Jessica.F

Molecules | Cas: 611-75-6 was involved in experiment

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is intended to support the body’s mechanisms for clearing mucus from the respiratory tract. Bromhexine is a synthetic derivative of the herbal active ingredient vasicine. It has been shown to increase the proportion of serous bronchial secretion, making it more easily expectorated. It is indicated as secretolytic therapy in bronchopulmonary diseases associated with abnormal mucus secretion and impaired mucus transport.Formula: C14H21Br2ClN2

Lisnund, Sireerat;Blay, Vincent;Muamkhunthod, Pratchaya;Thunyanon, Kittiya;Pansalee, Jaruwan;Monkrathok, Jirawan;Maneechote, Pachara;Chansaenpak, Kantapat;Pinyou, Piyanut published 《Electrodeposition of Cobalt Oxides on Carbon Nanotubes for Sensitive Bromhexine Sensing》 in 2022. The article was appeared in 《Molecules》. They have made some progress in their research.Formula: C14H21Br2ClN2 The article mentions the following:

We develop an electrochem. sensor for the determination of bromhexine hydrochloride (BHC), a widely use mucolytic drug. The sensor is prepared by electrodeposition of cobalt oxides (CoO_x) on a glassy carbon electrode modified with carboxylated single-walled carbon nanotubes (SWCNT). A synergistic effect between CoOx and SWCNT is observed, leading to a significant improvement in the BHC electrooxidation current. Based on cyclic voltammetry studies at varying scan rates, we conclude that the electrochem. oxidation of BHC is under mixed diffusion-adsorption control. The proposed sensor allows the amperometric determination of BHC in a linear range of 10-500μM with a low applied voltage of 0.75 V. The designed sensor provides reproducible measurements, is not affected by common interfering substances, and shows excellent performance for the anal. of BHC in pharmaceutical preparations And 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) was used in the research process.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Cas: 611-75-6 | Mehta, P. S. et al. made new progress in 2013

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) (BHH; 250μM; 24 hours) also significantly attenuates HGF-induced invasion of LNCaP and C4-2B cells that natively express TMPRSS2. No significant toxicity is observed over a 48-hour period exposing LNCaP, DU145, PC3, or HepG2 cells to Bromhexine hydrochloride concentrations ranging from 0μM to 250μM. Bromhexine hydrochloride exposure does not induce cell death or substantially suppress the growth of DU145 cells.Bromhexine hydrochloride (20 μM; 48 h) inhibits dendritic cells infection with HIV-1.HPLC of Formula: 611-75-6

Mehta, P. S.;Patel, V. B. published 《RP-HPLC method for simultaneous estimation of bromohexine hydrochloride, dextromethorphan hydrobromide and guaiphenesin in soft gel capsules》 in 2013. The article was appeared in 《Asian Journal of Chemistry》. They have made some progress in their research.HPLC of Formula: 611-75-6 The article mentions the following:

A simple, precise, and accurate reverse phase high performance liquid chromatog. method was developed for simultaneous determination of guaiphenesin, dextromethorphan hydrobromide and bromhexine hydrochloride in their soft gel formulations. The chromatog. conditions were standardized using Phenomenex Luna C₁₈ (250 mm × 4.6 mm i.d., 5 μm particle size) with UV detection at 258 nm and mobile phase consisting of methanol: 0.05 M phosphate buffer pH 3.0 (60 : 40 volume/volume). Mobile phase was delivered at the flow rate of 1.3 mL/min and separation was completed within 8 min. The retention times of guaiphenesin, dextromethorphan hydrobromide and bromhexine hydrochloride were 3.1 min, 4.1 min and 6.8 min resp. Calibration curves were linear with correlation coefficient 0.998. 0.999 And 0.999 over a concentration range of 50-250, 5-25 and 1-6 μg/mL for guaiphenesin, dextromethorphan hydrobromide and bromhexine hydrochloride resp. Recoveries were between 97.04-100.15, 101.92-104.67 and 102.01-102.55 resp. The proposed method was validated and successfully applied to the determination of 3 drugs in combined soft gel formulation. The experimental procedure involved many compounds, such as 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) .

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Explore more uses of cas: 611-75-6 | Monatshefte fuer Chemie

2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride(cas: 611-75-6) is a mucolytic agent that exerts both a secretagogic action on submucosal glands and a mucolytic action toward acid glycoproteins inside cells. Bromhexine Hydrochloride is a medication prescribed for coughs which works by dissolving hard phlegm. OthersBromhexine is a mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. In addition, bromhexine has antioxidant properties. Application of 611-75-6

Application of 611-75-6《Determination of bromhexine at a glassy carbon paste electrode using differential pulse voltammetry and flow injection analysis with amperometric detection》 was published in 2015. The authors were Mika, Jan;Moreira, Josino C.;Nemeckova, Andrea;Zima, Jiri;Barek, Jiri;Dejmkova, Hana, and the article was included in《Monatshefte fuer Chemie》. The author mentioned the following in the article:

Abstract: New electrochem. methods for the determination of bromhexine based on differential pulse voltammetry (DPV) and flow injection anal. with amperometric detection (FIA-ED) were developed using a glassy carbon paste electrode. Optimal supporting electrolyte for DPV measurement was methanol/Britton-Robinson buffer pH 9 (80:20, volume/volume). In the case of FIA-ED, optimal conditions were as follows: detection potential +1.1 V, flow rate 1.0 cm³ min^-1, injected volume 0.1 cm³, and carrier solution methanol-ten times diluted B-R buffer of pH 9 (80:20, volume/volume). Detection limit was 2.0 × 10^-6 mol dm^-3 for DPV and 3.1 × 10^-7 mol dm^-3 for FIA-ED. The applicability of the newly developed methods was verified by the determination of bromhexine in pharmaceutical preparations (tablets of Bromhexin-EGIS and Bromhexin 8 BC). To complete the study, the researchers used 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) .

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Cas: 611-75-6 | Abdel, Khalid et al. made new progress in 2016

Category: bromides-buliding-blocks《Different spectrophotometric methods manipulating ratio spectra for simultaneous determination of salbutamol and bromhexine in binary mixture》 was published in 2016. The authors were Abdel, Khalid;Attia, Salam M.;Nassar, Mohammed W. I.;Osman, Ayman, and the article was included in《Analytical Chemistry: An Indian Journal》. The author mentioned the following in the article:

Four simple, specific, accurate and precise spectrophotometric methods manipulating ratio spectra were developed and validated for simultaneous determination of Salbutamol (SL) and Bromhexine (BH) namely; dual wavelength, ratio difference, ratio derivative, mean centering. The proposed spectrophotometric procedures do not require any preliminary separation step. The accuracy, precision and linearity ranges of the proposed methods were determined The four methods were applied for the determination of the cited drugs in tablets and the obtained results were statistically compared with a reported spectrophotometric method. The comparison showed that there is no significant difference between the proposed methods and the reported method regarding both accuracy and precision.2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) were involved in the experimental procedure.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Explore more uses of cas: 611-75-6 | Pharmacia Sinica

Application In Synthesis of 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride《Simultaneous UV-spectrophotometric estimation of bromhexine hydrochloride and salbutamol sulphate by area under curve method in combined dosage form》 was published in 2015. The authors were Rele, Rajan V., and the article was included in《Pharmacia Sinica》. The author mentioned the following in the article:

The objective of the study was to develop a simple, accurate, precise and rapid UV spectrophotometric, area under curve (AUC), method for simultaneous estimation of bromhexine hydrochloride and salbutamol sulfate from combined dosage form. The validation was carried out by using ICH guidelines for the determination of bromhexine hydrochloride and salbutamol sulfate by using 0.1N hydrochloric acid as the solvent in pharmaceutical dosage form. The proposed area under curve method involves the measurement of area at selected anal. wavelength ranges and performing the anal. using “Cramer’s rule and Matrix method”. The two anal. wavelengths ranges were used i.e. 240-250 nm and 220-230 nm for estimation of bromhexine hydrochloride and salbutamol sulfate resp. The linearity of the proposed method was found in the concentration range of 2-14 μg /mL (r2 = 0.9998) for bromhexine hydrochloride and salbutamol sulfate (r2 = 0.9999) resp. The percentage mean recovery was found to be 100.083% for bromhexine hydrochloride and 100.111 % for salbutamol sulfate resp. The method was statistically validated for its linearity, accuracy and precision as per ICH guidelines. Both intra and inter day variation showed less percentage (%) RSD values indicating high grade of precision of this method. And 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) was used in the research process.

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Application of cas: 611-75-6 | Badyal, Pragya Nand et al. published an article in 2015

Badyal, Pragya Nand;Sharma, Chetan;Kaur, Navdeep;Shankar, Ravi;Pandey, Abhay;Rawal, Ravindra K. published 《Analytical techniques in simultaneous estimation: an overview》. The research results were published in《Austin Journal of Analytical and Pharmaceutical Chemistry》 in 2015.Synthetic Route of C14H21Br2ClN2 The article conveys some information:

A review. Simultaneous estimation plays a very important role in pharmaceutical world as it is very feasible and time saving. For the multi component anal. various techniques like spectrophotometric techniques (UV-VIS, IR, NMR and MASS spectrometry) and chromatog. techniques (Thin Layer Chromatog., High Performance Liquid Chromatog., Ultra-High Performance Liquid Chromatog., High Pressure Thin Layer Chromatog. and Gas Chromatog.) is used. These techniques provide high degree of specificity and selectivity and further provide the high degree of assurance that these techniques fit for the simultaneous estimation of the pharmaceutical dosage form. Chromatog. and spectrophotometric techniques together develop new hyphenated techniques which are useful for the simultaneous estimation and impurity profiling. The simultaneous anal. anal. provides specificity and assurance for the identification of the chem. entities in the pharmaceutical formulation. The main objective behind the anal. estimation is to provide the assurance that the particular formulation contains the equal amount of active pharmaceutical ingredient as mentioned in the label. To complete the study, the researchers used 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) .

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Cas: 611-75-6 | Obeid, M. et al. made new progress in 2016

Obeid, M.;Allous, I.;Hirbali, J. published 《Validated RP-HPLC method for determination of bromhexine hydrochloride, terbutaline sulfate and guaiphenesine in pharmaceutical dosage forms》 in 2016. The article was appeared in 《Asian Journal of Pharmaceutical Analysis and Medicinal Chemistry》. They have made some progress in their research.Safety of 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride The article mentions the following:

A simple and accurate reversed phase HPLC method for simultaneous estimation of Syrian cough syrup containing Bromhexine Hydrochloride, Terbutaline Sulfate, and Guaiphenesin was developed. Separations were carried out on Column: C18(1005) (25 × 4.6mm, with precolumn). The mobile phase was methanol: buffer (600:400 volume/volume). The elution of the analytes was achieved in less than 10 min with a flow rate of 1.5 mL/min. Detection was by using UV absorbance at a wavelength of 276 nm. Different anal. performance parameters such as linearity, precision, accuracy, and robustness were determined and found in the acceptance range of American pharmacopoeia (USP34). To complete the study, the researchers used 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) .

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

New progress of cas: 611-75-6 | Biomedical and Pharmacology Journal 2019

Shaban, Nema S.;Radi, Abeer M.;Bogzil, Alsadek H.;El-Banna, H. A.;Mobarez, Elham Ahmed;El-Gendy, A. A. M. published 《Effect of bromhexine on the pharmacokinetic of tilmicosin in broiler chickens》. The research results were published in《Biomedical and Pharmacology Journal》 in 2019.Synthetic Route of C14H21Br2ClN2 The article conveys some information:

Concurrent administration of drugs may alter their pharmacokinetic parameters, so; investigation to what extent bromhexine hydrochloride affects the pharmacokinetic behavior of tilmicosin was our aim of this work. Ten broiler chickens were classified into two groups as follow, the first one (tilmicosin group) was given single oral dose of tilmicosin (20 mg/kg.b.weight) while the 2nd (pre-treated group) was given single oral dose of bromhexine hydrochloride (1 mg/kg.b.weight) followed by single oral dose of tilmicosin (20 mg/kg.b.weight) one hour later. The serum concentration of tilmicosin was measured using High Pressure Liquid Chromatog. (HPLC) method. The results revealed that the mean serum concentrations of tilmicosin were significantly lower in pre-treated group when compared with tilmicosin alone group at the corresponding time intervals. Pharmacokinetic parameters were significantly differed (p<0.001) between both groups. The maximum serum concentration were (Cmax 0.70 ± 0.02, 0.81 ± 0.04μg/mL), achieved at Tmax of (tmax 0.89 ± 0.16, and 2.10 ± 0.06h), absorption half-life (t0.5ab) of 0.16 ± 0.08, and 0.37 ± 0.01 h, area under curve (AUC) of 12.96 ± 0.42 and 16.73 ± 0.42μg.h/mL) in tilmicosin-bromhexine and tilmicosin alone groups resp. In conclusion, based on the obtained pharmacokinetic parameters, these findings showed that bromhexine accelerates the tilmicosin penetration into body tissues, achieving higher and faster concentrations than when given tilmicosin alone. The experimental procedure involved many compounds, such as 2,4-Dibromo-6-((cyclohexyl(methyl)amino)methyl)aniline hydrochloride (cas: 611-75-6) .

Reference:
Bromide – Wikipedia,
bromide – Wiktionary

Dusold, Carolin team published research on Chemistry – A European Journal in 2021 | 1575-37-7

Formula: C6H7BrN2, 4-Bromo-1,2-diaminobenzene can be obtained from 1,2-diaminobenzene via acetylation followed by bromination and alkaline hydrolysis.
4-Bromobenzene-1,2-diamine, also known as 4-Bromobenzene-1,2-diamine, is a useful research compound. Its molecular formula is C6H7BrN2 and its molecular weight is 187.04 g/mol. The purity is usually 95%.
4-Bromo-1,2-diaminobenzene is a dye that is used in diagnostic
procedures to detect the presence of amide groups. 4-Bromo-1,2-diaminobenzene can be used as an inhibitor for cationic polymerization reactions. It also has tuberculostatic activity and inhibits the growth of Mycobacterium tuberculosis. This compound reacts with aniline to form a benzimidazole derivative that contains a reactive amine group. The reaction between this amine group and different electrophiles generates benzimidazole compounds with different properties that are useful in nucleophilic attack reactions. The reaction between 4-bromo-1,2-diaminobenzene and methyl ethyl sulfide produces a luminescent probe that can be used to detect hydrogen bonds., 1575-37-7.

One prominent application of synthetic organobromine compounds is the use of polybrominated diphenyl ethers as fire-retardants, and in fact fire-retardant manufacture is currently the major industrial use of the element bromine. 1575-37-7, formula is C6H7BrN2, Name is 4-Bromobenzene-1,2-diamine, Formula: C6H7BrN2

Dusold, Carolin;Haines, Philipp;Platzer, Benedikt;Guldi, Dirk M.;Hirsch, Andreas research published 《 Helically and Linearly Fused Rylenediimide-Hexabenzocoronenes》, the research content is summarized as follows. Perylene- as well as naphthalenediimides were fused to hexabenzocoronenes (HBCs) at their imide position to realize highly π-extended donor-acceptor (D-A)-hybrids. Successful isomer separation in the first step was decisive to guarantee a straightforward synthetic sequence. Hexaphenylbenzenes as precursors were accessed via Diels-Alder reactions and reacted in a Scholl oxidation to yield the resp. HBC derivatives The fully conjugated benzimidazole linker, which separates the electron donating HBC from the electron accepting rylenediimide, enabled the formation of either a linear or a helical configuration. Largely different chem., phys., and optoelec. characteristics were noted for the two configurations. What stood out was their aggregation and their excited state deactivation depending on the solvent polarity. Results from global anal. of the femtosecond transient absorption data corroborated the formation of a charge-transfer (CT) state that is stabilized in the helically fused configuration relative to the linear analog. However, a comparison with spectroelectrochem. experiments failed to disclose evidence for a charge-separated (CS) state.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary

Carmichael, Ian team published research on Journal of Physical and Chemical Reference Data in 1986 | 19111-87-6

19111-87-6, 2-Bromotriphenylene is a useful research compound. Its molecular formula is C18H11Br and its molecular weight is 307.2 g/mol. The purity is usually 95%.
2-Bromotriphenylene is a brominating agent that has the ability to react with sodium carbonate and emit light. The luminescence of 2-bromotriphenylene can be used as an indicator of the degree of dilution, or how much water is present in a solution. It also emits light when it reacts with chloride ions in a reaction solution. 2-Bromotriphenylene can be used as a polymer matrix to form polymeric films, which are then used as catalysts for organic reactions. The luminescence properties of 2-bromotriphenylene make it suitable for use in functional theory experiments. This chemical compound is relatively low cost, and has been shown to have high yield in catalysis., Reference of 19111-87-6

Organobromine compounds, also called organobromides, are organic compounds that contain carbon bonded to bromine. 19111-87-6, formula is C18H11Br, The most pervasive is the naturally produced bromomethane. Reference of 19111-87-6

Carmichael, Ian;Hug, Gordon L. research published 《 Triplet-triplet absorption spectra of organic molecules in condensed phases.》, the research content is summarized as follows. A review in which a compilation is given of spectral parameters associated with triplet-triplet absorption of organic mols. in condensed media. The wavelengths of maximum absorbance and the corresponding extinction coefficients, where known, were critically evaluated. Other data, for example, lifetimes, energies, and energy transfer rates, relevant to the triplet states of these mols., are included by way of comments, but have not been subjected to a similar scrutiny. An introduction is given to triplet state processes in solution and solids, developing the conceptual background and offering a historical perspective on the detection and measurement of triplet state absorption. Techniques employed to populate the triplet state are reviewed and the various approaches to the estimation of the extinction coefficient of tripley-triplet absorption are discussed. A statistical anal. of the available data is presented and recommendations for a hierarchical choice of extinction coefficients are made. Data collection is expected to be complete through the end of 1984.

Referemce:
Bromide – Wikipedia,
bromide – Wiktionary