Tang, Rong-Shiow published the artcilePalladium-Catalyzed Stereoselective Aza-Wacker-Heck Cyclization: One-Pot Stepwise Strategy toward Tetracyclic Fused Heterocycles, Safety of 2-Bromo-4-methoxybenzoic acid, the main research area is galanthan skeleton diastereoselective preparation; palladium catalyzed stereoselective aza Wacker Heck cyclization sequence; cis fused aza tetracycle diastereoselective preparation.
Palladium-catalyzed intramol. tandem cyclization reactions were conducted for the synthesis of densely cis/cis-fused aza-tetracyclic structures. The process involved a palladium(II)-catalyzed aerobic aza-Wacker reaction, followed by a palladium(0)-catalyzed Heck reaction. The effects of the solvent and benzene substitution pattern on the one-pot, two-step cascade reaction were studied systematically, and a probable mechanism was proposed. Strained pentahydrobenzo[f]cyclopenta[hi]indolizin-6-one and racemic γ-lycorane can also be synthesized rapidly using this palladium-catalyzed aza-Wacker-Heck cyclization reaction.
Organic Letters published new progress about C-C bond formation. 74317-85-4 belongs to class bromides-buliding-blocks, name is 2-Bromo-4-methoxybenzoic acid, and the molecular formula is C8H7BrO3, Safety of 2-Bromo-4-methoxybenzoic acid.
Referemce:
Bromide – Wikipedia,
bromide – Wiktionary