Tag: M.W=300-400

Synthetic Route of 955959-84-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 955959-84-9 as follows.

In a round bottom flask, 4.9 g of aniline, 30 g of starting material X1, t-BuONa 14.5 g, Pd2(dba)3 2.2 g, and (t-Bu)3P 2.3 m were dissolved in 200 ml of toluene, stirred at reflux. The reaction was confirmed by thin layer chromatography (TLC), and after adding water, the reaction was terminated. Use methyl cellulose (MC) to extract organic layers and reduce themAfter pressure filtration, column purification and recrystallization were carried out to obtain 16.2 g (yield 81percent) of IA-1.

According to the analysis of related databases, 955959-84-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Dongjin Shimeiken Co., Ltd.; Jin Jintai; Xian Haowan; Jin Dongjun; Lin Donghuan; Li Yingzhen; Lin Dazhe; Han Zhengyou; Pei Weizhen; Jin Yingsen; Li Dongxuan; (49 pag.)CN108689913; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52997-43-0, name is 7-(Bromomethyl)pentadecane, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 52997-43-0

250 mL of a condenser equipped with a magnetic stirrer and a reflux condenserAdd three bottles4-bromothiophenol10 g (52.89 mmol),N, N-dimethylformamide100 mL,Anhydrous potassium carbonate 10.94 g (79.33 mmol)Argon protection,Stirred at room temperature for 30 minutes,With a constant pressure dropping funnel1-bromo-2-hexyl decane16.2 mL (52.89 mmol) was added dropwise to the reaction system and the reaction was gradually progressedThe temperature was raised to 85 C and the reaction was carried out for 24 hours. The reaction was completed, cooled to room temperature, the reaction solution was poured into 150 mL of ice water,Stirring for 10 minutes, and then petroleum ether as extractant extraction 3 times, each 100mL, the organic phase, organic phase with distilled waterWash 3 times, each time 150mL. The organic phase was dried over anhydrous sodium sulfate, filtered, and the filtrate was spin-dried using a rotary evaporator to giveThe crude product was obtained by column chromatography using petroleum ether as eluent4-bromo-1- (2-hexylDecylthio) benzene(Colorless transparent liquid, 20.12 g, yield 92.0%)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 52997-43-0.

Reference:
Patent; Xiangtan University; Zhao, Bin; Liu, Hailu; Huang, Meihua; Tang, Bo; (8 pag.)CN106380431; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Related Products of 626-39-1,Some common heterocyclic compound, 626-39-1, name is 1,3,5-Tribromobenzene, molecular formula is C6H3Br3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of 1,3,5-tribromobenzene (7.96 g, 25.3 mmol), bis(pinacolato)diboron (21.2 g, 83.5 mmol), [1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium (2.78 g, 3.79 mmol), potassium acetate (22.3 g, 228 mmol) in anhydrous 1,4-dioxane (400 mL) was degassed for 80 minutes. Mixture was then heated to 80 C. overnight under argon. After cooling to room temperature, the remaining solids were filtered off. The filtrate was dried under vacuum, redissolved in methylene chloride (400 mL) then washed with water (2×300 mL) and brine (300 mL). Organic layer was dried over sodium sulfate and loaded onto silica gel. A silica plug (11% ethyl acetate in hexanes) and precipitation from methylene chloride/methanol gave 4 (9.76 g, 88% yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,3,5-Tribromobenzene, its application will become more common.

Reference:
Patent; Zheng, Shijun; US2011/196158; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

10016-52-1, name is 2,8-Dibromodibenzo[b,d]furan, belongs to bromides-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 2,8-Dibromodibenzo[b,d]furan

2.75 g (10 mmol) of 4-phenylaminodibenzothiophene, 1.63 g (5.0 mmol) of 2,8-dibromodibenzofuran, 2.5 g (26 mmol) of sodium t-butoxide in a 50 ml four-necked flask,50 ml of dehydrated toluene was added and nitrogen bubbling was performed for 1 hour. Then, 3460 mg (0.5 mmol) of Pd2 (dba),290 mg (1.0 mmol) of tri-t-butylphosphonium tetrafluoroborate (t-Bu3PH + BF4-) was added, and the mixture was heated under reflux for 53 hours while stirring under a nitrogen stream. The formation of the desired product was confirmed by TLC and MS. The reaction solution was cooled to room temperature, and the organic layer was extracted with toluene, washed with brine, dried over anhydrous magnesium sulfate, filtered and concentrated to obtain a brown viscous product. The obtained viscous material was dissolved in 10 ml of toluene and packed in a column. The resultant was directly purified by silica gel column chromatography (developing solvent: toluene / hexane = 1/4) to obtain the desired product.Yield 1.92g, 54%

The synthetic route of 10016-52-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; National University Corporation Yamagata University; Sasabe, Hisahiro; Kido, Junji; Kamata, Takahiro; (21 pag.)JP2019/26556; (2019); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 126930-72-1, A common heterocyclic compound, 126930-72-1, name is 1-Bromo-4-dodecylbenzene, molecular formula is C18H29Br, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Magnesium (3.3 g), tetrahydrofuran (20ml) were placed in aflask, and tetrahydrofuran (100ml) solution of 1-bromo-4-dodecylbenzene (40.1g) was added dropwise slowly at a rate to maintain reflux, and (4-dodecylphenyl) magnesium bromide was prepared. This was cooled in anice-water bath, and trimethyl borate (15.4g) was dropped slowly. After stirringfor 1 hour at room temperature, water and then concentrated hydrochloric acid(16 ml) were added, and stirred for 30 minutes. After extraction with ethylacetate, it was washed with water, dried over anhydrous sodium sulfate, andconcentrated to give (4-dodecylphenyl) boronic acid (32 g).

The synthetic route of 126930-72-1 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; JNC CORPORATION; KAWASHIMA, MASATOSHI; NOMURA, SHINTARO; (159 pag.)JP2015/203027; (2015); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 955959-84-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan belongs to bromides-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

In a stream of argon, 6.5 g of the intermediate-14′, 8.8 g of the intermediate-20′, 2.6 g of t-butoxy sodium, 92 mg of tris(dibenzylideneacetone)dipalladium, 42 mg of tri-t-butylphosphine, and 100 ml of dry toluene were loaded into a 300-ml three-necked flask, and then the mixture was subjected to a reaction at 80°C for 8 hours. After having been cooled, the reaction product was poured into 500 ml of water, and then the mixture was subjected to celite filtration. The filtrate was extracted with toluene, and was then dried with anhydrous magnesium sulfate. The dried product was concentrated under reduced pressure. The resultant coarse product was subjected to column purification, and was then recrystallized with toluene. The crystal was taken by filtration, and was then dried. As a result, 8.2 g of a pale yellow powder were obtained. The powder was identified as aromatic amine derivative (H-1′) by FD-MS analysis.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(4-Bromophenyl)dibenzo[b,d]furan, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Idemitsu Kosan Co., Ltd.; EP2468725; (2012); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 126930-72-1,Some common heterocyclic compound, 126930-72-1, name is 1-Bromo-4-dodecylbenzene, molecular formula is C18H29Br, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1-bromo-4-dodecylbenzene (5.0 g, 15.4 mmol, 1.0 eq.), bispinacolato diboron (4.7 g, 1.2 eq.), potassium acetate (4.5 g, 3 eq.), and a bis(diphenylphosphino) ferrocene-palladium(II) dichloride dichloromethane complex (0.38 g, 0.03 eq.) were weighed and put into a 200 mL three-necked round bottom flask. Degassing under reduced pressure and nitrogen purge were sufficiently performed. Thereafter, 50 mL of cyclopentyl methyl ether was added thereto in a nitrogen atmosphere, and the mixture was refluxed and stirred. After completion of the reaction, heating was stopped, and the temperature of the reaction liquid was returned to room temperature. Extraction was performed with toluene, the organic solvent layers were then unified, anhydrous sodium sulfate was added thereto, and the mixture was allowed to stand for a while. Sodium sulfate was filtered off, and the solution was concentrated under reduced pressure. The mixture containing a desired product was further caused to pass through an activated carbon column chromatography, and a fraction containing a desired product was collected and concentrated under reduced pressure. Thus, a desired product ?PC12Bpin? was obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-4-dodecylbenzene, its application will become more common.

Reference:
Patent; Kwansei Gakuin Educational Foundation; JNC Corporation; HATAKEYAMA, Takuji; KONDO, Yasuhiro; NAKAMOTO, Keiichi; YANAI, Motoki; (190 pag.)US2018/94000; (2018); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Some common heterocyclic compound, 30432-16-7, name is 1,4-Dibromo-2,3-bis(bromomethyl)but-2-ene, molecular formula is C6H8Br4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 30432-16-7

General procedure: Alkyl 4-hydroxy benzoate 2a,b (10 mmol) and potassium hydroxide (0.56 g, 10 mmol) were dissolved in absolute ethanol. 1,1,2,2-tetrayl-tetramethylene-tetrabromide (1) (1.00 g, 2.5 mmol) was then added into this solution. The reaction mixture was refluxed for 6 h. The mixture was cooled and filtrated. The white precipitate was filtered off and washed with H2O and crystallized from the appropriate solvent.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 30432-16-7, its application will become more common.

Reference:
Article; Er, Mustafa; De?irmencio?lu, Ismail; Tahtaci, Hakan; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 139; 1; (2015); p. 68 – 74;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 3344-70-5,Some common heterocyclic compound, 3344-70-5, name is 1,12-Dibromododecane, molecular formula is C12H24Br2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

In a two-necked flask under argon, NaH (43.7 mmol) is put into suspension in anhydrous THF (100 ml). The reaction medium is cooled down in an ice bath and acetoethyl acetate is added dropwise (39.7 mmol). After stirring for 10 minutes at 0° C. n-BuLi is added dropwise (1.56 M; 43.7 mmol). Stirring is carried out for a further 10 minutes at ambient temperature before proceeding with alkylation.Dibromododecane (15.9 mmol) in solution in 20 ml of anhydrous THF is added dropwise to the previous solution. The reaction medium is allowed to return to ambient temperature and stirring is continued for 1 hour. Water is added followed by extraction with ether (3 times). The organic phase is washed with a saturated NaCl solution, dried over sodium sulphate, filtered and evaporated to dryness. The product is purified by chromatography on silica-gel eluting with AcOEt-Hexane (1-1). A white solid is obtained (Yield=65percent); M.p.=60° C.NMR 1H (200 MHz, CDCl3): d 4.16 (q, 4H, 2CH2), 3.41 (s, 4H, 2CH2), 2.50 (t, 4H, 2CH2), 1.56-121 (m, 30H).

The synthetic route of 3344-70-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CNRS; US6972343; (2005); B1;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 955959-84-9,Some common heterocyclic compound, 955959-84-9, name is 4-(4-Bromophenyl)dibenzo[b,d]furan, molecular formula is C18H11BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

0.21 g of palladium(II) acetate, xylene (20 mL), and 0.76 g of tri-tert-butylphosphine were added.Stirred at 60 °C for 30 minutes. The above solution was added to a flask heated to 60°C under nitrogen to give the above compound 4 (16,18-Dihydrobenzo[4,5]furo[3,2-a]benzofurano[2′,3′:6,7]indolo[3,2-h]carbazole 7.4 g), 4-(4-bromophenyl)dibenzo[b,d]furan (13.2 g) and sodium tert-butoxide 5.2 g (54 mmol) were added to the above solution together with xylene (180 mL). Then, it heated up at 130 °C , and it heat-stirred for 6 hours. After cooling to room temperature, 200 mL of water was added. After the organic layer was extracted with chloroform, the organic layer was dried over MgSO4 , the solvent was removed, and silica gel column chromatography was performed, whereby Compound A-10 (6.4 g, 41percent) was obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 4-(4-Bromophenyl)dibenzo[b,d]furan, its application will become more common.

Reference:
Patent; Co., Ltd. LG Chemical; Hong Wanshao; He Zaicheng; Xu Shangde; Jin Zhengfan; Li Zaizhuo; Jin Yuanhuan; (73 pag.)CN108017654; (2018); A;,
Bromide – Wikipedia,
bromide – Wiktionary