Tag: M.W=300-400

These common heterocyclic compound, 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 4-(4-Bromophenyl)dibenzo[b,d]furan

Under an argon atmosphere, the intermediate body 3H-1 (2.36 g, 7.3 mmol), an intermediate body 3H-2 (3.0 g, 7.3 mmol), CuI (1.4 g, 7.3 mmol), tripotassium phosphate (2.3 g, 11 mmol), anhydrous dioxane (30 mL), and cyclohexanediamine (0.84 g, 7.3 mmol) were loaded in the stated order into a three-necked flask, and were then stirred at 100 C. for 8 hours. Water was added to the reaction liquid to precipitate a solid, and then the solid was washed with hexane and then with methanol. Further, the resultant solid was purified by silica gel column chromatography. Thus, a compound 3H (2.9 g, 60% yield) was obtained. The result of FD-MS analysis confirmed that the compound had a ratio m/e of 650 with respect to its molecular weight, i.e., 650.

The synthetic route of 4-(4-Bromophenyl)dibenzo[b,d]furan has been constantly updated, and we look forward to future research findings.

Reference:
Patent; IDEMITSU KOSAN CO. LTD.; UNIVERSAL DISPLAY CORPORATION; Yamamoto, Hitoshi; Weaver, Michael S.; Brown, Julia J.; Nishimura, Kazuki; Iwakuma, Toshihiro; (76 pag.)US9966541; (2018); B2;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 18648-66-3, name is 2-(4-Bromophenyl)-1,1-diphenylethylene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 18648-66-3, COA of Formula: C20H15Br

General procedure: A mixture of 1-bromo-4-(2,2-diphenylvinyl)benzene (1) (2.0 g, 5.97 mmol) and phenylboronic acid (873 mg, 7.16 mmol) was dissolved in toluene (15 mL) under argon atmosphere. Aqueous solution of K2CO3 (2 mL, 2 M), tricaprylylmethylammoniumchloride (Aliquat336) (3 drops) and Pd(PPh3)4 (10 mg) was added to the mixture. The reaction mixture was heated at 90C for 6 h. After being cooled to room temperature, distilled water (5 mL) was added and extracted with dichloromethane (310 mL). Organic layer was dried over anhydrous Na2SO4. The solvent was removed under reduced pressure, the residue was purified using column chromatography (silica gel, ethyl acetate/petroleum ether 5:95) afforded 2 (240 mg, 85%) as a white solid. Mp 97-98C; IR (KBr,cm-1): 3015, 1601, 1493; 1H NMR (300 MHz, CDCl3): delta 7.53 (d, 2H, J=7.5 Hz), 7.42-7.20 (m, 15H), 7.08 (d, 2H, J=7.5 Hz), 6.99 (s, 1H); 13C NMR (75 MHz, CDCl3): delta 143.2, 142.5, 140.4, 140.3, 139.1, 136.3, 130.0, 129.9, 128.7, 128.6, 128.1, 127.6, 127.5, 127.45, 127.4, 126.7, 126.4; LCMS (EI): m/z 333 (MH+, 100%); Anal. Calcd for C26H20: C,93.94; H, 6.06. Found: C, 93.88; H, 6.09.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-Bromophenyl)-1,1-diphenylethylene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Jana, Debabrata; Boxi, Shatabdi; Ghorai, Binay K.; Dyes and Pigments; vol. 99; 3; (2013); p. 740 – 747;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 626-39-1, name is 1,3,5-Tribromobenzene, A new synthetic method of this compound is introduced below., SDS of cas: 626-39-1

The synthesis processof PHT was the same as TPAT only used 1,3,5-Tribromobenzene(0.41 g, 1.3 mmol) to replace Tris(4-bromophenyl)amine and PHT was obtained as a white powder (0.38 g, yield 91%). MALDI-TOFMS(M) (m/z):325.7 [M + H]+. 1H NMR (500 MHz, CDCl3) delta 7.76(s, 1H), 7.43 (dd, J = 3.6, 1.2 Hz, 1H), 7.36 (dd, J = 5.1, 1.1 Hz, 1H),7.15 (dd, J = 5.0, 3.6 Hz, 1H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Li, Weijun; Chen, Lan; Pan, Yuyu; Yan, Shuanma; Dai, Yuyu; Liu, Jin; Yu, Yue; Qu, Xingxing; Song, Qingbao; Ouyang, Mi; Zhang, Cheng; Journal of the Electrochemical Society; vol. 164; 4; (2017); p. E84 – E89;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 88223-35-2, name is 2-Bromo-9,9-dibutyl-9H-fluorene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 88223-35-2, name: 2-Bromo-9,9-dibutyl-9H-fluorene

General procedure: 2-Bromo-9,9-dialkylfluorene (10.0 mmol, 1a, 1b or 1c) was dissolved in CH2Cl2 (60 mL), in the presence of a supported catalystof SiO2/H2SO4 (4.60 g) prepared according to the literature procedure.31 HNO3 (417 mL, 10.0 mmol) was added, and the heterogeneous mixture was stirred at room temperature for 10 min. The solution was then filtered, and the filtrate was washed with aqueous saturated NaHCO3 solution (10 mL) and water (10 mL). The organic layer was dried over anhydrous MgSO4 and the solvent was evaporated under reduced pressure.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-9,9-dibutyl-9H-fluorene, and friends who are interested can also refer to it.

Reference:
Article; Lazar, Laszlo; Nagy, Miklos; Racz, David; Zsuga, Miklos; Keki, Sandor; Tetrahedron; vol. 70; 23; (2014); p. 3691 – 3699;,
Bromide – Wikipedia,
bromide – Wiktionary

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 18648-66-3, name is 2-(4-Bromophenyl)-1,1-diphenylethylene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. name: 2-(4-Bromophenyl)-1,1-diphenylethylene

To a reaction vessel purged with nitrogen, 8.11 g of 2- (4-bromophenyl) -1,1-diphenylethylene, 4.24 g of 1,2,3,3a, 4,8b-hexahydrocyclopenta [b] indole, 56 mL of xylene was added, and 0.127 g of triphenylphosphine, 5.43 g of potassium t-butoxide, and 0.27 g of palladium acetate were added, followed by degassing under reduced pressure. The reaction was carried out for 10 hours while stirring at 125 C. Cool to 50 C, add 9.4 g of activated clay,After stirring for 1 hour, suction filtration was performed, 100 mL of water was added, and the mixture was stirred to extract an organic layer. The organic layer was washed with water, separated, dried over sodium sulfate, and concentrated under reduced pressure to obtain an oily crude product. The crude product was purified by column chromatography (carrier: silica gel, eluent: hexane / toluene = 10/1 (volume ratio)) to obtain a yellow solid (9.98 g). 2 g of the obtained yellow solid was brominated according to a conventional method to obtain 2.35 g of a bromo compound represented by the following formula (10).

The synthetic route of 18648-66-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hodogaya Chemical Industry Co., Ltd.; Okaji, Makoto; (40 pag.)JP2020/15898; (2020); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 1295502-53-2, The chemical industry reduces the impact on the environment during synthesis 1295502-53-2, name is 4,7-Dibromo-5,6-difluorobenzo[c][1,2,5]thiadiazole, I believe this compound will play a more active role in future production and life.

(1) Formula (IIb) the compounds of formula [brief records compound (IIb), the cartridge] (3.68 g, 11 . 60 mmol) dissolved in 200 ml anhydrous alcohol, under stirring at room temperature slowly adding NaBH4(4.52 G, 116.0 mmol), room temperature reaction 6 h. Adding water steaming and remove the anhydrous ethanol (100 ml) and methylene chloride (100 ml), the standing liquid, organic phase dried with anhydrous sodium sulfate, rotary evaporated to remove the dichloromethane to obtain white solid [compound IIIc] 2.84 g, yield 81.0%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4,7-Dibromo-5,6-difluorobenzo[c][1,2,5]thiadiazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; East China University of Science and Technology; Zhu Weihong; Wu Yongzhen; Zhang Hao; Li Erpeng; Shen Chao; Jiang Huiyun; Yang Zhuoran; Xu Zixing; (14 pag.)CN108191777; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1347736-74-6, name is 4,7-Dibromo-5-fluoro-2,1,3-benzothiadiazole, A new synthetic method of this compound is introduced below., category: bromides-buliding-blocks

To 150 ml of ethanol was added 4,7-dibromo-5-fluoro-2,1,3-benzothiadiazole (4,7-dibromo-5-fluoro-2,1,3- Benzothiadiazole (5 g, 0.016 mol) was dissolved, and sodium borohydride (12.1 g, 0.32 mol) was added at 0 C And stirred at room temperature for 20 hours. After evaporating the solution, 160 ml of water were added and the mixture was extracted with ethyl acetate. The extract was washed with brine, dried over magnesium sulfate and the residue was purified by silica column chromatography (hexane / ethyl acetate (25: 1)) to give 3,6-dibromo-4-fluoro

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; LG CHEM, LTD.; KIM, JIN-SEOK; LEE, JAE-CHOL; LEE, HANG-KEON; LIM, BO-GYU; (33 pag.)KR2017/50088; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 3344-70-5, The chemical industry reduces the impact on the environment during synthesis 3344-70-5, name is 1,12-Dibromododecane, I believe this compound will play a more active role in future production and life.

EXAMPLE 30 N, N’-Dodecane-1, 12-diyl-bis-isoquinolinium Dibromide (bIQDDB). 1, 12-Dibromododecane (mmol) was added to a solution (30 mL) of isoquinoline, and the solution heated for 24 hours at 65 C. The resulting precipitate was filtered, and the product washed five times with dry diethyl ether. The resulting off-white solid was isolated.’H NMR (300 MHz, DMSO-D6) S 10.06 (1H, d, C1-H), 8.78 (1H, d, C3-H), 8.58 (1H, d, C8-H), 8.48 (1H, d, C4-H), 8. 35 (1H, d, C7-H), 8.25 (1H, t, C5-H), 8.07 (1H, t, C6-H), 4.70 (2H, t, C’1-CH2), 2.0 (2H, m, C’2-CH2), 1.75 (1H, m, C’3-CH2), 1.15-1. 40 (7H, m, C’3-6-CH2).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,12-Dibromododecane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION; WO2005/66129; (2005); A2;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 3344-70-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3344-70-5, name is 1,12-Dibromododecane belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a stirred solution of n-dibromoalkane (1 equiv.) in anhydrous THF (0.1M) under an argon atmosphere was added tert-BuOK (1.15 equiv.) in portionwise over 30 min. After being stirred under reflux for 16h, the reaction was cooled and subsequently quenched with water. The resulting mixture was then diluted with diethylether, and the layers were separated. The aqueous layer was extracted several times with diethylether, and the combined organic layers were washed with brine, dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The resultant crude product was purified by flash column chromatography over silica gel using petroleum ether as eluent to afford the desired product.

The synthetic route of 1,12-Dibromododecane has been constantly updated, and we look forward to future research findings.

Reference:
Article; Saied, Essa M.; Le, Thuy Linh-Stella; Hornemann; Arenz, Christoph; Bioorganic and Medicinal Chemistry; vol. 26; 14; (2018); p. 4047 – 4057;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 52997-43-0, name is 7-(Bromomethyl)pentadecane, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 52997-43-0, Computed Properties of C16H33Br

TPh (1.6 g, 5.3 mmol), potassium carbonate (3.68 g, 26.7 mmol), potassium iodide (0.044 g, 0.3 mmol) and N, N-dimethylformamide (hereinafter abbreviated as ” DMF) (10 mL) and stirred at room temperature. Then 2-n-hexyl-1-bromodecane (2.1 g, 6.9 mmol) was added dropwise. After completion of the dropwise addition at room temperature overnight. After the reaction was completed, the mixture was extracted with water and methylene chloride and concentrated. Separation and purification on a silica gel column gave 1.23 g of 1- (2-hexyldecyl) -2- (thiophen-2-yl) -1H-phenan- thro [9,10- (Hereinafter referred to as TPh-C16). Yield 50.2%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 7-(Bromomethyl)pentadecane, and friends who are interested can also refer to it.

Reference:
Patent; Nanjing University of Posts and Telecommunications; Wang Lianhui; Zhao Baomin; Zhai Liuqing; He Cong; Wang Suiliang; Fu Nina; (11 pag.)CN105820169; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary