Tag: M.W=300-400

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1347736-74-6, name is 4,7-Dibromo-5-fluoro-2,1,3-benzothiadiazole, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 1347736-74-6

2.1.1 3,6-Dibromo-4-fluoro-1,2-phenylenediamine (1) 4,7-Dibromo-5-fluoro-2,1,3-benzothiadiazole (5 g, 0.016 mol) was dissolved in ethanol (150 ml), then sodium borohydride (12.1 g, 0.32 mol) was added portion wise at 0 C, and the reactants were stirred for 20 h at room temperature. After evaporation of the solvent, 160 ml water was added, and the mixture was extracted with ethyl acetate. The extract was washed with brine and dried over anhydrous magnesium sulfate. The residue was purified by column chromatography on silica gel using hexane/ethyl acetate (25:1) as eluent to afford 3,6-dibromo-4-fluoro-1,2-phenylenediamine (3.5 g) as a pale solid in 78% yield. 1H NMR (CDCl3, 500 MHz) delta(ppm): 6.81(d,1H,J = 8 Hz), 3.63(s,4H). 13C NMR(500 MHz, CDCl3): delta(ppm), 154.16, 152.25, 135.75, 135.73, 128.73, 128.71, 109.44, 109.35, 108.83, 108.62, 96.78, 96.58. mp: 94 C. Anal. Calcd for (C6H5Br2FN2) (%):C25.38, H 1.78, N 9.87. Found (%):C 24.29, H 1.83, N 10.14.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 1347736-74-6.

Reference:
Article; Wu, Haimei; Qu, Bo; Tian, Di; Cong, Zhiyuan; Gao, Bowen; Liu, Jianqun; An, Zhongwei; Gao, Chao; Xiao, Lixin; Chen, Zhijian; Gong, Qihuang; Wei, Wei; Reactive and functional polymers; vol. 73; 11; (2013); p. 1432 – 1438;,
Bromide – Wikipedia,
bromide – Wiktionary

2789-89-1, name is 1,2-Bis(4-bromophenyl)ethyne, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 1,2-Bis(4-bromophenyl)ethyne

General procedure: A 25 mL Schlenk-type tube (with a Teflon high pressure valve and side arm) was charged withcompound 1a (34.6 mg, 0.10 mmol), alkynes (0.20 mmol), Cu(OAc)2.H2O (5.0 mg, 0.025 mmol),[RuCl2(p-cymene)]2 (6.1 mg, 0.01 mmol), AgSbF6 (13.7 mg, 0.04 mmol) and THF (1 mL). Thereaction tube was evacuated and back-filled with N2 (3 times, ballon). After the reaction mixturewas stirred at 120 oC for 12 h, it was allowed to cool down to room temperature. The reactionmixture was diluted with ethyl acetate (20 mL), and then filtered through a pad of Celite. Thefiltrate was washed with brine (10 mL), dried over Na2SO4, and concentrated in vacuo. Theresidue was purified by silica gel preparative TLC to give the corresponding products

The synthetic route of 2789-89-1 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Pan, Shulei; Jiang, Hang; Zhang, Yu; Chen, Dushen; Zhang, Yanghui; Synlett; vol. 27; 13; (2016); p. 1997 – 2002;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10546-67-5, name is 2,6-Dibromo-4-(tert-butyl)aniline, A new synthetic method of this compound is introduced below., Recommanded Product: 10546-67-5

General procedure: To a mixtureof 500 mL of 96 % ethanol and 133 mL of 98 % H2SO4, 26.14g (89.2 mol) of 2,6-dibromo-4-isopropylaniline (S12n) was added withvigorous stirring at -5 C over 15 min. Then, 16.864 g of NaNO2 wasadded at this temperature over 1 h, and the resulting mixture was stirred at 80C overnight. Then, ice water was added to the reaction system and the organicproduct was extracted with 4 × 400 ml of dichloromethane. The combined extractwas dried over Na2SO4 and evaporated to get compound1,3-dibromo-5-isopropylbenzene (15.7 g, 63 %).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Yu, Lei; Huang, Minhao; Xu, Tianfeng; Tong, Linjiang; Yan, Xiao-e; Zhang, Zhang; Xu, Yong; Yun, Caihong; Xie, Hua; Ding, Ke; Lu, Xiaoyun; European Journal of Medicinal Chemistry; vol. 126; (2017); p. 1107 – 1117;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 401-84-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 401-84-3, name is 1,3-Dibromo-5-(trifluoromethyl)benzene, This compound has unique chemical properties. The synthetic route is as follows.

l,3-dibromo-5-(trifluoromethyl)benzene (1, 3.03 g, 10.00 mmol) was dissolved in dry diethyl ether (25 mL) and cooled to -78C. n-Butyllithium (4.24 mL, 2.35 M in hexanes, 10.0 mmol) was added drop-wise with stirring. After 15 minutes, dry N,N- dimethylformamide (1.44 mL, 20.0 mmol) was added in one portion and the resulting mixture was allowed to warm to ambient temperature over an hour. 1 M aqueous solution of hydrochloric acid (30 mL) was then added to quench the reaction and the reaction mixture was taken up in diethyl ether (30 mL) and washed with water (20 mL) and brine (20 mL), dried over anhydrous sodium sulfate, filtered and evaporated. The crude product was purified by flash column chromatography (Silicagel 60, 0.040-0.063 mm; eluent: cyclohexane/ethyl acetate 20: 1) to give 3-bromo-5-(trifluoromethyl) benzaldehyde (2) as colorless oil. Yield : 1366 mg (54%). JH NMR spectrum (300 MHz, CDCI3, deltaEta) : 10.02 (s, 1 H); 8.20 (bs, 1 H); 8.07 (bs, 1 H); 8.02 (bs, 1 H).

The chemical industry reduces the impact on the environment during synthesis 1,3-Dibromo-5-(trifluoromethyl)benzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; NOVO NORDISK A/S; KRUSE, Thomas; HANSEN, Mikael, Kofoed; MUeNZEL, Martin, Werner, Borchsenius; THØGERSEN, Henning; SAUERBERG, Per; RASMUSSEN, Jakob, Ewald; BEHRENS, Carsten; HØEG-JENSEN, Thomas; BAL?ANEK, Vojtech; DROBNAKOVA, Zuzana; DRO?, Ladislav; HAVRANEK, Miroslav; KOTEK, Vladislav; ?TENGL, Milan; ?NAJDR, Ivan; VANOVA, Hana; (202 pag.)WO2019/92125; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 43204-63-3, name is Bis(2-Bromoethyl)amine hydrobromide, A new synthetic method of this compound is introduced below., COA of Formula: C4H10Br3N

To a mixture of 5-amino-3,4-dihydroquinolin-2(1H)-one 1(5.00 g, 30.83 mmol), bis(2-bromoethyl)amine hydrobromide(9.05 g, 33.91 mmol) and water (40 mL), a solution of potassiumhydroxide (1.90 g, 33.91 mmol,10 mL)was added dropwise at 80 C.Then the reaction mixture was stirred at 100 C for 3 h. The progressof the reaction was monitored by TLC. After the reaction wascompleted, the reaction mixture was cooled to the room temperature.The mixture was filtered and the filtrate was adjusted toPH 10 with the 10% aqueous solution of potassiumhydroxide. Theresultant solid was filtered, washed with water to afford 6.4 g of 5-(piperazin-1-yl)-3,4-dihydroquinolin-2(1H)-one 2 as a white solid.Yield 61%, m. p. 235e237 C; 1H NMR (300 MHz, DMSO-d6) d: 10.01(s, 1H, quinolin, eCONHe), 7.07 (t, J 7.9 Hz, 1H, quinolin-H7), 6.65(d, J 8.0 Hz, 1H, quinolin-H8), 6.58 (d, J 7.8 Hz, 1H, quinolin-H6),3.94 (s, 1H, NH), 2.82e2.94 (m, 4H, quinolin-H4 and eCH2-),2.67e2.84 (m, 6H, eCH2-), 2.35 (t, J 7.3 Hz, 2H, quinolin-H3); 13CNMR (75 MHz, DMSO-d6) d: 170.59, 150.18, 139.44, 127.33, 117.62,112.55, 110.18, 51.34, 46.73, 30.16, 20.38; LC-MS (ESI): m/z 232[MH].

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Ji, Qinggang; Deng, Qiao; Li, Bing; Li, Baihui; Shen, Yangli; European Journal of Medicinal Chemistry; vol. 180; (2019); p. 204 – 212;,
Bromide – Wikipedia,
bromide – Wiktionary

Application of 2789-89-1, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2789-89-1 name is 1,2-Bis(4-bromophenyl)ethyne, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To an oven-dried screwed vial were added substituted 2-oxo-2-phenylacetic acid (0.1mmol), substituted alkyne (0.11mmol), [IrCp*Cl2]2 (0.01mmol, 7.97mg), (CH3OC6H4)3P (0.01mmol, 3.52mg), AgSbF6 (0.01mmol, 3.44mg), Cu(OAc)2 (0.02mmol, 3.99mg), and toluene (1mL). The mixture was vigorously stirred at 120C under air to the end of the reaction. Organic solvents were removed in vacuo, and then the residue was purified by a silica gel column chromatography to give the desired product.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1,2-Bis(4-bromophenyl)ethyne, and friends who are interested can also refer to it.

Reference:
Article; Yu, Xiaobo; Geng, Shudong; Liu, Guanchen; Guo, Weijie; Wang, Jianhui; Journal of Organometallic Chemistry; vol. 879; (2019); p. 139 – 143;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 18648-66-3, The chemical industry reduces the impact on the environment during synthesis 18648-66-3, name is 2-(4-Bromophenyl)-1,1-diphenylethylene, I believe this compound will play a more active role in future production and life.

A flask was charged with a mixture of 3-(4-vinylphenyl)-9-ethylcarbazole (1, 0.3 g, 1.01 mmol), 2-(4-bromophenyl)-1,1-diphenylethylene (triPE, 0.28 g, 0.84 mmol), palladium acetate(Pd(OAc)2, 2.3 mg, 0.01 mmol), P(o-tolyl)3 (15 mg, 0.05 mmol),dimethylformamide (8 mL) and trimethylamine (3 mL). The flaskwas degassed and purged with argon. The reaction mixture washeated at 90 C for 4 h under argon atmosphere. Then, it wasfiltered, and was purified by column chromatography using hexane/ethyl acetate (50/1) as an eluent. The target product wasrecrystallized from the eluent mixture of solvents. The yield ofyellow crystals was 43% (0.2 g). Mp 219-220 C. MS (APCI, 20V),m/z(%): 553 ([MH], 100). 1H NMR (400 MHz, CDCl3, d, ppm): 1.49(t, J 7.2 Hz, 3H, CH3), 4.40 (q, J 7.2 Hz, 2H, NCH2), 7.01 (s, 1H, CH),7.07 (d, J 8.4 Hz, 2H, Ar), 7.13 (d, J 6.3 Hz, 2H, Ar), 7.27e7.53 (m,16H, Ar, 2CH), 7.62 (d, J 8.3 Hz, 2H, Ar), 7.73e7.78 (m, 3H, Ar), 8.20(d, J 8.4 Hz, 1H, Ar), 8.34 (s, 1H, Ar). 13C NMR (100 MHz, CDCl3, d,ppm): 13.9 (CH3), 37.7 (CH2), 108.6, 108.7, 118.7, 119.0, 120.5, 123.1,123.5,125.0,125.9,126.1,127.0,127.4,127.5,127.6,127.8,127.9,128.2,128.8, 129.9, 130.4, 131.7, 135.5, 135.9, 136.8, 139.5, 140.4, 141.4,142.6, 143.4. IR. nmax in cm1 (KBr): (CeH Ar) 3048, 3021; (CeH)2970, 2929; (C]C Ar) 1597, 1456, 1443; (CeN) 1233; (trans, CH]CH) 978; (CeH, Ar) 801, 761, 701. Elemental analysis. Calcd. forC42H33N (%): C 91.43, H 6.03, N 2.54. Found (%): C 91.36, H 6.09, N2.64.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(4-Bromophenyl)-1,1-diphenylethylene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Tomkeviciene; Sutaite; Volyniuk; Kostiv; Simkus; Mimaite; Grazulevicius; Dyes and Pigments; vol. 140; (2017); p. 363 – 374;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 3344-70-5, These common heterocyclic compound, 3344-70-5, name is 1,12-Dibromododecane, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Phenothiazine and 1,12-dibromododecane (molar ratio = 1:10), potassium hydroxide and DMSO were added to a three-necked flask, filledwith nitrogen, and stirred at room temperature for 12 hours. The reaction mixture was washed with water and extracted with dichloromethane. , Drying over anhydrous, vortexing, andsilica gel column chromatographywith petroleum ether aseluent to give a colorless liquid in a yield of 76.5percent.

Statistics shows that 1,12-Dibromododecane is playing an increasingly important role. we look forward to future research findings about 3344-70-5.

Reference:
Patent; Jiangxi Agricultural University; Hong Yanping; Jiang Yan; Yin Xiaoli; Wu Guoqiang; Liao Xiaoning; Wang Chunrong; Li Liyu; (27 pag.)CN107698999; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 626-39-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 626-39-1, name is 1,3,5-Tribromobenzene belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

1,3,5-tribromobenzene (3.11 g, 10 mmol), pyridine-3-boronic acid (2.71 g, 22 mmol), tetrakis(triphenylphosphine)palladium(1.56 g, 1 mmol) and potassium carbonate (5.52 g, 40 mmol) were added to the reaction flask.The nitrogen was exchanged three times (10 min/time). Injecting solvent under nitrogen protection(toluene: ethanol: water = 8:1:1), after the completion of the injection, the reaction was refluxed at 120 C for 8 h;Extract, concentrate, make powder,Purification by column chromatography gave white solid product 1 in 65% yield.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3,5-Tribromobenzene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; South China University of Technology; Tang Benzhong; Zhao Zujin; Hu Shimin; Qin Anjun; Hu Rongrong; Wang Zhiming; (24 pag.)CN109593079; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 615-54-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 615-54-3, name is 1,2,4-Tribromobenzene, This compound has unique chemical properties. The synthetic route is as follows.

6.296 (0.02 mol) 1,2,4-tribromobenzene and 8.671 g (0.05 mol)3-aminobenzeneboronic acidHydrochlorideAdd to a 500 mL three-necked flask, add 400 mL of tetrahydrofuran (THF), and add 45 mL of 2 mol/L potassium carbonate solution.And add an appropriate amount of aliquat336, magnetically stirred and argon gas, after heating to 75 C in the oil bath,0.020 g of tetrakistriphenylphosphine palladium was added, and the reaction was refluxed for 24 hours, and the reaction liquid was poured into water to precipitate a large amount. The mixture was filtered with a funnel, and the solvent was evaporated under reduced pressure.The product was purified by column chromatography using dichloromethane: n-hexane = 2:1 (volume ratio) as mobile phase as the stationary phase. The product was collected and dried.Drying in a vacuum at 90 C for 24 h,The target product was obtained 5.834 g,The yield was 83%.

The chemical industry reduces the impact on the environment during synthesis 1,2,4-Tribromobenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Hunan University of Technology; Ke Shenghai; Liu Yiwu; Tan Jinghua; Zhu Heping; (19 pag.)CN108976138; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary