Tag: M.W=300-400

Application of 955959-84-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

In an argon atmosphere, in a three-necked 100mL flask, compound (x) 0.8g, the compound (xi) 0.54g, bis(dibenzylideneacetone)palladium (0) (Pd(dba)2) 0.06g, tri-t-butylphosphine ((t-Bu)3P) 0.12g, was added to sodium t-butoxide 0.3g, was heated under reflux for 7 hours in 30mL of toluene solvent. After air-cooling, water was added The organic layer was separated, and the solvent was distilled off. The crude product thus obtained was purified by silica gel column chromatography (dichloro methane and using a mixed solvent of hexane) was subjected to recrystallization with toluene and hexane mixture solvent to give the compound A-35 as a white solid 0.95g (80percent yield)

The synthetic route of 4-(4-Bromophenyl)dibenzo[b,d]furan has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Samsung DisplayCo., Ltd.; Huchiwaki, Junta; Oyama, Hiromi; Miyata, Yasuo; Sakamoto, Naoya; Ueno, Masatsuku; Takada, Echinori; (155 pag.)KR2015/90021; (2015); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 19190-91-1, name is 5,6-Dibromo-1,2-dihydroacenaphthylene, A new synthetic method of this compound is introduced below., COA of Formula: C12H8Br2

The preparation method of the raw material A (4,5-dibromoacenaphthene) is as follows: In a 1000 mL two-necked flask, 18.72 g (60 mmOl) of 4,5-dibromofluorene and 500 mL of acetic anhydride were added, stirred and heated to 110 C, and a solution of chromium trioxide in acetic anhydride (46.4 g of three) was slowly added dropwise over about two hours. The chromium oxide is dissolved in 300 mL of acetic anhydride). After the completion of the dropwise addition, the temperature was raised to 160 C and the reaction was continued for 30 minutes. After the reaction was completed, the reaction solution was poured into a beaker containing 1000 g of crushed ice, and stirred to dissipate heat, and then 20 mL of concentrated hydrochloric acid was slowly added dropwise, and the mixture was decompressed. After filtration, a yellow solid was obtained, then the residue was recrystallized from acetic acid, and filtered, and then filtered to give a dark brown solid 5.21 g, yield: 25·54%.

The synthetic route of 19190-91-1 has been constantly updated, and we look forward to future research findings.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, A new synthetic method of this compound is introduced below., Recommanded Product: 955959-84-9

To a round bottom flask was added 4- (4-bromophenyl) dibenzofuran (1.23 g, 3.8 mmol), aminobiphenyl (0.71 g, 4.19 mmol)sodium tert-butoxide (0.512 g, 5.33 mmol),tris (dibenzylideneacetone) dipalladium (0) (0.07 g, 0.076 mmol) was dissolved in 50 ml of toluene. tri-tert-butylphosphine (0.03 g, 0.15 mmol) was added and the mixture was refluxed for 24 hours.After confirming with HPLC and LC-MASS, the reaction was terminated. After removal of the solvent, it was extracted with MC / H2O. column (EA: Hex = 1: 4) and reprecipitated with MC / hexane. Vacuum drying and sublimation purification were conducted to obtain a solid compound (1.25 g, yield = 80%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; LG Display Co., Ltd.; Choi Hye-ok; Lee Seung-jae; Pin Jong-gwan; Seo Bo-min; (39 pag.)KR2018/44695; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 10016-52-1, The chemical industry reduces the impact on the environment during synthesis 10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, I believe this compound will play a more active role in future production and life.

The second scheme: to 250 ml three-mouth bottle adding 2.36g (3.8 × 10-3Mol) precursor 3 (through the implementation of example three preparation) and 0.5g (1.53 × 10-3Mol) 2, 8 – dibromodiphenyl benzofuran, adding 100g toluene. Opening stirring, system for the picture and the turbid, N2Replacement system 10min. In the system by adding 0.37g (3.84 × 10-3Mol) tertiary butyl alcohol sodium, 0.045g (6.14 × 10-5Mol) Pd (dppf) Cl2And 0.025g (1.24 × 10-4Mol) tri-butyl phosphine, 110 C reaction 20 hours. The said technological, cooling to 20 – 25 C, the reaction liquid filtration, filtrate directly filtering of the silica gel column, eluting with toluene, the solvent under reduced pressure, the crude product shall be light brown red foam. In the above-mentioned crude product is added n-hexane and toluene recrystallization (mass ratio of 4:1), gain the light yellow powdery product 1.7g, yield: 65%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,8-Dibromodibenzo[b,d]furan, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; CECEP Wanrun Co., Ltd.; Ren Huicai; Pang Maoyin; Yang Fushan; Tian Shaozhen; Shi Rujin; Hu Baohua; (14 pag.)CN105153085; (2017); B;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 955959-84-9, The chemical industry reduces the impact on the environment during synthesis 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, I believe this compound will play a more active role in future production and life.

Intermediate M-1 15g (46.4mmol) in a round bottom flask and 9,9-Dimethyl-9H-fluoren-2-ylamine 4.8g (23.2mmol),sodium-t- butoxide 6.7g (69.6mmol) ofIt was dissolved in toluene into a 185ml. Here Pd (dba) 2 0.53g (0.928mmol) and tri-tert-butylphosphine was placed to 0.38g (1.86mmol) in turn and the mixture was stirred under reflux for 4 hours under a nitrogen atmosphere. After completion of the reaction and then extracted with toluene the organic layer was dried and distilled over magnesium sulfate, filtered and the filtrate was concentrated under reduced pressure. The product n- hexane / dichloromethane (8: 2 by volume) to give compound 8 as a purification by a silica gel column chromatography as a white solid 14.4g (90percent yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(4-Bromophenyl)dibenzo[b,d]furan, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; SAMSUNG SDI CO., LTD.; JANG, YU NA; HONG, JIN SEOK; KIM, YOUNG KWON; YU, EUN SUN; KIM, CHANG WOO; KIM, HUN; MIN, SOO HYUN; CHO, PYEONG SEOK; (38 pag.)KR2016/12846; (2016); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 2789-89-1,Some common heterocyclic compound, 2789-89-1, name is 1,2-Bis(4-bromophenyl)ethyne, molecular formula is C14H8Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A glass tube equipped with a magnetic stir bar was charged with isoxazole 1 (0.2 mmol), alkyne 2 (0.62 mmol, 3.1 equiv),[Cp*Rh(MeCN)3](SbF6)2 (0.008 mmol, 4.0 mol%), and Cu(OAc)2 (0.8mmol, 4.0 equiv). The tube was evacuated and backfilled with N2 (3 ×)followed by addition of 1,4-dioxane (4.0 mL) via syringe. The resulting mixture was heated at 100 C for 12 h. After cooling to r.t., the mixture was poured into water and extracted with EtOAc (3 ×). The combined organic extracts were washed with brine, dried (Na2SO4), andc oncentrated under reduced pressure. The residue was subjected to column chromatography (silica gel) to afford the corresponding product .Further purification was performed by GPC if required. Note: the coupling products 3 exhibit broadened and split peaks inNMR spectra owing to the presence of rotamers, and the following data are reported as appeared in the spectra.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,2-Bis(4-bromophenyl)ethyne, its application will become more common.

Reference:
Article; Noguchi, Teppei; Nishii, Yuji; Miura, Masahiro; Synthesis; vol. 51; 1; (2019); p. 258 – 270;,
Bromide – Wikipedia,
bromide – Wiktionary

Adding a certain compound to certain chemical reactions, such as: 19190-91-1, name is 5,6-Dibromo-1,2-dihydroacenaphthylene, belongs to bromides-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 19190-91-1, HPLC of Formula: C12H8Br2

General procedure: Dibromoarene 1 (0.5 mmol), alkyne 2 (0.6 mmol), Pd(OAc)2 (5 mol%, 5.6 mg ),Xantphos (5.5 mol%,16 mg), K2CO3 (1.5 mmol, 207 mg) were added into a Schlenkflask. The flask was evacuated and backfilled with nitrogen (3 cycles). Dry DMF (5mL) was added by syringe. The mixture was heated to 120 C and stirred until thereaction finished (TLC analysis). After cooling to room temperature, the mixture wasextracted three times with ethyl acetate. The organic layers were combined and driedover Na2SO4. After filtration, the solvents were evaporated. The crude product wasfurther purified by silica gel chromatography, using petroleum ether and ethyl acetateas eluents to provide the pure product

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; An, Wenbo; Li, Gaoqiang; Ma, Jun; Tian, Youping; Xu, Feng; Synlett; vol. 25; 11; (2014); p. 1585 – 1590;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 52997-43-0, name is 7-(Bromomethyl)pentadecane, A new synthetic method of this compound is introduced below., Safety of 7-(Bromomethyl)pentadecane

General procedure: The general procedure for the alkylation of fluorene (C-alkylation) is as follows. A two-neck flask with a three-way stopcock and a rubber septum was charged with fluorene (4mmol, 0.664 g) and dry THF (20 mL). KOtBu (12mmol, 1.346 g) was added to the flask at room temperature, then the mixture was heated at reflux for 20min. The flask was allowed to reach room temperature with stirring for 30min. 1-Bromododecane (8.8mmol, 2.20 g) was slowly added to the reaction mixture at 0 C, then again the flask was allowed to reach room temperature with stirring for overnight. 2.2.1 The First Posttreatment: After checking TLC and the 1HNMR spectrum, the reaction mixture refluxed for one hour. The reaction was quenched by the addition of sat. NH4Cl aqueous solution, extracted into n-hexane (50 3 mL), was hed successively with water, brine, dried (anhydrous Na2SO4) and concentrated by rotary evaporator to afford the reaction mixture(including the target dialkylated fluorene and olefin.). 2.2.2 The Second Posttreatment: 2-(a): To a mixtureof the crude mixture of the first posttreatment, 5wt% Pd/C(0.100 g) and acetic acid (AcOH, 4mmol) in THF (10 mL) were slowly added portionwise NaBH4 (4mmol, 0.151 g), andthe resulting mixture was stirred at room temperature for 12 hours. Thereafter, the mixture was filtered and the precipitate was washed with hexane and concentrated by rotary evaporatorfor NMR measurement. 2-(b): Since the alkylation was an almost quantitative reaction, the expected amount of olefin in the mixture was equalto the excess amount of starting alkyl halide (0.8mmol in the above case). It could be assumed that 0.8 mmol of olefin should be treated with the small excess of 9-BBN (1.2mmol, 1.5 eqvs olefin). A two neck flask with a three-way stopcock and a rubber septum was charged with the above reaction mixture and dry THF (20 mL). 0.5M 9-BBN in THF (1.2mmol, 2.4mL) was added to the flask at 0 C and then the flask was allowed to warm to room temperature and stirred for one hour. To quench the remaining 9-BBN in the reaction, aminoalcohol (2-dimethylaminoethanol, 0.5mmol, 0.045 g) was added to the flask and stirred for another hour. 39 The final reaction mixture was quenched by the addition of water (5 mL), extracted into EtOAc (50 3 mL), washed successively with water, brine, dried (anhydrous Na2SO4) and concentrated by rotary evaporator to afford the crude mixture. 2.2.3 The Third Posttreatment: The crude product was purified on short silica-gel [5 cm (diameter of column) 10 cm (length of deposition of silica-gel) was enough for this scale] with n-hexane as eluent to give the dialkylated fluorene.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Okamoto, Ken; Lu, Fengniu; Nakanishi, Takashi; Bulletin of the Chemical Society of Japan; vol. 91; 8; (2018); p. 1258 – 1263;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 615-54-3, These common heterocyclic compound, 615-54-3, name is 1,2,4-Tribromobenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[00149] A suspension of compound 1 (27.0 g, 85.7mmol), potassium vinyltrifluoroborate (compound 4) (41.4 g, 0.31 mol), PdCI2 (0.76g, 4.3mmol), Cs2C03 (125.6 g, 0.39 mol) and PPh3 (3.38g, 12.9mmol) in a mixture of THF and water (400ml_, THF/H20 9:1 ) was heated at reflux for 17h under a nitrogen atmosphere. The reaction was cooled to room temperature and the solvent removed by evaporation. The residue obtained was diluted with water (300ml_) and extracted with ethyl acetate (100ml_ x 3). The combined organic extracts were washed with water (200mL) and brine (100ml_), dried (Na2S04) and concentrated to give the crude product, which was purified by column chromatography (neat petroleum ether), illustrated below, to afford compound 5 (1 1.40g, 85%) as an oil.

The synthetic route of 615-54-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BOULOS & COOPER PHARMACEUTICALS PTY LTD; BOULOS, Ramiz; FEUTRILL, John; (105 pag.)WO2017/27933; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 3344-70-5, The chemical industry reduces the impact on the environment during synthesis 3344-70-5, name is 1,12-Dibromododecane, I believe this compound will play a more active role in future production and life.

General procedure: A suspension of lithium acetylide ethylenediamine complex (247 mg, 2.70 mmol) in dry DMSO (4 mL) was stirred for 10 min at room temperature under nitrogen. After the mixture was cooled to 8 °C, 1-bromo-7-hexadecyne (708 mg, 2.35 mmol) was added dropwise. The reaction mixture was stirred at rt overnight and cooled to 0 °C. Water (1 mL) was added very slowly. The suspension was stirred for 10 min at rt, then poured into water (60 mL), and extracted with hexane. The combined organic phases were dried (Na2SO4), filtered, evaporated to dryness under reduced pressure, and purified by chromatography (elution with hexane) to give Yield 66percent: 1H NMR delta 1.25 (12H, m, (CH2)6); 1.36 (4H, m, CH2C-C-C?C); 1.49 (4H, m, CH2C-C?C); 1.91 (1H, t, J = 2.6 Hz, C?CH); 2.16 (4H, td, J = 2.6 Hz, J = 7.2 Hz, CH2-C?C); 13C NMR delta 18.4 (C-3 and 14), 28.5 (C-4 and 13), 28.7 (C-5 and 12), 29.1 (C-6 and 11), 29.5 and 29.6 (C-8, 9, 10 and 11), 68.0 (C-1 and 16), 84.8 (C-2 and 15).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,12-Dibromododecane, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Vilchze, Catherine; Leung, Lawrence W.; Bittman, Robert; Jacobs, William R.; Chemistry and Physics of Lipids; vol. 194; (2016); p. 125 – 138;,
Bromide – Wikipedia,
bromide – Wiktionary