Tag: M.W=300-400

Related Products of 268733-18-2, These common heterocyclic compound, 268733-18-2, name is 4-Bromo-3,5-bis(trifluoromethyl)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Phosphorus trichloride (0.13ml, 1.5mmol) was added to a stirred solution of 3,5-bis(trifluoromethyl)aniline (0.47ml, 3mmol), a catalytic amount of pyridine and 5-chloro salicylic acid (621.3mg, 3.6mmol) in anhydrous toluene (10ml) in in a Radley?s Carousel reaction tube under an argon atmosphere. After the reaction mixture was refluxed for overnight, it was cooled to room temperature and aq. sodium bicarbonate was added dropwise until PH=6 – 7. After extracting with ethyl acetate, the organic layers was dried, dried (MgSO4) and concentrated in vacuo. After chromatography (EA-Hex, 1:10) of the crude product, and followed by recrystalization from EtOAc/hexane provided 2a as a white solid (320mg, 28%).

The synthetic route of 268733-18-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kang, Sunghyun; Min, Hye-Jin; Kang, Min-Seo; Jung, Myung-Geun; Kim, Semi; Bioorganic and Medicinal Chemistry Letters; vol. 23; 6; (2013); p. 1748 – 1751;,
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Electric Literature of 52997-43-0,Some common heterocyclic compound, 52997-43-0, name is 7-(Bromomethyl)pentadecane, molecular formula is C16H33Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 2,7-dibromopyrene-4,5,9,10-tetraone (0.50 g, 1.2 mmol), n-Bu4NBr (0.50 g, 1.5 mmol), Na2S2O4 (2.5 g, 14 mmol), THF (8 mL), and H2O (4 mL) is stirred at 25 C. for 10 minutes 1-Bromo-2-hexyldecane (1.7 g, 7.9 mmol) and aqueous potassium hydroxide (4 mL, 36 mmol) are added to the solution and the mixture is stirred at 70 C. for 5 h. Then, THF and brine are added and the organic phase is washed with brine (3 times) and dried over MgSO4 and concentrated in vacuum. The residue is purified by column chromatography (SiO2, hexane: CH2Cl2=10:1) to give a colorless oil (0.62 g) in 53% yield. [0194] FD-MS (8 KV): m/z 986.3 (100%), calculated 985.1. [0195] 1H-NMR (CD2Cl2, 250 MHz): delta=0.84-0.86 (m, 24H), 0.98-1.00 (m, 12H), 1.47-2.00 (m, 40H), 4.23-4.36 (m, 8H), 8.50 (s, 4H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 7-(Bromomethyl)pentadecane, its application will become more common.

Reference:
Patent; BASF SE; Kawano, Shin-Ichiro; Baumgarten, Martin; Muellen, Klaus; Murer, Peter; Schaefer, Thomas; Saleh, Moussa; US2014/357898; (2014); A1;,
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Reference of 10546-67-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10546-67-5, name is 2,6-Dibromo-4-(tert-butyl)aniline belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a mixtureof 500 mL of 96 % ethanol and 133 mL of 98 % H2SO4, 26.14g (89.2 mol) of 2,6-dibromo-4-isopropylaniline (S12n) was added withvigorous stirring at -5 C over 15 min. Then, 16.864 g of NaNO2 wasadded at this temperature over 1 h, and the resulting mixture was stirred at 80C overnight. Then, ice water was added to the reaction system and the organicproduct was extracted with 4 × 400 ml of dichloromethane. The combined extractwas dried over Na2SO4 and evaporated to get compound1,3-dibromo-5-isopropylbenzene (15.7 g, 63 %).

The synthetic route of 2,6-Dibromo-4-(tert-butyl)aniline has been constantly updated, and we look forward to future research findings.

Reference:
Article; Yu, Lei; Huang, Minhao; Xu, Tianfeng; Tong, Linjiang; Yan, Xiao-e; Zhang, Zhang; Xu, Yong; Yun, Caihong; Xie, Hua; Ding, Ke; Lu, Xiaoyun; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 1107 – 1117;,
Bromide – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 4101-68-2, name is 1,10-Dibromodecan, A new synthetic method of this compound is introduced below., Computed Properties of C10H20Br2

General procedure: For example, to a solution of 7-hydroxycoumarin (5.0 g, 31.0 mmol) in acetone (60.0 mL) was added anhydrous K2CO3 (6.9 g, 50.0 mmol) and triethylamine (1.0 mL) at room temperature. After stirring at room temperature for 30 min, 1, 2-dibromoethane (12.6 g, 62.0 mmol) was added to the reaction mixture, and the whole was refluxed at 60C for 24 h. Then the reaction mixture was filtered, and the filtrate was evaporated under reduced pressure. The residue was treated with water (200.0 mL) and extracted with dichloromethane (4×200.0 mL). The organic layer was combined, dried with anhydrous Na2SO4, and concentrated under reduced pressure. The crude product was purified via silica gel column chromatography with mixed petroleum ether and ethyl acetate (5:1, v/v) as eluent, and resulted in a white solid.

The synthetic route of 4101-68-2 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Hu, Yang; Chen, Weichao; Shen, Yufeng; Zhu, Bin; Wang, Gao-Xue; Bioorganic and Medicinal Chemistry Letters; vol. 29; 14; (2019); p. 1749 – 1755;,
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Synthetic Route of 10016-52-1, A common heterocyclic compound, 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, molecular formula is C12H6Br2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 10 Synthesis of Compound 5 To a 20 mL DMSO solution of 2,8-dibromodibenzofuran (1 g, 3.07 mmol) was added bispinacolatiodiboron (1.74 g, 6.75 mmol), KOAc (2 g, 21 mmol) and PdCl2(PPh3)2 (149 mg, 0.21 mmol), and the solution was stirred at 80 C. for 24 h. The catalyst was removed by filtration and washed with CH2Cl2 after the reaction mixture was cooled to room temperature. The filtrate was then washed with de-ionized H2O (50 mL) for five times, and the organic layer was dried over Mg2SO4, filtrated, concentrated and purified by column chromatography on silica gel (hexane/EtOAc=10:1) to give 2,8-bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)dibenzofuran (0.4 g, 31%). 1H NMR (400 MHz, CDCl3) delta 8.51 (s, 2H), 7.92 (d, 2H), 7.57 (d, 2H), 1.40 (s, 24H).

The synthetic route of 10016-52-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GENERAL ELECTRIC COMPANY; US2009/289224; (2009); A1;,
Bromide – Wikipedia,
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Reference of 1295502-53-2,Some common heterocyclic compound, 1295502-53-2, name is 4,7-Dibromo-5,6-difluorobenzo[c][1,2,5]thiadiazole, molecular formula is C6Br2F2N2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a 25 mL dry two-necked flask was added 4,7-dibromo-5,6-difluorobenzo[c][1,2,5]thiadiazole (327 mg, 1 mmol). Tributyl(4-hexyl-2-thienyl)stannane (1.130 g, 2.5 mmol), and dissolved in dry and deoxygenated tetrahydrofuran (15 mL), The system replaces the air three times with nitrogen. Then tetrakis(triphenylphosphine)palladium Pd(PPh3)4 (50 mg, 0.04 mmol) was added to the system. Replace the air three times with nitrogen again, Heating to 110 C reflux for 72 hours; After cooling, the substance is loaded onto the silica gel. Purification using hexane/chloroform (4:1) as mobile phase silica gel column chromatography. Obtained 0.232 g of a yellow solid;

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4,7-Dibromo-5,6-difluorobenzo[c][1,2,5]thiadiazole, its application will become more common.

Reference:
Patent; Nanchang Hangkong University; Qin Yuancheng; He Anwang; Du Wanjun; Zhou Dan; (21 pag.)CN109836437; (2019); A;,
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Adding a certain compound to certain chemical reactions, such as: 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 10016-52-1, Product Details of 10016-52-1

2,8-Dibromodibenzofuran (1) (0.5 g, 1.53 mmol), 3,6-di-tert-butyl-9H-carbazole (2) (1.30 g, 4.66 mmol), Pd(OAc)2 (0.02 g, 0.096 mmol), tri-tert-butylphosphine solution (1.0 M in toluene) (0.06 g, 0.29 mmol), potassium tert-butoxide (0.29 g, 3.02 mmol) and 20 ml of dry toluene were heated at 110 C for 24 h under nitrogen. After cooling, the reaction mixture was diluted with ethyl acetate and the organic phase was washed with water and brine. After being dried over NaSO4 and filtered, the solvent was removed and the residue was purified by column chromatography using nhexane/ ethylacetate (7:1) as an eluent and crystallized from the eluent mixture of solvents to obtain DBO as white solid (0.54 g, yield: 49%); m.p. 155-156 C. 1H NMR (400 MHz, CDCl3, ppm): delta 8.10 (d, 3H, J 2.1 Hz, Ar), 8.02 (d, 1H, J 2.1 Hz, Ar), 7.85 (d, 1H, J 8.6 Hz, Ar), 7.68 (d, 1H, J 8.6 Hz, Ar), 7.60e7.50 (m, 3H, Ar), 7.47-7.38 (m, 5H, Ar), 7.26e7.20 (m, 3H, Ar), 7.17 (s, 1H, Ar), 1.40 (s, 36H, 12 -CH3). 13C NMR (75.4 MHz, CDCl3, ppm): delta 156.9, 154.8, 142.8, 139.9, 133.1, 127.8, 126.3, 125.6, 123.9, 123.6, 123.1, 120.9, 119.4, 116.2, 112.7, 111.9, 109.1, 34.7, 32.1. MS (APCI, 20 V), m/z: 724 ([M+H]+). Elemental analysis: calcd (%) for C52H54N2O: C 86.38, H 7.53, N 3.87, O 2.21; found C 86.43, H 7.54, N 3.81.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Gudeika, Dalius; Volyniuk, Dmytro; Grazulevicius, Juozas V.; Skuodis, Eigirdas; Yu, Sian-Yin; Liou, Wei-Tong; Chen, Li-Yin; Shiu, Yi-Jiun; Dyes and Pigments; vol. 130; (2016); p. 298 – 305;,
Bromide – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, A new synthetic method of this compound is introduced below., HPLC of Formula: C12H6Br2O

A mixture of 10 g (30.7 mmol) of 2,8-dibromodibenzo[b,d]furan, 6.07 g (30.7 mmol) of [1,1?-biphenyl]-2-ylboronic acid, 0.35 g (0.3 mmol) of Pd(Ph3)4, 30.7 ml of 2M Na2CO3, 80 ml of EtOH and 160 ml of toluene was degassed and placed under nitrogen, and then heated to reflux for 12 hrs. After the reaction finished, the mixture was allowed to cool to room temperature. Subsequently, the solvent was removed under reduced pressure, and the crude product was purified by column chromatography, yielding 6.8 g of 2-([1,1?-biphenyl]-2-yl)-8-bromodibenzo[b,d]furan as white solid (55.5%). 1H NMR (CDCl3, 400 MHz): chemical shift (ppm) 8.19(s, 1H), 7.88-7.81 (m, 5H), 7.74-7.72 (s, 2H), 7.52-7.39 (m, 7H)

The synthetic route of 10016-52-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LUMINESCENCE TECHNOLOGY CORPORATION; Yen, Feng-Wen; Chuang, Li-Chieh; (84 pag.)US2020/111971; (2020); A1;,
Bromide – Wikipedia,
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Related Products of 626-39-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 626-39-1 as follows.

Synthesis of Compound 1: Anhydrous DMF (10 mL) was purged with N2 and then transferred via a cannula into a three-neck round bottomed flask charged with 1, 3, 5-tribromobenzene (1.00 g, 3.17 mmol) and bis (pinacolato) diboron (2.54 g, 9.53 mmol) . Potassium acetate (1.87 g, 19.0 mmol) and Pd(dppf)Cl2 (0.087 g, 0.12 mmol) were then quickly added into the flask. The resulting mixture was stirred vigorously and heated at 90 C for 24 hours. After cooling down to room temperature, deionized water (120 mL) was added. Black precipitate was collected by filtration, and washed with deionized water three times, which was dried under vacuum (98% yield) .

According to the analysis of related databases, 626-39-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; THE REGENTS OF THE UNIVERSITY OF CALIFORNIA; YAGHI, Omar, M.; ZHANG, Yuebiao; DENG, Hexiang; WO2015/157239; (2015); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 1347736-74-6,Some common heterocyclic compound, 1347736-74-6, name is 4,7-Dibromo-5-fluoro-2,1,3-benzothiadiazole, molecular formula is C6HBr2FN2S, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A dried flask was charged with 4,7-Dibromo-5-fluoro-2,1,3-benzothiadiazole (3.0 g, 9.6 mmol), compound 5(3.83 g, 9.58 mmol), Pd2dba3 (0.174 g, 0.19 mml), PPh3 (0.202 g,0.77 mmol) and 100ml of toluene. The reaction mixturewas heatedto 80 C for 48 h. Upon cooling, 30 mL of 2 M HCl was added andthen stirred for 1 h. After extract with dichloromethane, the solventwas removed by vacuum evaporation, and then recrystallized withchloroform/methanol and filtered. The solid was washed withcopious methanol, and dried under vacuum for 24 h. Compound 6was a red solid.Yield: 40.9% (1.67 g). 1H NMR (CDCl3, 500 MHz, [ppm]): delta 9.904(s, 1H), 8.066 (d, 1H, J 4 Hz), 7.764 (m, 2H), 7.458 (d, 1H, J 4 Hz),7.392 (d, 1H, J 4 Hz); APCI: m/z 425.0, calcd 423.88.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4,7-Dibromo-5-fluoro-2,1,3-benzothiadiazole, its application will become more common.

Reference:
Article; Lim, Bogyu; Sun, Huabin; Noh, Yong-Young; Dyes and Pigments; vol. 146; (2017); p. 520 – 528;,
Bromide – Wikipedia,
bromide – Wiktionary