Author: Jessica.F

COA of Formula: C14H21Br2ClN2In 2020, Li, Ting;Sun, Laifang;Zhang, Wenwu;Zheng, Chanfan;Jiang, Chenchen;Chen, Mingjing;Chen, Di;Dai, Zhijuan;Bao, Shihui;Shen, Xian published 《Bromhexine hydrochloride tablets for the treatment of moderate COVID-19: an open-label randomized controlled pilot study》. 《Clinical and Translational Science》published the findings. The article contains the following contents:

This open-label randomized controlled pilot study aimed to test the study feasibility of bromhexine hydrochloride (BRH) tablets for the treatment of mild or moderate coronavirus disease 2019 (COVID-19) and to explore its clin. efficacy and safety. Patients with mild or moderate COVID-19 were randomly divided into the BRH group or the control group at a 2:1 ratio. Routine treatment according to China’s Novel Coronavirus Pneumonia Diagnosis and Treatment Plan was performed in both groups, whereas patients in the BRH group were addnl. given oral BRH (32 mg t.i.d.) for 14 consecutive days. The efficacy and safety of BRH were evaluated. A total of 18 patients with moderate COVID-19 were randomized into the BRH group (n = 12) or the control group (n = 6). There were suggestions of BRH advantage over placebo in improved chest computed tomog., need for oxygen therapy, and discharge rate within 20 days. However, none of these findings were statistically significant. BRH tablets may potentially have a beneficial effect in patients with COVID-19, especially for those with lung or hepatic injury. A further definitive large-scale clin. trial is feasible and necessary.2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) were involved in the experimental procedure.

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is a mucolytic agent that exerts both a secretagogic action on submucosal glands and a mucolytic action toward acid glycoproteins inside cells. Bromhexine Hydrochloride is a medication prescribed for coughs which works by dissolving hard phlegm. OthersBromhexine is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. In addition, bromhexine has antioxidant properties. COA of Formula: C14H21Br2ClN2

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Computed Properties of C14H21Br2ClN2In 2016, Bhyan, Bhupinder;Bhyan, Sarita Jangra;Chopra, Vivek;Berwal, Ravi published 《Formulation and evaluation of novel orodispersible drug delivery system for the administration of Bromhexine hydrochloride》. 《World Journal of Pharmacy and Pharmaceutical Sciences》published the findings. The article contains the following contents:

The aim of the research work was to formulate and evaluate novel orodispersible delivery of Bromhexine hydrochloride in the form of oral fast disintegrating films. Formulated films offers a various advantages over the liquid formulation of Bromhexine hydrochloride like ease of handling and administration, expected increased bioavailability due to elimination of hepatic first-pass metabolism These fast disintegrating films were prepared by solvent casting methods using HPMC E-3 and PVP k-30 as film forming polymers. Cardamom extract, sucralose were used as flavoring agent and sweetening agent to impart pleasant taste. To decrease the disintegration time of formulations sodium starch glycolate was used as disintegrating agent. All the prepared novel films formulations (F1-F8) was evaluated for their, weight variations, thickness tensile strength, percentage elongation, folding endurance, surface pH, in-vitro disintegration, drug content, in-vitro drug release. In the time range 40-80 s all the film formulation was completely disintegrated. Formulations F1 and F2 showed 90% in-vitro drug release within 8 min. The film showed an excellent stability at least for 3 mo when stored at 40° C and 75% in humidity.2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) were involved in the experimental procedure.

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is intended to support the body’s mechanisms for clearing mucus from the respiratory tract. Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. It is indicated as secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport.Computed Properties of C14H21Br2ClN2

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Category: bromides-buliding-blocks《HPLC simultaneous determination of four active components in sulfamethoxazole, trimethoprim, bromhexine hydrochloride and clorprenaline hydrochloride capsules》 was published in 2015. The authors were Wu, Jingfang;Li, Zhifang, and the article was included in《Zhongguo Yaopin Biaozhun》. The author mentioned the following in the article:

Objective: To establish an HPLC method for content determination of four active components in Sulfamethoxazole, Trimethoprim, Bromhexine Hydrochloride and Clorprenaline Hydrochloride Capsules. Methods: The HPLC anal. was performed on an Ecosil-C₁₈ (4.6 mm × 250 mm, 5 μm) column. The mobile phase was consisted of acetonitrile and 0.0015 mol·L^-1 sodium dodecyl sulfate of 0.1% triethylamine solution (pH was adjusted to 3.0 by phosphoric acid) (52:48) at the flow rate of 1.0 mL·min^-1. The detected wavelength was set at 215 nm. Results: Four active components were separated completely in 10 min, and had good linear relationship (r>0.9999) and recoveries (98.85%-99.58%) in their resp. detection scopes. Conclusion: The method can be applied for simultaneous determination of four active components in Sulfamethoxazole, Trimethoprim, Bromhexine Hydrochloride and Clorprenaline Hydrochloride Capsules. The experimental procedure involved many compounds, such as 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) .

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) (BHH; 250μM; 24 hours) also significantly attenuates HGF-induced invasion of LNCaP and C4-2B cells that natively express TMPRSS2. No significant toxicity is observed over a 48-hour period exposing LNCaP, DU145, PC3, or HepG2 cells to Bromhexine hydrochloride concentrations ranging from 0μM to 250μM. Bromhexine hydrochloride exposure does not induce cell death or substantially suppress the growth of DU145 cells.Bromhexine hydrochloride (20 μM; 48 h) inhibits dendritic cells infection with HIV-1.Category: bromides-buliding-blocks

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Shen, Yanfeng;Ma, Fengling;Zhu, Yanhua published 《Understanding of the check item related substance in bromhexine hydrochloride and glucose injection》. The research results were published in《Zhongguo Yaopin Biaozhun》 in 2014.COA of Formula: C14H21Br2ClN2 The article conveys some information:

A review on the understanding of the check item related substance in bromhexine hydrochloride and glucose injection. And 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) was used in the research process.

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is intended to support the body’s mechanisms for clearing mucus from the respiratory tract. Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. It is indicated as secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport.COA of Formula: C14H21Br2ClN2

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Feng, Guo published 《Improvement of quality standard of compound tulobuterol syrup》 in 2015. The article was appeared in 《Zhongguo Yaoshi (Beijing, China)》. They have made some progress in their research.Product Details of 611-75-6 The article mentions the following:

Objective: To establish a method for the assay of bromhexine hydrochloride and promethazine hydrochloride in compound tulobuterol syrup by HPLC to improve its quality standard Methods: The procedure was performed on the Agilent Eclipse Plus C18 column (250 mm × 4.6 mm, 5 μm) at 30°C, detected at 247 nm. The mobile phase was composed by a gradient of acetonitrile and 0.5% triethylamine solution (35 : 65, of which the pH was adjusted to 3.5 by phosphoric acid, fluxed at 1.0 mL·min^-1). Results: Bromhexine hydrochloride and promethazine hydrochloride were in good linear at 7.693-192.320 μg·mL^-1 (r = 0.9999), and 4.509-112.720 μg·mL^-1 (r = 0.9999), resp. The mean recoveries were 99.43% (RSD = 0.60%), and 99.34% (RSD = 0.64%) (n = 9). Conclusion: The method is proved to be specific, accurate, sensitive, simple and applicable for quality control of this product. And 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) was used in the research process.

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is intended to support the body’s mechanisms for clearing mucus from the respiratory tract. Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. It is indicated as secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport.Product Details of 611-75-6

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Yasui, Kosuke;Kamitani, Miharu;Fujimoto, Hayato;Tobisu, Mamoru published 《The Effect of the Leaving Group in N-Heterocyclic Carbene-Catalyzed Nucleophilic Aromatic Substitution Reactions》 in 2020. The article was appeared in 《Bulletin of the Chemical Society of Japan》. They have made some progress in their research.Recommanded Product: 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride The article mentions the following:

The reactivity order of the leaving group was F > Cl ≥ Br > I in N-heterocyclic carbene-catalyzed CS_NAr reactions of aryl halides bearing an α,β-unsaturated amide was discussed. Based on a qual. Marcus anal., the nature of the transition state in this catalytic CS_NAr was primarily determined by the potential energy of the Meisenheimer complex, even though it was not involved as a discrete intermediate in the reaction pathway.2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) were involved in the experimental procedure.

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is intended to support the body’s mechanisms for clearing mucus from the respiratory tract. Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. It is indicated as secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport.Recommanded Product: 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Musdal, Yaman;Hegazy, Usama M.;Aksoy, Yasemin;Mannervik, Bengt published 《FDA-approved drugs and other compounds tested as inhibitors of human glutathione transferase P1-1》 in 2013. The article was appeared in 《Chemico-Biological Interactions》. They have made some progress in their research.Electric Literature of C14H21Br2ClN2 The article mentions the following:

Glutathione transferase P1-1 (GST P1-1) is often overexpressed in tumor cells and is regarded as a contributor to their drug resistance. Inhibitors of GST P1-1 are expected to counteract drug resistance and may therefore serve as adjuvants in the chemotherapy of cancer by increasing the efficacy of cytostatic drugs. Finding useful inhibitors among compounds used for other indications would be a shortcut to clin. applications and a search for GST P1-1 inhibitors among approved drugs and other compounds was therefore conducted. We tested 1040 FDA-approved compounds as inhibitors of the catalytic activity of purified human GST P1-1 in vitro. We identified chlorophyllide, merbromine, hexachlorophene, and ethacrynic acid as the most effective GST P1-1 inhibitors with IC₅₀ values in the low micromolar range. For comparison, these compounds were even more potent in the inhibition of human GST A3-3, an enzyme implicated in steroid hormone biosynthesis. In distinction from the other inhibitors, which showed conventional inhibition patterns, the competitive inhibitor ethacrynic acid elicited strong kinetic cooperativity in the glutathione saturation of GST P1-1. Apparently, ethacrynic acid serves as an allosteric inhibitor of the enzyme. In their own right, the compounds investigated are less potent than desired for adjuvants in cancer chemotherapy, but the structures of the most potent inhibitors could serve as leads for the synthesis of more efficient adjuvants. The experimental procedure involved many compounds, such as 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) .

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is a mucolytic agent that exerts both a secretagogic action on submucosal glands and a mucolytic action toward acid glycoproteins inside cells. Bromhexine Hydrochloride is a medication prescribed for coughs which works by dissolving hard phlegm. OthersBromhexine is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. In addition, bromhexine has antioxidant properties. Electric Literature of C14H21Br2ClN2

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Socha, Ondrej;Hodgkinson, Paul;Widdifield, Cory M.;Yates, Jonathan R.;Dracinsky, Martin published 《Exploring Systematic Discrepancies in DFT Calculations of Chlorine Nuclear Quadrupole Couplings》 in 2017. The article was appeared in 《Journal of Physical Chemistry A》. They have made some progress in their research.Electric Literature of C14H21Br2ClN2 The article mentions the following:

Previous studies have revealed significant discrepancies between d. functional theory (DFT)-calculated and exptl. nuclear quadrupolar coupling constants (C_Q) for chlorine atoms, particularly in ionic solids. Various aspects of the computations are systematically investigated here, including the choice of the DFT functional, basis set convergence, and geometry optimization protocol. The effects of fast (fs) time-scale dynamics are probed using mol. dynamics (MD) and nuclear quantum effects (NQEs) are considered using path-integral MD calculations It is shown that the functional choice is the most important factor related to improving the accuracy of the quadrupolar coupling calculations, and that functionals beyond the generalized gradient approximation (GGA) level, such as hybrid and meta-GGA functionals, are required for good correlations with experiment The influence of mol. dynamics and NQEs is less important than the functional choice in the studied systems. A method which involves scaling the calculated quadrupolar coupling constant is proposed here; its application leads to good agreement with exptl. data. To complete the study, the researchers used 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) .

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is intended to support the body’s mechanisms for clearing mucus from the respiratory tract. Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. It is indicated as secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport.Electric Literature of C14H21Br2ClN2

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Siddappa, K.;Hanamshetty, Prashant C. published 《Spectrophotometric quantitative determination of bromhexine hydrochloride in bulk and pharmaceutical dosage form using p-nitrobenzaldehyde reagent》. The research results were published in《International Journal of Pharmaceutical Sciences Review and Research》 in 2016.Recommanded Product: 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride The article conveys some information:

An efficient, sensitive spectrophotometric method has been developed and validated for the determination of Bromhexine hydrochloride (BRH), in bulk drug and its pharmaceutical formulations. The method is based on the formation of Schiff base with pnitrobenzaldehyde (PNBZ) the reaction of drug with reagent gives a bright yellow color. The so formed colored species absorbance was measured at its absorption maximum (λmax) 410 nm. The Beer’s law has been obeyed in the concentration range 5-25 μg/mL. The optical parameters were calculated as 2.01561×10⁴ (L/mol/cm), 0.01866 (μg/cm²), molar absorptivity and Sandell sensitivity resp. The LOD and LOQ of the proposed method were calculated 0.1851 (μg/mL), 0.6165 (μg/mL) resp. All the variables were studied to optimize the reaction conditions. No interference was observed in the presence of common pharmaceutical excipients. The validity of the method was tested by analyzing BRH in its pharmaceutical formulations and critically tested for its accuracy by statistical tests. Good recoveries were obtained by the developed method; the obtained results were critically analyzed and successfully employed for the determination of BRH in its pharmaceutical dosage forms.2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) were involved in the experimental procedure.

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is a mucolytic agent that exerts both a secretagogic action on submucosal glands and a mucolytic action toward acid glycoproteins inside cells. Bromhexine Hydrochloride is a medication prescribed for coughs which works by dissolving hard phlegm. OthersBromhexine is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. In addition, bromhexine has antioxidant properties. Recommanded Product: 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride

Reference:
Bromide – Wikipedia,
bromide – Wiktionary