Category: bromides-buliding-blocks

Chen, Ying published the artcileStructure-activity relationship studies of (E)-3,4-dihydroxystyryl alkyl sulfones as novel neuroprotective agents based on improved antioxidant, anti-inflammatory activities and BBB permeability, Name: (2-Bromoethyl)cyclopentane, the publication is European Journal of Medicinal Chemistry (2019), 420-433, database is CAplus and MEDLINE.

(E)-3,4-dihydroxystyryl alkyl sulfones I [n = 0, 1, 2; R = Et, Pr, Bu, etc.], as new analogs of neurodegenerative agents, were designed and synthesized. The biol. results demonstrated that most of the target compounds preserved antioxidant and anti-inflammatory potency in scavenging reactive free radicals, protecting neuronal cells against neurotoxins such as H₂O₂, 6-hydroxydopamine and inhibiting lipopolysaccharide (LPS)-induced over-production of NO. Among these compounds, I [n = 2; R = cyclopentyl] exhibited prominent antioxidant activity at low concentration (2.5 μM) in H₂O₂ model (cell viability = 94.5%). In addition, I [n = 2; R = cyclopentyl] (IC₅₀ = 1.6 μM) displayed better anti-inflammatory activity than that of lead compound 1 (IC₅₀ = 13.4 μM). In view of the outstanding performance of I [n = 2; R = cyclopentyl], the apoptotic rates of H₂O₂-damaged PC12 cells were detected by Annexin V-FITC/PI assay. I [n = 2; R = cyclopentyl] showed higher potency in inhibition of apoptosis than 1 at low concentration (2.5 μM), consisting with the antioxidant and anti-inflammatory models. Furthermore, with the predicted CNS (+) blood-brain barrier (BBB) permeability (Pe = 6.84 x 10^-6 cm s^-1), low cytotoxicity and favorable physiochem. properties based on calculation, compound I [n = 2; R = cyclopentyl] can be further developed as a potential multifunctional neuroprotective agent.

European Journal of Medicinal Chemistry published new progress about 18928-94-4. 18928-94-4 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic cyclic hydrocarbon, name is (2-Bromoethyl)cyclopentane, and the molecular formula is C7H13Br, Name: (2-Bromoethyl)cyclopentane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Sun, Xiaoyang published the artcileHalogen-bond-promoted radical isocyanide insertion of o-diisocyanoarenes with perfluoroalkyl bromides under visible light irradiation, HPLC of Formula: 401-55-8, the publication is Huaxue Xuebao (2017), 75(1), 115-118, database is CAplus.

A halogen-bond-promoted double radical isocyanide insertion of o-diisocyanoarenes with perfluoroalkyl bromides was reported, in which perfluoroalkyl bromides as halogen bond donors and organic bases as halogen bond acceptors. Fluoroalkyl radicals could be generated by a visible-light-induced single electron transfer (SET) process. Fluoroalkyl radicals were trapped by o-diisocyanoarenes to give 2-fluoroalkylated quinoxaline derivatives These reactions could be carried out under mild conditions with good chem. yields and broad substrate scope. A broad range of fluoroalkyl bromides with different functionalities could undergo this reaction to give the corresponding quinoxaline derivatives in good yields. A variety of o-diisocyanides could be fluoroalkylated to give quinoxalines under our established conditions. The radical nature of this reaction was confirmed by ESR (EPR) experiments using tert-butyl-α-phenylnitrone (PBN) as a spin trap. When PBN was introduced into the reaction mixture, a spectrum signal attributed to the spin adduct C₈F₁₇-PBN appeared as a triplet of doublets. Without light and amine, almost no signal was observed These phenomena strongly suggested that the perfluoroalkyl radical was the key intermediate and the generation of the intermediate heavily relied on the presence of light and amine. A series of deuteration experiments were performed and these results suggested that both the amine and solvent could serve as the hydrogen source and solvent was the major source.

Huaxue Xuebao published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C20H12N2O2, HPLC of Formula: 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Lo, Ping Hsun published the artcileThe effect of C_X (alkyl groups) on the migration insertion polymerization (MIP) of ^PFpC_X [^PFp = (PPh₂(CH₂)₃Cp)Fe(CO)₂], Recommanded Product: 1-Bromododecane, the publication is Polymer (2022), 124574, database is CAplus.

Migration insertion polymerization (MIP) of organometallic monomers, ^PFpC_X [^PFp = (PPh₂(CH₂)₃Cp)Fe(CO)₂, C_X = (CH₂)_X-1CH₃, X = 12 or 18] was performed under various conditions. The oligomerization occurred in accompany with the monomer cyclization generating ^PFpC_X small rings at the early stage, which was followed by a complete cyclization of the oligomers generating P(^PFpC_X)_n macrocycles. ^PFpC_X small rings could be completely removed via precipitating the crude products in a poor solvent for the macrocycles. The solution and bulk MIP of ^PFpC_X (X = 12 or 18) had a similar cyclization rate but both were significantly accelerated at a higher MIP temperature (100°C). It is explained by the temperature-dependent tendency for the cyclization. The dependence of d.p. (DP) on the MIP conditions was discussed and the self-assembly of resultant P(^PFpC₁₂)_n was examined

Polymer published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C12H25Br, Recommanded Product: 1-Bromododecane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Sokolsky, Alexander published the artcileSpirastrellolide E: synthesis of an advanced C(1)-C(24) southern hemisphere, Formula: C7H13BrSi, the publication is Tetrahedron Letters (2015), 56(23), 3160-3164, database is CAplus and MEDLINE.

The synthesis of a C(1)-C(24) advanced southern hemisphere fragment (I) towards the total synthesis of spirastrellolide E has been achieved. Highlights of the route include a highly convergent Type I Anion Relay Chem. (ARC) tactic for fragment assembly, in conjunction with a directed, regioselective gold-catalyzed alkyne functionalization to generate the central unsaturated [6,6]-spiroketal.

Tetrahedron Letters published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C5H9IO2, Formula: C7H13BrSi.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Fan, Tian-Yun published the artcileSynthesis and antibacterial evaluation of 13-substituted cycloberberine derivatives as a novel class of anti-MRSA agents, Safety of (4-(Bromomethyl)phenyl)(trifluoromethyl)sulfane, the publication is European Journal of Medicinal Chemistry (2018), 877-886, database is CAplus and MEDLINE.

A series of new 13-substituted cycloberberine (CBBR) derivatives I [R = H, 2-Me, 4-iso-Pr, 3′,5′-(CF₃)₂, etc.], II (R = 3′-pyridyl, 4′-pyridyl), and III (R = Me, CO₂Me) were prepared and evaluated for their antibacterial activities against Gram-pos. bacteria taking CBBR as the lead. Structure-activity relationship revealed that the introduction of a suitable electron-donating group at the 13-position in CBBR might be beneficial for the antibacterial potency. Among them, compounds I (R = 2-Me) (IV) and III (R = Me) exhibited high potency against methicillin-sensitive (MSSA) and resistant strains of S. aureus (MRSA) with MIC values of 1-4 μg/mL. Both of them also displayed high stabilities in blood, and good in vivo safety profiles with LD₅₀ values of 65.6 and 41.2 mg kg^-1 in i.v. route, resp. Mol. docking anal. indicated that compound IV might target FtsZ protein that could inhibit cell division, with the advantage of activity against multidrug resistant S. aureus. Therefore, we consider 13-substituted CBBR derivatives to be a novel class of anti-MRSA agents worthy of further investigation.

European Journal of Medicinal Chemistry published new progress about 21101-63-3. 21101-63-3 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,sulfides,Benzyl bromide,Benzene, name is (4-(Bromomethyl)phenyl)(trifluoromethyl)sulfane, and the molecular formula is C8H6BrF3S, Safety of (4-(Bromomethyl)phenyl)(trifluoromethyl)sulfane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Chen, Fengli published the artcileSelective adsorption of C₂H₂ and CO₂ from CH₄ in an isoreticular series of MOF constructed from unsymmetrical diisophthalate linkers and the effect of alkoxy group functionalization on gas adsorption, Application of 1,3-Dibromonaphthalene, the publication is Journal of Materials Chemistry A: Materials for Energy and Sustainability (2018), 6(8), 3471-3478, database is CAplus.

For acetylene production and natural gas purification, development of porous materials exhibiting highly selective C₂H₂/CH₄ and CO₂/CH₄ separations is very important but remains a major challenge. This work used three unsym. diisophthalate ligands to construct an isoreticular series of Cu-based metal-organic frameworks (MOF) exhibiting highly selective adsorption of C₂H₂ and CO₂ from CH₄ under ambient conditions. Gravimetric uptake capacities at 298° K and 1 atm varied from 171.7 to 200.4 cm³ (STP)/g for C₂H₂ and from 104.1 to 115.6 cm³ (STP)/g for CO₂. IAST adsorption selectivity was 27.6-34.5 for an equimolar C₂H₂/CH₄ mixture, and 5.73-7.14 for an equimolar CO₂/CH₄ mixture at 298° K and 1 atm. These values are among the highest reported for MOF constructed from bent diisophthalate ligands under the same conditions. The effect of alkoxy group functionalization on gas adsorption was also examined and showed, that compared to the parent compound, alkoxy group functionalized MOF exhibited a reduced uptake capacity but an improved adsorption selectivity. Results showed the three MOF are promising materials for C₂H₂/CH₄ and CO₂/CH₄ separations, and provided a fundamental understanding of alkoxy group functionalization on gas adsorption properties.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about 52358-73-3. 52358-73-3 belongs to bromides-buliding-blocks, auxiliary class Bromide,Naphthalene, name is 1,3-Dibromonaphthalene, and the molecular formula is C10H6Br2, Application of 1,3-Dibromonaphthalene.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Xu, Jun published the artcileCopper-catalyzed endo-type trifluoromethylarylation of alkynes, Quality Control of 1997-80-4, the publication is Chemical Communications (Cambridge, United Kingdom) (2014), 50(85), 12915-12918, database is CAplus and MEDLINE.

A new copper-catalyzed trifluoromethylarylation reaction of alkynes has been developed. The transformation represents the first example of endo-type carbotrifluoromethylation of unsaturated carbon-carbon bonds and provides efficient access to a variety of CF₃-substituted dihydronaphthalenes and chromenes.

Chemical Communications (Cambridge, United Kingdom) published new progress about 1997-80-4. 1997-80-4 belongs to bromides-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Bromide,Benzene, name is 1-(2-Bromoethyl)-3-(trifluoromethyl)benzene, and the molecular formula is C17H18N3NaO3S, Quality Control of 1997-80-4.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zou, Jian-Yu published the artcilePhotoredox-catalyzed redox-neutral difluoroalkylation to construct perfluoroketones with difluoroenoxysilanes, Name: Ethylbromofluoroacetate, the publication is Organic & Biomolecular Chemistry (2021), 19(40), 8696-8700, database is CAplus and MEDLINE.

A mild and facile approach to construct various perfluoroketones via photo-catalyzed difluoroalkylation of difluoroenoxysilanes is developed. The reaction includes a strategy of combination of two fluorine-containing functional groups, which confers the reaction with characteristics like high efficiency, mild conditions, and broad scope. A variety of fluoroalkyl halides including perfluoroalkyl iodides, bromo difluoro esters and amides can be employed as radical precursors. Control experiments indicate that a single-electron transfer pathway may be involved in the reaction.

Organic & Biomolecular Chemistry published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C16H14O6, Name: Ethylbromofluoroacetate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Qu, Yongzheng published the artcileAsymmetric Total Synthesis of (+)-Waihoensene, Quality Control of 69361-41-7, the publication is Journal of the American Chemical Society (2020), 142(14), 6511-6515, database is CAplus and MEDLINE.

The asym. total synthesis of (+)-waihoensene (I), which has a cis-fused [6,5,5,5] tetracyclic core bearing an angular triquinane, a cis-fused six-membered ring, and four contiguous quaternary carbon atoms, was achieved through a sequence of chem. reactions in a stereochem. well-defined manner. The total synthesis features the following: (1) Cu-catalyzed asym. conjugated 1,4-addition; (2) diastereoselective Conia-ene type reaction; (3) diastereoselective intramol. Pauson-Khand reaction; (4) Ni-catalyzed diastereoselective conjugated 1,4-addition; and (5) radical-initiated intramol. hydrogen atom transfer (HAT). Control experiments and d. functional theory calculations support the proposed HAT process.

Journal of the American Chemical Society published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Quality Control of 69361-41-7.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Bao, Yinwei published the artcilePalladium-catalyzed tandem cyclization of fluorinated imidoyl chlorides with 2-bromophenylboronic acid: synthesis of 6-fluoroalkyl-phenanthridines, Synthetic Route of 89694-44-0, the publication is Tetrahedron (2019), 75(10), 1450-1456, database is CAplus.

An efficient method was developed to synthesize 6-fluoroalkyl-phenanthridines I [R = CF₃, C₂F₅, CF₂Cl; R¹ = H, 8-MeO, 8-CF₃; R² = H, 2-F, 4-Cl, etc.] via the palladium-catalyzed tandem cyclization of fluorinated imidoyl chlorides with 2-bromophenylboronic acid. This methodol. facilitated the rapid synthesis of 6-fluoroalkyl-phenanthridines I through dual C-C bond formation in an oxidant-free one-pot manner.

Tetrahedron published new progress about 89694-44-0. 89694-44-0 belongs to bromides-buliding-blocks, auxiliary class Bromide,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is 2-Bromo-5-methoxybenzene boronic acid, and the molecular formula is C7H8BBrO3, Synthetic Route of 89694-44-0.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary