Category: bromides-buliding-blocks

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52997-43-0, name is 7-(Bromomethyl)pentadecane, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 52997-43-0

250 mL of a condenser equipped with a magnetic stirrer and a reflux condenserAdd three bottles4-bromothiophenol10 g (52.89 mmol),N, N-dimethylformamide100 mL,Anhydrous potassium carbonate 10.94 g (79.33 mmol)Argon protection,Stirred at room temperature for 30 minutes,With a constant pressure dropping funnel1-bromo-2-hexyl decane16.2 mL (52.89 mmol) was added dropwise to the reaction system and the reaction was gradually progressedThe temperature was raised to 85 C and the reaction was carried out for 24 hours. The reaction was completed, cooled to room temperature, the reaction solution was poured into 150 mL of ice water,Stirring for 10 minutes, and then petroleum ether as extractant extraction 3 times, each 100mL, the organic phase, organic phase with distilled waterWash 3 times, each time 150mL. The organic phase was dried over anhydrous sodium sulfate, filtered, and the filtrate was spin-dried using a rotary evaporator to giveThe crude product was obtained by column chromatography using petroleum ether as eluent4-bromo-1- (2-hexylDecylthio) benzene(Colorless transparent liquid, 20.12 g, yield 92.0%)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 52997-43-0.

Reference:
Patent; Xiangtan University; Zhao, Bin; Liu, Hailu; Huang, Meihua; Tang, Bo; (8 pag.)CN106380431; (2017); A;,
Bromide – Wikipedia,
bromide – Wiktionary

Synthetic Route of 2550-36-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2550-36-9, name is (Bromomethyl)cyclohexane, This compound has unique chemical properties. The synthetic route is as follows.

2,4-Dibenzyloxyphenol was dissolved in 2 mL of DMF, bromomethylcyclohexane (0.23 g, 1.2 mmol) and K2CO3 (0.46 g, 3.30 mmol) were added and stirred at 50 C. overnight. Ethyl acetate (30 mL) was added to the reaction solution to giveThe separated organic layer was washed three times with water (5 mL) and saturated brine (5 mL).The aqueous layers were combined and further extracted three times with ethyl acetate (5 mL), and all the obtained organic layers were dried over anhydrous sodium sulfate. The anhydrous sodium sulfate was filtered off, and the filtrate was concentrated to give a crude product. thisThe crude product is subjected to silica gel column chromatography (1-2.5% ethyl acetate / hexane)Then, 0.25 g of colorless oil 2,4-dibenzyloxy-1- (cyclohexylmethoxy) benzene was obtained (yield 90%).

The chemical industry reduces the impact on the environment during synthesis (Bromomethyl)cyclohexane. I believe this compound will play a more active role in future production and life.

Reference:
Patent; National University corporation Utsunomiya University; Nihei, Ken’ichi; (23 pag.)JP5893442; (2016); B2;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 10269-01-9,Some common heterocyclic compound, 10269-01-9, name is (3-Bromophenyl)methanamine, molecular formula is C7H8BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A suspension of 2,5-dihydroxybenzaldehye 1 (0.107g,1 mmol, 1equiv.) and MnO2 (0.860g, 10 mmol) in toluene, were cooledin ice bath to 0C under constant stirring for 15 min and amine (1 mmol, 1equiv.) was added. The mixture was refluxed for 10 h. The mixture was filtered through celite and washed withtoluene. Removal of the solvent under reduced pressure followed by columnchromatography (5% EtOAc/Hexane) yielded pure benzo[d]oxazole derivative.

The synthetic route of 10269-01-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Tangellamudi, Neelima D.; Shinde, Suchita B.; Pooladanda, Venkatesh; Godugu, Chandraiah; Balasubramanian, Sridhar; Bioorganic and Medicinal Chemistry Letters; vol. 28; 23-24; (2018); p. 3639 – 3647;,
Bromide – Wikipedia,
bromide – Wiktionary

These common heterocyclic compound, 41825-73-4, name is 2-Bromo-4,6-dimethylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C8H10BrN

General procedure: In the MW method, a mixture of 4-chloro-5,6,7-trimethoxyquinazoline (3.0 mmol) and aryl amine (3.0 mmol) in 2-propanol (10 mL) was stirred for 3 min and then reacted under MW at 100 W and 80 C for 20 min. Upon reaction completion as monitored by thin-layer chromatography (TLC), the solvent was removed under reduced pressure. The residue was dissolved with methanol or chloroform and purified by TLC (petroleum ether/ethylacetate, 1:2, V:V). The target compound was eluted from the silica gel with ethyl acetate to give the title compounds.

The synthetic route of 2-Bromo-4,6-dimethylaniline has been constantly updated, and we look forward to future research findings.

Reference:
Article; Zhang, Ying; Jin, Linhong; Xiang, Hongmei; Wu, Jian; Wang, Peiyi; Hu, Deyu; Xue, Wei; Yang, Song; European Journal of Medicinal Chemistry; vol. 66; (2013); p. 335 – 344;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 452-62-0, name is 3-Bromo-4-fluorotoluene, This compound has unique chemical properties. The synthetic route is as follows., Formula: C7H6BrF

EXAMPLE 3 4-Methyl-10-aza-tricyclo[6.3.1.02,7]dodeca-2(7),3,5-triene Hydrochloride The title compound was prepared by the methods described in Examples 1 and 2 starting with 2-fluoro-5-methylbromobenzene. (data for free base) 1H NMR (400 MHz, CDCl3) delta 7.04 (d, J=7.5 Hz, 1H), 6.99 (s, 1H), 6.98 (d, J=7.5 Hz, 1H), 2.98-2.90 (m, 4H), 2.63 (m, 2H), 2.35 (m, 1H), 2.32 (s, 3H), 1.87 (d, J=11.5 Hz, 1H). APCI MS m/e 174.2 [(M+1)+]. (HCl salt) M.p. 254-255 C. Anal. Calcd. for C12H12F3N.HCl.1/3H2O: C, 53.44; H, 5.11; N. 5.19. Found C, 53.73; H, 4.82; N, 5.15.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 452-62-0.

Reference:
Patent; Pfizer Inc; US6605610; (2003); B1;,
Bromide – Wikipedia,
bromide – Wiktionary

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2606-51-1 as follows. Recommanded Product: 2606-51-1

Boc-L-Pyroglutamic acid methyl ester (1.05 g, 4.32 mmol) was dissolved in dry THF (20mL). The mixture was cooled to -78 C. LiHMDS (1 M in THF, 4.40 mL, 4.40 mmol) was addeddropwise at -78 C over 10 minutes. The solution was stirred at -78 C for 1 hour. A solution of 5-(bromomethyl)-1 ,3-benzodioxole (0.975 g, 4.53 mmol) in dry THF (5 mL) was then added dropwise at -78 C over 30 minutes. The solution was stirred at -78 C for 2 hours. Sat. NaHCO3 (aq) (40 mL) was added dropwise with continual stirring until the solution reached room temperature. The mixture was diluted with EtOAc (50 mL) and the layers separated. The organic phase was washed with sat. brine (aq) (40 mL) then dried (Mg504), filtered and the solvent evaporated in vacuo. The crudeproduct was purified by flash chromatography (Biotage Isolera; 50 g SNAP cartridge) eluting with isohexane -* 40% EtOAc – isohexane to yield the title compound (1.08 g, 66 %) as a white solid.AnalpH2_MeOH_4MIN: Rt: 3.03 mi mlz 378.3 [M+H]+

According to the analysis of related databases, 2606-51-1, the application of this compound in the production field has become more and more popular.

Reference:
Patent; UNIVERSITY OF LEEDS; PHILIPPOU, Helen; FOSTER, Richard; FISHWICK, Colin; REVILL, Charlotte; YULE, Ian; TAYLOR, Roger; NAYLOR, Alan; FALLON, Philip, Spencer; CROSBY, Stuart; HOPKINS, Anna; GUETZOYAN, Lucie, Juliette; MACNAIR, Alistair, James; STEWART, Mark, Richard; WINFIELD, Natalie, Louise; (273 pag.)WO2019/186164; (2019); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Reference of 393-37-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 393-37-3, name is 5-Bromo-2-fluorobenzotrifluoride, This compound has unique chemical properties. The synthetic route is as follows.

DESCRIPTION FOR D414-bromo-1-[(1-methylethyl)oxy]-2-(trifluoromethyl)benzene (D41)To a solution of 2-propanol (1.997 mL) in dry tetrahydrofuran (THF) (50 mL) under nitrogen was added potassium tert-butoxide (3.49 g). The reaction mixture was heated to 50 C. for 10 min, then 4-bromo-1-fluoro-2-(trifluoromethyl)benzene (D40) (6.3 g) was added. The resulting mixture was stirred at 50 C. overnight. After cooling the reaction, the solvent was removed in vacuo, the residue was diluted with ethyl acetate (100 mL), washed with water, the organic phase was dried over sodium sulphate, concentrated and the residue was purified by column chromatography to give 4-bromo-1-[(1-methylethyl)oxy]-2-(trifluoromethyl)benzene (D41) (5.21 g) as a clear oil. deltaH (CDCl3, 600 MHz): 1.36 (6H, d), 4.60 (1H, m), 6.88 (1H, d), 7.55 (1H, dd), 7.66 (1H, d).

The chemical industry reduces the impact on the environment during synthesis 5-Bromo-2-fluorobenzotrifluoride. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Glaxo Group Limited; US2011/269738; (2011); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Electric Literature of 7745-91-7,Some common heterocyclic compound, 7745-91-7, name is 3-Bromo-4-methylaniline, molecular formula is C7H8BrN, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: The substituted amines (2mmol) and triethylamine were taken in THF (20mL) and anhydrous potassium carbonate was added (600mg) to it. A solution of 3 (2mmol), in THF (10mL) was added drop wise with stirring for 30min. The reaction mixture was refluxed for 10h. After completion of the reaction (TLC), the reaction mixture was then desolventized in rotavapor and the compound is extracted in dichloromethane. The dichloromethane layer was washed with water and dried over anhydrous Na2SO4 and further desolventization in rotary evaporator to get the desired compound. Structure verification data for novel compounds are documented in Supplementary File.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Bromo-4-methylaniline, its application will become more common.

Reference:
Article; Prashanth; Madaiah; Revanasiddappa; Veeresh; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 110; (2013); p. 324 – 332;,
Bromide – Wikipedia,
bromide – Wiktionary

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 937046-98-5, name is 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine, A new synthetic method of this compound is introduced below., Recommanded Product: 7-Bromopyrrolo[2,1-f][1,2,4]triazin-4-amine

The bromopyrazole (prepared according to WO2009/132135) (0.5 g, 2.4 mmol) was suspended in anhydrous THF (10 mL) under N2(g). The suspension was stirred and TMSCl (0.67 mL, 5.28 mmol) was added. The mixture was stirred for 20 min. at RT and then cooled to -78 C. after which time a solution of n-BuLi (6 mL, 1.6 N in hexanes, 9.6 mmol) was added slowly. The reaction mixture was stirred for 10 min. at -78 C. and then the lactone (1 g, 2.4 mmol) was added via syringe. When the reaction was complete as measured by LCMS, AcOH was added to quench the reaction. The mixture was concentrated under reduced pressure and the residue dissolved in a mixture of CH2Cl2 and H2O (100 mL, 1:1). The organic layer was separated and washed with H2O (50 mL). The organic layer was then dried over anhydrous MgSO4, filtered and concentrated under reduced pressure. The residue was subjected to silica gel chromatography eluting with 0-50% EtOAc in hexanes to provide the product as a 1:1 mixture of anomers (345 mg, 26% yield). LCMS m/z 553 [M+H].

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Gilead Sciences, Inc.; Clarke, Michael O’ Neil Hanrahan; Feng, Joy Yang; Jordan, Robert; Mackman, Richard L.; Ray, Adrian S.; Siegel, Dustin; (116 pag.)US2017/71964; (2017); A1;,
Bromide – Wikipedia,
bromide – Wiktionary

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 24358-62-1, name is 1-(4-Bromophenyl)ethylamine, This compound has unique chemical properties. The synthetic route is as follows., name: 1-(4-Bromophenyl)ethylamine

EXAMPLE 141 N-[1-(4-bromophenyl)ethyl]-3-(biphenyl-2-carbonylamino)-benzoic acid amide Prepared analogously to Example 34 from 3-(biphenyl-2-carbonylamino)-benzoic acid, 1-(4-bromophenyl)ethylamine, TBTU and N-ethyldiisopropylamine in dimethylformamide. C28H23BrN2O2 (499.41) Mass spectrum:(M-H)-=497/499 (bromine isotopes)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 24358-62-1.

Reference:
Patent; Priepke, Henning; Hauel, Norbert; Thomas, Leo; Mark, Michael; Dahmann, Georg; US2002/32238; (2002); A1;,
Bromide – Wikipedia,
bromide – Wiktionary