Synthetic Route of 58971-11-2,Some common heterocyclic compound, 58971-11-2, name is 3-Bromophenethylamine, molecular formula is C8H10BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a stirred solution of 2-(3-bromophenyl)ethanamine (500mg) and tetrakis(triphenylphosphine)palladium(0) (60mg) in pyrrolidine (4ml) under nitrogen, was added a solution of (5R)-3-[6-(but-3-ynyloxy)hexyl]-5-(2,2-dimethyl4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one (example 1 vi) (912mg) in pyrrolidine (4ml) and the reaction mixture was heated to 80C. After 18h, water (10ml) was added and extracted with EtOAc (3x25ml), the combined organic layers dried (MgSO4) and the solvent removed in vacuo. The residue was dissolved in CH2Cl2 (25ml) and applied to a Biotage cartridge (40g) and eluted with CH2Cl2, EtOAc and CH2Cl2 : EtOH: aq NH3 (100 : 8 : 1) to give the title compound (668mg). LCMS RT=3.09min.
The synthetic route of 58971-11-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; WO2003/72539; (2003); A1;,
Bromide – Wikipedia,
bromide – Wiktionary