Author: Jessica.F

Luan, Yu-Yong published the artcileThree-Component Ruthenium-Catalyzed meta-C-H Alkylation of Phenol Derivatives, Synthetic Route of 401-55-8, the publication is Organic Letters (2022), 24(5), 1136-1140, database is CAplus and MEDLINE.

Herein, synthesis of phenyl-(pyrimidinyloxyphenyl)butanoates I [R¹ = H, Me, Cl, etc.; R² = H, Me, F, etc; R³ = Me, F; R⁴ = Ph, 4-FC₆H₄, 4-BrC₆H₄, etc.; R² = R³ = Me, F; R⁵ = OEt, piperidin-1-yl, N(n-Bu)₂] via three-component ruthenium catalyzed C-H alkylation of phenoxypyrimidines and vinylbenzene and ethyl-bromo-difluoroacetates/alkyl bromides was reported. This strategy exhibited good substrates suitability and functional group tolerance with various phenol derivatives, which provided a synthetic potential drug approach. Mechanistic studies showed that a radical process might be involved in this process. In addition, the meta alkylated phenol was obtained by further removal of the directing group.

Organic Letters published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Synthetic Route of 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Derince, Betul published the artcileArchitectural design of new conjugated systems carrying donor-π-acceptor groups (carbazole-CF₃): Characterizations, optical, photophysical properties and DSSC′s applications, SDS of cas: 111-83-1, the publication is Journal of Molecular Structure (2022), 1250(Part_2), 131689, database is CAplus.

In this study, two new organic dyes containing substituted N-octyl carbazole as electron donor and -CF₃ units as electron acceptor group were designed and synthesized for ZnO-based dye sensitized solar cells (DSSCs). The synthesized carbazole derivatized compounds 3,6-bis(3,5-bis(trifluoromethyl)phenyl)-9-octyl-9H-carbazole (IVa) and 3,6-bis(4-(trifluoromethyl)phenyl)-9-octyl-9H-carbazole (IVb) were characterized by FT-IR, ¹H NMR, ¹³C NMR, HMBC and CHN analyses. The spectroscopic (UV-Vis and FL) and thermal properties (TGA-DTA) of these compounds were also investigated. The produced (IVa and IVb) ZnO films were used as photoanodes in all DSSCs. Microwave-assisted hydrothermal method was used to synthesize ZnO nanopowders with different morphologies which are used as photoanodes in DSSCs. The structural and morphol. properties of ZnO nanopowders were investigated using X-ray diffraction (XRD) and field emission SEM (FESEM). ZnO-DSSCs were produced through coating ZnO nanopowders on transparent conductive fluorine-doped tin oxide (FTO) coated glass substrate using the Doctor Blade method. Current-voltage measurements of all produced DSSCs were carried out under a solar simulator with AM 1.5 G filter having an irradiance of 100 mW/cm². Solar cell performances of all DSSCs such as; open-circuit voltage (V_oc), short circuit current (J_sc), fill factor (FF) and power conversion efficiency (PCE) were analyzed.

Journal of Molecular Structure published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H17Br, SDS of cas: 111-83-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Predeus, Alexander V. published the artcileRational Synthesis for All All-Homocalixarenes, Quality Control of 111865-47-5, the publication is Angewandte Chemie, International Edition (2013), 52(3), 911-915, database is CAplus and MEDLINE.

The reaction of bis(carbene) complexes with bis(alkyne)s in a triple annulation provides direct access to homocalixarenes with three and four aromatic rings. Through proper choice of tether length, these macrocycles were assembled with ring sizes ranging from 15 to 56 carbon atoms. This method allows full control over the ring size and symmetry, and its ability to provide the synthesis of a series of all-homocalixarenes was illustrated for compounds having 2,3,5 and 11 methylene linkers between each ring. This method is also flexible enough to allow the incorporation of a pyrrole unit in place of one of the benzene rings in the calixarene. The macrocycles are always isolated as a single product and can be prepared conveniently on a gram scale. Six of the twelve homocalixarenes that were prepared were characterized by single-crystal x-ray anal.

Angewandte Chemie, International Edition published new progress about 111865-47-5. 111865-47-5 belongs to bromides-buliding-blocks, auxiliary class Benzenes, name is Mono(N,N,N-trimethyl-1-phenylmethanaminium) tribromide, and the molecular formula is C10H16Br3N, Quality Control of 111865-47-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lee, Mitchell T. published the artcileSynthesis of Isomerically Pure (Z)-Alkenes from Terminal Alkynes and Terminal Alkenes: Silver-Catalyzed Hydroalkylation of Alkynes, Application of 7-Bromohept-1-yne, the publication is Journal of the American Chemical Society (2019), 141(43), 17086-17091, database is CAplus and MEDLINE.

Here, an efficient synthesis of diastereopure Z-alkenes (Z:E > 300:1) through a silver-catalyzed hydroalkylation of terminal alkynes using alkylboranes as coupling partners is demonstrated. The exploration of the substrate scope, which reveals the broad functional group compatibility of the new method, is also described. Preliminary mechanistic studies suggest that a 1,2-metalate rearrangement of the silver borate intermediate is the key step responsible for the stereochem. outcome of the reaction.

Journal of the American Chemical Society published new progress about 81216-14-0. 81216-14-0 belongs to bromides-buliding-blocks, auxiliary class Linker,PROTAC Linker, name is 7-Bromohept-1-yne, and the molecular formula is C7H11Br, Application of 7-Bromohept-1-yne.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Armstrong, Megan K. published the artcileDiastereodivergent Reductive Cross Coupling of Alkynes through Tandem Catalysis: Z- and E-Selective Hydroarylation of Terminal Alkynes, Category: bromides-buliding-blocks, the publication is Journal of the American Chemical Society (2018), 140(32), 10233-10241, database is CAplus and MEDLINE.

A diastereodivergent hydroarylation of terminal alkynes is accomplished using tandem catalysis. The hydroarylation allows highly selective synthesis of both E and Z diastereoisomers of aryl alkenes, from the same set of starting materials, using the same combination of palladium and copper catalysts. The selectivity is controlled by simple changes in the stoichiometry of the alc. additive. The hydroarylation has excellent substrate scope and can be accomplished in the presence of various classes of compounds, including esters, nitriles, alkyl halides, epoxides, carbamates, acetals, ethers, silyl ethers, and thioethers. The Z-selective hydroarylation is accomplished using a new approach based on tandem Sonogashira coupling and catalytic semiredn. The E-selective hydroarylation involves an addnl. catalytic isomerization of the Z-alkene. Our explorations of the reaction mechanism explain the role of individual reaction components and how the subtle changes in the reaction conditions influence the rates of specific steps of the hydroarylation. Our studies also show that, although the Z- and E-selective hydroarylation reactions are mechanistically closely related, the roles of the palladium and copper catalysts in the two reactions are different.

Journal of the American Chemical Society published new progress about 81216-14-0. 81216-14-0 belongs to bromides-buliding-blocks, auxiliary class Linker,PROTAC Linker, name is 7-Bromohept-1-yne, and the molecular formula is C7H11Br, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhegalova, Natalia G. published the artcileSynthesis of nitric oxide probes with fluorescence lifetime sensitivity, Quality Control of 53484-26-7, the publication is Organic & Biomolecular Chemistry (2013), 11(47), 8228-8234, database is CAplus and MEDLINE.

The authors present the rationale, synthesis and evaluation of the 1st activatable fluorescent probe that uses fluorescence lifetime change for detection of nitric oxide. The new probe I (R = R’ = H) features a near-IR polymethine skeleton with a diaminobenzene functionality incorporated into the meso-position. The probe is partially quenched, and upon reaction with nitric oxide shows an increase in the fluorescence lifetime from 1.08 ns to 1.24 ns.

Organic & Biomolecular Chemistry published new progress about 53484-26-7. 53484-26-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Nitro Compound,Amine,Benzene, name is 4-Bromo-N-methyl-2-nitroaniline, and the molecular formula is C8H7NaO4S, Quality Control of 53484-26-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Qi, Zhigang published the artcileSynthesis and characterization of acid-base polyimides bearing pendant sulfoalkoxy groups for direct methanol fuel cell applications, Product Details of C3H6BrNaO3S, the publication is Journal of Applied Polymer Science (2015), 132(29), 42238/1-42238/8, database is CAplus.

A series of acid-base polyimides with sulfonic acid groups in the side chains have been prepared, based on a new synthesized sulfonated diamine monomer containing pyridine functional group. The effect of the introduction of pyridine groups into copolymer backbone on the properties of membrane were evaluated through the investigation of membrane parameters. The copolymers produced flexible, tough, and transparent membranes by solvent casting method. All the prepared membranes displayed high thermal stability, great oxidative stability and good mech. properties. They exhibited appropriate water uptake (15.8-30.2 wt % at 80°C) and remarkable dimensional stability (2.5-6.9% at 80°C). The proton conductivity of SPI-80 was 1.01 × 10^-2 S cm^-1 at room temperature Moreover, the methanol permeability of SPI-80 membrane was 1.22 × 10^-7 cm² s^-1, which was lower than 23.8 × 10^-7 cm² s^-1 of Nafion 117. Therefore, these acid-base polyimides materials have a promising prospect for direct methanol fuel cell applications. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42238.

Journal of Applied Polymer Science published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, Product Details of C3H6BrNaO3S.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Fortuna, Andreia published the artcileSynthesis and Exploitation of the Biological Profile of Novel Guanidino Xylofuranose Derivatives, Name: 1-Bromododecane, the publication is ChemMedChem (2022), 17(14), e202200180, database is CAplus and MEDLINE.

The synthesis and biol. evaluation of novel guanidino sugars as iso-nucleoside analogs is described. 5-Guanidino xylofuranoses containing 3-O-saturated/unsaturated hydrocarbon or aromatic-containing moieties were accessed from 5-azido xylofuranoses via reduction followed by guanidinylation with N,N’-bis(tert-butoxycarbonyl)-N”-triflylguanidine. Mols. comprising novel types of iso-nucleosidic structures including 5-guanidino 3-O-methyl-branched N-benzyltriazole iso-nucleosides and a guanidinomethyltriazole 3′-O-dodecyl xylofuranos-5′-yl iso-nucleoside were accessed. The guanidinomethyl triazole derivative and a 3-O-dodecyl (N-Boc)guanidino xylofuranose were revealed as selective inhibitors of acetylcholinesterase (K_i=22.87 and 7.49μM, resp.). The latter also showed moderate antiproliferative effects in chronic myeloid leukemia (K562) and breast cancer (MCF-7) cells. An aminomethyltriazole 5′-iso-nucleoside was the most potent mol. with low micromolar GI₅₀ values in both cells (GI₅₀=6.33μM, 8.45μM), similar to that of the drug 5-fluorouracil in MCF-7 cells. Moreover, the most bioactive compounds showed low toxicity in human fibroblasts, further indicating their interest as promising lead mols.

ChemMedChem published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, Name: 1-Bromododecane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Mercanton, Roger published the artcileBromonaphthalenesulfonic acids, Category: bromides-buliding-blocks, the publication is Helvetica Chimica Acta (1945), 533-9, database is CAplus.

4-Amino-2-naphthalenesulfonic acid gives by the Sandmeyer reaction 71% Na 4-bromo-2-naphthalenesulfonate (I) (Ag salt, 86% yield, Me ester m. 132° (all m.ps. corrected), Et ester m. 90°, acid chloride m. 112.5°, amide m. 183-5°, anilide m. 172°). Similarly is obtained 74% Na 5-bromo-2-naphthalenesulfonate (II) (Ag salt, 96% yield, Me ester m. 110°, Et ester m. 125°, acid chloride m. 100°, amide m. 225°, anilide m. 207.5°). All derivatives of II are less soluble than those of I. The reaction gives 61% K 8-bromo-2-naphthalenesulfonate (III) (Ag salt, 88% yield, Me ester m. 97°, Et ester m. 92.5°, acid chloride m. 120-1.5°, amide m. 193°, anilide m. 170°), and 70% K 2-bromo-1-naphthalenesulfonate (IV) (Ag salt, 87% yield, Me ester m. 93°, Et ester m. 65.5°, acid chloride m. 98°, amide m. 145°, anilide m. 144°). Treatment of the acid chlorides with NaHSO₃ and NaOH gives bromonaphthalenesulfinic acids which with HgCl₂ form bromonaphthylmercuric chlorides. When these are refluxed with Br and KBr in EtOH they form dibromonaphthalenes, I giving the 1,3-, II the 1,6-, III the 1,7-, and IV the 1,2-dibromides.

Helvetica Chimica Acta published new progress about 52358-73-3. 52358-73-3 belongs to bromides-buliding-blocks, auxiliary class Bromide,Naphthalene, name is 1,3-Dibromonaphthalene, and the molecular formula is C10H6Br2, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Eseola, Abiodun Omokehinde published the artcileImportance of monodentate mono-ligand designs in developing N-stabilized palladium catalysts for efficient ambient temperature C-C coupling: Donor strengths and steric features, Synthetic Route of 89694-44-0, the publication is Molecular Catalysis (2019), 110398, database is CAplus.

Unfriendly temperature profiles and costs of carbon coupling catalysis, which pose challenge to both synthetic organic chemists as well as industrial applicability, motivated our design of new monodentate N-donors as support ligands for the purpose of constructing ambient temperature precatalysts that are molecularly close to the hypothetical active forms. Therefore, a series of sterically varied monodentate N-donor imidazoles (1-7) and oxazoles (8-9) have been synthesized and their N-donor strengths, which were estimated as pK_as, are systematically varied from 0.9 to 8.5 by substituent variations. Eleven target mono-ligand complexes (1-PdCl₂MeCN – 9-PdCl₂MeCN, 6-PdCl₂PhCN and 7-PdCl₂PhCN) and six trans-bis-ligand complexes (1₂-PdCl₂, 2₂-PdCl₂, 3₂-PdCl₂, 6₂-PdCl₂, 1₂-Pd(OAc)₂ and 2₂-Pd(OAc)₂) were isolated and catalytically studied along with PdI₂(PPh₃)₂. Results of coupling reactions, which were conducted both via in situ ‘Pd(II) salt + ligand’ approach and by use of the precatalysts, show that the mono-ligand precatalyst designs (1-PdCl₂MeCN – 9-PdCl₂MeCN, 6-PdCl₂PhCN and 7-PdCl₂PhCN) represent a true catalyst improvement initiative among the phosphine-free catalyst community; i.e. yields approaching 100% (TOF ≈ 2000) at 0.2 mol % catalyst loading, 45°C and within 15 min. On the other hand, the complexes with trans-bis-ligand coordination were inactive at ambient temperatures Therefore, it was concluded that coordinative saturation, which results from implementing two or more ligand equivalent or use of polydentate ligands on palladium, should be strongly discouraged. Such saturation necessitates the undesirable and avoidable high temperature necessities, long reflux durations and needlessly high catalyst loadings. Correlation between catalyst activity and donor strengths or steric properties were analyzed leading to important conclusions. The catalyst design also supported coupling of activated aryl chlorides from 60°C while Heck coupling activities were observed only at the early minutes of reactions.

Molecular Catalysis published new progress about 89694-44-0. 89694-44-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 2-Bromo-5-methoxybenzene boronic acid, and the molecular formula is C7H8BBrO3, Synthetic Route of 89694-44-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary