Category: bromides-buliding-blocks

Craig, Sandra published the artcileSynthesis and evaluation of aryl boronic acids as fluorescent artificial receptors for biological carbohydrates, Synthetic Route of 166821-88-1, the publication is Bioorganic Chemistry (2012), 137-142, database is CAplus and MEDLINE.

Carbohydrates in various forms play a vital role in numerous critical biol. processes. The detection of such saccharides can give insight into the progression of such diseases such as cancer. Boronic acids react with 1,2 and 1,3 diols of saccharides in non-aqueous or basic aqueous media. Herein, we describe the design, synthesis and evaluation of three bisboronic acid fluorescent probes, each having about ten linear steps in its synthesis. Among these compounds that were evaluated, 9b was shown to selectively label HepG2, liver carcinoma cell line within a concentration range of 0.5-10 μM in comparison to COS-7, a normal fibroblast cell line.

Bioorganic Chemistry published new progress about 166821-88-1. 166821-88-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester, name is 2-(2-(Bromomethyl)phenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C12H16BBrO2, Synthetic Route of 166821-88-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Hou, Jin published the artcileEvaluation of Novel N-(piperidine-4-yl)benzamide Derivatives as Potential Cell Cycle Inhibitors in HepG2 Cells, Formula: C7H5Br2F, the publication is Chemical Biology & Drug Design (2015), 86(2), 223-231, database is CAplus and MEDLINE.

In this study, a series of novel N-(piperidine-4-yl)benzamide derivatives was designed, synthesized, and evaluated for antitumor activity. Some compounds were found to have potent antitumor activity. In particular, compound 47 (N-(1-(2,6-difluorobenzyl)piperidine-4-yl)-4phenoxybenzamide) showed the most potent biol. activity against HepG2 cells, with an IC₅₀ value of 0.25 μM. Western blot anal. demonstrated that compound 47 inhibited the expression of cyclin B1 and p-Rb and enhanced the expression of p21, p53, Rb, and phospho-adenosine monophosphate-activated protein kinase (p-AMPK). Further, cell cycle arrest was observed by flow cytometry (FCM). In summary, compound 47 was screened to have potential activity for the treatment of hepatocarcinoma via the induction of cell cycle arrest by a p53/p21-dependent pathway.

Chemical Biology & Drug Design published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Formula: C7H5Br2F.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Sun, Xin published the artcileMetal-Free Hypervalent-Iodine-Promoted C3 Difluorination and C2 Oxidation of N-Substituted Indoles, Category: bromides-buliding-blocks, the publication is Asian Journal of Organic Chemistry (2017), 6(6), 690-693, database is CAplus.

A metal-free, highly regioselective C3 difluorination and C2 oxidation of N-substituted indoles I (R¹ = 5-Br, 7-Cl, 3,6-F₂, etc.; R² = Bn, 4-ClC₆H₄CH₂, 2,3,5-F₃C₆H₂CH₂, etc.) with the aid of in situ generated PhIF₂ in the presence of two types of fluorinating agents such as Pyr·HF and Et₃N·HF was reported. This reaction provided 3,3-difluoro-2-oxindoles II with yields up to 64% under mild reaction conditions. A mechanism for this reaction was proposed.

Asian Journal of Organic Chemistry published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H10BNO4S, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Li, Chengwen published the artcileSynthesis of difluoroalkylated 2-azaspiro[4.5]decane derivatives via copper-catalyzed difluoroalkylation/dearomatization of N-benzylacrylamides, Related Products of bromides-buliding-blocks, the publication is Organic & Biomolecular Chemistry (2020), 18(41), 8376-8380, database is CAplus and MEDLINE.

An efficient method for the synthesis of difluoroalkylated 2-azaspiro[4.5]decanes I [R¹ = H, 7-OMe, 7-F, etc.; R² = iPr, tBu, adamantan-1-yl; R³ = H, Me; R⁴ = EtO₂C, Et₂NCO, 1-pyrrolidinylcarbonyl, 1-piperidinylcarbonyl, 2,3-dihydro-1-indolylcarbonyl] via copper-catalyzed difluoroalkylation of N-benzylacrylamides with halo- fluoroacetate/difluoroacetate was established. The reaction experienced a tandem radical addition and dearomatizing cyclization process. In addition, the resultant products could be smoothly converted into a difluoroalkylated quinolinone and saturated spirocyclohexanone scaffold.

Organic & Biomolecular Chemistry published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Related Products of bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Yuan, Xiyue published the artcileAchieving 16% Efficiency for Polythiophene Organic Solar Cells with a Cyano-Substituted Polythiophene, Computed Properties of 111-83-1, the publication is Advanced Functional Materials (2022), 32(24), 2201142, database is CAplus.

Polythiophenes (PTs) are promising electron donors in organic solar cells (OSCs) due to their simple structures and excellent synthetic scalability. However, the device performance of PT-based OSCs is rather poor due mainly to large photon energy losses and an unfavorable active layer morphol. Herein, the authors report a new PT, which is abbreviated as P5TCN-2F and features cyano-group substituents for high-efficiency OSCs. The cyano-group endows P5TCN-2F with a deep-lying HOMO energy level, which thereby contributed to high open-circuit voltage in OSCs as a result of reduced non-radiative recombination energy loss. Moreover, the cyano-group leads to strong interchain interaction, improved polymer crystallinity, and appropriate miscibility with the prevailing non-fullerene acceptors. Consequently, P5TCN-2F offers over 15% power conversion efficiency when blended with various Y-series non-fullerene acceptors (Y6, Y6-BO, eC9, and L8-BO). Particularly, a champion efficiency of 16.1% is obtained by the P5TCN-2F:Y6 blend, which is largely higher than that of any previous PT-based OSCs. Moreover, the average figure of merit of the active layer based on P5TCN-2F is much superior to that of benzodithiophene-based polymers. These results suggest the renaissance of PT-based OSCs and have opened an avenue to access high-performance materials for the large-scale production of OSC modules.

Advanced Functional Materials published new progress about 111-83-1. 111-83-1 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromooctane, and the molecular formula is C8H6BrClO, Computed Properties of 111-83-1.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Li, Lixin published the artcileSynthesis of remote fluoroalkylated alkenes by a palladium-catalyzed relay Heck-type reaction, SDS of cas: 401-55-8, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(65), 9384-9387, database is CAplus and MEDLINE.

Palladium-catalyzed relay Heck-type reaction of fluoroalkyl bromide and terminal alkenes was reported. The reaction involved fluoroalkylation of alkenes and migration of double bonds via a 1,5-hydrogen atom transfer strategy. Through this method, a series of remote fluoroalkylated alkenes was obtained under mild conditions.

Chemical Communications (Cambridge, United Kingdom) published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, SDS of cas: 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Ponomarev, I. I. published the artcileSynthesis of N-(2-hydroxyphenyl)-1,8-naphthalimide and its derivatization at the hydroxy group, Product Details of C3H6BrNaO3S, the publication is Russian Chemical Bulletin (2011), 60(3), 512-520, database is CAplus.

The reaction of 1,8-naphthalic anhydride with 2-aminophenol afforded N-(2-hydroxyphenyl)-1,8-naphthalimide. N-(2-hydroxyphenyl)-1,8-naphthalimide was alkylated at the hydroxyl group and then subjected to [2+3]-cycloaddition with azides to afford 1,2,3-triazoles, e.g., I.

Russian Chemical Bulletin published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, Product Details of C3H6BrNaO3S.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Sergienko, S. R. published the artcileTransformations of diene compounds in the presence of oxide catalysts. Transformations of 2,3-dimethyl-1,3-butadiene on aluminosilicate, Safety of 2,3-Dibromo-2,3-dimethylbutane, the publication is Doklady Akademii Nauk SSSR (1953), 803-6, database is CAplus.

cf. C.A. 48, 11290g. Passage of 2,3-dimethyl-1,3-butadiene over pelleted aluminosilicate at 250° (at 200° little reaction takes place, while above 250° much decomposition occurs) gave 7-10% C₅-hydrocarbons and 35-40% dimeric products, the remainder being trimers and higher condensation products. The identified products were 2,3-dimethyl-2-butene, 2,3-dimethylbutane, apparently cyclic dimers, b. 187-95°, and higher products. The fresh catalyst is gradually coated not with C but with a hydrocarbon C_nH_2n-18, a resinous solid, the composition of which was between a pentamer and a hexamer of the diene.

Doklady Akademii Nauk SSSR published new progress about 594-81-0. 594-81-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 2,3-Dibromo-2,3-dimethylbutane, and the molecular formula is C3H8N2S, Safety of 2,3-Dibromo-2,3-dimethylbutane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Li, Ya-Wei published the artcile^tBuOK-Promoted Cyclization of Imines with Aryl Halides, Synthetic Route of 76283-09-5, the publication is Organic Letters (2020), 22(11), 4553-4556, database is CAplus and MEDLINE.

A transition-metal-free indole synthesis using radical coupling of 2-halotoluenes and imines via the later-stage C-N bond construction was reported for the first time. It includes an aminyl radical generation by C-H cleaving addition of 2-halotoluenes to imines via the carbanion radical relay and an intramol. coupling of aryl halides with aminyl radicals. One standard condition can be used for all halides including F, Cl, Br, and I. No extra oxidant or transition metal is required.

Organic Letters published new progress about 76283-09-5. 76283-09-5 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Benzyl bromide,Benzene, name is 4-Bromo-1-(bromomethyl)-2-fluorobenzene, and the molecular formula is C7H5Br2F, Synthetic Route of 76283-09-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhao, Xiaojuan published the artcileA supramolecular approach towards strong and tough polymer nanocomposite fibers, Quality Control of 1207448-58-5, the publication is RSC Advances (2018), 8(19), 10361-10366, database is CAplus and MEDLINE.

Polymer nanocomposite fibers are important one-dimensional nanomaterials that hold promising potential in a broad range of technol. applications. It is, however, challenging to organize advanced polymer nanocomposite fibers with sufficient mech. properties and flexibility. Here, we demonstrate that strong, tough and flexible polymer nanocomposite fibers can be approached by electrospinning of a supramol. ensemble of dissimilar and complementary components including flexible multiwalled carbon nanotubes (CNT), and stiff cellulose nanocrystals (CNC) in an aqueous poly(vinyl alc.) (PVA) system. CNT and CNC are bridged by a water-soluble aggregation-induced-emission (AIE) mol. that forms π-π stacking with CNT via its conjugated chains, and electrostatic attraction with CNC through its pos. charges leading to a soluble CNT-AIE-CNC ensemble, which further assembles with PVA through hydrogen bonds. A high level of ordering of the nanoscale building blocks combined with hydrogen bonding leads to a more efficient stress transfer path between the reinforcing unit and the polymer. The nanocomposite fiber mat is capable of selective detection of nitroarom. explosives.

RSC Advances published new progress about 1207448-58-5. 1207448-58-5 belongs to bromides-buliding-blocks, auxiliary class Bromide,Benzene,Phenol,Ether,Aldehyde, name is 4-((6-Bromohexyl)oxy)-2-hydroxybenzaldehyde, and the molecular formula is C8H17Br, Quality Control of 1207448-58-5.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary