Some common heterocyclic compound, 201138-91-2, name is 4,6-Dibromodibenzo[b,d]furan, molecular formula is C12H6Br2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 201138-91-2
General procedure: The triolborate, dibromides (0.2 mmol), Pd(PPh3)4 (10 mol %), and K2CO3 (2 equiv) were placed in flask under an atmosphere of nitrogen. DMF (15 mL) was added, and heated at 80 C for 14 h. After cooling to room temperature, 15 mL water was added, extracted with dichloromethane, dried over MgSO4, and then purified by chromatography on silica gel.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 201138-91-2, its application will become more common.
Reference:
Article; Li, Gao-Qiang; Yamamoto, Yasunori; Miyaura, Norio; Tetrahedron; vol. 67; 36; (2011); p. 6804 – 6811;,
Bromide – Wikipedia,
bromide – Wiktionary