Author: Jessica.F

Magagnano, G. published the artcilePhotocatalytic ATRA reaction promoted by iodo-Bodipy and sodium ascorbate, Recommanded Product: Ethylbromofluoroacetate, the publication is Chemical Communications (Cambridge, United Kingdom) (2017), 53(10), 1591-1594, database is CAplus and MEDLINE.

Using ascorbate as a sacrificial reductant, iodo-Bodipy dye 1b is able to promote the ATRA reaction between bromoderivatives and alkenes. This finding expands the possibility of using Bodipy dyes to promote photocatalytic reactions in efficient ways.

Chemical Communications (Cambridge, United Kingdom) published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Recommanded Product: Ethylbromofluoroacetate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Foster, G. E. published the artcileAssay of 2,7-diamino-9-phenyl-10-methylphenanthridinium bromide, Quality Control of 518-67-2, the publication is Analyst (1946), 287-8, database is CAplus.

The organic compound mentioned in the title of this paper, which is more commonly known as dimidium bromide or as phenanthridium 1553 [3,8-diamino-5-methyl-6-phenylphenanthridinium bromide (C.A. numbering)], has been tested for its trypanocidal activity in the treatment of T. congolense and T. brucei infections in mice and cattle. The Br content can be easily determined by treating about 0.25 g. of sample with a little dilute HNO₃ and titrating electrometrically, with AgNO₃. To determine the C₂₀H₁₈N₃⁺, dissolve 1 g. in 200 ml. of warm water and to the solution add 5 g. of NaOAc and 200 ml. of 0.1 M K₄Fe(CN)₆ with vigorous shaking. After 5 min. filter and wash the precipitate with two 25-ml. portions of water. To the filtrate add 5 ml. of concentrated HCl + 5 g. of NaCl + 2 g. KI + 3 g. ZnSO₄.7-H₂O. Wait for each salt to dissolve before adding the next one. After 5 min. titrate with 0.1 N Na₂S₂O₃. After allowing for a blank, each ml. of 0.1 N K₄Fe(CN)₆ = 0.1141 g. of C₂₀H₁₈N₃Br.

Analyst published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Quality Control of 518-67-2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lutter, Ferdinand H. published the artcileCobalt-Catalyzed Cross-Coupling of Functionalized Alkylzinc Reagents with (Hetero)Aryl Halides, Product Details of C7H13BrSi, the publication is Angewandte Chemie, International Edition (2020), 59(14), 5546-5550, database is CAplus and MEDLINE.

A combination of 10% CoCl₂ and 20% 2,2′-bipyridine ligands enables cross-coupling of functionalized primary and secondary alkylzinc reagents RZnY (R = 3-phenylpropyl, 3-(2,5-dimethyl-1H-pyrrol-1-yl)propyl, cyclopropyl, etc.; Y = Cl, Br) with various (hetero)aryl halides R¹X (R¹ = 5-cyanopyridin-2-yl, quinolin-2-yl, pyrimidin-2-yl, etc.; X = Cl, Br). Couplings with 1,3- and 1,4-substituted cycloalkylzinc reagents R²ZnI (R² = 3-methylcyclohexyl, 4-(1H-pyrrol-1-yl)cyclohexyl, (4R,4aS,6R,8aR)-4,4a-dimethyl-6-(propan-2-yl)-decahydronaphthalen-2-yl, etc.) proceeded diastereoselectively leading to functionalized heterocycles R¹R² with high diastereoselectivities of up to 98:2. Furthermore, alkynyl bromides R³CCBr (R³ = Ph, tris(propan-2-yl)silyl) react with primary and secondary alkylzinc reagents RZnY (R = 2-(1,3-dioxan-2-yl)ethyl, 4-phenylcyclohexyl; Y = Cl, I) providing the alkylated alkynes RCCR³.

Angewandte Chemie, International Edition published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Product Details of C7H13BrSi.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Elgendy, Bahaa published the artcileSynthesis and structure activity relationship of the first class of LXR inverse agonists, HPLC of Formula: 1997-80-4, the publication is Bioorganic Chemistry (2022), 105540, database is CAplus and MEDLINE.

Liver X Receptors (LXRs) are members of the nuclear receptor family, and they play significant role in lipid and cholesterol metabolism Moreover, they are key regulators of several inflammatory pathways. Pharmacol. modulation of LXRs holds great potential in treatment of metabolic diseases, neurodegenerative diseases, and cancer. We were the first group to identify LXR inverse agonists SR9238 and SR9243 and demonstrate their potential utility in treating liver diseases and cancer. Here, we present the results of structure-activity relationship (SAR) studies, based around SR9238 and SR9243. This study led to identification of I, II, III and IV which were more potent inverse agonists than SR9238 and SR9243 and inhibited expression of the fatty acid synthase gene in DU145 cells. We previously demonstrated that inhibition of FASN is correlated to the anticancer activity of SR9243 and this suggests that new inverse agonists have great potential as anticancer agents. We identified compounds with distinct selectivity toward both LXR isoforms, which can be excellent tools to study the pharmacol. of both isoforms. We employed mol. dynamic (MD) simulations to better understand the mol. mechanism underlying inverse agonist activity and to guide our future design.

Bioorganic Chemistry published new progress about 1997-80-4. 1997-80-4 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Benzene, name is 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene, and the molecular formula is C9H8BrF3, HPLC of Formula: 1997-80-4.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Kelso, Robert G. published the artcileThe synthesis and properties of 1,1,2-trimethylcyclopropane, Category: bromides-buliding-blocks, the publication is Journal of the American Chemical Society (1952), 287-92, database is CAplus.

The reaction between Me₂CBrCH₂CHBrMe and Zn in aqueous PrOH at 0° carried out on a large scale permitted a thorough study of the reaction products. 1,1,2-Trimethylcyclopropane (I) comprised 68% of the hydrocarbon mixture obtained in 67% yield. Me₂CHPr, CH₂:CMePr (II), b₇₆₀ 61°, n_D²⁵ 1.3916, and Me₂C:CHEt, b₇₆₀ 64.5-5.5°, n_D²⁵ 1.3987-1.3995, were also obtained; MeCH:CHCHMe₂ was present in minor amount Com. Me₂C(OH)CH₂CH(OH)Me (18 moles) and PBr₃ yielded 4112 g. crude Me₂CBrCH₂CHBrMe (III), b₅ 65-70°, n_D²⁰ 1.496-1.498. (CMe:CH₂)₂, and anhydrous HBr yielded 70% H₂CBrCHMeCBrMe₂, b₁₀ 76°, and 30% (CBrMe)₂, m. 160-4°, b₁₀ 78°. The product of AcII and Me₂CH₂CHO reduced over Raney Ni at 70° and 1500 lb./sq. in. yielded 13% MeCH(OH)CMe₂CH₂OH (IV), b₂₀ 121°, n_D²⁰ 1.4408; IV with PBr₃ at 0° yielded MeCHBrCH₂CBrMe₂. The following constants were determined: for I, f.p., -138.27°, m.p. -138.30°, b₇₆₀ 52.55, dt/dp 0.039, d₄²⁰ 0.6947, n_D²⁰ 1.3864, dn_D/dt 0.00054, n_D²⁵ 1.3834; for CH₂:CMeCHMe₂, b₇₆₀ 55.6°, n_D²⁵ 1.3874; for (Me₂C:)₂, b₇₆₀ 73.3°, n_D²⁵ 1.4070.

Journal of the American Chemical Society published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Garcia-Lopez, Jose-Antonio published the artcileUse of 2-Bromophenylboronic Esters as Benzyne Precursors in the Pd-Catalyzed Synthesis of Triphenylenes, Quality Control of 89694-44-0, the publication is Organic Letters (2014), 16(9), 2338-2341, database is CAplus and MEDLINE.

Ortho-Substituted aryl boronates, e.g., I (X= Br, OTf), are introduced as aryne precursors for transition-metal-catalyzed transformations. On treatment with ^tBuOK and Pd(0), metal-bound aryne intermediates are formed that undergo effective trimerization to form useful triphenylene compds, e.g., II. For meta-substituted arynes, the 3:1 product ratio in favor of non-C₃ sym. material is indicative of a benzyne mechanism.

Organic Letters published new progress about 89694-44-0. 89694-44-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 2-Bromo-5-methoxybenzene boronic acid, and the molecular formula is C7H8BBrO3, Quality Control of 89694-44-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Erickson, Paul R. published the artcilePhotochemical Formation of Brominated Dioxins and Other Products of Concern from Hydroxylated Polybrominated Diphenyl Ethers (OH-PBDEs), Safety of Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, the publication is Environmental Science & Technology (2012), 46(15), 8174-8180, database is CAplus and MEDLINE.

The photochem. conversion of selected hydroxylated polybrominated di-Ph ethers (OH-PBDEs) to dioxins and other products was investigated. OH-PBDEs, which are both transformation products of polybrominated di-Ph ethers and naturally occurring compounds, undergo direct photolysis to yield a number of products that may have a higher toxicity than their parent. The compounds investigated were 6-OH-PBDE 99, 6′-OH-PBDE 100, and 6′-OH-PBDE 118. Of special interest was 6′-OH-PBDE 118, a potential transformation product of PBDE 153 that is capable of photochem. generating 2,3,7,8-tetrabromodibenzo-p-dioxin, the most toxic brominated dioxin congener. Photolysis experiments were conducted at two different pH values to assess the photochem. behavior of both the phenol and phenolate form of the compounds The percent conversion to dioxin and other photoproducts was determined and the natural product, 6-OH-PBDE 99, was found to have the highest conversion to dioxin (7%). The reaction quantum yields ranged from 0.027 to 0.16 across all photolysis conditions. In addition, it is shown that all three compounds are capable of photochem. generating other compounds of concern, including brominated phenols and a dibenzofuran.

Environmental Science & Technology published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Safety of Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Levitre, Guillaume published the artcileSynthesis of α-Fluorinated Areneacetates through Photoredox/Copper Dual Catalysis, Application In Synthesis of 401-55-8, the publication is Organic Letters (2022), 24(17), 3194-3198, database is CAplus and MEDLINE.

A metallaphotoredox method for the preparation of α-fluorinated areneacetates R-R¹ [R = 4-MeC₆H₄, 3-FC₆H₄, 4-BrC₆H₄, etc.; R¹ = CFC(O)OEt, CF₂C(O)OEt, CF₂P(O)OEt₂] based on the synergistic combination of Ir/Cu dual catalysis from boronic acids was reported. The mild conditions allowed broad functional group tolerance, including substrates containing aldehydes, free phenols and N-Boc-protected amines. Mechanistic investigations support a process proceeding via photoredox/copper dual catalysis.

Organic Letters published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Application In Synthesis of 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Casalta, Clement published the artcileIridium(III) Catalyzed Z-Selective Allylic Arylation of α-Fluoro But-1-enoic Acid Amides via β-F-Elimination in Water, Synthetic Route of 89694-44-0, the publication is Organic Letters (2021), 23(21), 8122-8126, database is CAplus and MEDLINE.

Allylic arylation of α-fluoro but-1-enoic acid amides with arylboronic acids was carried out in water by comparing the catalytic activity of iridium(III) and rhodium(III). Ir(III) has shown a strong superiority over Rh(III) to give allyl-aryl coupling products with excellent stereoselectivity in favor of the Z-isomer. The origin of high stereoselectivity is perhaps because of the a coordination of iridium Ir-N or Ir-O.

Organic Letters published new progress about 89694-44-0. 89694-44-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 2-Bromo-5-methoxybenzene boronic acid, and the molecular formula is C7H8BBrO3, Synthetic Route of 89694-44-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Crimmins, Michael T. published the artcileIntramolecular photocycloaddition-cyclobutane fragmentation: total synthesis of (±)-laurenene, Formula: C7H13BrSi, the publication is Journal of the American Chemical Society (1987), 109(20), 6199-200, database is CAplus.

Nature’s only known existing fenestrane, laurenene (I) was prepared via an elevated temperature intramol. [2+2] photochem. cycloaddition of diene II. This established the highly sterically congested center of the laurenene skeleton which contains 3 contiguous quaternary C. Reductive cleavage of the cyclobutane produced during the photocycloaddition provides an intermediate which was used to form the remaining 7 membered ring via an intramol. aldol-dehydration reaction. The [5.5.5.7] fenestrane III which was prepared in 12.7% yield was transformed to I in 5 steps.

Journal of the American Chemical Society published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Formula: C7H13BrSi.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary