemistry; vol. 7; 3; (2015); p. 227 – 233;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 24468-88-0, name is N-Benzyl-2-bromo-N-(2-bromoethyl)ethanamine, A new synthetic method of this compound is introduced below., Safety of N-Benzyl-2-bromo-N-(2-bromoethyl)ethanamine

To a 0 C solution of 6,7-dihydro-5H-cyclopenta[b]pyridin-5-one (1.70 g, 12.77 mmol) in DMF (20 mL) under nitrogen atmosphere was added NaH (60% dispersion in mineral oil, 982 mg, 24.55 mmol) in three portions, and the mixture was heated to 60 C, stirred for 1 h at thistemperature. Then N-benzyl-2-bromo-N-(2-bromoethyl)ethan-1-amine (4.54 g, 14.14 mmol) was added and stirred at 60 C for another 1 h. After cooling to RT, the reaction mixture was quenchedwith water (80 mL), extracted with EA (3 > 80 mL). The combined organic layers were washed with water (3 x 80 mL), dried over anhydrous Na2504, filtered and concentrated under reduced pressure. The residue was purified by silica chromatography (eluting with EA) to give1?-benzylspiro[cyclopenta[b]pyridine-6,4?-piperidin]-5(7H)-one (1.14 g). MS: m/z 293 (M+H).

The synthetic route of 24468-88-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JACOBIO PHARMACEUTICALS CO., LTD.; JACOBIO-ALPHA PHARMACEUTICALS CO., LTD.; MA, Cunbo; GAO, Panliang; HU, Shaojing; XU, Zilong; HAN, Huifeng; WU, Xinping; KANG, Di; LONG, Wei; (202 pag.)WO2018/172984; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 1347736-74-6,Some common heterocyclic compound, 1347736-74-6, name is 4,7-Dibromo-5-fluoro-2,1,3-benzothiadiazole, molecular formula is C6HBr2FN2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(2) a thiadiazole compound of the B-1 (4,7- dibromo-5-fluoro-benzo [c] [1,2,5]; 4,7-dibromo-5-fluorobenzo [c] [1,2,5] thiadiazole) (3.00 g, 9. 6 mmol), A-1Of the compound (3.84 g, 9.58 mmol),Pd2 (dba) 3 (0.174 g, 0.19 mmol), Then triphenylphosphine (triphenylphosphine) (0.202 g, 0.77 mmol) was dissolved in 100 mL of toluene was stirred for 48 hours at 80 .After the reaction, After lowered to normal temperature, into a 2M hydrochloric acid (HCl) and stirred for 1 hour.After the reaction was washed with dichloromethane (dichloromethane) and the solvent removed under reduced pressure. The resulting solid with chloroform (chloroform) to silica column purificationThe compounds of the orange A-2 (1.67 g, yield: 41%) was obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4,7-Dibromo-5-fluoro-2,1,3-benzothiadiazole, its application will become more common.

Reference:
Patent; LG Chem Co.Ltd.; Lim, Bo-Gyu; Bang, Ji-Won; Lee, Jae-Chol; Lee, Ji-Young; Kim, Jin-Seok; Cho, Geun; (37 pag.)KR2015/142609; (2015); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 10546-67-5,Some common heterocyclic compound, 10546-67-5, name is 2,6-Dibromo-4-(tert-butyl)aniline, molecular formula is C10H13Br2N, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirring solution of 2,6-dibromo-4-tert-butylaniline in 115 mL of EtOH was added 11.5 mL of concentrated H2SO4. To the stirring solution at 90 0C was added 8.8 g of NaNO2 in several portions. After 37 h, EtOAc and 120 mL of H2O were added, and the layers separated. The organic layer was washed with 40 mL of brine, dried over Na2SO4, filtered, and concentrated. Purification by flash silica gel chromatography (hexanes) provided 8.15 g of l,3-dibromo-5-tert-butylbenzene as a yellow-brown oil with some impurity.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2,6-Dibromo-4-(tert-butyl)aniline, its application will become more common.

Reference:
Patent; COMENTIS, INC.; PURDUE RESEARCH FOUNDATION; WO2009/42694; (2009); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 3975-77-7, name is 2-Bromo-1,3,5-tri-tert-butylbenzene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 3975-77-7, Recommanded Product: 3975-77-7

2,4,6-Tri-tert-butylbenzoicacid (mes*CO2H, S3). The Br/Liinterchange reaction between mes*Br and n-BuLi in Et2O (see above)was carried out according to the protocol of Staab and LauerS9 but with a reaction period shortened to lessthan 1 hour at room temperature. Afterpouring onto solid CO2 andaqueous workup, the acid fraction furnished mes*CO2H (S3, crude yield up to 75%); m.p.284-286 C (toluene), Ref. S9: 298-300 C.1H NMR (80 MHz, 2,4,6-Tri-tert-butylbenzoicacid (mes*CO2H, S3). The Br/Liinterchange reaction between mes*Br and n-BuLi in Et2O (see above)was carried out according to the protocol of Staab and LauerS9 but with a reaction period shortened to lessthan 1 hour at room temperature. Afterpouring onto solid CO2 andaqueous workup, the acid fraction furnished mes*CO2H (S3, crude yield up to 75%); m.p.284-286 C (toluene), Ref. S9: 298-300 C.1H NMR (80 MHz,

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Bromo-1,3,5-tri-tert-butylbenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Knorr, Rudolf; Rossmann, Eva C.; Knittl, Monika; Boehrer, Petra; Tetrahedron; vol. 70; 34; (2014); p. 5332 – 5338;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 10546-67-5, These common heterocyclic compound, 10546-67-5, name is 2,6-Dibromo-4-(tert-butyl)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Take 3g of 2,6-dibromo-4-tert-butylaniline, 80mg of PdCl2(PPh3)2, 40mg of CuI, add 100mL of triethylamine, under argon protection, then slowly add 840mg of 2-methyl-3- Butyn-2-ol was stirred at 50 C for 60 hours. After the solution was cooled to room temperature, ethyl acetate was added to the reaction mixture, which was filtered. Then, it was extracted with dichloromethane and water, and the solvent was evaporated from dichloromethane.4-(2-Amino-3-bromo-5-(tert-butyl)phenyl)-2-methylbut-3-yn-2-ol(Compound of the formula (III)).

The synthetic route of 10546-67-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shanxi Datong University; Yuan Yuehua; Zhu Yongjun; Tian Maozhong; Chen Zezhong; Qin Jun; Feng Feng; (15 pag.)CN109810019; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 2789-89-1, The chemical industry reduces the impact on the environment during synthesis 2789-89-1, name is 1,2-Bis(4-bromophenyl)ethyne, I believe this compound will play a more active role in future production and life.

Synthesis route a) 1 ,2-bis(4-bromophenyl)-3,4,5,6-tetraphenylbenzene A mixture of tetraphenylcydopentadienone (5.0 mmol), and bis(p-promophenyl) acetylene (5.0 mmol) in diphenyl ether (20 ml) was heated to 260 C overnight. Then the temperature was raised to 270 C. After 69 h, the reaction mixture was cooled, and methanol (100 ml) was added. After stirring for 1 h, the product was filtered off, washed with methanol, and finally dried in vaccuo overnight. Yield: Quantitative.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,2-Bis(4-bromophenyl)ethyne, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SINVENT AS; PAUCHARD, Vincent Olivier; WO2013/162381; (2013); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 61921-39-9, These common heterocyclic compound, 61921-39-9, name is 4-Bromotetraphene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

N 2 is bubbled and the 4 l flask is heat dried and 100 g (325.5 mmol) of 4-bromobenzo [a] anthracene is initially introduced into 1400 ml of anhydrous THF. The batch is cooled to -72 C. and 190 ml of 2.5 M n-butyllithium are rapidly added dropwise. In the process, it is warmed from -72 C. to -61 C. (addition time: 2 minutes). The reaction mixture is stirred for an additional 3 hours at -70 C.150 ml (637 mmol) triisopropylborate is immediately added to the solution via a dropping funnel, during which the batch is warmed to -68 C. The batch is subsequently stirred for 2 hours at -70 C. and then warmed to RT. The reaction solution is diluted with 1300 ml of ethyl acetate and 690 ml of water in a cleaned 6 l flask under N 2 flow and stirred for 60 min. The aqueous layer is subsequently separated off and the organic phase is washed twice with 750 ml of water each time. The organic phase is dried using Na 2 SO 4 and evaporated in a rotary evaporator with 70 ml of ethyl acetate solution.Yield 62.13 g(70% of the theoretical value).

The synthetic route of 61921-39-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MERCK PATENTGMBH; SPREITZER, HUBERT; SCHWAIGER, JOCHEN; BECKER, HEINRICH; VOGES, FRANK; HEIL, HOLGER; (117 pag.)JP5851999; (2016); B2;,
Bromide – Wikipedia,
bromide – Wiktionary