Category: bromides-buliding-blocks

Hellenbrand, Tim published the artcileConjugate addition of organomagnesium cuprates to guvacine derivatives, Recommanded Product: (4-Bromobut-1-yn-1-yl)trimethylsilane, the publication is European Journal of Organic Chemistry (2014), 2014(20), 4398-4409, database is CAplus.

The synthesis of 4-substituted piperidine-3-carboxylates was achieved by conjugate addition of organomagnesium cuprates to N-Me and N-tert-butoxycarbonyl guvacine derivatives Good to excellent yields were obtained with primary Grignard reagents containing alkyl, alkenyl, alkynyl, or masked aldehyde groups in a copper(I)-trimethylsilylacetylide-catalyzed and Me₃SiCl-mediated procedure.

European Journal of Organic Chemistry published new progress about 69361-41-7. 69361-41-7 belongs to bromides-buliding-blocks, auxiliary class PROTAC Linker,Aliphatic Linker, name is (4-Bromobut-1-yn-1-yl)trimethylsilane, and the molecular formula is C7H13BrSi, Recommanded Product: (4-Bromobut-1-yn-1-yl)trimethylsilane.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Hardy, A. published the artcile7-Nitro-1-naphthylamine. I. Its preparation, halogenation, and diazo coupling; and 1,2,4,7-tetrahalonaphthalenes, Product Details of C10H6Br2, the publication is Journal of the Chemical Society (1956), 1979-84, database is CAplus.

7-Nitro-1-naphthylamine (I), m. 132-3° (from EtOH), was prepared in 38-45% yield by rearrangement of 1,2,3,4-tetrahydro-7-nitro-1-oxonaphthalene oxime acetate (cf. Schroeter, et al., C.A. 24, 4291), in 22% yield by passage of HCl for 2 hrs. through a suspension of 3.6 g. of the oxime phenylcarbamate in 30 cc. EtOH at 90°, in 10% yield by rearrangement of the oxime in tetraphosphoric acid, and in 42 % yield by reduction of 1,7-dinitronaphthalene (cf. Hodgson and Turner, C.A. 37, 6258¹). The first method was considered to be the best. Derivatives of I had the following m.ps.: N-formyl, 218°; N-acetyl (II), 213°; N-(p-toluenesulfonyl), 202°; N-(p-nitrobenzylidene), 210°. I.HCl was unstable in air. Slow passage of Cl into a solution of 1 g. II in 25 cc. HOAc at 50° until l’mole was absorbed gave 50% 1-acetamido-4-chloro-7-nitronaphthalene (III), m. 256° (from HOAc). Refluxing 0.8 g. III 6 hrs. with 10 cc. EtOH and 10 cc. 50% weight/volume aqueous H₂SO₄ gave after basification with aqueous NH₃ 90% 4-chloro-7-nitro-1-naphthylamine (IV), m. 206° (from EtOH). Deamination of IV gave 37% 1-chloro-6-nitronaphthalene, m. 126° (from EtOH). Passage of Cl through 1 g. II in 25 cc. HOAc at 50° until 2 moles were absorbed gave 64% 1-acetamido-2,4-dichloro-7-nitronaphthalene (V), m. 237° (from HOAc). Hydrolysis of V in EtOH-H₂SO₄ 8 hrs. gave 97% 2,4-dichloro-7-nitro-1-naphthylamine (VI), m. 228° (from EtOH). Diazotization of VI and addition of the solution to aqueous NaOAc gave 4-chloro-1-diazo-7-nitro-2-naphthol, m. 175° (decomposition), in quant. yield. VI was converted to 2,4-dichloro-1,7-naphthylenediamine (VII), m. 135-6° (from EtOH), by refluxing 1.0 g. 10 hrs. with 20 cc. H₂O containing 2.5 g. Fe dust and 0.2 g. FeNH₄(SO₄)₂ under CO₂. VII (0.75 g.) in 12 cc. HOAc and 2 cc. H₂SO₄ was diazotized with 0.6 g. NaNO₂ in 4 cc. H₂SO₄, and the mixture added rapidly to 15 cc. MeOH containing 1.75 g. Cu₂O and then to 100 cc. H₂O to give 1,3-dichloronaphthalene. VII was diazotized as above, the solution poured into 6 cc. aqueous HCl containing 0.6 g. CuCl at 60°, and then into 25 cc. H₂O to give 1,2,4,7-tetrachloronaphthalene, m. 143-4° (from EtOH), identical with the 1,2,4,x-tetrachloronaphthalene of Turner and Wynne (C.A. 35 5885⁷). Dropwise addition of 10 g. I in 200 cc. CHCl₃ to 18.5 g. Br in 6 cc. CHCl₃ gave after basification 90% 2,4-dibromo-7-nitro-1-naphthylamine (VIII), m. 237° (from EtOH). Use of 1 mole Br gave the same product. Addition of 0.6 g. VIII in 12 cc. HOAc to 0.2 g. NaNO₂ in 1 cc. H₂SO₄ and after 30 min. to 5 g. NaOAc in 50 cc. H₂O gave 4-bromo-1-diazo-7-nitro-2-naphthol, m. 156.5° (from aqueous dioxane). Reduction of VIII by a method similar to that used for VI gave 51% 2,4-dibromo-1,7-naphthylenediamine (IX), m. 122° (decomposition) (from aqueous EtOH). IX was diazotized and converted to 7% 1,3-dibromonaphthalene, m. 63°. Addition of Br in 10 cc. HOAc to 2 g. II in 10 cc. HOAc containing 0.75 g. NaOAc during 45 min. under reflux and heating 30 min. gave 84% 1-acetamido-4-bromo-7-nitronaphthalene (X), m. 265° (from HOAc). X (2 g.) was refluxed with 10 cc. aqueous H₂SO₄ and 10 cc. EtOH for 3 hrs., and the residue was separated and refluxed again with the hydrolyzing solution 5 hrs. The amine sulfates from the 2 solutions were basified with aqueous NH₃ at 0° to give 92% 4-bromo-7-nitro-1-naphthylamine (XI), m. 197° (from ligroine b. 100-20°). Deamination of XI gave 18% 1-bromo-6-nitronaphthalene, m. 129°. Diazotization of 0.8 g. IX and reaction of the solution with 0.9 g. CuBr in 6 cc. aqueous HBr (50% weight/volume) gave 20% 1,2,4,7-tetrabromonaphthalene, m. 165° (from EtOH). This differed from the tetrabromonaphthalene of Guareschi [Gazz. chim. ital. 16, 146 (1886)], indicating that the latter was the 1,2,4,6-derivative Slow addition of 0.65 g. p-O₂NC₆H₄N₂HSO₄ in 15 cc. H₂O to 0.5 g. I in 15 cc. EtOH containing 0.36 g. NaOAc at 0° gave after 30 min. 88% 7-nitro-4-(p-nitrophenylazo)-1-naphthylamine (XII), purple-black needles, m. 297° (from PhNO₂). XII (0.15 g.) was acetylated by refluxing in 10 cc. AcOH, 2 cc. Ac₂O, and 1 g. NaOAc to give 75% 1-acetamido-7-nitro-4-(p-nitrophenylazo)naphthalene, m. 329-30°. Diazotization of XII and coupling with β-naphthol in aqueous NaOH gave 7-nitro-4-(p-nitrophenylazo)-1-naphthylazo-2-naphthol, violet-black needles, m. 292° (decomposition).

Journal of the Chemical Society published new progress about 52358-73-3. 52358-73-3 belongs to bromides-buliding-blocks, auxiliary class Bromide,Naphthalene, name is 1,3-Dibromonaphthalene, and the molecular formula is C10H6Br2, Product Details of C10H6Br2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Fumagalli, Fernando published the artcileArene-Ligand-Free Ruthenium(II/III) Manifold for meta-C-H Alkylation: Remote Purine Diversification, Computed Properties of 401-55-8, the publication is Chemistry – A European Journal (2018), 24(16), 3984-3988, database is CAplus and MEDLINE.

Meta-Selective C-H alkylations of bioactive purine derivatives were accomplished by versatile ruthenium catalysis. Thus, the arene-ligand-free complex [Ru(OAc)₂(PPh₃)₂] enabled remote C-H functionalizations with ample scope and excellent levels of chemo- and positional selectivities. Detailed exptl. and computational mechanistic studies provided strong support for a facile C-H activation within a ruthenium(II/III) manifold.

Chemistry – A European Journal published new progress about 401-55-8. 401-55-8 belongs to bromides-buliding-blocks, auxiliary class Fluoride,Bromide,Aliphatic hydrocarbon chain,Ester, name is Ethylbromofluoroacetate, and the molecular formula is C4H6BrFO2, Computed Properties of 401-55-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Horii, Zenichi published the artcileSyntheses of oxytocics. II. Synthesis of 2-[(1,2,3,4-tetrahydro-2-naphthyl)aminomethyl]propionic acid derivatives, Category: bromides-buliding-blocks, the publication is Yakugaku Zasshi (1961), 1786-91, database is CAplus and MEDLINE.

cf. ibid. 83,706-10(1962); CA 55, 23560d. 1,2,3,4-Tetrahydro-2-naphthylamine (29.4 g.), 80.8 g. CH₂:CMeCO₂Me, and 100 ml. MeOH refluxed 28 hrs. and the product distilled gave 38 g. Me 2-[(1,2,3,4-tetrahydro-2-naphthyl)-aminomethyl]propionate (I), b_0.02 126°. Saponification of 4.9 g. I in 50 ml. 3% KOH by refluxing 30 min., washing the solution with Et₂O and neutralization with 10% HCl gave 3.3 g. free acid (II) of I, m. 185-6° (EtOH). Catalytic reduction of 4.8 g. I in 4.4 g. 37% HCHO and 20 ml. MeOH with 2.5 g. 10% Pd-C, removing of the MeOH, removing of non-methylated NH₂ (II) by acetylation with Ac₂O, alkalizing with K₂CO₃, and extracting the product with Et₂O gave 3.5 g. Me 2-[N-methyl-(1,2,3,4-tetrahydro-2-naphthyl)aminomethyl]propionate (III), b_0.06 137-8°. Saponification of 1.3 g. III in 10 ml. 10% KOH by refluxing 4-5 hrs. and neutralization with 10% HCl to pH 6 gave 0.6 g. of the free acid (IV) of III, sublimed at 100-20°/0.1 mm., m. 123-5°. IV (0.5 g.) in 5 ml. MeOH treated dropwise with HCl in Et₂O and the solvent removed gave N-methyl-(1,2,3,4-tetrahydro-2-naphthyl)amine-HCl (V), m. 212°. A mixture of 16.1 g. V, 20 ml. EtOH, 45.6 g. CH₂:CMeCO₂Et and 1-2 drops AcOH refluxed 100 hrs. and the product distilled gave 2.3 g. Et ester (VI) of IV, b_0.03 118-23°. I (4.9 g.) and 50 ml. MeOH saturated with NH₃ at 0° in autoclave heated 8 hrs. at 120-30° and the product distilled gave 2.3 g. 2-[(1,2,3,4-tetrahydro-2-naphthyl)aminomethyl]propionamide, m. 91-2° (AcOEt). MeCH(CH₂Br)CO₂H, b₁₄ 115°. MeCH(CH₂Br)COCl, b₂₇ 72-3°. MeCH(CH₂Br)CONHPh, m. 109-11° (EtOH-H₂O). MeCH(CH₂Br)CONMe₂ (VII), b₃ 94-5°. MeCH(CH₂Br)CONEt₂ (VIII), b_0.2 85°. 1,2,3,4-Tetrahydro-2-naphthylamine (IX) (14.7 g.) and 9.7 g. VII in 50 ml. CHCl₃ refluxed 4 hrs., the solution filtered and the filtrate extracted with 10% HCl gave 3.4 g. N,N-dimethyl-2-[(1,2,3,4-tetrahydro-2-naphthyl)aminomethyl]propionamide (X), b_0.01 168-70°. Similarly, 11.7 g. IX and 8.8 g. VIII gave 7 g. N,N-di-Et analog of X, b_0.05 205-20°. IX (14.7 g.) and 10 g. CH₂:CHCO₂Me in 100 ml. MeOH kept 3 days at room temperature gave 21 g. N-(1,2,3,4-tetrahydro-2-naphthyl)-β-alanine Me ester, b_0.1 154-7°; HCl salt, m. 152-3°.

Yakugaku Zasshi published new progress about 56970-78-6. 56970-78-6 belongs to bromides-buliding-blocks, auxiliary class Bromide,Carboxylic acid,Aliphatic hydrocarbon chain,Inhibitor, name is 3-Bromo-2-methylpropanoic acid, and the molecular formula is C4H7BrO2, Category: bromides-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhao, Mengyu published the artcileConverting thermally activated delayed fluorescence into hybridized local and charge-transfer via an addition acceptor moiety, COA of Formula: C12H25Br, the publication is Organic Electronics (2022), 106365, database is CAplus.

High-efficiency blue materials for Organic Light Emitting Diodes (OLEDs) are challenging but urgently needed, especially for solution-processed devices. Herein, based on a model compound of acridine-benzophenone, two blue materials were designed and synthesized, with the addnl. electron-withdrawing groups benzophenone and pentafluorobenzophenone connected to the acridine donor resp. to prepare BC and BC5F. The solution-processed OLED based on BC showed an emission peak at 486 nm, while the device with BC5F showed the electroluminescent peak at 478 nm. BC featured the thermally active delayed fluorescent (TADF) properties, but BC5F exhibited hybridized local and charge-transferring (HLCT) characteristics. This work showed that linking addnl. acceptors to the donor side could not only achieve deeper blue emission but also change the luminescent mechanism. Therefore, we provided a new strategy to manipulate the transition between TADF and HLCT.

Organic Electronics published new progress about 143-15-7. 143-15-7 belongs to bromides-buliding-blocks, auxiliary class Bromide,Aliphatic hydrocarbon chain, name is 1-Bromododecane, and the molecular formula is C5H9IO2, COA of Formula: C12H25Br.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Zhai, Lipeng published the artcileCationic Covalent Organic Frameworks for Fabricating an Efficient Triboelectric Nanogenerator, SDS of cas: 518-67-2, the publication is ACS Materials Letters (2020), 2(12), 1691-1697, database is CAplus.

Covalent organic frameworks (COFs) have developed as a precisely tailor-made platform for integrating different functionalities into the frameworks via reticular chem. In this work, two COFs with a similar topol. and skeleton but different charge state over the skeleton are designed and applied to clarify the contributions of cationic groups to the output performance of a triboelec. nanogenerator (TENG). The cationic functional centers are distributed alternately over both sides of the pore channels. The cationic COF possesses unconventional electrostatic functions due to the ionic interface over the skeletons. The output performance of a cationic COF decorated with an elec.-dipole-based TENG is improved by a 2-fold contrast to the neutral analog. Moreover, a cationic COF-based TENG is further employed to charge com. capacitors (0.1 F), light up light-emitting diodes (LEDs), and power a stopwatch. This work illustrates the facile construction of a cationic COF and its application in fabricating a TENG, generating an ecofriendly and excellent-performance energy harvesting and self-powered device.

ACS Materials Letters published new progress about 518-67-2. 518-67-2 belongs to bromides-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Salt,Amine,Benzene, name is Dimidium bromide, and the molecular formula is C5H10Cl3O3P, SDS of cas: 518-67-2.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Bernstein, A. published the artcileSynthesis and stability of triorganostannylalkylsulfonic acids, Recommanded Product: Sodium 3-bromopropane-1-sulfonate, the publication is Zeitschrift fuer Anorganische und Allgemeine Chemie (1991), 41-7, database is CAplus.

Sodium triorganostannylalkylsulfonates R₃Sn(CH₂)_nSO₃Na (I, R = Me, Ph, n = 2,3) are obtained by reaction of triorganostannylsodium with sodium haloalkylsulfonates or propane solution in liquid ammonia. I can be converted by ion-exchange in the free sulfonic acids R₃Sn(CH₂)_nSO₃H which are of limited stability and undergo cyclocondensation reactions with formation of the cyclic triorganotin alkanesulfonates II (R = Me, Ph, n = 1, 2).

Zeitschrift fuer Anorganische und Allgemeine Chemie published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, Recommanded Product: Sodium 3-bromopropane-1-sulfonate.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Bauer, Heiko published the artcileChromocene, ferrocene, cobaltocene, and nickelocene derivatives with isopropyl and methyl or trimethylsilyl substituents, Application of Cobalt(II) dibromo(1,2-dimethoxyethane), the publication is Journal of Organometallic Chemistry (2016), 63-73, database is CAplus.

From sodium 2,3-diisopropyl-1,4-dimethyl-cyclopentadienide and MBr₂(dme) (M = Fe, Co, Ni) the corresponding ferrocene (1), cobaltocene (2) and nickelocene (3) could be obtained as pure, crystalline solids. From an analogous reaction of sodium 2,3,5-triisopropyl-1,4-dimethyl-cyclopentadienide with FeCl₂, only the mixed-substituted ferrocene (³₂Cp)(²₂Cp)Fe (4) could be crystallized (³₂Cp = 2,3,5-triisopropyl-1,4-dimethyl-cyclopentadienyl, ²₂Cp = 2,3-diisopropyl-1,4-dimethyl-cyclopentadienyl). The trimethylsilyl substituted ferrocene (5) and nickelocene (6) were synthesized from the corresponding metal halides and potassium 2,3-diisopropyl-1,4-dimethyl-5-trimethylsilyl-cyclopentadienide as well as a series of chromocenes with silylated or alkylated cyclopentadienyl ligands (7–10) from chromium(II) acetate. Octaisopropylnickelocene (11) has been obtained and converted to octaisopropylnickelocenium hexafluorophosphate (12). 1,2,3,4-Tetraisopropylnickelocenium tetrabromoaluminate (13) was obtained from tetraisopropylcyclopentadienylnickel(II) tetrabromoaluminate and nickelocene. Crystal structures have been obtained for metallocenes 1–5, 7–9, and 11.

Journal of Organometallic Chemistry published new progress about 18346-57-1. 18346-57-1 belongs to bromides-buliding-blocks, auxiliary class Cobalt, name is Cobalt(II) dibromo(1,2-dimethoxyethane), and the molecular formula is C4H10Br2CoO2, Application of Cobalt(II) dibromo(1,2-dimethoxyethane).

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Bhaumik, Jayeeta published the artcileSynthesis and Photophysical Properties of Sulfonamidophenyl Porphyrins as Models for Activatable Photosensitizers, HPLC of Formula: 55788-44-8, the publication is Journal of Organic Chemistry (2009), 74(16), 5894-5901, database is CAplus and MEDLINE.

2,4-Dinitrophenylsulfonamido-substituted tetraphenylporphyrins with varying polarities or with functionality to allow conjugation to biomols. are prepared The fluorescence quantum yields of the dinitrophenylsulfonamido-substituted tetraphenylporphyrins and their parent amino-substituted tetraphenylporphyrins are determined; the kinetics of the cleavage of the dinitrophenylsulfonyl groups by small mol. thiols and the chemoselectivity of cleavage are also determined

Journal of Organic Chemistry published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, HPLC of Formula: 55788-44-8.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary

Natrajan, Anand published the artcileA green synthesis of chemiluminescent N-sulfopropyl acridinium esters in ionic liquids without using the carcinogen 1,3-propane sultone, Formula: C3H6BrNaO3S, the publication is Green Chemistry Letters and Reviews (2013), 6(3), 237-248, database is CAplus.

Chemiluminescent acridinium dimethylphenyl esters containing hydrophilic N-sulfopropyl groups in the acridinium ring are used as labels in automated immunoassays for clin. diagnostics. Introduction of the N-sulfopropyl group in these labels is normally accomplished by N-alkylation of the corresponding, nonchemiluminescent acridine ester precursors with the toxic carcinogen 1,3-propane sultone. In the current study, we report that sodium 3-bromopropane sulfonate in ionic liquids (ILs) is a benign alternative to 1,3-propane sultone for introducing the N-sulfopropyl group in chemiluminescent acridinium ester labels. The sultone reagent can be eliminated in the synthesis of N-sulfopropyl acridinium dimethylphenyl ester labels by taking advantage of the increased reactivity of acridan esters toward nontoxic sodium 3-bromopropane sulfonate in [BMIM][BF₄]. Sodium 3-bromopropane sulfonate in ILs is also potentially a nontoxic alternative to 1,3-propane sultone for introducing the water-soluble, three-carbon sulfobetaine moiety in other mols. as well.

Green Chemistry Letters and Reviews published new progress about 55788-44-8. 55788-44-8 belongs to bromides-buliding-blocks, auxiliary class Bromide,Salt,Aliphatic hydrocarbon chain,Aliphatic hydrocarbon chain, name is Sodium 3-bromopropane-1-sulfonate, and the molecular formula is C3H6BrNaO3S, Formula: C3H6BrNaO3S.

Referemce:
https://en.wikipedia.org/wiki/Bromide,
bromide – Wiktionary