Tag: M.W=350-400

Foster, G. E. published the artcileAssay of 2,7-diamino-9-phenyl-10-methylphenanthridinium bromide, Quality Control of 518-67-2, the publication is Analyst (1946), 287-8, database is CAplus.

The organic compound mentioned in the title of this paper, which is more commonly known as dimidium bromide or as phenanthridium 1553 [3,8-diamino-5-methyl-6-phenylphenanthridinium bromide (C.A. numbering)], has been tested for its trypanocidal activity in the treatment of T. congolense and T. brucei infections in mice and cattle. The Br content can be easily determined by treating about 0.25 g. of sample with a little dilute HNO₃ and titrating electrometrically, with AgNO₃. To determine the C₂₀H₁₈N₃⁺, dissolve 1 g. in 200 ml. of warm water and to the solution add 5 g. of NaOAc and 200 ml. of 0.1 M K₄Fe(CN)₆ with vigorous shaking. After 5 min. filter and wash the precipitate with two 25-ml. portions of water. To the filtrate add 5 ml. of concentrated HCl + 5 g. of NaCl + 2 g. KI + 3 g. ZnSO₄.7-H₂O. Wait for each salt to dissolve before adding the next one. After 5 min. titrate with 0.1 N Na₂S₂O₃. After allowing for a blank, each ml. of 0.1 N K₄Fe(CN)₆ = 0.1141 g. of C₂₀H₁₈N₃Br.

Analyst published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Quality Control of 518-67-2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Rao, P. Suryachandra published the artcileKinetics and mechanism of the oxidation of phosphinic, phenylphosphinic and phosphorous acids by benzyltrimethylammonium tribromide, SDS of cas: 111865-47-5, the publication is Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry (1998), 37B(11), 1129-1132, database is CAplus.

The oxidation of phosphorus-(I) and -(III) oxyacids by benzyltrimethyl ammonium tribromide (BTMAB), in 9:1 (volume/volume) acetonitrile-acetic acid, leads to the formation of corresponding phosphorus-(III) and -(V) oxyacids. The reaction is first order with respect to each of the BTMAB and oxyacid. There is no effect of benzyltrimethylammonium chloride or bromide ion on the reaction rate. The oxidation of deuterated phosphinic and phosphorous acids exhibit the presence of a substantial kinetic isotope effect. The rate decreases with an increase in the proportion of acetic acid in the solvent. It has been shown that the reactive reducing species is the penta-coordinated form of the oxyacid. Tribromide ion has been postulated as the reactive oxidizing species. A mechanism involving a hydride-ion transfer in the rate-determining step has been proposed.

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, SDS of cas: 111865-47-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Predeus, Alexander V. published the artcileRational Synthesis for All All-Homocalixarenes, Quality Control of 111865-47-5, the publication is Angewandte Chemie, International Edition (2013), 52(3), 911-915, database is CAplus and MEDLINE.

The reaction of bis(carbene) complexes with bis(alkyne)s in a triple annulation provides direct access to homocalixarenes with three and four aromatic rings. Through proper choice of tether length, these macrocycles were assembled with ring sizes ranging from 15 to 56 carbon atoms. This method allows full control over the ring size and symmetry, and its ability to provide the synthesis of a series of all-homocalixarenes was illustrated for compounds having 2,3,5 and 11 methylene linkers between each ring. This method is also flexible enough to allow the incorporation of a pyrrole unit in place of one of the benzene rings in the calixarene. The macrocycles are always isolated as a single product and can be prepared conveniently on a gram scale. Six of the twelve homocalixarenes that were prepared were characterized by single-crystal x-ray anal.

Angewandte Chemie, International Edition published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Quality Control of 111865-47-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wroblewska, E. K. published the artcile5-(3-bromo-4-hydroxy-5-methoxyphenyl)-7,7-dimethyl-7H-indolo[1,2-a] quinolinium perchlorate as a new indicator for anionic surface active agents determination, Synthetic Route of 518-67-2, the publication is Tenside, Surfactants, Detergents (2010), 47(2), 119-122, database is CAplus.

5-(3-Bromo-4-hydroxy-5-methoxyphenyl)-7,7-dimethyl-7H-indolo[1,2-a]quinolinium perchlorate (la) was used as an indicator for anionic surface active agents determination in the manual direct two-phase titration according to the International Standard [ISO 2271: 1989] Surface active agents. The solvatochromic dye (la) can successfully replace the recommended mixed indicator consisting of a mixture of Acid Blue I and carcinogenic dimidium bromide. The detection of the titration endpoint with use of this dye turned out much easier than with the use of the mixed indicator. The procedure was also modified replacing carcinogenic and mutagenic chloroform with less toxic dichloromethane. The concentrations of the anionic surface – active substances in few com. available products were determined using modified two-phase titration method.

Tenside, Surfactants, Detergents published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C22H12F6O6S2, Synthetic Route of 518-67-2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Wroblewska, Elwira Katarzyna published the artcile5-(3-Bromo-4-hydroxy-5-methoxyphenyl)-7,7-dimethyl-7H-indolo[1,2-a]quinolinium perchlorate as a new indicator for anionic surface active agents determination. Part II. Influence of pH on the titration results, Application of Dimidium bromide, the publication is Tenside, Surfactants, Detergents (2011), 48(2), 127-129, database is CAplus.

The work refers to the already published modification of widely used method for anionic active agents determination which concerns the replacement of the mixed indicator, consisting of Acid Blue 1 and carcinogenic Dimidium Bromide, applied in the International Standard ISO 2271:1989 with solvatochromic dye, i.e. 5-(3-bromo-4-hydroxy-5-methoxyphenyl)-7,7-dimethyl-7H-indolo[1,2-a]quinolinium perchlorate (1). The value of pK_a for examined dye (1) amounts to 6.59, and the effect of pH of the probes on the anal. results was studied, i.e. precision of determination of titration endpoint. The change of pH for aqueous and apparent pH for organic phase were determined during the titration process. It was shown that there was no effect of the pH change in the range from 3.5 to 5.0 on the results. The modification of the method for the probes which pH do not fit to the above range is presented.

Tenside, Surfactants, Detergents published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C9H21NO3, Application of Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Yamato, Takehiko published the artcileMedium-sized cyclophanes. Part 57. Synthesis, conformations and stereodynamics of [2.n]metacyclophan-1-enes and their conversion to [2.n]metacyclophan-1-ynes, Application In Synthesis of 111865-47-5, the publication is New Journal of Chemistry (2001), 25(5), 728-736, database is CAplus.

Anti- and syn-[2.8]Metacyclophan-1-enes I, which are both conformationally rigid structures, were prepared in good yields by a McMurry cyclization of 1,8-bis(5-tert-butyl-3-formyl-2-methoxyphenyl)octane. Similarly, McMurry cyclization of 1,10-bis(5-tert-butyl-2-methoxy-3-formylphenyl)decane afforded (E)- and (Z)-[2.10]-metacyclophan-1-enes II in good yields. The assignment of the E and Z structures was confirmed by ¹H-NMR analyses and single crystal X-ray diffraction studies. Bromination of (E)- and (Z)-II with benzyltrimethyl- ammonium tribromide affords exclusively the cis-adduct to the bridged double bond. When treated with potassium tert-butoxide in refluxing tert-BuOH at 80°C for 3 h, the bromine meso adduct gave the dehydrobrominated product [2.10]metacyclophan-1-yne in 93% yield, along with a 1-bromo[2.10]metacyclophan-1-ene in 7% yield; the same reaction with the dl-bromine adduct from II gave 29% of [2.10]metacyclophan-1-yne along with 71% of the 1-bromo[2.10]metacyclophan-1-ene. Similarly, anti- and syn-[2.8]metacyclophan-1-ynes were also prepared by bromination of syn-[2.n]metacyclophan-1-ene syn-I, followed by the dehydrobromination of the bromine adduct. The characterization and the reaction pathway of these products are discussed. The dynamics of the ring inversion and UV spectra are also presented.

New Journal of Chemistry published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C5H8N2O, Application In Synthesis of 111865-47-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Belyaeva, T. N. published the artcileSanguinarine cytotoxicity for transformed mouse fibroblast L-cells in culture, sensitive and resistant to ethidium bromide, as compared to that of some other DNA-complexing agents, Safety of Dimidium bromide, the publication is Tsitologiya (1989), 31(11), 1363-8, database is CAplus.

A natural DNA intercalator, the benzo[c]phenanthridine alkaloid sanguinarine, is more toxic to mouse transformed fibroblast L-cells in culture than the synthetic DNA intercalator ethidium bromide (EtB) and the alkaloid berberine. Dimidium bromide is also an inhibitor of L-cell growth. In assay conditions, growth of L-cells is stopped by 1.5 x 10^-5M sanguinarine. Lebr-625 cells, resistant to 25 μg EtB/mL, have sanguinarine sensitivity close to that of L-cells, but Lebr-625 cells are resistant to dimidium bromide. Sanguinarine is more toxic to L-cells in culture than the anticancer drug cis-Pt(NH₃)₂Cl₂. trans-Pt(NH₃)₂Cl₂ is less toxic to these cells. The strong toxicity of sanguinarine for L- and Lebr-625 cells in culture, as compared to other DNA-complexing drugs, seems to be associated with the wide range of potential cell targets for sanguinarine. Besides the inhibition of nucleic acid metabolism reactions, characteristic of DNA intercalators, and disruption of mitochondrial ATP synthesis, also characteristic of organic heterocyclic cationic DNA intercalators, sanguinarine can modify the SH groups of enzymes including SH-sensitive membrane-bound Na⁺, K⁺-ATPase of cerebral cortex and Ca²⁺-ATPase of skeletal muscle sarcoplasmic reticulum.

Tsitologiya published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Safety of Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Taylor, Edward C. published the artcileReplacement of the 1′,4′-Phenylene Region in 5,10-Dideaza-5,6,7,8-tetrahydrofolic Acid (DDATHF) by 4,5,6,7-Tetrahydrobenzo[c]thiophene and 4,5,6,7-Tetrahydroisobenzofuran Nuclei, Name: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, the publication is Journal of Organic Chemistry (1997), 62(6), 1599-1603, database is CAplus.

Two new analogs of DDATHF, in which the 1′,4′-phenylene unit is replaced by 4,5,6,7-tetrahydrobenzo[c]thiophene and 4,5,6,7-tetrahydroisobenzofuran nuclei, have been prepared and evaluated for in vitro cytotoxicity, glycinamide ribonucleotide formyltransferase (GARFT) inhibition, and folyl polyglutamate synthetase (FPGS) affinity as potential antitumor agents.

Journal of Organic Chemistry published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C8H8O3, Name: Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Li, Yang published the artcileEffect of Alkanolamide on Interfacial Tension and Loss of Petroleum Sulfonates for Enhanced Oil Recovery, Recommanded Product: Dimidium bromide, the publication is Journal of Dispersion Science and Technology (2010), 31(6), 722-726, database is CAplus.

Exptl. studies are conducted in order to elucidate the mechanisms of monoethanolamide responsible for synergism on lowering interfacial tension and decreasing loss due to adsorption on surface of reservoir sand and precipitation with multivalent cations in model oil/water/surfactants/brine systems. The interfacial tensions between solutions containing crude oil and monoethanolamide, petroleum sulfonates, or mixture of monoethanolamide and petroleum sulfonates at different ratios are studied without any alkali added in the solution The results show significant synergic effect between monoethanolamide and petroleum sulfonates can reduce the interfacial tension to ultralow. Adsorption isotherms of monoethanolamide, petroleum sulfonates and mixture solution are determined to assess the effect of monoethanolamide on reducing the loss of petroleum sulfonates in formation. Static adsorption experiments indicate that the loss of petroleum sulfonates for adsorption and precipitation can be reduced on a great degree when monoethanolamide is mixed with petroleum sulfonates. The core-flooding tests show that the enhanced oil recovery with the formulation of surfactants of 0.3 wt% petroleum sulfonates and 0.2 wt% monoethanolamide can be increased by 26.6% without any alkali added in the flooding solution

Journal of Dispersion Science and Technology published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Recommanded Product: Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Li, Yang published the artcileInfluence of polymer on oil displacement efficiency of petroleum sulfonates system, Safety of Dimidium bromide, the publication is Xinan Shiyou Daxue Xuebao, Ziran Kexueban (2009), 31(5), 135-138, database is CAplus.

The effect of polymer, such as partially hydrolyzed polyacrylamide, on the dynamic and equilibrium interfacial tension of petroleum sulfonates and oil/water systems is examined It is testified that polymer added in a certain concentration scope in the system only prolongs the time which the system needs to reach at the equilibrium interfacial tension, but the ability of the system for washing oil is not influenced. The simulation test by changing the injection sequence or injection mode of polymer and petroleum sulfonate indicates that the maximum oil displacement efficiency is acquired by the injection mode in which the petroleum sulfonate solution is injected after polymer flooding. The main reason is the decrease of adsorption site on the surface of rock for the adsorption of partially hydrolyzed polyacrylamide by hydrogen bond and the reduction of association body formed by polar group, so the loss of petroleum sulfonate in the core is decreased, as a result, the oil displacement efficiency of petroleum sulfonate for enhanced oil recovery is relatively increased.

Xinan Shiyou Daxue Xuebao, Ziran Kexueban published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Safety of Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary