Synthetic Route of 2550-36-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2550-36-9, name is (Bromomethyl)cyclohexane, This compound has unique chemical properties. The synthetic route is as follows.
2,4-Dibenzyloxyphenol was dissolved in 2 mL of DMF, bromomethylcyclohexane (0.23 g, 1.2 mmol) and K2CO3 (0.46 g, 3.30 mmol) were added and stirred at 50 C. overnight. Ethyl acetate (30 mL) was added to the reaction solution to giveThe separated organic layer was washed three times with water (5 mL) and saturated brine (5 mL).The aqueous layers were combined and further extracted three times with ethyl acetate (5 mL), and all the obtained organic layers were dried over anhydrous sodium sulfate. The anhydrous sodium sulfate was filtered off, and the filtrate was concentrated to give a crude product. thisThe crude product is subjected to silica gel column chromatography (1-2.5% ethyl acetate / hexane)Then, 0.25 g of colorless oil 2,4-dibenzyloxy-1- (cyclohexylmethoxy) benzene was obtained (yield 90%).
The chemical industry reduces the impact on the environment during synthesis (Bromomethyl)cyclohexane. I believe this compound will play a more active role in future production and life.
Reference:
Patent; National University corporation Utsunomiya University; Nihei, Ken’ichi; (23 pag.)JP5893442; (2016); B2;,
Bromide – Wikipedia,
bromide – Wiktionary