Category: bromides-buliding-blocks

Bergmann, A. G. published the artcileReactions of combination with conjugated systems of double linkings. II. Combination of hydrogen bromide with di-isopropenyl [β,γ-dimethyl-Δ^αγ-butadiene], Recommanded Product: 2,3-Dibromo-2,3-dimethylbutane, the publication is Zhurnal Russkago Fiziko-Khimicheskago Obshchestva (1920), 37-40, database is CAplus.

The combination of HBr with β,γ-dimethyl-Δ^αγ-butadiene in glacial AcOH takes place in the 2 stages: (1) CH₂:CMeCMe:CH₂ + HBr = CMe₂BrCMe:CH₂, and (2) the latter + HBr = CMe₂BrCMe₂Br (30%) + CMe₂BrCHMeCH₂Br (70%). γ-Bromo-β,γ-dimethyl-Δ^α-butene, C₆H₁₁Br, b₁₀₀ 84-6°, d₂₀ 1.2201, yields dimethylisopropenylcarbinol when hydrolyzed by means of aqueous KOH. β,γ-Dibromo-β,γ-dimethylbutane was described by Thiele (Ber. 27, 454). α,γ-Dibromo-β,γ-dimethylbutane is a liquid, b_16.5 88-9°, d₂₀ 1.6065. The product of the union of 1 mol. of HBr with isoprene, viz., γ-bromo-γ-methyl-Δ^α-butene, combines with a 2nd mol. of HBr, apparently giving only βδ-dibromo-β-methylbutane.

Zhurnal Russkago Fiziko-Khimicheskago Obshchestva published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Recommanded Product: 2,3-Dibromo-2,3-dimethylbutane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Beveridge, Elizabeth published the artcileActivity of phenanthridine compounds against Babesia rodhaini in mice, Recommanded Product: Dimidium bromide, the publication is Annals of Tropical Medicine & Parasitology (1956), 85-91, database is CAplus.

A series of phenanthridine compounds previously reported to have trypanocidal activity (C.A. 44, 8545e) was tested against B. rodhaini in mice. General requirements for babesicidal activity are the same as for trypanocidal activity. For high potency against B. rodhaini there must be: (1) a 10-quaternary group; (2) at least one free amino or easily hydrolyzed acylamino group in the 2, 3, 6, or 7 position of the phenanthrene nucleus; (3) an alkyl, phenyl, or p-aminophenyl group in position 9. Urethan derivatives have little activity; and acylation of amino groups does not greatly diminish babesicidal potency, in contrast to the effect on trypanocidal action.

Annals of Tropical Medicine & Parasitology published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Recommanded Product: Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Bogonostseva, N. P. published the artcileReaction of some halogen derivatives with sodium diethyl phosphite, Recommanded Product: 2,3-Dibromo-2,3-dimethylbutane, the publication is Uchenye Zapiski, Kazan. Gosudarst. Univ. im. V. I. Ul’yanova-Lenina (1956), 116(No. 2), 71-128, database is CAplus.

Ph₂CHBr (10 g.) in Et₂O-C₆H₆ with (EtO)₂PONa from 5.35 g. ester and 0.9 g. Na gave NaBr and 61.33% (Ph₂CH)₂ and 5.3 g. unidentified yellow liquid Ph₂CHCl and (EtO)₂PONa did not react in Et₂O; in iso-Am₂O a little NaCl formed; in MePh a reaction took place after 2 h. reflux yielding a little Ph₂CHOH, (Ph₂CH)₂O, and 21% Ph₂CHP(O)(OEt)₂, b₄ 184-8°, d₀²⁰ 1.1277, n_D²⁰ 1.5460, m. 38-40°; the latter hydrolyzed with 10% HCl to the free acid, m. 223-5° (from H₂O); the same ester formed in 43.65% yield from (EtO)₃P with Ph₂CHBr in Et₂O; the ester, b₂ 180-1°, d₀²⁰ 1.1287, n_D²⁰ 1.5445, m. 39-40°, which hydrolyzed with 10% HCl at 150-80° to the free acid, m. 227-8°. (EtO)₂PONa in Et₂O with PhCH₂Cl readily gave 49.35% PhCH₂PO(OEt)₂ (I), b₁₁ 153-4°, d₀⁰ 1.1200, n_D²⁰ 1.4965, which hydrolyzed with 10% HCl to the free acid, m. 169-70°. Similarly, PhCH₂Br gave 44% I, b₁₂ 153-5°, d₀⁰ 1.1189, n_D²⁰ 1.4892, while PhCH₂I gave 21.1% I. To (EtO)₂PONa from 2.5 g. ester and 0.32 g. Na in Et₂O was added Ph₂CBrCCl₃ in Et₂O and after refluxing 2 h. there was obtained 1.9 g. NaBr, 32.05% (Ph₂CCCl₃)₂ (II), a glassy solid, b₃ 180-90°, and a range of products, b₈ 60° to b₃ 160°, which contain P; a substance C₁₀H₁₄O₃ClP, b₃ 154-60°, n_D²⁰ 1.5010, d₂₀²⁰ 1.2332, was isolated but not identified. Heating 8 g. (EtO)₃P with 15.4 g. Ph₂CBrCCl₃ to 155-60° 2 h. gave 42.4% II and some low-boiling material. Refluxing (EtO)₂PONa in Et₂O with Ph₂CClCCl₃ 6 h. gave NaCl and much unreacted halide; a similar reaction in dioxane in a sealed tube at 130-50° gave in 7 h. unreacted halide and Ph₂C:CCl₂. Ph₂CClCCl₃ (5 g.) and 3 g. (EtO)₈P refluxed 3 h. gave unreacted halide, Ph₂C:CCl₂, and no P-containing substance. Ph₂C:CH₂ with HBr gave crude Ph₂CBrMe, 10 g. of which with (EtO)₂PONa from 7.5 g. ester and 1.2 g. Na in Et₂O gave after refluxing 4 h. 6.35 g. NaBr, 6.9% Ph₂C:CH₂, and a crude substance, b_2.5 168-85°, which contains P. Ph₂CBrMe (5.05 g.) with 3.2 g. (EtO)₃P gave in 5 h. reflux EtBr and 44.9% crude Ph₂C:CH₂. Crude Ph₂CClMe (prepared from the olefin and HCl) with (EtO)₂PONa in Et₂O gave, after 3 h. reflux, NaCl and Ph₂C:CH₂; Ph₂CClMe with (EtO)₃P refluxed 3 h. gave mainly Ph₂C:CH₂. No appreciable reaction took place between (EtO)₂PONa and (1-C₁₀H₇)₂CHBr in Et₂O; the result was the same with (EtO)₃P in 2 h. at 200°; the same result was obtained with (1-C₁₀H₇)₂CHCl and (EtO)₂PONa in Et₂O, or in dioxane at 130-40°. Only slight reaction took place between (EtO)₂PONa and 9-bromofluorene in Et₂O; the latter with (EtO)₃P in 6 h. at 260° gave no EtBr and no reaction could be detected. 9-Chlorofluorene failed to react with (EtO)₂PONa or (EtO)₃P. 2-Bromocyclohexanone with (EtO)₂PONa in Et₂O gave 31% di-Et cyclohexanone-2-phosphonate, b_11.5 148-9, d₀⁰ 1.1270, n_D²⁰ 1.4578, which gave no definite products after hydrolysis with 10% HCl; similarly, 2-chlorocyclohexanone gave 35% above ester, b_11.5 151.5-3°, d₀⁰ 1.1380, n_D²⁰ 1.4518, which again failed to yield definite products after hydrolysis with HCl. 2-Chlorocyclohexanone with (EtO)₃P after 2 h. at 110-20° gave 54.5% above ester; hydrolysis of this with HCl gave some cyclohexanone and H₃PO₄. Bz₂CHBr with (EtO)₂PONa in Et₂O gave NaBr and 69.1% Bz₂CH₂; the same reaction in C₆H₆ gave 42.7% Bz₂CH₂, while 82.3% NaBr was isolated. Bz₂CHBr with (EtO)₃P gave 60.8% Bz₂CH₂. Bz₃CBr with (EtO)₂PONa in Et₂O gave 58.3% Bz₃CH, some Bz₂CH₂, and a substance, b₈ 90-1°, identified as (EtO)₃PO. Bz₃CBr with (EtO)₃P gave 56.6% Bz₃CH, and (EtO)₃PO. Bz₂CHBr in MePh with Na gave Bz₂CH₂ and some Bz₄C₂H₂; Na and Bz₃CBr in MePh gave a trace of Bz₃CH and unreacted halide. (EtO)₂PONa with o-C₆H₄(CO)₂CBrCO₂Et gave indanedione and some diphthalylethane, decompose 215°; (EtO)₃P gave the same products. o-C₆H₄(CO)₂CNaCO₂Et with (EtO)₂POCl in Et₂O gave diphthalylethane and indanedione. Bromoindanedione and (EtO)₂PONa gave diphthalylethane; (EtO)₃P gave indanedione. Bromoindanedione and Na in MePh gave indanedione. (EtO)₂PONa (from 15.85 g. ester) and 14 g. (Me₂CBr)₂ in Et₂O reacted completely in 7 min. yielding 60% (Me₂C:)₂ and unidentified material, b₄ 60-70°, which reacts with Na. 9,10-Phenanthrenedibromide and (EtO)₂PONa in Et₂O gave phenanthrene and (EtO)₂POH, and unidentified material, b₉₀ 110°, which on hydrolysis gave H₃PO₄. Dibromophenanthrene and (EtO)₃P gave phenanthrene and (EtO)₂POH. (EtO)₂PONa (from 26.6 g. ester) with 24.6 g. (CH₂OCH₂CH₂Br)₂ on 2 days standing gave 14.7% (CH₂OCH₂CH₂PO₃Et₂)₂, b₂ 228-9°, d₂₀²⁰ 1.1416, n_D²⁰ 1.4478, which with HCl hydrolyzed to an uncrystallizable free acid, which was analyzed as the Ba salt. (CH₂OCH₂CH₂Br)₂ with (EtO)₃P gave impure ester identical with that above but decomposing on distillation (EtO)₂PONa (from 33 g. ester) with 25.7 g. Br(CH₂)₄Br gave 61% (CH₂CH₂PO₃Et₂)₂, b₇ 214-17°, d₂₀²⁰ 1.1173, n_D²⁰ 1.4460, decompose on boiling; hydrolysis gave an uncrystallizable oil. (CH₂)₄Br₂ (10 g.) with 15.5 g. (EtO)₃P gave 58.4% above ester, b₈ 215-16°, d₂₀²⁰ 1.1176, n_D²⁰ 1.4495. (EtO)₂PONa (from 19.2 g. ester) with 30 g. 1-iodo-2-ethoxy-3-butene refluxed 1 h. in Et₂O gave 33.5% crude, or 17% pure, CH₂:CHCH(OEt)CH₂PO(OEt)₂, b₇ 119-20°, d₀⁰ 1.0409, n_D²⁰ 1.4231, and much polymerized undistillable matter; the same ester formed in 30% yield in a larger experiment The iodide with (EtO)₃P refluxed 2 h. yielded 30% same ester as above. (EtO)₂PONa with 1-chloro-2-ethoxy-3-butene gave NaCl and liquid material which decomposed extensively on attempted distillation and much polymeric matter; the chloride and (EtO)₃P gave much unreacted material and a little substance, b_4.5 124-6°, d₀⁰ 1.0592, n_D²⁰ 1.4495, containing 14-14.5% P. (EtO)₂PONa with 1-chloro-4-ethoxy-2-butene gave NaCl, unreacted halide, MePO(OEt)₂ (uncertain), and material, b₃ to 205°, which analyzed as C₅H₁₃O₃P to C₁₈H₄₁O₁₀P₃. 1-Chloro-4-ethoxy-2-butene with (EtO)₃P gave a little substance, b_4-6 136-42°, with much decomposition The nature of the products is unknown.

Uchenye Zapiski, Kazan. Gosudarst. Univ. im. V. I. Ul’yanova-Lenina published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C6H12Br2, Recommanded Product: 2,3-Dibromo-2,3-dimethylbutane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Booker-Milburn, Kevin I. published the artcileTandem ring expansion-cyclization reactions: a novel method for the rapid construction of the bicyclo[5.3.0]decane ring system, Recommanded Product: (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is Synlett (1992), 809-10, database is CAplus.

Treatment of the cyclopropyl silyl ether I with ferric chloride in DMF gave the 5,7-bicyclic chloro ketone II via a tandem free radical ring expansion-cyclization sequence. The acetylenic derivatives III (R = SiMe₃, CO₂Me) underwent the same expansion-cyclization sequence to yield similar 5,7-carbocycles.

Synlett published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Recommanded Product: (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Braun, Aleksander published the artcileQuantitative determination of anionic surfactants by two-phase titration, Category: bromides-buliding-blocks, the publication is Barwniki – Srodki Pomocnicze (1979), 23(1), 16-20, database is CAplus.

The mixed indicators Disulphine Blue VN 150 [129-17-9] and 3,8-diamino-6-phenylphenanthridine methobromide [518-67-2] gave statistically more reliable results in the determination of Na alkylarenesulfonates by acidimetric titration than only 1 indicator, e.g. cetylpyridinium bromide. The historical development of 1- and 2-indicator procedures for surfactant determinations is described. A statistical comparison of the 2 methods is given.

Barwniki – Srodki Pomocnicze published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Buschmann, N. published the artcileIndicator for the two-phase titration of ionic surfactants is possibly mutagenic, Product Details of C20H18BrN3, the publication is Rivista Italiana delle Sostanze Grasse (1995), 72(11), 513, database is CAplus.

For the two-phase titration of anionic or cationic surfactants, the most frequently used indicator is a mixed indicator system consisting of dimidium bromide and Disulphine Blue. Recently, we noticed a similarity between ethidium bromide and dimidium bromide (I). Ethidium bromide is well known as a strong mutagenic and cancerogenic agent, reacting with DNA either by intercalation or external binding. The literature shows that I reacts with DNA in a similar way. When mixing aqueous solutions of DNA and I a change in the color of the solution can be observed, as well as a strong enhancement in the fluorescence intensity. Both the literature and the exptl. findings make it very likely that I shows mutagenic and cancerogenic properties that are similar to those of ethidium bromide. This estimation is shared by the USA National Cancer Institute. Up to now, only little is known about the ways of incorporation for both dyes. Ethidium bromide shows mutagenic and cancerogenic properties when coming in contact with the mucous membrane. The author has no information whether I will be incorporated if an aqueous solution is in contact with the intact epidermis. That would be the most probable way of incorporation when carrying out a two phase titration For that reason, the appropriate safety precautions should be taken when working with I: protection gloves and goggles and addnl., when working with the solid substance, dust mask. When titrating anionic surfactants, I will be found in the aqueous phase at the end of the titration The dye should be removed from the solution by adsorption on activated charcoal or on a polymeric resin like Amberlite XAD-16. After our experience an amount of 10 g activated charcoal is sufficient for the removal of I from one liter of the aqueous phase.

Rivista Italiana delle Sostanze Grasse published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Product Details of C20H18BrN3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Buschmann, N. published the artcileDoes the two-phase titration of surfactants require a mutagenic indicator?, Recommanded Product: Dimidium bromide, the publication is Journal of the American Oil Chemists’ Society (1995), 72(10), 1243, database is CAplus.

Appropriate safety precautions are recommended when using the indicator mixture of dimidium bromide and disulphine blue, as dimidium bromide is chem. similar to ethidium bromide which is a known mutagen. When titrating anionic surfactants, dimidium bromide is found in the aqueous phase at the end of the titration; the dye should be removed by adsorption on activated charcoal which must be disposed of according to regulatory guidelines.

Journal of the American Oil Chemists’ Society published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C20H18BrN3, Recommanded Product: Dimidium bromide.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Cade, J. A. published the artcileMethylenediphosphonates and related compounds. I. Synthesis from methylene halides, Synthetic Route of 66197-72-6, the publication is Journal of the Chemical Society (1959), 2266-72, database is CAplus.

Two established methods for preparing Et methylenediphosphonates were extended to allyl systems, but with limited success. Only 1 method gave a product suitable for the preparation of resins for complex formation with metals. The yield of saturated alkyl esters was improved, and some new esters containing P were described. Diethyl chloromethylphosphonate (I) was prepared from the acid chloride, which was obtained from PCl₃ and paraformaldehyde. AlBr₃ (280 g.) and 272 g. PBr₃ treated portionwise with 500 cc. CH₂Br₂ with cooling, the mixture refluxed 2 hrs., the bulk of the CH₂Br₂ distilled, the residual sirup solidified, added in lumps to 1.2 l. CH₂Cl₂, at -20°, 160 cc. H₂O added dropwise, the precipitate collected, washed, the filtrate and washings distilled and degassed and the residue distilled gave pure bromomethylphosphonyl dibromide (II), b₇ 118-20°, n²⁰_D 1.512. Na (4.6 g.) in 100 cc. CH₂:CHCH₂OH treated at 0° with 32.4 g. diallyl phosphite, 26.8 g. CH₂I₂ added during 0.5 hr., the solution warmed 2 hrs. at 60°, the bulk of the alc. removed, the residual volatile matter removed at 60°/0.1 mm., the combined distillate and trap contents treated with H₂O, the insoluble material dried, and distilled gave 16 g. CH₂:CHCH₂I, b. 98-102°; S-thiuronium picrate, m. 154-6°, and 4.2 g. CH₂I₂, b₂₅ 79-82°, d²⁰ 3.32. The pasty residue (43 g.) washed with 1:1 Me₂CO-Et₂O and recrystallized gave 15 g. symmetrical di-Na diallyl methylenediphosphonate (III), m. 209-11° (MeOH-Et₂O). The washings treated with H₂O and the oil distilled gave 6.5 g. diallyl allylphosphonate (IV), b_0.5 75-8°, n²⁰_D 1.4614. Na diallyl phosphonate prepared as described above from 4.6 g. Na and 32.4 g. diallyl H phosphite in allyl alc., the dry product in 200 cc. PhMe distilled with removal of 100 cc. PhMe, the process repeated, the solution treated during 0.5 hr. at 0° with 17.5 g. CH₂Br₂ gave III. The process was unreliable. CH₂Cl₂ gave similar results, and addition of quinol also did not give reliable reactions. III (9 g.) refluxed 3 hrs. with 80 cc. constant boiling HBr, the mixture distilled 3.8 g. allyl bromide removed, the residual sirup treated with more acid and 4.9 g. NaBr removed, the filtrate evaporated, treated with 50 cc. alc., filtered, and evaporated gave 1.5 g. methylenediphosphonic acid, m. 201° (tert-BuOH). Et₃PO₄ (425 g.) and 311 g. CH₂I₂ were heated together under a column. At 148° a reaction set in and the temperature rose spontaneously to 200°; a liquid distilled and the temperature remained at 190-200° until distillation ceased. The residue on repeated distillation gave 263.6 g. diethyl ethylphosphonate (V), b_0.1 43-5°, n²⁰_D 1.4150, 56.3 g. diethyl iodomethylphosphonate (VI), b_0.2 90-100°, 81.2 g. tetraethyl methylenediphosphonate (VII), b_0.5 122-8°, n²⁰_D 1.4300, and mixed fractions and residues. The primary distillate was combined and after treatment with dilute HCl and drying gave 68.6 g. EtI, b. 70-3°, 18.9 g. mixed fraction, and 45.8 g. recovered CH₂I₂. Et₃PO₄ (183 g.) and 134 g. CH₂I₂ mixed at 185°, the rate of addition adjusted so that distillation occurred steadily and heating continued 10 min. gave products consisting of 128 g. EtI, 27.5 g. crude V, 82 g. crude VI, and 32.3 g. residue. The foregoing procedure with 83 g. Et₃PO₄ and 200 g. CH₂I₂ gave 74 g. EtI, 68 g. CH₂I₂, and 120 g. VI. The residue of 11 g. contained no iodine but pure VII was not obtained from it. Et₃PO₄ (33.2 g.) and 27.8 g. VI heated to 160° and finally to 180° (when liquid began to distil), and the temperature held 1 hr. at 195° gave a distillate containing 2 g. EtI contaminated with Et₃PO₄. The reaction mixture gave 4.6 g. forerun containing Et₃PO₄, 29.0 g. V, and 13.5 g. VI. Pure VII was not obtained from the residues. Et₃PO₄ (33.9 g.) added at 220° to 37.6 g. VI (the final temperature was 240°) gave a product containing 17.6 g. EtI and 23 g. VII; very little VI was recovered. Et₃PO₄ (40 g.) added in 1 hr. to 44 g. diethyl bromomethylphosphonate at 220-35° (as described above for VI) gave after the usual work up 14.5 g. EtBr, 19 g. V, and 263 g. VII. Et₃PO₄ (60 g.) added to 60 g. I at such a rate that the temperature never fell below 220° (14 hrs.) 4 g. crude EtCl collected in a trap, the mixture heated a further 2 hrs., and distilled afforded 36.1 g. V, and 40.8 g. of a residue which decomposed on further heating. Methylenediphosphonic acid was not obtained by hydrolysis of this residue. (CH₂:CHCH₂)₃PO₄ (VIII) (60.6 g.) and 26.8 g. CH₂I₂ heated as above with vigorous reaction beginning at 130° and the liquid distilled (after 2 hrs. heating at 170-85° distillation ceased) gave 14.2 g. CH₂:CHCH₂I, b. 98-102°, 7.5 g. CH₂I₂, 25.5 g. IV, 12 g. diallyl iodomethylphosphonate (IX), 4 g. tetraallyl methylenediphosphonate (X), various mixed fractions, and 18 g. residue. The maximum yield of X was 12%. In one experiment 8% IX was isolated. VIII (40.4 g.) and 81 g. CH₂I₂ gave 24.8 g. IX. The following compounds were prepared by the modified procedure (compound, % yield, b.p./mm., n_D, and d given): VIII, 90-2, 34°/0.06, 1.4589, 0.999; diallyl phosphite, 70-6, 40°/0.07, 1.4478, 1.087; IV, 82, 54°/0.08, 1.4622, 1.046; diallyl chloromethylphosphonate, 60, 83°/0.15, 1.4665, 1.175; diallyl bromomethylphosphonate, 72, 76°/0.1, 1.4842, 1.373; IX, 8(41), 102°/0.1, 1.5015, 1.552; X, 12, 142°/0.1, 1.4675, 1.132; diethyl bromomethylphosphonate, 82, 121°/15, 1.4595, 1.432; tetrabutyl methylenediphosphonate, 45, 150-5°/5 × 10^-4, 1.4455, 1.041; tetrabutyl ethylenediphosphonate, 51, 175-8°/5 × 10^-4, 1.4484, 1.035.

Journal of the Chemical Society published new progress about 66197-72-6. 66197-72-6 belongs to bromides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyl (bromomethyl)phosphonate, and the molecular formula is C5H12BrO3P, Synthetic Route of 66197-72-6.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Cakmak, Osman published the artcileBromination of naphthalene. Preparation of 1,3-dibromonaphthalene, Quality Control of 52358-73-3, the publication is Journal of Chemical Research, Synopses (1999), 366-367, database is CAplus.

Photobromination of naphthalene with mol. bromine gives only one stereoisomer, 1α,2β,3α,4β-tetrabromo-1,2,3,4-tetrahydronaphthalene (I) in 90% yield; dehydrobromination of I results in the formation of 1,3-dibromonaphthalene in 88% yield.

Journal of Chemical Research, Synopses published new progress about 52358-73-3. 52358-73-3 belongs to bromides-buliding-blocks, auxiliary class Bromide,Naphthalene, name is 1,3-Dibromonaphthalene, and the molecular formula is C10H6Br2, Quality Control of 52358-73-3.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Cal, Dariusz published the artcileA convenient synthesis of ω-hydrazinoalkylphosphonic acids, Recommanded Product: Diethyl (bromomethyl)phosphonate, the publication is Tetrahedron Letters (2016), 57(1), 126-128, database is CAplus.

A simple, efficient, and cost effective method has been developed for the synthesis of ω-hydrazinoalkylphosphonic acids via the nucleophilic substitution reaction of di-Et ω-haloalkylphosphonates and hydrazine using mild reaction conditions, followed by hydrolysis with hydrochloric acid.

Tetrahedron Letters published new progress about 66197-72-6. 66197-72-6 belongs to bromides-buliding-blocks, auxiliary class Aliphatic Chain, name is Diethyl (bromomethyl)phosphonate, and the molecular formula is C5H12BrO3P, Recommanded Product: Diethyl (bromomethyl)phosphonate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary